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  • Receptors
  • We used electron microscopy to determine the stoichiometry and orientation of rhodopsin (rho)-containing NABBs prepared under various conditions and correlated stability and signaling efficiency of rho in NABBs with either one or two receptors. (nih.gov)
  • ADRP
  • In this study I have developed a cellular model that can mimic the gain-of function and dominant-negative disease mechanisms in rhodopsin ADRP patients. (bl.uk)
  • Molecular classification of ADRP and further sub-classification based on the region of the mutation in the rhodopsin gene allowed better prediction of a particular disease course. (wikipedia.org)
  • molecules
  • Rhodopsin molecules have very high sensitivity to light and are the pigment responsible for enabling vision in dim light conditions and monochromatic vision in the dark. (ukessays.com)
  • Thousands of rhodopsin molecules are found in each outer segment disc of the host rod cell. (wikipedia.org)
  • GRK1
  • Specifically, a study has proven that GRK1 acts on the cytoplasmic loops of rhodopsin both the second and third loops. (wikipedia.org)
  • Antibody
  • RHO antibody LS-C17694 is an unconjugated mouse monoclonal antibody to RHO (Rhodopsin) from human, mouse and rat. (lsbio.com)
  • bound
  • Rapid incorporation of functional rhodopsin into nanoscale apolipoprotein bound bilayer (NABB) particles. (nih.gov)
  • amino
  • At any amino acid position in rhodopsin, the set of disease-associated amino acids does not show any commonality with the set of amino acids present among species. (nih.gov)
  • visual
  • Hubbard made many important contributions to the visual sciences but her single most important was the fact that visual excitation is initiated by a chemical rearrangement of the visual pigment (rhodopsin) which is called a cis-trans isomerization. (wikipedia.org)
  • mutation
  • The availability of rhodopsin sequences from a large number of vertebrates has allowed us to investigate factors important in the development of RP by contrasting interspecific differences (long-term evolutionary patterns) with RP disease mutation data. (nih.gov)
  • Another mechanism, whereby a mutation caused a truncated rhodopsin, was found to affect rod function and increased the rate of photoreceptor degeneration. (wikipedia.org)