OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth CareGeographicals
gamma-GlutamyltransferaseHydroxylaminesAnellovirusBelizeMediterranean SeaRanavirusPhocaBottle-Nosed DolphinDNA Virus InfectionsGlutamate-Ammonia LigaseAcyltransferasesAnthozoaPoriferaMortalityFat Emulsions, IntravenousSoybean OilEmulsionsFatty Acids, NonesterifiedLipoprotein-XPropofolHealth Personnel
MorbidityPredictorsGlutamyl transferaseComplicationsFactorsTransferasePatientsIncidenceIndependent risk for cardiovascularCoronaryMetabolicAdverseAlkalinePrematureMajor cardiovascular eventsSurvivalElderlyMyocardialSuggestsASCVDStratificationRatioSevereLiverDiabetesFindingsModeratelyTissuesHigherSignificantlyAssociated with an increased riskProgressionConventionalChronicInfectionsRate
Morbidity8
  • Severe alcoholic hepatitis is implicated as a costly, worldwide public health issue with high morbidity and mortality. (wjgnet.com)
  • Coronary artery diseases (CAD) have become a serious epidemic reason of morbidity and mortality. (springeropen.com)
  • Liver transplantation (LT) is an important treatment option for HPS, but it has high mortality and morbidity. (transpopmed.org)
  • However, the risk of developing severe complications, mortality and morbidity after LT remains high, especially in severe HPS. (transpopmed.org)
  • Despite beneficial effects of current glucose-lowering treatments, disease-related morbidity and mortality remain considerable in T2DM patients, galvanising the search for innovative medications that target the multiple metabolic abnormalities as well as inflammatory processes and other pathways predisposing to diabetes-associated disorders. (ddw-online.com)
  • Hepatocellular carcinoma (HCC) one of the most common digestive system tumors, threatens the tens of thousands of people with high morbidity and mortality world widely. (biomedcentral.com)
  • Osteoporosis has become a leading cause of morbidity and mortality worldwide and is an ever-increasing drain on healthcare resources. (biomedcentral.com)
  • Often, diagnostic tests or procedures are used as predictors of surgical risk or morbidity and mortality rates because, in some cases, the risk may outweigh the benefit. (basicmedicalkey.com)
Predictors5
  • In the univariate Cox regression analysis, the neutrophil‑to‑lymphocyte ratio and haematological malignancy were identified as predictors of progression to severe disease, and albumin levels, the C‑reactive protein‑to‑albumin ratio (CAR) and haematological malignancy were identified as predictors of 28‑day mortality. (spandidos-publications.com)
  • This study aimed to assess the risk and predictors of HCC in Korean patients with alcoholic cirrhosis by using competing risk analysis. (nature.com)
  • Age, alpha-fetoprotein level, and albumin level were identified as independent predictors of HCC and incorporated in the ALICE score, which discriminated low, intermediate, and high risk for HCC in alcoholic cirrhosis at the cut-off of 60 and 100. (nature.com)
  • In this study, we sought to perform a competing-risk analysis for predicting the risk and predictors of HCC in alcoholic cirrhosis patients in Korea. (nature.com)
  • The main predictors of mortality were cardiogenic shock, stroke, and advanced cancer. (jgc301.com)
Glutamyl transferase3
  • Gamma glutamyl transferase (GGT) was significantly higher in repeat donors (70.5 ± 13.5 μl) than the first time donors (62.5 ± 13.3 μl) (P (scirp.org)
  • Serum total bilirubin, gamma-glutamyl transferase, alkaline phosphatase, ALT and AST should be closely monitored during treatment if elevated values are observed. (pillintrip.com)
  • Gamma glutamyl transferase (GGT) is an enzyme found in cell membranes of many tissues mainly in the liver, kidney, and pancreas. (medscape.com)
Complications6
  • OBJECTIVE: To evaluate the association of atherosclerotic cardiovascular disease (ASCVD) risk factors with incident ASCVD events among type 2 diabetes (T2D) individuals with microvascular complications. (bvsalud.org)
  • Multivariable-adjusted Cox proportional hazards models were used to study the association between ASCVD risk factors with adjudicated incident ASCVD in T2D participants with only microvascular complications. (bvsalud.org)
  • After multivariable-adjustment, high-density lipoprotein cholesterol (HDL-C) level was linearly associated with a decreased risk of incident ASCVD [hazard ratio (HR): 0.49, 95% Confidence interval (CI): 0.32-0.75, Plinear = 0.011] and each 10 nmol/L increase of lipoprotein(a) [Lp(a)] level (HR: 1.02, 95% CI: 1.00-1.04, Plinear = 0.012) was linearly associated with an increased risk of incident ASCVD in T2D participants with only microvascular complications. (bvsalud.org)
  • CONCLUSION: HDL-C levels and Lp(a) levels (per 10 nmol/L) showed an independent linear relation with ASCVD risk among T2D individuals with only microvascular complications at long-term follow-up. (bvsalud.org)
  • The role of potential risk factors (e.g. liver function, platelets count, number of rubber bands placed, etc.) for PRB has not yet been entirely clarified, but a better understanding of these factors could help to avoid such complications. (springer.com)
  • Prospective studies in T2DM have shown an association between the degree of hyperglycemia and the risk of micro- and macrovascular complications, including fatal CVD events. (ddw-online.com)
Factors22
  • We assessed prospectively whether NAFLD predicts future cardiovascular disease (CVD) events among type 2 diabetic individuals, independent of metabolic syndrome features and other classical risk factors. (diabetesjournals.org)
  • This relationship is independent of classical risk factors and is only partly explained by occurrence of metabolic syndrome. (diabetesjournals.org)
  • A great deal of evidence suggests that the metabolic syndrome predicts incident cardiovascular disease (CVD) ( 5 - 8 ), so it is possible to hypothesize that NAFLD patients might portend a greater CVD risk and that NAFLD itself might confer a CVD risk above that associated with individual metabolic syndrome risk factors. (diabetesjournals.org)
  • Risk factors for coronary artery disease (CAD) were not formally established until the initial findings of the Framingham Heart Study in the early 1960s. (medscape.com)
  • The understanding of such factors is critical to the prevention of cardiovascular morbidities and mortality. (medscape.com)
  • Many risk factors are modifiable and account for the majority of the population's attributable risk for myocardial infarction (MI). (medscape.com)
  • The expanding risk factors are included in this review following but are by no means exhaustive of all the current attributing factors. (medscape.com)
  • Traditional versus nontraditional risk factors for coronary artery disease (CAD). (medscape.com)
  • The expanding list of nontraditional biomarkers is outweighed by the standard risk factors for predicting future cardiovascular events and adds only moderately to standard risk factors. (medscape.com)
  • A. Gebre-Yohannes, S. I. Rehelbeck, "Coronary Heart Disease Risk Factors among Blood Donors in North West Ethiopia," East African Medical Journal, Vol. 75, No. 9, 1998, pp. 495-500. (scirp.org)
  • A restricted cubic spline approach was employed to evaluate potential nonlinear associations between ASCVD risk factors and ASCVD. (bvsalud.org)
  • Current management approaches for patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are based on the clinical course, the patient's risk factors and the availability of the agents ( 2 ). (spandidos-publications.com)
  • Identification of individuals with risk factors for the development of severe alcoholic hepatitis may provide insight to the diverse clinical spectrum and prognosis of the disease. (wjgnet.com)
  • The aim of this retrospective multicenter study was to assess potential risk factors for procedure-related bleeding (PRB) within 30 days after first elective/prophylactic EBL in patients with liver cirrhosis and portal hypertension. (springer.com)
  • These factors also comprise the risk profile for CAD. (springeropen.com)
  • As both progression of NAFLD and increasing epicardial adipose tissue (EAT) mass have the same risk factors, therefore these two conditions might be associated with each other [ 6 ]. (springeropen.com)
  • This finding should be considered when prescribing raloxifene for postmenopausal women with a history of stroke or other significant stroke risk factors, such as transient ischemic attack or atrial fibrillation. (pillintrip.com)
  • This altered glucose metabolism state is associated with an increased risk of developing T2DM (Figure 1), although other parameters including excess adiposity, inflammation and dyslipidemia are risk factors associated with the development of insulin resistance, loss of pancreatic function, worsening of hyperglycemia and progression to diabetes (1). (ddw-online.com)
  • Therefore, other independent risk factors may exist that contribute significantly to CVD risk in these patients. (ddw-online.com)
  • Other risk factors for VOD in patients treated with BESPONSA included ongoing or prior liver disease, prior HSCT, increased age, later salvage lines, and a greater number of BESPONSA treatment cycles. (pfizermedicalinformation.com)
  • Elevated blood pressure, smoking, diabetes and hyperlipidemia still remain the main risk factors for development of the coronary heart disease, while physical inactivity, obesity, poor nutrition and low socio-economic status are considered to be the predisposing factors. (amegroups.org)
  • Kevin J. Cummings, Clarkberg, M., Busche, J. Alexander J. Travis, G.R. Meredith, I. Weisfuse, Casey L. Cazer, G.A. Koretzky and Lorin D. Warnick (2022) Case-control study to identify risk factors for SARS-CoV-2 infection among university students . (cornell.edu)
Transferase1
  • T. Adias, A. Igwilo and Z. Jeremiah, "Repeat Whole Blood Donation Correlates Significantly with Reductions in BMI and Lipid Profiles and Increased Gamma Glutamic Transferase (GGT) Activity among Nigerian Blood Donors," Open Journal of Blood Diseases , Vol. 2 No. 4, 2012, pp. 90-94. (scirp.org)
Patients29
  • Using risk-set sampling, 496 patients (control subjects) among those who remained free of diagnosed CVD during follow-up were randomly selected in a 2:1 ratio, matched for age and sex to the case subjects. (diabetesjournals.org)
  • Increased risk in patients who receive PN for extended periods of time, especially preterm neonates. (drugs.com)
  • Increased risk in patients with renal impairment, including preterm neonates. (drugs.com)
  • Most common adverse drug reactions (≥5%) from clinical trials in pediatric patients were anemia, vomiting, increased gamma-glutamyltransferase, and cholestasis. (drugs.com)
  • This efficacy, together with extended exposure in the largest safety database in NASH, supports a positive benefit:risk for OCA in patients with fibrosis due to NASH," said Dr. Arun Sanyal, Chair, Division of Gastroenterology/Hepatology/Nutrition & Director, Stravitz-Sanyal Liver Institute, VCU Health, Department of Internal Medicine. (biospace.com)
  • REZUROCK has been well tolerated and adverse events have been consistent with those expected in patients with advanced cGVHD receiving corticosteroids and/or other immunosuppressants. (yahoo.com)
  • After proving to be effective in hospitalized patients, its use gained approval in early‑stage disease for symptomatic outpatients who are at a high risk of progression to severe disease. (spandidos-publications.com)
  • In another study, remdesivir was shown to decrease the likelihood of patients requiring high-flow supplementary oxygen and invasive mechanical ventilation, as well as the risk of 14-day mortality, when compared to the placebo ( 8 ). (spandidos-publications.com)
  • The risk of HCC can be stratified by using a combination of readily available clinical parameters (age, AFP level, and albumin level) in patients with alcoholic cirrhosis. (nature.com)
  • In building a HCC prediction model, deaths and liver transplantations should be considered as competing events because many ALD patients experience hepatic decompensations and deaths before HCC is detected. (nature.com)
  • Solifenacin succinate is not recommended for use in patients at high risk of QT prolongation, including patients with a known history of QT prolongation and patients taking medications known to prolong the QT interval. (nih.gov)
  • Bristol Myers Squibb (NYSE: BMY) today announced the Phase 3 CheckMate -77T trial met its primary endpoint of improved event-free survival (EFS) as assessed by Blinded Independent Central Review (BICR) in patients with resectable stage IIA to IIIB non-small cell lung cancer (NSCLC). (santaclara.com)
  • CheckMate -914 is a Phase 3, randomized, double-blind, placebo-controlled trial evaluating Opdivo in combination with Yervoy compared to placebo (Part A), and Opdivo alone compared to placebo (Part B), in patients with localized renal cell carcinoma (RCC) who have undergone surgery to remove part or all of a kidney and who are at moderate to high risk of relapse. (wapakdailynews.com)
  • The risk-benefit balance should be considered in patients at risk of venous thromboembolic events of any aetiology. (pillintrip.com)
  • In addition, in pulmonary AVF, typically in ESLD patients with HPS, the risk of development is very high [ 2 , 4 ]. (transpopmed.org)
  • However, the recent ACCORD and ADVANCE trials in patients with longstanding T2DM have shown that aggressive glucose control in such patients has no clear benefits, or may even increase CVD events (3). (ddw-online.com)
  • DoR, based on a later cutoff date than CR/CRi, was defined for patients who achieved CR/CRi per investigator's assessment as time since first response of CR/CRi per investigator's assessment to the date of a progression-free survival (PFS) event or censoring date if no PFS event was documented. (pfizerpro.com)
  • Neupogen is indicated for the reduction in the duration of neutropenia and the incidence of febrile neutropenia in patients treated with established cytotoxic chemotherapy for malignancy (with the exception of chronic myeloid leukaemia and myelodysplastic syndromes) and for the reduction in the duration of neutropenia in patients undergoing myeloablative therapy followed by bone marrow transplantation considered to be at increased risk of prolonged severe neutropenia. (medicines.org.uk)
  • In patients, children or adults, with severe congenital, cyclic, or idiopathic neutropenia with an absolute neutrophil count (ANC) of ≤ 0.5 × 10 9 /l, and a history of severe or recurrent infections, long term administration of Neupogen is indicated to increase neutrophil counts and to reduce the incidence and duration of infection-related events. (medicines.org.uk)
  • Neupogen is indicated for the treatment of persistent neutropenia (ANC less than or equal to 1.0 × 10 9 /l) in patients with advanced HIV infection, in order to reduce the risk of bacterial infections when other options to manage neutropenia are inappropriate. (medicines.org.uk)
  • Evolving data suggests that, contrary to intuition, liver transplant recipients and patients with autoimmune liver disease on immunosuppression do not have increased mortality. (xiahepublishing.com)
  • Patients who have experienced prior VOD or have serious ongoing hepatic liver disease (e.g., cirrhosis, nodular regenerative hyperplasia, active hepatitis) are at an increased risk for worsening of liver disease, including developing VOD, following treatment with BESPONSA. (pfizermedicalinformation.com)
  • In the INO-VATE ALL trial, a higher post-HSCT non-relapse mortality rate was observed in patients receiving BESPONSA compared to the Investigator's choice of chemotherapy arm, resulting in a higher Day 100 post-HSCT mortality rate. (pfizermedicalinformation.com)
  • However, there are little data on in-hospital mortality in patients with HF ≥ 75 years in Spain. (jgc301.com)
  • CONCLUSIONS In-hospital mortality in patients with HF ≥ 75 years between 2016 and 2019 was 12.7%, higher in males and elderly patients. (jgc301.com)
  • Characteristics and in-hospital mortality of elderly patients with heart failure in Spanish hospitals. (jgc301.com)
  • Identification of biomarkers known to be associated with neurodegeneration in patients with PTSD would shed light on the pathophysiological mechanisms linking these disorders, and would also help in the development of preventive approaches aimed at reducing the risk of neurodegenerative disorders in PTSD. (preprints.org)
  • RÉSUMÉ Tous les patients de sexe masculin soignés en psychiatrie et en médecine générale adressés à deux hôpitaux de Basra (Iraq) de septembre 2000 à avril 200l ont été soumis à un dépistage de l'alcoolisme par le test AUDIT (Alcohol Use Disorder Identification Test). (who.int)
  • We recorded patients' em- ing at levels causing detectable biochemical ployment and economic status (monthly abnormalities is associated with mortality or daily income) and consumption of other that is twice that of the normal population psychoactive drugs. (who.int)
Incidence4
  • A higher Anti-Empirical Dietary Inflammatory Index is associated with a lower risk of 14 individual chronic diseases and a higher incidence of two diseases. (bvsalud.org)
  • Key secondary endpoints include overall survival (OS) and incidence of adverse events (AEs). (wapakdailynews.com)
  • In a study of postmenopausal women with documented coronary heart disease or at increased risk for coronary events, raloxifene did not affect the incidence of myocardial infarction, hospitalized acute coronary syndrome, overall mortality, including overall cardiovascular mortality, or stroke, compared to placebo. (pillintrip.com)
  • The incidence of stroke mortality was 2.2 per 1000 women per year for raloxifene versus 1.5 per 1000 women per year for placebo. (pillintrip.com)
Independent risk for cardiovascular2
  • South Asians appear to have a higher independent risk for cardiovascular disease as well. (medscape.com)
  • NAFLD is recently suggested to be an independent risk for cardiovascular diseases and is also associated with higher cardiovascular mortality [ 4 ]. (springeropen.com)
Coronary3
  • High epicardial adipose tissue thickness may represent a marker of severity of non-alcoholic fatty liver disease as well as an independent predictor of coronary artery disease risk. (springeropen.com)
  • One of the main concerns of the cardiology studies is how to prevent coronary artery disease development and how to estimate the risk of the disease before it becomes clinically symptomatic [ 1 ]. (springeropen.com)
  • Congestive heart failure and chronic coronary artery disease: The level of elevation correlates with the risk of death secondary to cardiovascular disease. (medscape.com)
Metabolic1
  • Regional adiposity has a significant impact on the formation of adverse metabolic and cardiovascular risk profiles. (springeropen.com)
Adverse3
  • Compared to NSBB, EBL is associated with a lower rate of adverse events, however, potential adverse events of EBL could be more severe and life-threatening (e.g. (springer.com)
  • There were no ch-OSA related adverse events observed and biochemical safety parameters remained within the normal range. (biomedcentral.com)
  • A total of five adverse events (1.70%) and one serious adverse event (0.34%) were related to the pathway in target group. (jgc301.com)
Alkaline1
Premature1
  • The aim of the study and the questions in a substantial contribution to the burden of the questionnaire form were fully explained disease and premature mortality [ 2 ]. (who.int)
Major cardiovascular events1
  • The most informative biomarkers for predicting major cardiovascular events were BNP and the urinary albumin-to-creatinine ratio. (medscape.com)
Survival3
  • Surveillance for HCC is recommended for high-risk groups in order to facilitate early detection and improve survival 3 . (nature.com)
  • For competing-risk survival analysis, cause-specific hazards or Fine-Gray model is recommended 12 . (nature.com)
  • The primary endpoint of the trial is event-free survival (EFS). (santaclara.com)
Elderly1
  • COVID-19 is responsible for disproportionately high rates of mortality among the elderly, particularly those with multiple comorbidities ( 9-12 ). (spandidos-publications.com)
Myocardial1
  • T. Pekka and R. Salonen, "Cohort Study of Relationship between Donating Blood and the Risk of Myocardial Infarction," British Medical Journal, Vol. 314, No. 7083, 1997, pp. 793-794. (scirp.org)
Suggests1
  • Recent evidence suggests that PTSD may be a risk factor for the development of subsequent neurodegenerative disorders, including Alzheimer's dementia and Parkinson's disease. (preprints.org)
ASCVD1
  • Over a median follow-up of 11.7 years, a total of 1,180 cases of incident ASCVD were documented, of which 1,040 were CHD, 100 were stroke, and 40 were both CHD and stroke events. (bvsalud.org)
Stratification2
  • The AHA/ACC and US Preventive Services Task Force (USPSTF) use the above as their recommendations for current risk stratification. (medscape.com)
  • These findings suggest that HCC screening for all alcoholic cirrhosis may not be cost-effective, and that further risk stratification is warranted to identify ideal candidates for surveillance in alcoholic cirrhosis. (nature.com)
Ratio1
  • The association of thrombocytopenia, high INR (international normalized ratio) and liver dysfunction with the risk of procedure-related bleeding (PRB) remains debated and recommendations are controversial. (springer.com)
Severe1
  • Severe clinical presentations include acute decompensation and acute-on-chronic liver failure in a patient with chronic liver disease, leading to high mortality. (xiahepublishing.com)
Liver2
  • Subdistribution hazards model of Fine and Gray was used with deaths and liver transplantation treated as competing risks. (nature.com)
  • Hepatocellular carcinoma (HCC), the most common form of primary liver cancer in ALD, is responsible for one-third of ALD-related mortality, and one-third of all HCC-related deaths are attributed to alcohol use globally 2 . (nature.com)
Diabetes2
  • Type 2 diabetics, but also prediabetics, are at increased risk for a wide range of debilitating diseases and diabetes is the leading cause of new cases of kidney failure and blindness and of nontraumatic lower limb amputation. (ddw-online.com)
  • On this retrospective examine of 15,104 sufferers with sort 2 diabetes, members adhering 4 to five low-risk way of life behaviors versus 0 to 1 had a 35% decrease danger of diabetic retinopathy, 57% decrease danger of diabetic kidney illness, 54% decrease danger of diabetic neuropathy, and 46% decrease danger of the composite consequence. (outfitoffice.uk)
Findings1
  • Our findings demonstrate how the local environment directly affects disease risk phenotypes and that genetic variation, including less common variants, can modulate individual's response to environmental challenges. (nature.com)
Moderately1
  • In conclusion, NAFLD is significantly associated with a moderately increased CVD risk among type 2 diabetic individuals. (diabetesjournals.org)
Tissues1
  • When determining the choice of Evista or other therapies, including oestrogens, for an individual postmenopausal woman, consideration should be given to menopausal symptoms, effects on uterine and breast tissues, and cardiovascular risks and benefits. (pillintrip.com)
Higher2
  • BMIs under 20 and over 25 have been associated with higher all-cause mortality, with the risk increasing with distance from the 20-25 range. (wikipedia.org)
  • Higher Alternate Mediterranean Diet score is associated with a lower risk of 32 (all 8 cardiometabolic disorders, 3 out of 10 types of cancers, 7 out of 10 psychological/neurological disorders, 5 out of 6 digestive disorders, and 9 out of 14 other chronic diseases). (bvsalud.org)
Significantly1
  • use of HSCT conditioning regimens containing 2 alkylating agents (e.g., busulfan in combination with other alkylating agents) and last total bilirubin level greater than or equal to the ULN before HSCT are significantly associated with an increased risk of VOD. (pfizermedicalinformation.com)
Associated with an increased risk1
  • Raloxifene is associated with an increased risk for venous thromboembolic events that is similar to the reported risk associated with current use of hormone replacement therapy. (pillintrip.com)
Progression1
  • It is unclear which core events drive the malignant progression of gliomas. (biomedcentral.com)
Conventional1
  • The aforementioned alcohol-related HCC prediction models, however, used conventional cox regression without competing risk analysis. (nature.com)
Chronic3
  • Using the UK Biobank, we examine associations of four individual healthy dietary scores with the risk of 48 individual chronic diseases. (bvsalud.org)
  • Alternate Healthy Eating Index-2010 and Healthful Plant-based Diet Index are inversely associated with the risk of 29 and 23 individual chronic diseases, respectively. (bvsalud.org)
  • Post-traumatic stress disorder (PTSD) is a chronic psychiatric disorder that occurs following exposure to traumatic events. (preprints.org)
Infections1
Rate1
  • The post-HSCT non-relapse mortality rate was 31/79 (39%) and 8/35 (23%) in the BESPONSA arm compared to the Investigator's choice of chemotherapy arm, respectively. (pfizermedicalinformation.com)