• Humans
  • MORT (Mortal Obligate RNA Transcript (also known as ZNF667-AS1)) is a long non-coding RNA (lncRNA) of the intergenic type (lincRNA) that is specific to humans and great apes. (wikipedia.org)
  • H19 is a gene for a long noncoding RNA, found in humans and elsewhere. (wikipedia.org)
  • The let-7 RNA was found to be conserved in many species, leading to the suggestion that let-7 RNA and additional "small temporal RNAs" might regulate the timing of development in diverse animals, including humans. (wikipedia.org)
  • Gene
  • IMPDH2 has been identified as an intracellular target of the natural product sanglifehrin A This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. (wikipedia.org)
  • The H19 gene codes for a 2.3 kb RNA product. (wikipedia.org)
  • Germline mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. (wikipedia.org)
  • A microRNA (abbreviated miRNA) is a small non-coding RNA molecule (containing about 22 nucleotides) found in plants, animals and some viruses, that functions in RNA silencing and post-transcriptional regulation of gene expression. (wikipedia.org)
  • isolated the lin-4 gene, they found that instead of producing an mRNA encoding a protein, it produced short non-coding RNAs, one of which was a ~22-nucleotide RNA that contained sequences partially complementary to multiple sequences in the 3' UTR of the lin-14 mRNA. (wikipedia.org)
  • Mutation
  • In this study we analyzed a series of 33 BRCA1, 22 BRCA2, and 128 sporadic tumors by RNA profiling to investigate the classification potential of RNA profiles to predict BRCA1/2 mutation status. (forskningsdatabasen.dk)
  • We found that breast tumors from BRCA1 and BRCA2 mutation carriers display characteristic RNA expression patterns, allowing them to be distinguished from sporadic tumors. (forskningsdatabasen.dk)
  • Although additional validation studies are required, indication of BRCA1/2 involvement ('BRCAness') by RNA profiling could potentially be valuable as a tool for distinguishing pathogenic mutations from benign variants, for identification of undetected mutation carriers, and for selecting patients sensitive to new therapeutics such as PARP inhibitors. (forskningsdatabasen.dk)
  • synthesis
  • It works by inhibiting the synthesis of RNA and DNA of carcinoma cells. (wikipedia.org)
  • It is a competitive inhibitor of cell-free RNA and DNA synthesis, and blocks the action of DNase I. Anthramycin-methyl-ether (AME) forms a complex with DNA which blocks off synthesis by prohibiting DNA binding with proper enzymes. (wikipedia.org)
  • It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. (wikipedia.org)
  • Chlorambucil alkylates and cross-links DNA during all phases of the cell cycle, inducing DNA damage via three different methods of covalent adduct generation with double-helical DNA: Attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA. (wikipedia.org)
  • miRNAs
  • Micro-RNAs (miRNAs) belong to a class of small non-coding messenger RNA species that have emerged as potent regulators of a variety of biological processes including oncogenesis. (bmj.com)
  • Estimates of the average number of unique messenger RNAs that are targets for repression by a typical miRNA vary, depending on the estimation method, but multiple approaches show that mammalian miRNAs can have many unique targets. (wikipedia.org)
  • microRNA
  • Together with translin-associated factor X, translin forms the component 3 of promoter of RISC (C3PO) complex which facilitates endonucleolytic cleavage of the passenger strand during microRNA loading into the RNA-induced silencing complex (RISC). (wikipedia.org)
  • expression
  • MORT has orthologs only in great apes - chimpanzees, gorillas and orangutans, and the RNA expression data indicates that the MORT transcript is expressed in these species. (wikipedia.org)
  • Using data from human cancers curated in TCGA, MORT RNA expression and DNA methylation state were evaluated in the 10 most common male cancers and the 10 most common female cancers (totalling 17 different cancer types based on TCGA classification). (wikipedia.org)
  • The many RNAs of this class resembled the lin-4 and let-7 RNAs, except their expression patterns were usually inconsistent with a role in regulating the timing of development. (wikipedia.org)
  • amino
  • Folic acid is essential for the body to make DNA, RNA, and metabolise amino acids which are required for cell division. (wikipedia.org)
  • species
  • Likewise, experiments show that a single miRNA species can reduce the stability of hundreds of unique messenger RNAs. (wikipedia.org)
  • found
  • A year later, the lin-4 and let-7 RNAs were found to be part of a large class of small RNAs present in C. elegans, Drosophila and human cells. (wikipedia.org)
  • small
  • Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). (wikipedia.org)
  • At the time, the lin-4 small RNA was thought to be a nematode idiosyncrasy. (wikipedia.org)
  • In 2000, a second small RNA was characterized: let-7 RNA, which represses lin-41 to promote a later developmental transition in C. elegans. (wikipedia.org)
  • class
  • RSV is a class VI enveloped virus with a positive sense RNA genome having a DNA intermediate. (wikipedia.org)
  • long
  • The RNA genome of RSV contains an extremely long 3' UTR that ranges between 5-7 kb in length which would usually direct it toward nonsense mediated decay (NMD) within the eukaryotic host cell. (wikipedia.org)
  • shown
  • This element has been shown to prevent the degradation of the unspliced viral RNA. (wikipedia.org)
  • Anthramycin has been shown particularly effective against sarcomas, lymphomas, and gastrointestinal neoplasms. (wikipedia.org)
  • pattern
  • Currently, a considerable degree of interobserver variability exists in the morphological diagnosis of certain types of thyroid carcinomas especially the follicular pattern neoplasm. (bmj.com)
  • cells
  • suggest that the accumulation of H19 RNA in skeletal muscle cells is solely due to the stabilization of that RNA in the muscle cells during differentiation. (wikipedia.org)