AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesDisciplines and OccupationsAnthropology, Education, Sociology and Social PhenomenaHumanitiesInformation ScienceHealth Care
Arthritis, RheumatoidArthritisArthritis, ExperimentalArthritis, InfectiousArthritis, JuvenileArthritis, PsoriaticArthritis, ReactiveSynovial MembraneJointsSynovial FluidArthritis, GoutyRheumatoid FactorMice, Inbred DBASynovitisOsteoarthritisCollagen Type IIMethotrexateSeverity of Illness IndexRats, Inbred LewAutoantibodiesBlood SedimentationInjections, Intra-ArticularTumor Necrosis Factor-alphaRheumatic DiseasesImmunoglobulin GArthrographyRheumatologyKnee JointMetacarpophalangeal JointSpondylitis, AnkylosingSulfasalazinePeptides, CyclicAutoimmune DiseasesAntibodies, MonoclonalGold Sodium ThiomalateWrist JointRheumatoid NoduleCollagenHLA-DRB1 ChainsFinger JointDisease Models, AnimalTreatment OutcomeTarsal JointsLyme DiseaseReceptors, Tumor Necrosis FactorHLA-DR4 AntigenAnti-Inflammatory AgentsJoint DiseasesHLA-DR AntigensCitrullineCytokinesSpondylarthropathiesFoot JointsPsoriasisCartilage, ArticularAnkle JointInflammationT-LymphocytesInterleukin-17EdemaFreund's AdjuvantTarsus, AnimalEnzyme-Linked Immunosorbent AssayTenosynovitisHLA-B27 AntigenBiological MarkersOrganogold CompoundsDrug Therapy, CombinationHand JointsGlucose-6-Phosphate IsomeraseDisability EvaluationPainLupus Erythematosus, SystemicCells, CulturedInterleukin-6Chronic DiseaseInterleukin-1Genetic Predisposition to DiseaseInterleukin 1 Receptor Antagonist ProteinCartilageNational Institute of Arthritis and Musculoskeletal and Skin Diseases (U.S.)Time FactorsMice, Inbred C57BLCase-Control StudiesIsoxazolesAutoantigensPrednisolonePenicillamineBorrelia burgdorferiImmunoglobulin MHindlimbYersinia InfectionsArthralgiaSpondylarthritisAutoimmunityPain MeasurementToe JointFollow-Up StudiesFibroblastsOsteoclasts
PatientsRheumatologyPsoriatic arthritisInflammationChronicCause of rheumatoid arthritis is not2022Women with rheumatoid arthritisAbstractOsteoarthritis and rheumatoidSymptoms of rheumatoidDiagnosis of rheumatoidFactor2018SpondyloarthritisACPAJointsGoutObservationalRheumatismAutoimmune diseasesDiseaseTuberculosisMiddle AgedAffectsSTAtinsFractureAdverseSignificantlyDevelopsComplications2017MedscapeDiseasesOpioidsSynovitisPathogenesisResearchersConclusionAssociated with decreasedTofacitinibStudySystemic sclerosisTreatmentSusceptibilityProgressionChanges during prLung
Patients72
  • The 24,445 women and 28,364 men who had neither arthritis nor a history of it at the start of the study were followed until the end of 1989 using record linkage with the Institution's population register to identify patients entitled to free antirheumatic medication. (nih.gov)
  • This study was undertaken to investigate which patients are at highest risk, and whether antirheumatic treatment is hazardous or protective. (nih.gov)
  • Risk of lymphoma is substantially increased in a subset of patients with RA, those with very severe disease. (nih.gov)
  • Objectives - Patients with rheumatoid arthritis (RA) are at increased risk of tuberculosis (TB). (ices.on.ca)
  • Little is known regarding the risk of nontuberculous mycobacterial (NTM) disease in these patients. (ices.on.ca)
  • NTM disease is associated with an increased risk of death in RA patients. (ices.on.ca)
  • By how much is the risk of cardiovascular disease increased in patients with rheumatoid arthritis compared to the general population? (consultantlive.com)
  • Roughly 12% of patients, or more than 9,700 patients, were diagnosed with an autoimmune disease, those included rheumatoid arthritis, lupus, inflammatory bowel disease like ulcerative colitis, and connective tissue diseases like osteoarthritis and multiple sclerosis. (aboutlawsuits.com)
  • Increasing evidence indicates that the risk of acquiring tuberculosis (TB) and nontuberculous mycobacterial disease is elevated among patients with rheumatoid arthritis (RA). (cdc.gov)
  • The risk for development of TB or nontuberculous mycobacterial disease was 2.28-fold and 6.24-fold higher among RA patients than among the general population, respectively. (cdc.gov)
  • Among RA patients, risk for development of mycobacterial disease was higher among those who were older, male, or both. (cdc.gov)
  • Furthermore, among RA patients with mycobacterial infections, the risk for death was increased. (cdc.gov)
  • Therefore, RA patients, especially those with other risk factors, should be closely monitored for development of mycobacterial disease. (cdc.gov)
  • Among RA patients, the risks of acquiring or dying of an infectious disease are increased, possibly because of disease-related immune dysfunction or the immunosuppressive effects of therapeutic agents ( 11 ). (cdc.gov)
  • In Europe and the United States, an increased risk for TB among RA patients has been reported ( 12 ), and the risk for active TB is even higher among those receiving anti-tumor necrosis factor α (TNF-α) therapy ( 13 ). (cdc.gov)
  • In addition, prevalence of concurrent medical conditions is higher among RA patients ( 17 , 18 ), which may affect their risk for TB ( 19 ). (cdc.gov)
  • Investigators identified both facilitators and barriers for trial participation in patients at risk for rheumatoid arthritis (RA) in order to enhance inclusion in trials designed to prevent RA. (hcplive.com)
  • 1 Results emphasize education about RA, trial medication, debunking misconceptions, listening to patients' concerns, addressing personal risk, limiting study burden, and encouraging physicians to mention trial participation and trial aim. (hcplive.com)
  • Unfortunately, preventative trial participation for at-risk patients have historically severe recruitment difficulties, sometimes needing up to 5 years to achieve their aims. (hcplive.com)
  • Conclusion Use of opioids, SSRIs and glucocorticoids were associated with increased risk of any fracture in patients with RA, whereas statins and TNFi were associated with decreased vertebral fractures. (bmj.com)
  • Are patients with rheumatoid arthritis still at an increased risk of tuberculosis and what is the role of biological treatments? (bmj.com)
  • Objective To estimate the risk of tuberculosis (TB) in patients with rheumatoid arthritis (RA) both with and without exposure to biological therapy and to directly compare the risks between therapies. (bmj.com)
  • Conclusions In the past decade, the risk of TB has decreased among biological-exposed RA patients but remains higher than in biological-naïve RA patients. (bmj.com)
  • Most cases of TB in RA occur in biological-naïve RA patients, underscoring the elevated risk also in these patients. (bmj.com)
  • Background: Risk of fragility fractures in patients with rheumatoid arthritis (RA) is increased. (lu.se)
  • Patients with rheumatoid arthritis (RA) and spondyloarthritis (SpA) experience several nutritional challenges and are prone to develop malnutrition. (uib.no)
  • Calvin J. Brown, MD, a rheumatologist at Northwestern Memorial Hospital in Chicago, told MedPage Today that RA patients are at higher risk for bone thinning because the inflammation associated with the disease produces chemical messengers, called cytokines, that can interfere with the formation of new bone cells. (creakyjoints.org)
  • CreakyJoints is a digital community for millions of arthritis patients and caregivers worldwide who seek education, support, advocacy, and patient-centered research. (creakyjoints.org)
  • Recently, a study also found that MD could reduce pain and increase physical function of patients with RA [ 13 ], implicating that there might be a combined effect of RA and MD on the risk of CVD. (biomedcentral.com)
  • We believe that the research would be useful reference for reducing the risk of CVD in patients with RA. (biomedcentral.com)
  • BACKGROUND: Patients with rheumatoid arthritis (RA) commonly use oral glucocorticoids (GCs) and proton pump inhibitors (PPIs), both associated with osteoporotic fractures. (maastrichtuniversity.nl)
  • We investigated the association between concomitant use of oral GCs and PPIs and the risk of osteoporotic fractures among patients with RA. (maastrichtuniversity.nl)
  • We investigated the association between concomitant use of oral GCs and PPIs and the risk of osteoporotic fractures among patients with RA.METHODS: This was a cohort study including patients with RA aged 50+ years from the Clinical Practice Research Datalink between 1997 and 2017. (maastrichtuniversity.nl)
  • The risk of incident osteoporotic fractures (including hip, vertebrae, humerus, forearm, pelvis and ribs) was estimated by time-dependent Cox proportional-hazards models, statistically adjusted for lifestyle parameters, comorbidities and comedications.RESULTS: Among 12 351 patients with RA (mean age of 68 years, 69% women), 1411 osteoporotic fractures occurred. (maastrichtuniversity.nl)
  • Lifestyle interventions which combine different non-pharmacological therapies have shown synergizing effects in improving outcomes in patients with other chronic diseases or increased risk thereof, especially cardiovascular disease. (biomedcentral.com)
  • The objective is to study the effect of this program on disease activity in patients with RA (randomized controlled trial [RCT] 1), on a risk score for developing RA in patients with anti-citrullinated protein antibody (ACPA) positive arthralgia (RCT 2) and on pain, stiffness, and function in patients with MSOA (RCT 3), all in comparison with usual care. (biomedcentral.com)
  • We designed three 16-week observer-blind RCTs with a waiting-list control group for patients with RA with low to moderate disease activity (2.6 ≤ Disease Activity Score [DAS28] ≤ 5.1, RCT 1, n = 80), for patients at risk for RA, defined by ACPA-positive arthralgia (RCT 2, n = 16) and for patients with metabolic syndrome and OA in the knee and/or hip (RCT 3, n = 80). (biomedcentral.com)
  • Primary outcomes are: difference in mean change between intervention and control groups within 16 weeks for the DAS28 in RA patients (RCT 1), the RA-risk score for ACPA positive arthralgia patients (RCT 2), and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) score for MSOA patients (RCT 3). (biomedcentral.com)
  • For both RA patients and patients at increased risk for RA, the heart rate is controlled increasingly by the sympathetic nervous system in contrast to the parasympathetic nervous system. (biomedcentral.com)
  • Here we use mass cytometry to analyse activated T cells in joint tissue from patients with rheumatoid arthritis, a chronic immune-mediated arthritis that affects up to 1% of the population 2 . (nature.com)
  • This approach revealed a markedly expanded population of PD-1 hi CXCR5 − CD4 + T cells in synovium of patients with rheumatoid arthritis. (nature.com)
  • C gene polymorphism confers an increased risk for subclinical atherosclerosis and CV events in patients with RA. (biomedcentral.com)
  • Patients with rheumatoid arthritis (RA) have increased risk of cardiovascular (CV) disease due to accelerated atherosclerosis [ 1 ]. (biomedcentral.com)
  • However, of these shared risk factors, only older age, cigarette smoking, and occupational exposures have been specifically investigated as risk factors for airway disease among patients with RA. (nih.gov)
  • Patients' Perceptions of Their Relatives' Risk of Developing Rheumatoid Arthritis and of the Potential for Risk Communication, Prediction, and Modulation. (ox.ac.uk)
  • OBJECTIVE: To understand the perspectives of patients with rheumatoid arthritis (RA) about the risk of their relatives developing RA in the future, and about communicating with their relatives concerning risk and its modulation. (ox.ac.uk)
  • Exome sequencings were conducted using 59 patients having rheumatoid arthritis (RA) and 93 controls. (nature.com)
  • This could be as high as one in three patients who have rheumatoid arthritis or fibromyalgia, the authors said. (yahoo.com)
  • The authors of the study concluded that taking the birth control pill for more than seven years was associated with a lower risk of developing RA, regardless of whether or not those patients had positive RA antibodies. (gearsofbiz.com)
  • To compare infectious risk between JAK inhibitors (JAKis) versus TNF inhibitors (TNFis) among rheumatoid arthritis (RA) patients in Korea. (biomedcentral.com)
  • This population-based cohort study on RA patients treated with JAKi or TNFi in Korea showed an exceptionally high IR of HZ in both treatment groups compared to that from Western countries, with an approximately doubled risk associated with JAKi versus TNFi use. (biomedcentral.com)
  • Overall, there is a twofold risk of serious infections among RA patients compared to the non-RA population [ 7 ]. (biomedcentral.com)
  • To meet this end, we compared the risk of HZ, serious bacterial infections (SBI), and opportunistic infections (OI) among RA patients treated with JAKis versus TNFis using the nationally representative Korea National Health Insurance Service (KNHIS) database. (biomedcentral.com)
  • Clinical Characteristics of the 119 Patients With Rheumatoid Arthritis of the HGUCR. (reumatologiaclinica.org)
  • We studied the presence of subclinical atherosclerosis in low-risk patients. (reumatologiaclinica.org)
  • Of the total of 119 RA patients, 73.1% had traditional risk factors. (reumatologiaclinica.org)
  • An overview for rheumatologists on the management of cancer risk in patients with rheumatoid arthritis. (rheumatologyadvisor.com)
  • 1 For patients with rheumatoid arthritis (RA), this risk may be increased due to the shared etiology between cancer and RA and the immunomodulatory nature of agents commonly used in RA treatment. (rheumatologyadvisor.com)
  • Patients with RA were at highest risk for lymphoma and lung cancer. (rheumatologyadvisor.com)
  • There was no consistent trend in the risk for other cancers such as melanoma, prostate cancer, and cervical cancer in patients with RA. (rheumatologyadvisor.com)
  • For breast and colorectal cancers, there was a decreased risk among patients with RA compared with the general population. (rheumatologyadvisor.com)
  • 4 However, studies have shown increased risk for nonmelanoma skin cancer in patients receiving biologic DMARDs (bDMARDs), specifically tumor necrosis factor inhibitors (TNFi). (rheumatologyadvisor.com)
  • 4 On the other hand, research evaluating RA and cancer risk often include patients receiving treatment with DMARDs, therefore making accurate assessments of the risks difficult. (rheumatologyadvisor.com)
  • Limited data that are available show that patients with RA who have received treatment with bDMARDs (both TNFi and non-TNFi) had a numerical, but nonsignificant, increase in risk for new or recurrent cancer, particularly nonmelanoma skin cancer. (rheumatologyadvisor.com)
  • COVID-19 vaccinations do yield humoral immunogenicity in patients with rheumatoid arthritis, according to new data presented during the 2022 American College of Rheumatology Convergence Meeting in Philadelphia. (healtharcadia.com)
  • A team, led by Esther Vicente-Rabaneda, Division of Rheumatology, Hospital Universitario de La Princesa, identified the efficacy and safety of the SARS-CoV-2 vaccine in a series of patients with rheumatoid arthritis. (healtharcadia.com)
  • Overall, the study included 118 patients with rheumatoid arthritis, with a mean age of 65.4±11.6 years and a mean evolution of 12.0±9.6 years. (healtharcadia.com)
  • The study, " Efficacy and Safety of the SARS-CoV-2 Vaccine in Patients with Rheumatoid Arthritis, " was published online by ACR . (healtharcadia.com)
  • Over the years, numerous observational studies have associated patients with RA with the increased risk of osteoporosis fracture involving mainly the hip or vertebral. (valuebasedrheumatology.com)
  • The risk of bone fracture in RA patients has not been summarized and little is known whether the risk of fracture is site-specific," Mr Xue and colleagues explained. (valuebasedrheumatology.com)
  • To determine the relationship between RA and bone fracture risk, particularly with regard to sex and site-specific fractures, the investigators conducted a meta-analysis of 13 studies related to bone fractures in patients with RA. (valuebasedrheumatology.com)
  • In patients with early clinical arthritis , pharmacological intervention has the potential to prevent RA development. (bvsalud.org)
Rheumatology1
  • COVID-19 Global Rheumatology Alliance physician registry data highlight need to maintain adequate disease control to lower risk for death from COVID-19. (the-hospitalist.org)
Psoriatic arthritis3
  • Other diseases that may present similarly include systemic lupus erythematosus, psoriatic arthritis, and fibromyalgia among others. (wikipedia.org)
  • The new paper, published in the Annals of the Rheumatic Diseases, examined information on more than 800,000 people registered at GP surgeries across the UK who have a diagnosis of rheumatoid arthritis, psoriatic arthritis, axial spondyloarthritis, systemic lupus erythematosus, osteoarthritis or fibromyalgia. (yahoo.com)
  • Biological agents used for the treatment of psoriatic arthritis (PsA) and rheumatoid arthritis (RA) are associated with serious adverse effects (SAEs). (frontiersin.org)
Inflammation19
Chronic13
  • Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease characterized by persistent symmetric polyarthritis (synovitis) primarily affecting the hands and feet. (medscape.com)
  • Chronic inflammatory conditions such as rheumatoid arthritis (RA) have been associated with malignant lymphomas. (nih.gov)
  • People with chronic pain who were on prescription painkillers were at 49% higher risk of mental illness and 82% higher risk of developing substance abuse. (medicaldaily.com)
  • Chronic exposure to levels above the threshold for human protection was associated with a 10% higher risk of developing immune-mediated diseases. (aboutlawsuits.com)
  • Rheumatoid arthritis (RA), a chronic articular inflammatory disease ( 8 ), affects 0.5%-1.0% of the adult population and is a major cause of disability in industrialized countries ( 9 , 10 ). (cdc.gov)
  • Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints. (everydayhealth.com)
  • Rheumatoid arthritis (RA) is a chronic autoimmune condition in which your immune system mistakes the linings of your joints as foreign and attacks them. (everydayhealth.com)
  • As a next step, the data from the food frequency questionnaire were used to calculate the 2010 Alternate Healthy Eating Index, a high score on which has been associated with reduced risk for a variety of chronic diseases. (medscape.com)
  • Also known as gout or inflammatory arthritis, is an autoimmune and chronic inflammatory disorder. (mountelizabeth.com.sg)
  • Osteoarthritis and rheumatoid arthritis are both chronic joint disorders that cause joint pain. (hdkino.org)
  • Commenting on the study, Deborah Alsina, chief executive of the charity Versus Arthritis, said: "People with arthritis experiencing relentless and excruciating chronic pain are often desperate for pain relief, and it is sometimes appropriate for doctors to prescribe opioids in the short term. (yahoo.com)
  • State the evidence related to effectiveness and potential risk associated with non-opioid treatment for chronic pain. (cdc.gov)
  • Among men, the risk was higher among those with greater BMI (odds ratio {OR}=1.3 {95% confidence interval (CI)=1.1-1.4} for overweight, OR=1.7 {95% CI=1.5-2.0} for obese), and those who were underweight (OR=1.4 {95% CI=1.0-1.8}), could cause chronic weight loss (e.g., infections and neoplasms). (cdc.gov)
Cause of rheumatoid arthritis is not2
20222
  • The risk seems to last at least a year after infection, leading the authors of one large 2022 study to report that virus-induced proteins and activated platelets may contribute to stroke risk. (arthritis.org)
  • 2022). Inhalant and Additional Mucosal-Related Environmental Risks for Rheumatoid Arthritis. (cdc.gov)
Women with rheumatoid arthritis2
  • The risk of heart attack and stroke is increased for women with rheumatoid arthritis and psoriasis, and for men with psoriasis. (theconversation.com)
  • Men and women with rheumatoid arthritis (RA) are at risk for bone fractures, with comparable risks for fractures specific to the vertebral and hip, according to results from a recent meta-analysis by A-Li Xue, BS, Department of Hematology, The Third Affiliated Hospital of Wenzhou Medical University (Ruian People's Hospital), Zhejiang, China, and colleagues (Xue AL, et al. (valuebasedrheumatology.com)
Abstract1
  • ABSTRACT A better understanding of risk factors for neonatal intensive care unit (NICU) admission can inform interventions to improve neonatal survival. (who.int)
Osteoarthritis and rheumatoid1
Symptoms of rheumatoid3
  • Symptoms of rheumatoid arthritis tend to come and go," said the charity online. (express.co.uk)
  • Exercise - alongside standard treatments - may help improve strength and flexibility, and other symptoms of rheumatoid arthritis. (theconversation.com)
  • One recent study evaluated the effectiveness of quercetin, a strong antioxidant with anti-inflammatory properties, in improving the symptoms of rheumatoid arthritis . (naturalnews.com)
Diagnosis of rheumatoid1
  • RA-ILD and airway disease generally can be found in combination in the same patient, a finding that favors the diagnosis of rheumatoid lung disease. (nih.gov)
Factor12
  • Exposure to tobacco smoke, or some factor or cluster of factors associated with smoking, may trigger the production of rheumatoid factors and, in interaction with the male sex, subsequently contribute to the development of clinically manifest RA. (nih.gov)
  • Although no single laboratory test is diagnostic of RA, the presence of both anti-cyclic citrullinated protein antibody (ACPA) and rheumatoid factor (RF) positivity is highly specific for this condition. (medscape.com)
  • Rheumatoid arthritis is known risk factor for cardiovascular disease, but how much do you know about the association? (consultantlive.com)
  • 3× the normal limit or both ACPA and rheumatoid factor (RF), and no medical diagnosis of arthritis were considered. (hcplive.com)
  • RA is a risk factor for death from COVID-19 by using the UK Biobank cohort. (medpagetoday.com)
  • While many studies have investigated asthma as a risk factor for RA [4], less is known about how RA and asthma contribute to clinical outcomes [5]. (nih.gov)
  • Some participants did not consider RA to be hereditable, and few reported smoking as a risk factor. (ox.ac.uk)
  • You have a positive test for rheumatoid factor or anti-CCP antibody. (medlineplus.gov)
  • to your bath water this aids in detoxification, so eliminating toxins that are not to be a causative factor to many areas of ill-health, including arthritis. (selfgrowth.com)
  • Our results show a similar increased risk of fracture in men and women with RA than those without RA, further suggesting that RA is an independent risk factor for fracture. (valuebasedrheumatology.com)
  • To examine the relative importance of these factors, CDC used data from the 1989-1991 National Health Interview Survey (NHIS) and a multivariate model to estimate the independent effect of each factor on self-reported arthritis. (cdc.gov)
  • Diagnosis is based mainly on symptoms but also on blood tests for rheumatoid factor and anti-cyclic citrullinated peptide (anti-CCP) and on x-rays. (msdmanuals.com)
20181
Spondyloarthritis1
  • This is also more common than we initially thought, in rheumatoid arthritis and axial spondyloarthritis. (yahoo.com)
ACPA1
  • The proportional risk elevation for fractures was associated with BMI ≤ 20 kg/m 2 , DAS28 at baseline, 6-month and at 1-year, cumulative DAS28 over the two years, RF, erosion score progression at 2-year, HAQ score and HAQ ≥ 1 at 6-month and 1-year and showed a trend for ACPA positivity. (lu.se)
Joints15
Gout1
Observational7
  • Objective To examine the fracture risk with use of disease-modifying antirheumatic drugs (DMARDs), statins, proton pump inhibitors (PPIs), opioids, non-opioid analgesics and psychotropic medications in a US-wide observational rheumatoid arthritis (RA) cohort. (bmj.com)
  • This observational study aimed to perform a comprehensive nutritional assessment of outpatients diagnosed with RA and SpA, as well as to evaluate methods to identify nutritional risk. (uib.no)
  • In the retrospective, observational study, the investigators examined rheumatoid arthritis, fulfilling the ACR/EULAR 2010 classification criteria, vaccinated against the SARS-CoV-2 virus between December 2020 to October 2021. (healtharcadia.com)
  • EULAR points to consider for conducting clinical trials and observational studies in individuals at risk of rheumatoid arthritis. (bvsalud.org)
  • Despite growing interest, there is no guidance or consensus on how to conduct clinical trials and observational studies in populations at risk of rheumatoid arthritis (RA). (bvsalud.org)
  • These consensus statements provide data-driven guidance for rheumatologists , health professionals and investigators conducting clinical trials and observational studies in individuals at risk of RA. (bvsalud.org)
  • Statins have been associated with a significantly lower risk of breast (8), colorectal (9), and lymph cancers (10-12) in several observational studies (10,13). (cdc.gov)
Rheumatism2
  • The study is published online in Arthritis and Rheumatism. (healthjockey.com)
  • Arthritis/rheumatism was associated in our study with occurrence of injury because of farm work across all four waves. (cdc.gov)
Autoimmune diseases5
  • Not only did exposure to air pollution increase the risk of rheumatoid arthritis, but it also increased the risk of suffering from other autoimmune diseases, such as inflammatory bowel disease, according to findings published last month in the journal RMD Open . (aboutlawsuits.com)
  • The data indicated a positive association between exposure to PM 10 and increased risk of autoimmune diseases. (aboutlawsuits.com)
  • Long-term exposure to air pollution was associated with higher risk of developing autoimmune diseases, in particular rheumatoid arthritis, connective tissue diseases and inflammatory bowel disease," the researchers concluded. (aboutlawsuits.com)
  • The study, published Wednesday in the Journal of the American Heart Association , helps fill a gap in what's known about the long-term cardiovascular health of people with autoimmune diseases such as rheumatoid arthritis, psoriasis and lupus, researchers say. (heart.org)
  • Autoimmune diseases are known to increase the risk for cardiovascular disease, perhaps because people who have them also tend to have more traditional cardiovascular risk factors, including high blood pressure, Type 2 diabetes and kidney disease. (heart.org)
Disease35
  • Older adults with rheumatoid arthritis (RA) have a higher risk than those without the disease of developing shingles, a virus related to chickenpox that causes pain and a blistering rash. (arthritis.org)
  • Relative risks (odds ratios [ORs]) for lymphomas (by subtype) associated with deciles of cumulative disease activity were assessed, as were ORs associated with drug treatments. (nih.gov)
  • The relative risks of lymphoma were only modestly elevated up to the seventh decile of cumulative disease activity. (nih.gov)
  • Relative to the non-RA group, adjusted hazard ratios (95% CI) for TB (1.92 (1.50-2.47)) and NTM disease (2.07 (1.84-2.32)) demonstrated increased risks in the RA group. (ices.on.ca)
  • Given the rising rates of NTM disease worldwide, determining whether this risk is due to the use of immunosuppressive medications versus RA itself is an important objective for future research. (ices.on.ca)
  • Exposure to PM 10 above 30 micrograms per cubic meter (µg/m3) and PM 2.5 above 20 µg/m3 was associated with a 12% and 13% increased risk of autoimmune disease, respectively. (aboutlawsuits.com)
  • Every 10 µg/m3 increase in PM 10 concentration was linked with an 7% increased risk of an autoimmune disease diagnosis, according to the findings. (aboutlawsuits.com)
  • The study's findings also indicated long-term exposure to traffic and industrial air pollutants was linked with a 40% increased risk of rheumatoid arthritis, a 20% increased risk of inflammatory bowel disease, and a 15% higher risk of connective tissue disease. (aboutlawsuits.com)
  • A growing body of research has also linked air pollution to brain degenerative diseases like Parkinson's and Alzheimer's , as well as increased risk of suffering from conditions like hypertension and heart disease . (aboutlawsuits.com)
  • The adult lifetime risk in the United States of developing some form of inflammatory autoimmune disease probably is 8.4 percent for women and 5.1 percent among men. (healthjockey.com)
  • The at-risk phase is defined as the period before clinical arthritis onset, during disease development, in which symptoms and biomarkers are present. (hcplive.com)
  • Traditional (cardiovascular disease) risk factors are accentuated in this population, and how these risk factors manifest is also unique," Wassif said. (heart.org)
  • Also, some autoimmune disease treatments may increase risk, she said. (heart.org)
  • Long-term fracture risk in rheumatoid arthritis : impact of early sustained DAS28-remission and restored function, progressive erosive disease, body mass index, autoantibody positivity and glucocorticoids. (lu.se)
  • Kaplan-Meier and Cox regression analysis, adjusted for traditional factors, prior fracture, disease activity and period of inclusion, were used to estimate the risk of the outcome. (lu.se)
  • A proportional risk reduction for the outcome was associated with Body Mass Index (BMI) at baseline, BMI ≥ 30 kg/m 2 , and over the first two years sustained Disease Activity Score (DAS28)-remission, DAS28-low disease activity and Health Assessment Questionnaire (HAQ) ≤ 0.5. (lu.se)
  • The estimated fracture risk was increased in users of glucocorticoids (GC), associated with a higher GC-dosage at follow-ups and a higher cumulative dosage over two years, independently of disease activity. (lu.se)
  • The specific causes of RA are unknown, but some factors can increase the risk of developing the disease. (cdc.gov)
  • The most common type of arthritis, osteoarthritis is considered more of a mechanical (wear and tear) disease. (everydayhealth.com)
  • Rheumatoid arthritis is a complex disease that is not well understood by medical practitioners or researchers. (everydayhealth.com)
  • Lung disease is a well-known comorbidity in rheumatoid arthritis (RA). (nih.gov)
  • Compare and contrast the biology and risk factors for airway disease in RA as well as non-RA conditions to identify potential shared mechanisms of disease that could be leveraged to improve diagnosis and treatment. (nih.gov)
  • There is a broad variety of airway disease patterns, including cricoarytenoid arthritis, bronchiectasis, cellular or follicular bronchiolitis, and constrictive bronchiolitis [2, 3]. (nih.gov)
  • There is research linking risk factors for the development of RA and airway disease independently. (nih.gov)
  • Across these independent studies, shared risk factors for RA and airway disease were determined to include older age, cigarette smoking, lower socioeconomic status, infections and microbial dysbiosis, occupational exposures and air pollutants, and poor nutrition [6, 7]. (nih.gov)
  • Elevated COVID-19-related risks, many associated with comorbidities, emerged in a match-control study, whereas a systematic review delivers more encouraging news for people living with rheumatic disease. (the-hospitalist.org)
  • However, in analyses that were adjusted for a variety of factors, including body mass index (BMI) and smoking, a healthier diet was associated with significantly reduced risk for RA in women whose disease onset occurred at 55 years of age or younger, and in particular for women in that age group who developed seropositive RA. (medscape.com)
  • [ 3 , 4 ] Following this, the results of this study suggest that a generally healthier diet before RA develops is associated with reduced risk for seropositive RA, and in particular in women who have onset of disease before 55 years of age. (medscape.com)
  • In particular, given that the most striking relationship between diet and reduced RA risk in Hu and colleagues' study was seen in younger-onset seropositive RA, it is curious how diet may specifically relate to the development of this disease subtype. (medscape.com)
  • Specifically, could dietary changes alter risk for progression to RA of individuals who are already at high risk for this disease on the basis of elevated circulating RA-related autoantibody titers? (medscape.com)
  • Several genome-wide association studies based on the common disease-common variant hypothesis as well as meta-analyses have been conducted to elucidate the genetic risk of RA. (nature.com)
  • What Role Does Rheumatoid Arthritis Disease Activity Have in Cardiovascular Risk? (reumatologiaclinica.org)
  • Findings from studies assessing the risk for cancer from disease-modifying antirheumatic drugs (DMARDs) have often found to be mixed and inconclusive. (rheumatologyadvisor.com)
  • I'm Dr. Loretta Jackson-Brown and I'm representing the Clinician Outreach and Communication Activity, COCA in the Emergency Risk Communication Branch at the Centers for Disease Control and Prevention. (cdc.gov)
  • See Rheumatoid Arthritis: In and Out of the Joint , a Critical Images slideshow, to help identify the distinguishing features of RA as well as the signs of extra-articular manifestations of this disfiguring disease. (medscape.com)
Tuberculosis1
  • The risk of SBI was comparable, but the risk of OI, particularly tuberculosis, was less among JAKi than TNFi initiators. (biomedcentral.com)
Middle Aged2
  • However, to date, there were few studies focusing on the interaction analysis between RA and MD. Thus, our study aims to outline the relationship of coexistence of RA and MD on the risk of CVD for the middle aged and elderly. (biomedcentral.com)
  • Rheumatoid arthritis is also more common in middle-aged people. (mountelizabeth.com.sg)
Affects2
STAtins5
  • Participants were able to choose between 2 multicenter, randomized, double-blind, placebo-controlled clinical prevention trials: The STAtins to Prevent Rheumatoid Arthritis (STAPRA) trialand the Arthritis Prevention In the Pre-clinical Phase of RA with abatacept (APIPPRA) trial. (hcplive.com)
  • Statins (0.77 (0.62 to 0.96)) and TNFi (0.72 (0.54 to 0.97)) were associated with reduction in vertebral fracture risk only. (bmj.com)
  • Our study demonstrated that persistent use of statins is associated with a lower overall cancer risk and particularly the risk of incident hematopoietic malignancies. (cdc.gov)
  • Large randomized controlled trials (RCTs) that examined the safety and effectiveness of statins in preventing cardiovascular diseases indicated that statins were not associated with increased cancer risk (5). (cdc.gov)
  • The objective of this study was to investigate the association between persistent use of statins and the risk of overall and site-specific cancer in adults, to assess dose-response relationship, and to examine the effects of varying types of statins. (cdc.gov)
Fracture5
  • Fracture Risk Assessment Tool (FRAX) scores estimating for 10-year major osteoporotic fractures were calculated. (bmj.com)
  • PPIs and other psychotropic medications were not associated with increased fracture risk. (bmj.com)
  • This was statistically different from a 1.2-fold increased osteoporotic fracture risk associated with oral GC or PPI use alone. (maastrichtuniversity.nl)
  • Among concomitant users, fracture risk did not increase with higher daily dose or duration of PPI use. (maastrichtuniversity.nl)
  • Fracture risk assessment could be considered when a patient with RA is co-prescribed oral GCs and PPIs. (maastrichtuniversity.nl)
Adverse5
  • The evidence about the risk of adverse events after heart attack for people with autoimmune disorders is less robust than evidence for people without these disorders, and mainly from small or single-center studies," senior study author Dr. Amgad Mentias said in a news release. (heart.org)
  • It is important to counsel women of childbearing age about the teratogenicity and adverse effects of the medications used to treat rheumatoid arthritis (RA) before starting therapy. (medscape.com)
  • To determine the frequency and severity of adverse effects associated with the long-term use of biologics in the treatment of PsA and RA, and possible risk factors for such events in a real-life setting. (frontiersin.org)
  • The investigators also looked at vaccine safety by recording adverse events and rheumatoid arthritis flares. (healtharcadia.com)
  • Do WTC responders have increased risk of adverse health outcomes compared to general population? (cdc.gov)
Significantly6
  • The biologics also posed a significantly higher risk. (arthritis.org)
  • Genetically determined per unit increment of absolute circulating levels of retinol was significantly associated with a reduced risk of hip OA [odds ratio (OR) = 0.45, 95% confidence interval (CI) 0.26-0.78, p = 4.43 × 10 −3 ], while genetically determined per unit increase in absolute circulating levels of β-carotene was suggestively associated with increased risk of RA (OR = 1.32, 95% CI 1.07-1.62, p = 9.10 × 10 −3 ). (frontiersin.org)
  • Research suggests that people with certain genetics, namely the human leukocyte antigen (HLA) genes, have a significantly increased risk of developing RA. (everydayhealth.com)
  • Because few available data suggest a significantly increased risk for preterm birth, preeclampsia, or fetal growth restriction, no special obstetric monitoring is indicated beyond what is performed for usual obstetric care. (medscape.com)
  • In this study of older farm ers, the type of work, and not the amount of work was significantly associated with injury risk. (cdc.gov)
  • Notably, responders who used a full/half-face respirator on 9/11-9/18 had a significantly lower risk (IRR=0.70 (0.60-0.82) than when none was worn. (cdc.gov)
Develops1
  • Worldwide, rheumatoid arthritis develops in about 1% of the population, regardless of race or country of origin, affecting women 2 to 3 times more often than men. (msdmanuals.com)
Complications2
20171
Medscape1
Diseases8
  • Even in the presence of prevalence as well as incidence rates, prevalence figures may underestimate individual risk for rheumatic diseases. (healthjockey.com)
  • Investigators from the Mayo Clinic have ascertained the lifetime risk of developing rheumatoid arthritis and six other autoimmune rheumatic diseases for both sexes. (healthjockey.com)
  • Cardiovascular diseases (CVD) occurrence were associated with rheumatoid arthritis (RA) and Mediterranean diet (MD), but few studies have been conducted to explore the combined effect. (biomedcentral.com)
  • It not only benefits conditions such as arthritis, but also prevents other diseases such as cancer, heart problems, high blood pressure, diabetes, kidney and liver problems. (selfgrowth.com)
  • There is considerable evidence that the lungs may serve as an initial site of tolerance loss in the generation of RA-related autoimmunity, and several environmental inhalant exposures and lung diseases have been associated with RA risk. (cdc.gov)
  • Results from this study have the potential to make a significant public health impact through the identification of new diseases and high-risk groups within the WTC cohort, and aid future development of new guidelines for the implementation of an occupational health surveillance system for disasters, which is essential for disaster preparedness. (cdc.gov)
  • Arthritis and other rheumatic conditions are among the most prevalent diseases in the United States, particularly for women and some racial/ethnic groups (1-3). (cdc.gov)
  • Editorial Note: The category of arthritis and other rheumatic conditions comprises several specific diseases associated with a spectrum of etiologies ( Table 2 ). (cdc.gov)
Opioids2
  • However, there are some who have a negative experience taking opioids, including risk of dependence due to long-term use. (yahoo.com)
  • This research can be used by doctors to inform people with arthritis of the possible benefits and risks of opioids and whether it is the right medicine for them. (yahoo.com)
Synovitis2
Pathogenesis2
  • McInnes, I. B. & Schett, G. The pathogenesis of rheumatoid arthritis. (nature.com)
  • The aggregation of SNVs in the mitochondria respiratory chain suggests the pivotal role of those SNVs in the pathogenesis of RA with severe erosive arthritis. (nature.com)
Researchers4
  • Researchers have studied a number of genetic and environmental factors to determine if they change a person's risk of developing RA. (cdc.gov)
  • Researchers find long-term use of contraception to prevent pregnancy might lower the risk for RA in women. (gearsofbiz.com)
  • Implications for future studies of farm injury include the need for nurse researchers and others to incorporate objective validated measures of mobility and health care provider diagnoses of arthritis, and arthritis type. (cdc.gov)
  • Nurse researchers should proceed with ongoing evaluation of the farm task injury risk index to determine its validity, reliability, and usefulness as a predictor of farm injuries. (cdc.gov)
Conclusion1
Associated with decreased1
  • In this group of older farm ers, aging was protective for injury, and was associated with decreased farm task injury risk index. (cdc.gov)
Tofacitinib1
  • The same rheumatoid arthritis drug (tofacitinib citrate) has recently shown to reverse two other disfiguring skin conditions, vitiligo and alopecia areata. (scitechdaily.com)
Study18
  • Almost every study shows that using prednisone at dosages commonly prescribed for RA [10 mg/day] doubles the risk of developing shingles," he says. (arthritis.org)
  • Among the many other negative health effects from air pollution exposure, a new study indicates exposure also increases the risk of developing rheumatoid arthritis. (aboutlawsuits.com)
  • The authors of this recent study 2 looked at UK Biobank data from nearly 90,000 people to identify the "metabolic signature" of a healthy lifestyle that reduced one's risk of developing RA. (mindbodygreen.com)
  • Experts will continue to study exactly what this means, but for now, you can rest assured that the tried-and-true healthy living pillars are helping you in more ways than one, including reducing your risk of RA. (mindbodygreen.com)
  • The study focused on offering an easy-to-understand average risk over a person's lifetime, keeping in mind that the threat alters with progression in age. (healthjockey.com)
  • For example, one study found that children whose mothers smoked had double the risk of developing RA when they were adults. (cdc.gov)
  • This new study found that women who are much younger and not yet menopausal are also at high risk of thinning bones if they have RA. (creakyjoints.org)
  • This study was to outline the relationship of coexistence of RA and MD on the risk of CVD based on the National Health and Nutrition Examination Survey (NHANES) database. (biomedcentral.com)
  • A recent study conducted in mice shows that blocking the receptor for the proinflammatory protein IL-1 using the FDA-approved rheumatoid arthritis drug Anakinra may attenuate the deficits in the functioning of hematopoietic stem cells due to aging. (medicalnewstoday.com)
  • [ 5 ] Indeed, in this new study, Hu and colleagues found that moderate alcohol consumption and lower BMI were associated with reduced risk for RA. (medscape.com)
  • Up to one in three people diagnosed with rheumatoid arthritis could be at risk of long-term opioid use, a new study suggests. (yahoo.com)
  • The study was done by the Swedish Epidemiological Investigation of Rheumatoid Arthritis (EIRA) cohort. (gearsofbiz.com)
  • The study found that the risk of developing RA was lower in current users of the birth control pill, as well as in women who formerly took the pill. (gearsofbiz.com)
  • The study, which was published in the Journal of the American College of Nutrition , was a randomized, double-blind trial with female participants who are currently suffering from rheumatoid arthritis. (naturalnews.com)
  • The findings of the study indicate that quercetin has beneficial effects on rheumatoid arthritis symptoms. (naturalnews.com)
  • A large-scale study finds a link between the antibiotics doctors use to treat some types of infection and a higher risk of developing rheumatoid arthritis. (seniorshomecareproducts.com)
  • The objective of this study was to investigate the association between persistent statin use and the risk of primary cancer in adults. (cdc.gov)
  • This study analyzed the socioeconomic impact of major risk factors of public health by estimating both direct and indirect costs of smoking, alcohol consumption and obesity in Korea in 2005-2013. (who.int)
Systemic sclerosis1
  • Their most common autoimmune conditions were rheumatoid arthritis, followed by systemic lupus, psoriasis, systemic sclerosis and myositis/dermatomyositis. (heart.org)
Treatment5
  • High inflammatory activity, rather than its treatment, is a major risk determinant. (nih.gov)
  • Research shows that the sooner you start treatment for rheumatoid arthritis, the more effective it's likely to be, so early diagnosis is important," said ARUK. (express.co.uk)
  • Forearms of eczema patient before and after treatment with arthritis medication. (scitechdaily.com)
  • RA most often requires long-term treatment by an expert in arthritis called a rheumatologist. (medlineplus.gov)
  • For example, discussions of the more risky farm tasks, injury prevention strategies, and treatment modalities including those that promote improved mobility should be targeted to older farm ers with arthritis and actual or potential mobility issues. (cdc.gov)
Susceptibility1
Progression1
Changes during pr2
Lung2
  • Philips DreamStation, CPAP and BiPAP machines sold in recent years may pose a risk of cancer, lung damage and other injuries. (aboutlawsuits.com)
  • Over time, rheumatoid arthritis (RA) can lead to lung tissue damage, which can result in a condition doctors call pulmonary fibrosis. (medicalnewstoday.com)