• reduction
  • The authors concluded that regular use of statins was associated with a modest reduction in PD risk. (acc.org)
  • Many countries now routinely vaccinate infants against hepatitis B. In countries with high rates of hepatitis B infection, vaccination of newborns has not only reduced the risk of infection, but has also led to marked reduction in liver cancer. (wikipedia.org)
  • Observed stroke reduction is consistent with the reduction in pulse pressure produced by folate supplementation of 5 mg per day, since hypertension is a key risk factor for stroke. (wikipedia.org)
  • METHODS
  • RESEARCH DESIGN AND METHODS We carried out a prospective cohort study of incident cases of doctor-diagnosed NIDDM in a group of 7,458 nondiabetic men (aged 40-59 years) followed for a mean of 12.8 years (range 11.5-13.0). (diabetesjournals.org)
  • METHODS To examine the association of weight training with risk of T2DM in US men and to assess the influence of combining weight training and aerobic exercise, we performed a prospective cohort study of 32 002 men from the Health Professionals Follow-up Study observed from 1990 to 2008. (biomedsearch.com)
  • Methods: As part of a US nested case-control study, antibody response against the PyV VP1 capsid proteins of BK and JC was measured using multiplex serology on 113 SCC cases and 229 gender, age, and study center-matched controls who had a prior keratinocyte cancer. (aacrjournals.org)
  • factors
  • We sought to identify potentially modifiable risk factors for development and/or progression of carcinoid heart disease. (ahajournals.org)
  • To explore to what extent different lifestyle factors are associated with the risk of pancreatic cancer, data from a large health screening survey in a county in Norway were analyzed. (springer.com)
  • Ji BT, Hatch MC, Chow WH (1996) Anthropometric and reproductive factors and the risk of pancreatic cancer: a case-control study in Shanghai, China. (springer.com)
  • We analysed data from the PROspective Study of Pravastatin in the Elderly at Risk (PROSPER) study of 5804 participants aged 70-82 years with a history of, or risk factors for cardiovascular disease. (sigmaaldrich.com)
  • All associations were independent of respective mean blood pressure levels, age, gender, in-trial treatment group (pravastatin or placebo) and prior vascular disease and cardiovascular disease risk factors. (sigmaaldrich.com)
  • After adjustment for matching and known diabetes risk factors, odds ratios per 1-kilobase increment were 1.00 (95% CI 0.90-1.11) in whites, 0.95 (0.85-1.06) in blacks, 0.96 (0.79-1.17) in Hispanics, and 0.88 (0.70-1.10) in Asians. (diabetesjournals.org)
  • Although leukocyte TL was weakly associated with diabetes risk, this association was not independent of known risk factors. (diabetesjournals.org)
  • However, it remains unclear whether this association is mediated by other one-carbon cofactors and/or inflammatory factors, which may be associated with the risk of colorectal cancer ( 7 - 10 ). (aacrjournals.org)
  • Risk factors for mental illness include genetic inheritance, such as parents having depression, repeating generational patterns, and dispositions like personality. (wikipedia.org)
  • The appropriateness of surgery depends on a patient's particular functional and visual needs and other risk factors, all of which may vary widely. (wikipedia.org)
  • In 1988, in response to a dramatic increase in the number of stress-related worker compensation claims in the U.S., the National Institute for Occupational Safety and Health (NIOSH) added psychological factors to its list of factors "leading occupational health risk" (p. 201). (wikipedia.org)
  • Maslach, Schaufeli and Leiter identified six risk factors for burnout: mismatch in workload, mismatch in control, lack of appropriate awards, loss of a sense of positive connection with others in the workplace, perceived lack of fairness, and conflict between values. (wikipedia.org)
  • alcohol
  • Alcohol increased OPL risk in never-users of tobacco as well as in past or current users. (aacrjournals.org)
  • Alcohol is an independent risk factor for OPL, regardless of beverage type or drinking pattern. (aacrjournals.org)
  • Alcohol has been found to increase the risk of OPL in the presence of tobacco ( 4 , 5 ), but the independent association between alcohol and OPL remains unclear. (aacrjournals.org)
  • A difficulty that all studies of alcohol and OPL must deal with is that the exact mechanism of alcohol in carcinogenesis is uncertain. (aacrjournals.org)
  • Results from a recent case-control study support the theory that alcohol is a promoter rather than an initiator, as it was unrelated to the occurrence of leukoplakia, but doubled the risk of malignant transformation ( 13 ). (aacrjournals.org)
  • Indeed, there is strong evidence that alcohol is an independent risk factor for oral cancer ( 4 , 21 - 27 ). (aacrjournals.org)
  • Conflicting results in case-control studies of alcohol and OPL may be the result of methodologic shortcomings, such as recall bias, insufficient control for tobacco, and selection bias. (aacrjournals.org)
  • Heavy regular binge drinking is associated with adverse effects on neurologic, cardiac, gastrointestinal, hematologic, immune, musculoskeletal organ systems as well as increasing the risk of alcohol induced psychiatric disorders. (wikipedia.org)
  • Excessive alcohol intake is associated with an elevated risk of alcoholic liver disease (ALD), heart failure, some cancers, and accidental injury, and is a leading cause of preventable death in industrialized countries. (wikipedia.org)
  • A logical possibility is that some of the alcohol abstainers in research studies previously drank excessively and had undermined their health, thus explaining their high levels of risk. (wikipedia.org)
  • To test this hypothesis, some studies have excluded all but those who had avoided alcohol for their entire lives. (wikipedia.org)
  • Analyzing 54 prospective studies, the authors found that those studies which were free of the potential error (including former drinkers in the abstaining group) did not demonstrate significant cardiac protection from alcohol, although they continued to exhibit a J-shaped relationship in which moderate drinkers were less likely (but not at a statistically significantly level of confidence) to suffer cardiac disease than lifelong abstainers. (wikipedia.org)
  • Dr. Arthur Klatsky noted that the flaw pointed out by Fillmore existed in one of his early studies of alcohol consumption, but that his later studies illustrating a protective effect of moderate alcohol consumption did not contain this flaw. (wikipedia.org)
  • clinical
  • At each visit, study participants are asked in a structured interview for a number of predefined clinical signs that potentially precede the onset of ataxia. (clinicaltrials.gov)
  • However, there are as yet no prospective studies directly examining the predictive role of TL and relevant candidate genes in the development of clinical diabetes. (diabetesjournals.org)
  • We also evaluated whether single nucleotide polymorphisms (SNPs) in nine candidate genes coding for telomere binding proteins and telomerase may explain the individual variability in TL and clinical diabetes risk. (diabetesjournals.org)
  • His work ranging from basic inquiry of the genetic basis for cardiometabolic diseases to molecular epidemiology and clinical risk modeling and interventions has been consistently funded by the National Institute of Health (NIH), the Center for Disease Control and Prevention (CDC), and private foundations including the American Heart Association (AHA) and the Burroughs-Wellcome Fund. (wikipedia.org)
  • Incorporating genotypes and plasma phenotypes into risk prediction, his team was the first to show conclusively the causal role of SHBG in diabetes pathogenesis and validate its clinical utilities in diverse human populations, opening a new path for early detection and risk management of the disease. (wikipedia.org)
  • The proposed efficacy of various megavitamin therapies to reduce cancer risk has been contradicted by results of one clinical trial. (wikipedia.org)
  • significantly
  • Risk of cancer of the pancreas, endometrium, urinary tract, and of malignant melanoma was statistically significantly associated with high fasting glucose with RRs of 2.49 (1.23-5.45) ( P trend = 0.006), 1.86 (1.09-3.31) ( P trend = 0.02), 1.69 (0.95-3.16) ( P trend = 0.049), and 2.16 (1.14-4.35) ( P trend = 0.01), respectively. (diabetesjournals.org)
  • Of the 80 single nucleotide polymorphisms (SNPs) in nine genes involved in telomere regulation, 14 SNPs were predictive of TL, but none were significantly associated with diabetes risk. (diabetesjournals.org)
  • As defined by experts with a biomedical background, a mental disorder is "a clinically significant behavioral or psychological syndrome or psychological pattern that occurs in an individual and that is associated with present disability or with a significantly increased risk of suffering, death, pain, disability, or an important loss of freedom. (wikipedia.org)
  • disorders
  • We therefore propose to perform a prospective observational study of individuals at risk for the most common SCA disorders, SCA1, SCA2, SCA3 and SCA6 (RISCA). (clinicaltrials.gov)
  • Many of the symptoms associated with PCS are common or may be exacerbated by other disorders, so there is considerable risk of misdiagnosis. (wikipedia.org)
  • In February 2013 a study found common genetic links between five major psychiatric disorders: autism, ADHD, bipolar disorder, major depressive disorder, and schizophrenia. (wikipedia.org)
  • Studies have indicated[citation needed] that variation in genes can play an important role in the development of mental disorders, although the reliable identification of connections between specific genes and specific categories of disorder has proven more difficult. (wikipedia.org)
  • Traumatic brain injury may increase the risk of developing certain mental disorders. (wikipedia.org)
  • The specific risks and pathways to particular disorders are less clear, however. (wikipedia.org)
  • found
  • Compared with never smokers, we found a two-fold increased risk among current smokers, and a dose-response association with number of cigarettes ( p for trend = 0.02 for both men and women) and with number of pack-years ( p for trend = 0.02 for men and 0.01 for women). (springer.com)
  • Moreover, we found that the risk of former smokers may approach the risk of never smokers within a few years subsequent to quitting. (springer.com)
  • In 2012, researchers at UCLA found that tiny amounts (1 mM, or 0.005%) of ethanol doubled the lifespan of Caenorhabditis elegans, a round worm frequently used in biological studies, that were starved of other nutrients. (wikipedia.org)
  • A 2007 study found that over 137 million people in more than 70 countries are probably affected by arsenic poisoning of drinking water. (wikipedia.org)
  • Taking folic acid over years reduced the risk of cardiovascular disease by 4%, where another study found it did not affect cardiovascular disease, even while reducing homocysteine levels. (wikipedia.org)
  • The view that burnout is a form of depression has found support in several recent studies. (wikipedia.org)
  • One study found 3% awake time in the first ninety-minute sleep cycle, 8% in the second, 10% in the third, 12% in the fourth, and 13-14% in the fifth. (wikipedia.org)
  • lower risk
  • Engaging in weight training or aerobic exercise for at least 150 minutes per week was independently associated with a lower risk of T2DM of 34% (95% CI, 7%-54%) and 52% (95% CI, 45%-58%), respectively. (biomedsearch.com)
  • The current study reports an association between regular use of statins and lower risk of developing PD. (acc.org)
  • Vitamin B 6 may lower risk of colorectal cancer by preventing aberrations in one-carbon metabolism or by anti-inflammatory effects. (aacrjournals.org)
  • A lower risk of colorectal cancer associated with higher intake of vitamin B 6 has been summarized in a recent review of three cohort and six case-control studies ( 4 ). (aacrjournals.org)
  • The observation of a lower risk of cardiovascular disease (CVD) in France despite a diet rich in saturated fat was labeled the French Paradox. (wikipedia.org)
  • Likewise a meta-analysis of folate supplementation during pregnancy reported a 28% lower risk of newborn congenital heart defects. (wikipedia.org)
  • drinkers
  • When BEACH (Bettering the Evaluation of care and health) conducted a study which gathered information of people over the age of 18, it defined binge drinkers as those who consumed six or more standard drinks on one occasion whether that be weekly or monthly. (wikipedia.org)
  • The conclusion remained the same in some studies: moderate drinkers are less likely to suffer heart disease. (wikipedia.org)
  • Relative
  • Relative risk (RR) of cancer for levels of fasting and postload glucose was calculated with the use of Poisson models, with adjustment for age, year of recruitment, fasting time, and smoking status. (diabetesjournals.org)
  • Men in the highest quartile of IGF-I levels had a relative risk of 4.3 (95 percent confidence interval 1.8 to 10.6) compared with men in the lowest quartile. (uni-bonn.de)
  • Relative risks (RRs) and 95% confidence intervals were computed using Cox proportional hazard models adjusting for age, smoking, caffeine intake, duration of hypercholesterolemia, and other covariates. (acc.org)
  • Compared with persons who reported never or infrequently to be physically worn out after a day's work, the relative risk (RR) among those who nearly always became worn out was 2.9 (95% confidence interval (CI) = 1.4-5.8) for men and 3.8 (95% CI = 1.6-9.2) for women. (springer.com)
  • incident
  • Recently, total cancer risk was reported to be modestly increased in women and men with elevated levels of fasting glucose in a very large cohort study of 1.3 million Korean men and women with 53,833 incident cases of cancer ( 3 ). (diabetesjournals.org)
  • Our study included 31,000 men and 32,374 women initially free from any diagnosed cancer, and during 12 years of follow-up, 166 incident cases of pancreatic cancer were diagnosed at the Cancer Registry. (springer.com)
  • Moreover
  • Moreover, a study by Bianchi, Schonfeld, and Laurent (2014) showed that about 90% of workers with full-blown burnout meet diagnostic criteria for depression. (wikipedia.org)
  • moreover, postmordem studies of individuals with Parkinson's disease that were treated with levodopa have also observed similar dorsal striatal ΔFosB overexpression. (wikipedia.org)
  • individuals
  • It is estimated that there are 30,000 individuals in the European Community that directly descend from individuals affected by a SCA disorder and thus carry a 50% risk of having inherited an SCA mutation. (clinicaltrials.gov)
  • The rates of PCS vary, but most studies report that about 15% of individuals with a history of a single concussion develop persistent symptoms associated with the injury. (wikipedia.org)
  • The implications of a permanent hyperinsulinemic stage is the risk of comorbidities related to diabetes observed in subclinical diabetic individuals , including cardiovascular diseases , retinopathy , cancer and dementia Prediabetes Impaired fasting glucose Lima, Luis Mauricio TR (2017). (wikipedia.org)
  • consistent
  • This observed association between statin use and lower PD risk is consistent with the results of in vivo and in vitro experimental studies in models of PD, which suggest that statins could alleviate neuroinflammation and reduce PD risk. (acc.org)
  • evidence
  • Howe GR, Jain M, Burch JD, Miller AB (1991) Cigarette smoking and cancer of the pancreas: evidence from a population-based case-control study in Toronto, Canada. (springer.com)
  • To provide further evidence minimizing residual confounding and reverse causation that could explain the association between TL and diabetes risk, we used a Mendelian randomization analysis using TL-related polymorphisms as instruments ( 14 ). (diabetesjournals.org)
  • levels
  • 2016 High hemoglobin A1c levels within the non-diabetic range are associated with the risk of all cancers. (wikipedia.org)
  • pancreas
  • 1996) Cigarette smoking and pancreas cancer: a case-control study of the search programme of the IARC. (springer.com)
  • baseline
  • Leukocyte TL at baseline was measured using quantitative PCR, and Mendelian randomization analysis was conducted to test whether TL is causally associated with diabetes risk. (diabetesjournals.org)
  • stroke
  • Long term supplementation is also associated with small reductions in the risk of stroke and cardiovascular disease. (wikipedia.org)
  • Long-term supplementation with folic acid reduced the risk of stroke by 10%, which may be due to the role folate plays in regulating homocysteine concentration. (wikipedia.org)
  • Physicians
  • the active form of vitamin B 6 ) and risk of colorectal cancer in a nested case-control study within the Physicians' Health Study. (aacrjournals.org)
  • The Physicians' Health Study was a randomized, double-blind, placebo-controlled trial of aspirin and β-carotene among 22,071 U.S. male physicians ages 40 to 84 years in 1982, without a history of heart disease, cancer, or major chronic diseases ( 13 ). (aacrjournals.org)
  • participants
  • It is planned to enroll 480 study participants and to follow them at regular intervals over six years. (clinicaltrials.gov)
  • Study participants will further perform the SCA Functional Composite (SCA-FC) which is a comprehensive measure of functional capacity based on results in quantitative tests related to gait (8m timed walk), speech (PATA rate) and hand function (9 hole pegboard). (clinicaltrials.gov)
  • In a subset of study participants, we will record eye movements and obtain volumetric MRIs. (clinicaltrials.gov)
  • high-risk
  • A history of PyV infection may be involved in the occurrence of SCC in a population at high risk for this malignancy. (aacrjournals.org)
  • Blood testing to verify that the vaccine has worked is recommended in those at high risk. (wikipedia.org)
  • results
  • Here, we report the results from a prospective study in northern Sweden, with the aim to estimate the relationship of hyperglycemia, as measured by fasting and postload glucose, with the risk of cancer overall and the risk of cancer at specific organ sites. (diabetesjournals.org)
  • Study record managers: refer to the Data Element Definitions if submitting registration or results information. (clinicaltrials.gov)
  • Given that the results were only marginally significant and could be due to chance, additional prospective studies are needed to explore the potential effects of different subtypes of statins on risk of PD and other neurodegenerative diseases. (acc.org)
  • increase the risk
  • Therefore, deficiency of vitamin B 6 may increase the risk of cancer through aberrations in DNA methylation, imbalance in DNA precursors, and disruption in DNA repair ( 1 ). (aacrjournals.org)