Risk lymphopenia. Medical search. Frequent questions

Clinical laboratory findings can include lymphopenia, thrombocytopenia, and elevated creatinine. (cdc.gov)
Conclusion Our study found a significant association between lymphopenia, thrombocytopenia and elevated levels of CRP, PCT, LDH, D-dimer and COVID-19 severity. (bmj.com)

We sought to assess the risk of ICU-acquired infection and of mortality according to the absolute lymphocyte count at ICU admission and its changes over 3 days. (springeropen.com)
The main objective of this study was to evaluate the risk of development of an ICU-acquired infection according to the absolute lymphocyte blood count at admission and its evolution at day 3. (springeropen.com)
We also explore the potential aetiologies of the lymphopenia associated with severe COVID-19: the virus' expanded tropism, elevated serum cytokines (particularly interleukin-6 and tumour necrosis factor-α), and excessive lymphocyte recruitment to the lungs. (ersjournals.com)
We speculate that the ability of SARS-CoV-2 to affect T-lymphocyte and myeloid cell physiology coupled with age-related maladaptive biological phenomena explain the strong association between advanced age and increased risk of COVID-19-related morbidity and mortality. (ersjournals.com)
The association between the admission lymphocyte and neutrophil counts and the risk of bacteraemia was assessed. (ox.ac.uk)
Even though circulating lymphocytes only present ~2-5% of the total lymphocyte population in the body, a correlation of lymphopenia and treatment outcome, due to dose to circulating lymphocytes, has been demonstrated. (iomp.org)

The myeloid growth factors such as granulocyte colony-stimulating factor (G-CSF) have been shown to reduce the risk of neutropenia complications while enabling safe and effective chemotherapy dose intensity. (jnccn.org)
Factors associated with severe or critical disease included hematologic malignancy, lung cancer, peri-diagnosis lymphopenia, and baseline neutropenia. (ascopost.com)

However, biomarkers or clinical parameters for risk stratification of PUUV infection are lacking. (cdc.gov)
Note: Everyone should avoid unnecessary exposure to mold, especially anyone at high risk for infection and anyone with a disease caused by immune sensitization to mold and mold constituents. (cdc.gov)
Lymphopenia at ICU admission and its persistence at day 3 were associated with an increased risk of ICU-acquired infection, while only persisting lymphopenia predicted increased 28-day mortality. (springeropen.com)
they are associated with a higher risk of infection and adverse outcome [ 1 , 2 ]. (springeropen.com)
Paraguay has not reported any Zika cases in 2023 and although the risk of Zika virus infection is currently low, clinicians should consider Zika as part of the differential diagnosis for anyone who tests negative for these other pathogens. (cdc.gov)
He noted that similar to influenza infection, cancer patients who are infected with SARS-CoV-2 are at very high risk of requiring longer length of hospital stay and mechanical ventilation, as well as higher case-fatality rates if they are older than 60 years of age and have chronic medical conditions. (medpagetoday.com)
It is important to recognize that in addition to underlying malignancy and cytotoxic agents, COVID-19 infection in itself also causes lymphopenia, which further weakens the immune system. (medpagetoday.com)
However, this long lasting lymphopenia in patients with a previously normal immune system was not associated with an increased risk of serious opportunistic infection. (bmj.com)
To identify predictors associated with disease progression, we evaluated clinical risk factors for exacerbation of SARS-CoV-2 infection. (researchsquare.com)
1,2,3 In contrast to other respiratory viruses, children seem to have a lower risk of infection than adults 4 and the vast majority of reported infections in children are mild or asymptomatic, with few recorded childhood fatalities attributed to COVID-19. (pediatriconcall.com)
The risk of donor-derived infection should be balanced with the benefits of transplantation on an individual basis. (tts.org)
These policies may vary depending upon the prevalence of HTLV-III/LAV infection and the incidence of vaccine-preventable diseases in the community, individual assessment of a child's health status, and the risks and benefits of immunization in a particular situation. (cdc.gov)
This discussion considers the risks and benefits of immunization for children residing in the United States based on the risks of vaccine-preventable diseases and the prevalence of HTLV-III/LAV infection and is intended for use by health-care providers in the United States. (cdc.gov)
The recommendations may not pertain to other countries with different risks of vaccine-preventable diseases and prevalence of HTLV-III/LAV infection among children. (cdc.gov)
Since these recommendations are based upon information and knowledge available at this time, periodic reassessment and revision will be required as more data concerning risk and benefits associated with immunization of HTLV-III/LAV-infected children become known and as the prevalences of specific vaccine-preventable diseases and HTLV-III infection change. (cdc.gov)
Two risk factors are predominately associated with HTLV-III/LAV infection in children: a) being born to a mother who has HTLV-III/LAV infection, and b) receiving blood or clotting factors containing HTLV-III/LAV. (cdc.gov)
women of Haitian or central African origin are also at a higher risk of acquiring HTLV-III/LAV infection, and a small percentage of infected women have a history of being transfused with blood (4). (cdc.gov)
The following descriptors were used: coronavirus infection, acute kidney injury and risk factors in five databases, namely PudMed, Scopus, Embase, Virtual Health Library and Web of Science. (bvsalud.org)
Coronavirus infection, acute kidney injury, risk factors. (bvsalud.org)
21,31-33 Virologic studies using RT-PCR detection have reported tests with low cycle thresholds, indicating larger quantities of viral RNA and viable virus has been cultured from persons with asymptomatic and pre- symptomatic SARS-CoV-2 infection.25,27,30,34 The relationship between SARS-CoV-2 viral RNA shedding and transmission risk is not yet clear. (cdc.gov)

Lemtrada's most common side effects are infusion-associated reactions, infections of the upper respiratory tract and urinary tract, lymphopenia, and leukopenia, while serious autoimmune conditions can also occur in patients receiving the drug. (genengnews.com)

[2] It is associated with higher risks of opportunistic infections and cancer. (wikidoc.org)
Subject has tested positive for HIV (due to potential drug-drug interactions between antiretroviral medications and venetoclax, as well as anticipated venetoclax mechanism-based lymphopenia that may potentially increase the risk of opportunistic infections). (dana-farber.org)
Therefore, it is important for the transplant community to be aware of the risk of ZIKV infections. (tts.org)
Increased risk of serious bacterial, fungal, viral and opportunistic infections leading to hospitalization or death, including tuberculosis (TB). (nih.gov)

The main symptoms and signs of COVID-19 patients are with fever, dry cough, dyspnea, fatigue and lymphopenia. (researchsquare.com)

In addition, we confirm what has been observed in other studies: disturbances in the immune system such as neutrophilia or lymphopenia, for example, are related to the severity of the disease in hospitalized patients, but are not specific to SARS-CoV-2. (eurekalert.org)
AIMS: To determine the relevance of lymphopenia to the diagnosis of bacteraemia in patients admitted with medical emergencies, relative to peripheral blood white cell count and neutrophilia. (ox.ac.uk)
RESULTS: Neutrophilia and lymphopenia were both associated with bacteraemia. (ox.ac.uk)
Both neutrophilia and lymphopenia were more predictive of bacteraemia than the total white blood cell count. (ox.ac.uk)
The study also confirms disturbances in the immune system such as neutrophilia or lymphopenia are related to the severity of the disease in hospitalized patients but are not specific to SARS-CoV-2. (integrativepractitioner.com)

The primary hypothesis was that cytotoxic chemotherapy administered within 35 days of COVID-19 diagnosis would be associated with an increased risk of severe or critical COVID-19. (ascopost.com)
On univariate analysis, no increased risk of severe or critical COVID-19 was observed among the 102 patients (33.0%) who received cytotoxic chemotherapy within 35 days of COVID-19 diagnosis (hazard ratio [HR] = 1.10, 95% confidence interval [CI] = 0.73-1.60, P = .74). (ascopost.com)

Furthermore, a very recent study showed that persistent lymphopenia on the fourth day after bacteremia diagnosis predicts early and late mortality in those patients, including in the subgroup of patients with sepsis [ 15 ]. (springeropen.com)
Patients with an active malignancy who were treated with chemotherapy within 35 days of diagnosis did not exhibit an increased risk of adverse COVID-19 outcomes (HR = 0.87, 95% CI = 0.57-1.30). (ascopost.com)
No increased risk of severe or critical COVID-19 was observed among the relatively small group of patients (n = 18) who received immunotherapy alone within 35 days of diagnosis (HR = 1.80, 95% CI = 0.89-3.50, P = .11). (ascopost.com)
In a sensitivity analysis, receipt of targeted therapy alone (n = 49) within 35 days of diagnosis was associated with a trend toward an increased risk of intensive care unit stay or death after diagnosis (HR = 2.2, 95% CI = 1.1-4, P = .02). (ascopost.com)
Collectively, these data have given the rheumatology community pause and an impetus to reflect on this rare complication, including its basic biology, diagnosis and treatment and the risks it may pose to patients. (bmj.com)

Patients with cancer and COVID-19 have a higher risk of severe disease and mortality, researchers reported. (medpagetoday.com)
Additionally, patients who are immunocompromised either due to underlying disorder or those on chronic immunosuppressive therapy are at increased risk of both morbidity and mortality related to COVID-19," Saif said. (medpagetoday.com)

Genzyme said it will implement a comprehensive risk-management program that will support early detection and management of the autoimmune events. (genengnews.com)
A total of 2525 children in Skåne with increased genetic risk for autoimmune (type 1) diabetes were identified at birth (2004-2010) and then followed quarterly until four years of age and thereafter bi-annually until the children turn 15 years of age. (lu.se)
Overall the research aim at the prediction and prevention primarily of autoimmune (type 1) diabetes by combining screening for HLA and non-HLA genes to identify subjects at risk and to measure and develop tests for beta cell autoimmunity and to carry out primary and secondary prevention trials eventually to prevent and thereby cure autoimmune (type 1) diabetes. (lu.se)

Identification of patients at a high individual risk for FN and its consequences may offer the potential for optimal chemotherapy delivery and patient outcomes. (jnccn.org)
2 - 6 The myeloid growth factors (MGFs), including granulocyte colony-stimulating factor (G-CSF), have been shown to decrease the risk of neutropenic complications, facilitating the safe delivery of planned chemotherapy dose intensity on schedule. (jnccn.org)
The risk of FN in patients receiving systemic chemotherapy has generally been based on the rates of FN in patients eligible for randomized controlled clinical trials (RCTs). (jnccn.org)
14 Variation in chemotherapy treatment intensity and intent as well as additional risk factors, including patient characteristics and comorbidities, have been identified for chemotherapy-induced FN. (jnccn.org)
In contrast to chemotherapy, radiation therapy has always been seen as a very localized form of cancer therapy, because one tries to eradicate the tumor with a defined prescription dose while minimizing dose to organs at risk. (iomp.org)
CHICAGO - Many patients with locally advanced rectal cancer who do not have high-risk disease can skip radiotherapy to the pelvic area, and instead be treated with chemotherapy alone and then surgery, say researchers reporting results from the PROSPECT trial. (medscape.com)

Key features of this disorder include a lack of bleeding risk, only mildly low platelet counts, elevated plasma fibrinogen levels, and detection of both severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and complement components in regions of thrombotic microangiopathy (TMA). (nature.com)

The contributions of predisposing factors such as underlying disease and immunosuppressive drug selection are incompletely understood but it would appear that patients with systemic lupus erythematosus may be at highest risk. (bmj.com)

We also consider important differences between COVID-19 and influenza, mainly the protean clinical presentation and associated lymphopenia of COVID-19, the contrasting role of interferon-γ in mediating the host immune response to these viruses, and the tropism for vascular endothelial cells of SARS-CoV-2, commenting on the potential limitations of influenza as a model for COVID-19. (ersjournals.com)
Patients with cancer are at a higher risk of developing complications secondary to COVID-19 because of myelosuppressive effects of treatment, as well as the underlying cancer, which suppresses their immune system," he added. (medpagetoday.com)
Understanding the immune responses generated during the course of the disease is therefore essential to determine which patients are at highest risk for serious complications and death from the disease. (eurekalert.org)
Based on the immune profiling you conducted, how were you able to identify the patients most at risk for a poor prognosis? (eurekalert.org)

PNP deficiency causes profound T lymphopenia and variable numbers of B and NK cells. (medscape.com)

The risk factors for developing renal worsening in patients with COVID-19 were the extremes of age, race, sex, pre-existing diseases, and the disease evolution. (bvsalud.org)
The majoritary findings concluded that Acute Kidney Injury (AKI) was the main renal finding in patients contaminated by SARS-coV-2, follow by the risk factors identified for developing renal worsening in patients with COVID-19, like the extremes of age, race, sex, pre-existing diseases and disease evolution. (bvsalud.org)

The goal of this study is to establish a birth cohort that collects prenatal and early life biosamples and environmental samples and rigorously phenotypes young children for food allergy and Atopic Dermatitis (AD) to identify prenatal and early life markers of high risk for food allergy and AD, as well as biological pathways (endotypes) that result in these conditions. (stanford.edu)
Lymphopenia was the better predictor in this cohort. (ox.ac.uk)

Management of immunosuppressive drugs may be helpful to avoid severe symptoms and lymphopenia. (tts.org)
Abacavir is associated with a risk for hypersensitivity reactions (HSR) (see section 4.8) characterized by fever and/or rash with other symptoms indicating multi-organ involvement. (who.int)

Daratumumab appeared to improve poor outcomes associated with high risk cytogenetics, and these data support its consistent clinical benefit in combination with two of the most widely used treatment classes. (jnj.com)
0.00001) were independently associated with higher risk of poor outcomes. (bmj.com)
These results provide real-world evidence that PI is a risk factor for adverse COVID-19 outcomes. (cdc.gov)

The Chinese handbook 1 included multiple tests in its 'screening criteria', including RT-PCR, CT abnormalities, fever and reduced white cell counts or lymphopenia. (cebm.net)

Risk of airway colonization and subsequent diseases following mold exposure is unknown. (cdc.gov)

Multivariable logistic regression revealed that AST/ALT ratio, urea nitrogen, TBIL and LDH on admission were positively correlated with death risk of COVID-19 patients. (researchsquare.com)
Conclusion Older age, lower oxygenation index and comorbidities on admission elevate death risk of COVID-19 patients. (researchsquare.com)

Additionally, 40% of patients experienced grade 3/4 lymphopenia. (cancernetwork.com)
Provide Pneumocystis pneumonia (PCP) prophylaxis during concomitant phase and continue in patients who develop lymphopenia until resolution to Grade 1 or less. (nih.gov)

Age and weight were independent risk factors for disease severity. (researchsquare.com)
In this paper, a retrospective analysis of inpatients diagnosed with SARS-CoV-2 in Hangzhou, Zhejiang, China, over the period from January 19, 2020, to February 19, 2020, was performed to explore the relevant factors that may predict the risk factors for disease severity. (researchsquare.com)

Similar to influenza, advanced age has emerged as the leading host risk factor for developing severe COVID-19. (ersjournals.com)
Our review explores influenza A virus-induced acute respiratory distress syndrome (ARDS) as a paradigm for understanding coronavirus disease 2019 (COVID-19)-induced ARDS pathogenesis and ageing as a risk factor for severe disease. (ersjournals.com)
That condition is a known risk factor for PML. (bostonglobe.com)
A change in the drug's label could persuade many of those patients -- especially those with a virus known as a PML risk factor -- to stop taking the pill, he said. (bostonglobe.com)

In October 2015, the Food and Drug Administration (FDA) instituted an update to the mandatory Risk Evaluation and Mitigation Strategy (REMS) program for clozapine to improve safety monitoring of hematologic events. (allenpress.com)

In a model developed and validated by the ANC Study Group, half of patients were classified as high risk and half as low risk based on patient-, disease-, and treatment-related factors. (jnccn.org)
15 - 18 Current guidelines distinguish between risk factors that increase the likelihood of FN and those that increase the risk of serious medical consequences or death in those who develop FN, which may be important even among patients considered at low or intermediate risk for developing FN ( Table 1 ). (jnccn.org)
As this frightening pandemic has spread rapidly throughout the world, the sometimes contradictory reports of its manifestations should be understood in the context of the heterogeneous populations that have been infected, and the immense spectrum of genetic predispositions, coexisting risk factors and pre-existing medications that can hinder cohesive understanding. (nature.com)
Due to these unknown factors, there is currently no specific treatment for SARS-CoV-2, and the risk of death for severely ill patients is very high. (researchsquare.com)
The aim of this study was to analyze the influence factors of death risk among 200 COVID-19 patients. (researchsquare.com)
We show that older ages, lower oxygenation index and comorbidities are death risk factors of COVID-19 patients. (researchsquare.com)
Biogen Idec has modified its label for Tysabri to note several risk factors for PML. (bostonglobe.com)
Information about risk factors is incomplete for 3% of children with AIDS. (cdc.gov)
to identify the risk factors that lead patients infected by the new coronavirus to develop kidney disease. (bvsalud.org)

It also highlights those at increased risk for severe disease and prevention measures to mitigate additional spread of the virus and potential importation into unaffected areas, including the United States. (cdc.gov)

Lung cancer (n = 29) was associated with an increased risk for severe or critical COVID-19 (HR = 2.00, 95% CI = 1.20-3.30, P = .01). (ascopost.com)

Rheumatologists need to become familiar with PML and feel able to help patients make shared and informed decisions about the risks when starting treatment with immunosuppressive therapies. (bmj.com)

Relation between lymphopenia and bacteraemia in UK adults with medical emergencies. (ox.ac.uk)

Severe lymphopenia has been associated with poor overall survival, occurrence of distant metastases, and disease recurrence. (iomp.org)

Advise females of reproductive potential of the potential risk to a fetus and to use effective contraception. (nih.gov)

Stratified analysis revealed that older ages, lower oxygenation index and comorbidities elevated death risk of COVID-19 patients. (researchsquare.com)

Geriatric patients and women have a higher risk of developing myelosuppression. (nih.gov)

Consequently, circulating lymphocytes might soon be treated as an organ at risk in treatment planning. (iomp.org)

Intermediate master presentation: Is vagotomy associated with an increeased risk of developing psychiatric disorders? (uzh.ch)

Concerns about the high costs of these agents along with limited physician adherence to clinical practice guidelines, resulting in both overuse and underuse, has stimulated interest in models for individual patient risk assessment to guide appropriate use of G-CSF. (jnccn.org)
1987. Physiologically based pharmacokinetics and the risk assessment process for methylene chloride. (cdc.gov)

According to Federico, the results achieved in patients with advanced and high-risk FL using a combination of three "simple ingredients" such as rituximab, IFN alfa-2b, and dose-dense CVP, were probably beyond even the expectations of the investigators. (cancernetwork.com)
ADA deficiency results in absence of T, B, and NK cells, resulting in a SCID with marked lymphopenia. (medscape.com)
The results have the potential to be used as an early biomarker to improve the management of COVID-19 patients, by identification of high-risk patients and appropriate allocation of healthcare resources in the pandemic. (bmj.com)

His mother was not known to be HIV positive nor at high risk for HIV. (hawaii.edu)
p=0.0053) in patients with high risk cytogenetics (n=44) compared to Vd alone. (jnj.com)
In a clinical setting, this could help track the progress of patients over time and ultimately identify those at high risk who would require closer monitoring. (eurekalert.org)
The risk for abacavir HSR to occur is high for patients who test positive for the HLA-B*5701 allele. (who.int)

and ii) administering methylprednisolone to patients with ARDS was associated with lower risk of death. (spandidos-publications.com)

Most radiation therapy patients develop radiation-induced lymphopenia. (iomp.org)

She said the patient had been taking the drug for four and a half years, and for three and a half years had experienced severe prolonged lymphopenia, a lowering of the white blood cell count. (bostonglobe.com)

En el análisis univariado, la presencia de comorbilidades, la coinfección viral y la inmunosupresión se asociaron estadísticamente con el requerimiento de internación. (bvsalud.org)

The association of demographic data, clinical characteristics and biochemical indexes with death risk was analyzed. (researchsquare.com)
Univariable logistic regression showed that ALT, TBIL, AST, myoglobin and LDH, AST/ALT ratio, creatinine, urea nitrogen and uric acid were positively associated with death risk of COVID-19 patients. (researchsquare.com)

Humoral and cellular studies are conducted first to detect a trigger that will induce beta cell autoimmunity in children at increased genetic risk. (lu.se)

Investigation of the epidemiological risk is mandatory and should focus especially upon travel to epidemic regions. (tts.org)

Anatomy12

Organisms4

Diseases11

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Phenomena and Processes10

Thrombocytopenia2

Lymphocyte6

Neutropenia2

Infection20

Leukopenia1

Infections4

Dyspnea1

Neutrophilia5

Cytotoxic2

Diagnosis5

Mortality2

Autoimmune3

Chemotherapy6

Platelet1

Patients with systemic lupus erythem1

Immune4

Profound1

Renal2

Cohort2

Symptoms2

Outcomes3

Counts1

Diseases1

Admission2

Grade2

Severity2

Factor4

Hematologic1

Factors9

Severe disease1

Increased risk for severe1

Immunosuppressive1

Adults1

Occurrence1

Reproductive1

Comorbidities1

Higher1

Treatment1

Presentation1

Assessment2

Results3

High4

ARDS1

Develop1

White1

Viral1

Death2

Genetic1

Mandatory1