• COPEGUS
  • Therefore, ribavirin, including COPEGUS, is contraindicated in women who are pregnant and in the male partners of women who are pregnant. (nih.gov)
  • fetal
  • It is recommended that sofosbuvir/ribarivin combinations be avoided in pregnant females and their male sexual partners in order to reduce harmful fetal defects caused by ribavirin. (wikipedia.org)
  • compartments
  • The consensus is that rapid distribution phase is attributed to the distribution of ribavirin into tissues such as striated muscles and erythrocytes, and the long terminal half-life is attributed to the slow redistribution of ribavirin out of these peripheral compartments. (news-medical.net)
  • Oral
  • After oral ingestion of ribavirin (which is the most typical route of administration), the plasma concentration exhibits a characteristic three-phase profile, consisting of two rapid phases (absorption and distribution) and one long terminal elimination phase. (news-medical.net)
  • significantly
  • The bioavailability of ribavirin increases significantly with high fat meals, and adenine kinase enzyme (which is more active in virally infected cells) is required to convert the drug into the active nucleotide form. (news-medical.net)
  • whereas
  • Approximately one-third of absorbed ribavirin is excreted into the urine unchanged, whereas the rest is excreted as deribosylated base 1,2,4-triazole 3-carboxamide, and its hydrolysis product, 1,2,4-triazole 3-carboxylic acid. (news-medical.net)
  • Ribavirin is the INN and USAN, whereas tribavirin is the BAN. (wikipedia.org)
  • Treatments
  • In a piece of reassuring news, the study appeared to allay fears about switching to less aggressive drug treatments in response to severe side effects with anemia, showing it can be safe and effective to reduce the does of the antiviral drug ribavirin to doses below those initially prescribed. (medhelp.org)
  • Extensive clinical studies have demonstrated that combination therapy with ribavirin and interferons or pegylated interferons are efficacious treatments for HCV. (clinicaltrials.gov)
  • anemia
  • The anemia associated with ribavirin therapy may result in worsening of cardiac disease and lead to fatal and nonfatal myocardial infarctions. (nih.gov)
  • drug
  • At physiologic pH, the positive charge on the molecule from partial protonation of the carboximide group contributes to the relative slowness with which the drug crosses cell membranes (such as in red blood cells) until it has been metabolized into ribavirin. (wikipedia.org)
  • viruses
  • For this reason, when ribavirin is incorporated into RNA, as a base analog of either adenine or guanine, it pairs equally well with either uracil or cytosine, inducing mutations in RNA-dependent replication in RNA viruses. (wikipedia.org)
  • form
  • It is noted by the USAMRIID that "Ribavirin has poor in vitro and in vivo activity against the filoviruses (Ebola and Marburg) and the flaviviruses (dengue, yellow fever, Omsk hemorrhagic fever, and Kyasanur forest disease)" The aerosol form has been used in the past to treat respiratory syncytial virus-related diseases in children, although the evidence to support this is rather weak. (wikipedia.org)