• chain
  • Ricin B chain binds complex carbohydrates on the surface of eukaryotic cells containing either terminal N-acetylgalactosamine or beta-1,4-linked galactose residues. (wikipedia.org)
  • effect
  • The active acidification of endosomes is thought to have little effect on the functional properties of ricin. (wikipedia.org)
  • cells
  • Treatment with antioxidant compounds conferred significant protection in Jurkat cells through the restoration of the antioxidant enzymes depleted after abrin treatment (Saxena et al. (thefreedictionary.com)
  • In addition, the mannose-type glycans of ricin are able to bind cells that express mannose receptors. (wikipedia.org)
  • growth
  • Some lectins are beneficial, such as CLEC11A which promotes bone growth, while others may be powerful toxins such as ricin. (wikipedia.org)
  • Follow
  • Ricin molecules are thought to follow retrograde transport via early endosomes, the trans-Golgi network, and the Golgi to enter the lumen of the endoplasmic reticulum (ER). (wikipedia.org)
  • little
  • Because ricin is stable over a wide pH range, degradation in endosomes or lysosomes offers little or no protection against ricin. (wikipedia.org)