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Arthritis, RheumatoidArthritisInterleukinsArthritis, ExperimentalArthritis, InfectiousSynovial MembraneAntirheumatic AgentsArthritis, JuvenileSynovial FluidRheumatoid FactorArthritis, PsoriaticJointsArthritis, ReactiveInterleukin-6SynovitisOsteoarthritisCytokinesTumor Necrosis Factor-alphaMethotrexateInterleukin-1Blood SedimentationSeverity of Illness IndexSulfasalazineRheumatoid NoduleMetacarpophalangeal JointAutoantibodiesGold Sodium ThiomalateInterleukin-4ArthrographyInterleukin-8RheumatologyInterleukin-2Peptides, CyclicRheumatic DiseasesHLA-DRB1 ChainsCells, CulturedInflammationWrist JointMice, Inbred DBAImmunoglobulin GT-LymphocytesBiological MarkersFinger JointInterleukin-10Anti-Inflammatory AgentsInflammation MediatorsHLA-DR4 AntigenHLA-DR AntigensAntibodies, MonoclonalCollagen Type IIEnzyme-Linked Immunosorbent AssayCitrullineTreatment OutcomeSpondylitis, AnkylosingReceptors, Tumor Necrosis FactorCase-Control StudiesArthritis, GoutyAutoimmune DiseasesOrganogold CompoundsFoot JointsFibroblastsTime FactorsLupus Erythematosus, SystemicDrug Therapy, CombinationIsoxazolesHydroxychloroquinePenicillamineKnee JointInjections, Intra-ArticularReceptors, InterleukinInterferon-gammaB-LymphocytesRNA, MessengerInterleukin-1betaLymphocyte ActivationInterleukin-5Hand JointsDisease Models, AnimalDisability EvaluationPrednisoloneJoint DiseasesMonocytesRats, Inbred LewSignal TransductionInterleukin-15Prospective StudiesMacrophagesGenetic Predisposition to DiseaseSpondylarthropathiesAuranofinInterleukin-7Felty SyndromeTarsal JointsHand Deformities, AcquiredTenosynovitisFlow CytometryAntibodies, Monoclonal, HumanizedSjogren's SyndromeC-Reactive ProteinImmunoglobulin M
CytokineTreat rheumatoid arthritisAnakinraCytokinesPatientsSingle nucleotide poReceptor Antagonist ProteinCourse of rheumatoid arthritisTreatment for rheumatoid arthritisRheumatologyTumorBiologicInterstitial lung diProteinInflammationGenePolymorphismsJuvenile IdiopathiSystemicSymptomsJointsChronicAntibodyImmuneAutoimmune diseaseHumansProgressionAutoimmunityBlockadeDisordersSerumMethotrexateFactorBindsAsthmaDiagnosisDIRAMusculoskeletalAdults
Cytokine8
  • IL-1RA is a member of the interleukin 1 cytokine family. (wikipedia.org)
  • Interleukin-6 (IL-6) is a multifunctional cytokine that regulates pleiotropic roles in immune regulation, inflammation, hematopoiesis, and oncogenesis. (sbhsciences.com)
  • Interleukin-33 (IL-33) is a recently identified cytokine, an important member of the interleukin-1 family. (frontiersin.org)
  • The notion that deranged cytokine behavior fostered rheumatoid arthritis had snagged his attention as well, and the two scientists teamed up, hoping eventually to harness the chaos. (laskerfoundation.org)
  • Here, we found that both diseases feature elevated levels of CXCL1 and interleukin (IL)-6, an important proinflammatory cytokine that participates in OA and RA pathogenesis. (researchsquare.com)
  • The current data strongly supports that the combination of natural ingredients in QuadraMune(TM) possesses a synergistic effect at suppressing key components of 'Cytokine Storm,' namely interleukin-6 and TNF-alpha. (epicos.com)
  • The cytokine interleukin-6 is considered a cornerstone of the inflammatory response. (epicos.com)
  • Another was interleukin-17, a cytokine protein implicated in several inflammatory disorders such as rheumatoid arthritis and psoriasis. (epfl.ch)
Treat rheumatoid arthritis5
  • Currently, most physicians use HGWD to treat rheumatoid arthritis (RA), and it has proved to have high efficacy. (hindawi.com)
  • The Food and Drug Administration (FDA) approved the first biologic in 1988 to treat rheumatoid arthritis. (healthline.com)
  • It is important to counsel women of childbearing age about the teratogenicity and adverse effects of the medications used to treat rheumatoid arthritis (RA) before starting therapy. (medscape.com)
  • Anakinra is FDA-approved to treat rheumatoid arthritis, deficiency of interleukin-1 antagonist, and neonatal-onset multisystem inflammatory disease (NOMID). (rheumatology.org)
  • It is not a first-line drug but is used in individuals who have failed at least one of the other disease-modifying drugs that are used to treat rheumatoid arthritis . (hdkino.org)
Anakinra13
  • A recent study conducted in mice shows that blocking the receptor for the proinflammatory protein IL-1 using the FDA-approved rheumatoid arthritis drug Anakinra may attenuate the deficits in the functioning of hematopoietic stem cells due to aging. (medicalnewstoday.com)
  • A recombinant, slightly modified version of interleukin 1 receptor antagonist called anakinra is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. (wikipedia.org)
  • Anakinra differs from native human IL-1Ra in that it has the addition of a single methionine residue at its amino terminus Interleukin 1 receptor antagonist is used in horses for the treatment of equine lameness secondary to joint and soft-tissue injury. (wikipedia.org)
  • Kineret contains the active ingredient anakinra, which is an interleukin-1 (IL-1) receptor antagonist medication. (healthline.com)
  • Anakinra is a biologic drug that helps to decrease inflammation in rheumatoid arthritis (RA) and other inflammatory diseases. (rheumatology.org)
  • Although not FDA-approved, anakinra is sometimes used for systemic juvenile idiopathic arthritis (SJIA), Adult-Onset Still's Disease (AOSD), gout, and other autoinflammatory syndromes. (rheumatology.org)
  • In NOMID, systemic juvenile idiopathic arthritis, Adult-Onset Still's Disease, gout, and other autoinflammatory disorders, anakinra may begin to relieve symptoms within hours. (rheumatology.org)
  • Anakinra is used, alone or in combination with other medications, to reduce the pain and swelling associated with rheumatoid arthritis. (epnet.com)
  • Anakinra is in a class of medications called interleukin antagonists. (epnet.com)
  • Anakinra (Kineret) is a synthetic (man-made), injectable, interleukin-1 (IL-1) receptor antagonist that blocks the effects of human interleukin-1. (hdkino.org)
  • Anakinra is used for treating the signs and symptoms of moderate to severe rheumatoid arthritis in individuals 18 years of age or older. (hdkino.org)
  • The dose of anakinra for rheumatoid arthritis is one subcutaneous injection of 100 mg daily. (hdkino.org)
  • Anakinra blocks the effects of human interleukin-1, and is used in the treatment of rheumatoid arthritis . (hdkino.org)
Cytokines7
  • The diurnal variation of IL-6, and possibly other cytokines, might explain the conflicting results previously reported on the inter-relationship between circulating IL-6 levels and disease activity in rheumatoid arthritis. (bmj.com)
  • In the present study, we investigated the effect of LPS on the releasing function of afferent terminals as measured by calcitonin gene-related peptide (CGRP) release in ex vivo perfused rat trachea, and examined the possible role of the cytokines interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) as intermediaries in this effect. (jneurosci.org)
  • Cytokines such as interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) can be generated by inflammatory and nonimmune cells in response to inflammation, tissue injury, microbial invasion, and immunological reactions ( Dinarello, 1994 ). (jneurosci.org)
  • The interleukin-1 (IL-1) family is a growing group of cytokines, consisting of at least 11 members, and the balance between pro- and anti-inflammatory cytokines is crucial in the pathogenesis of many human diseases ( 3 ). (frontiersin.org)
  • Rheumatoid arthritis causes damage mediated by cytokines, chemokines, and metalloproteases. (merckmanuals.com)
  • Macrophages and lymphocytes produce pro-inflammatory cytokines and chemokines (eg, tumor necrosis factor [TNF]-alpha, granulocyte-macrophage colony-stimulating factor [GM-CSF], various interleukins, interferon-gamma) in the synovium. (merckmanuals.com)
  • The two researchers, as well as others, showed that the joints of people with rheumatoid arthritis teem with proinflammatory cytokines. (laskerfoundation.org)
Patients28
  • To evaluate the efficacy and safety of interleukin-1 receptor antagonist (IL-1Ra) in patients with rheumatoid arthritis (RA). (nih.gov)
  • At enrollment, the mean age, sex ratio, disease duration, and percentage of patients with rheumatoid factor and erosions were similar in the 4 treatment groups. (nih.gov)
  • In four of the patients with rheumatoid arthritis, serum IL-6 levels were measured before and after one week of treatment with prednisolone 15-20 mg daily. (bmj.com)
  • However, serum IL-6 levels were substantially increased in patients with rheumatoid arthritis. (bmj.com)
  • Furthermore, patients with rheumatoid arthritis showed a statistically significant circadian variation in levels of IL-6. (bmj.com)
  • Levels of TNF-alpha were low in patients with rheumatoid arthritis and high in patients with other connective tissue diseases, but without circadian rhythm. (bmj.com)
  • In a post hoc analysis of two phase 3 trials, therapy with Sarilumab lowered HbA1c concentrations in diabetic and nondiabetic rheumatoid arthritis (RA) patients. (esanum.com)
  • Combination with DMARDs on Fasting Glucose and Glycosylated Hemoglobin in Patients with Rheumatoid Arthritis With and Without Diabetes. (esanum.com)
  • Detection of interleukin 8 biological activity in synovial fluids from patients with rheumatoid arthritis and production of interleukin 8 mRNA by isolated synovial cells. (ox.ac.uk)
  • The presence of neutrophils in the synovial joint of patients with rheumatoid arthritis (RA) is thought to be due to the activity of chemotactic factors released by activated cells in the joint. (ox.ac.uk)
  • We have shown in this report, for the first time, the abundance of one such factor, interleukin 8 (IL 8), in the synovial fluid of patients both with RA and other non-RA joint diseases, and the spontaneous production of IL 8 mRNA by RA synovial cells in culture. (ox.ac.uk)
  • Although rheumatoid arthritis is often a chronic disease, some patients can taper and discontinue medications and remain in long-term remission. (aafp.org)
  • Methotrexate should be the first-line disease-modifying antirheumatic drug in patients with rheumatoid arthritis unless there are contraindications. (aafp.org)
  • Patients with rheumatoid arthritis should be treated as early as possible to have the best chance of remission. (aafp.org)
  • Patients should be screened for chronic infections, including latent tuberculosis, hepatitis B virus, and hepatitis C virus, before starting rheumatoid arthritis treatment. (aafp.org)
  • Patients who are in remission from rheumatoid arthritis for more than six months and on stable medication regimens are candidates for tapering or discontinuing disease-modifying antirheumatic drug or biologic treatment. (aafp.org)
  • The recommended dose of KINERET for the treatment of patients with rheumatoid arthritis is 100 mg/day administered daily by subcutaneous injection. (drugs.com)
  • Interstitial lung disease and neuropathy as predominant extra-articular manifestations in patients with rheumatoid arthritis: a prospective study. (medscimonit.com)
  • IL-33 is involved in the pathogenesis of immune diseases, such as rheumatoid arthritis and atopic dermatitis, and may reflect the degree of inflammation in patients with immune diseases ( 6 , 7 ). (frontiersin.org)
  • An excess of the proinflammatory substance IL-18 is present in joints of patients with rheumatoid arthritis (RA), and expression of IL-18 receptor (IL-18R) regulates IL-18 bioactivity in various cell types. (uni-frankfurt.de)
  • Agents such as corticosteroids and so-called disease-modifying anti-rheumatoid drugs posed problems because they helped only half of the patients and caused side effects. (laskerfoundation.org)
  • He chose rheumatoid arthritis, because it would provide the opportunity to study tissue at the height of inflammation, which was not possible in Graves' disease: Doctors routinely remove diseased tissue from rheumatoid arthritis patients to relieve symptoms. (laskerfoundation.org)
  • Patients with rheumatoid arthritis (RA) frequently display an atherogenic lipid profile which has been linked with inflammation. (researchgate.net)
  • Interleukin-1 gene cluster polymorphisms are associated with nutritional status and inflammation in patients with end-stage renal disease. (dadamo.com)
  • Mannose-binding lectin gene polymorphisms are associated with disease activity and physical disability in untreated, anti-cyclic citrullinated peptide-positive patients with early rheumatoid arthritis. (cdc.gov)
  • Association of Killer Cell Immunoglobulin- Like Receptor Genes in Iranian Patients with Rheumatoid Arthritis. (cdc.gov)
  • Polymorphisms in DNA repair genes XRCC1 and OGG1 lead to the progression of rheumatoid arthritis in Pakistani patients. (cdc.gov)
  • Cesarean delivery does not appear to be performed more commonly in patients with rheumatoid arthritis (RA). (medscape.com)
Single nucleotide po2
  • We want to investigate whether the single nucleotide polymorphisms (SNPs) of the Ang2 gene can predict the risk of rheumatoid arthritis (RA). (medsci.org)
  • To investigate the relationship between single-nucleotide polymorphisms (SNPs) of interleukin-10 (IL-10) and syndrome types of traditional Chinese medicine (TCM) in posthepatitis B cirrhosis. (jcimjournal.com)
Receptor Antagonist Protein1
Course of rheumatoid arthritis2
  • The course of rheumatoid arthritis (RA) often changes during pregnancy. (medscape.com)
  • Pregnancy alters the immune state, possibly contributing to a change in the course of rheumatoid arthritis (RA). (medscape.com)
Treatment for rheumatoid arthritis3
Rheumatology1
  • A mutual acquaintance recommended that Feldmann meet Maini, a leading rheumatologist and researcher at the Arthritis Research Campaign's Kennedy Institute of Rheumatology at Imperial College in London. (laskerfoundation.org)
Tumor1
Biologic1
  • Purpose of review Blockade of interleukin (IL)-1 signaling is one of the oldest biologic therapies, yet the use of these agents is on the rise as the role of IL-1 activation is being recognized in a wide spectrum of inflammatory disorders. (medscape.com)
Interstitial lung di2
  • The impact of disease severity measures on survival in U.S. veterans with rheumatoid arthritis-associated interstitial lung disease. (cdc.gov)
  • Genetic, social, and environmental risk factors in rheumatoid arthritis-associated interstitial lung disease. (cdc.gov)
Protein4
  • This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. (wikipedia.org)
  • In a patient with inflammatory arthritis, the presence of a rheumatoid factor and/or anti-citrullinated protein antibody, elevated C-reactive protein level, or elevated erythrocyte sedimentation rate is consistent with a diagnosis of rheumatoid arthritis. (aafp.org)
  • It works by blocking the activity of interleukin, a protein in the body that causes joint damage. (epnet.com)
  • The secreted form of the interleukin-1 receptor antagonist (IL-1Ra) is an acute-phase protein intervening in the counterregulation of inflammatory processes. (diabetesjournals.org)
Inflammation5
  • The contribution of interleukin (IL)-6 signaling in obesity-induced inflammation remains controversial. (uni-koeln.de)
  • Interleukin-1beta (IL-1beta) and its receptor antagonist (IL-1Ra) may play a pivotal role in the pathogenesis of wasting and inflammation. (dadamo.com)
  • However, vitamin D deficiency has been reported in several chronic conditions associated with increased inflammation and deregulation of the immune system, such as diabetes, asthma, and rheumatoid arthritis. (mdpi.com)
  • If studies continue to support these conclusions, future use of QuadraMune(TM) in conditions such as cancer inflammation and rheumatoid arthritis will be considered. (epicos.com)
  • Suppression of interleukin-6 for pathological inflammation, such as in rheumatoid arthritis, is the basis of the drug Actemra (Tocilizumab). (epicos.com)
Gene2
  • Mutations in the IL1RN gene results in a rare disease called deficiency of the interleukin-1-receptor antagonist (DIRA). (wikipedia.org)
  • Association of the CCR5 gene with juvenile idiopathic arthritis. (cdc.gov)
Polymorphisms1
  • TGF beta1 polymorphisms are candidate predictors of the clinical response to rituximab in rheumatoid arthritis. (cdc.gov)
Juvenile Idiopathi2
Systemic4
  • Rheumatoid arthritis (RA), a common chronic systemic autoimmune disease, is characterized by synovial hyperproliferation and inflammatory/immune cell infiltration [ 1 , 2 ]. (hindawi.com)
  • Rheumatoid arthritis is the most commonly diagnosed systemic inflammatory arthritis, with a lifetime prevalence of up to 1% worldwide. (aafp.org)
  • Physicians must use history and physical examination findings to differentiate the inflammatory arthritis in RA from another etiology, including systemic lupus erythematosus, systemic sclerosis, psoriatic arthritis, sarcoidosis, crystal arthropathy, and spondyloarthropathy. (aafp.org)
  • Rheumatoid arthritis is a chronic systemic autoimmune disease that primarily involves the joints. (merckmanuals.com)
Symptoms1
  • CONCLUSIONS--The circadian rhythm of circulating IL-6 might correspond to the circadian rhythm of symptoms in rheumatoid arthritis. (bmj.com)
Joints3
Chronic3
  • They made their breakthroughs by studying rheumatoid arthritis, a chronic autoimmune disease that afflicts approximately 0.5 to 1.0 percent of the population. (laskerfoundation.org)
  • One of these proteins, interleukin 6, has been linked to conditions such as rheumatoid arthritis, Type 2 diabetes and chronic stress. (foodnavigator.com)
  • Is the long-term use of glucocorticoids essential in people with chronic inflammatory diseases such as rheumatoid arthritis, or can early discontinuation prevent characteristic side effects? (hospitalhealthcare.com)
Antibody5
  • Tocilizumab is a monoclonal antibody that competitively inhibits binding of interleukin-6 (IL-6) to its receptor. (cdc.gov)
  • A 41-year-old man who had a diagnosis of nonerosive RA (seronegative for rheumatoid factor and anticyclic citrillinated peptide antibody) in 1994 had fevers in May 2010. (cdc.gov)
  • Plasma cells produce antibodies (eg, rheumatoid factor [RF], anticyclic citrullinated peptide [anti-CCP] antibody) that contribute to these complexes, but destructive arthritis can occur in their absence. (merckmanuals.com)
  • Both groups received the anti-interleukin-6 receptor antibody tocilizumab as adjunctive therapy. (hospitalhealthcare.com)
  • An antibody, Interleukin-6 receptor (IL-6), which has already started clinical trials in rheumatoid arthritis, will be the first therapeutic to enter clinical trials under the collaboration. (genengnews.com)
Immune1
Autoimmune disease1
  • It is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. (dadamo.com)
Humans1
  • Interleukin-33 (IL-33) is an important member of the IL-1 family, and in humans is expressed predominantly in skin, lung, adipocytes, and synovial fibroblasts ( 4 ). (frontiersin.org)
Progression1
  • However, new forms of diagnosis are being used to evaluate the onset and progression of periodontitis, such as the identification of concentrations of inflammatory mediators, such as the interleukins, as well as the analysis of specific mediators of bone metabolism, following the example of the activating receptor of nuclear factor Kappa B (RANK), its ligand RANKL and osteoprotegerin (OPG) 8-11 . (bvsalud.org)
Autoimmunity1
Blockade1
  • Initially approved for the treatment of rheumatoid arthritis (RA), IL-1 blockade strategies have diversified in number and in the diseases for which they are used. (medscape.com)
Disorders1
  • Osteoarthritis (OA) and rheumatoid arthritis (RA) are common joint disorders that are considered to be different diseases due to their unique molecular mechanisms and pathogenesis. (researchsquare.com)
Serum1
Methotrexate3
Factor2
Binds2
  • IL-1RN is an agent that binds non-productively to the cell surface interleukin-1 receptor (IL-1R), the same receptor that binds interleukin 1 family (IL-1), preventing IL-1's from sending a signal to that cell. (wikipedia.org)
  • The interleukin-1 receptor antagonist (IL-1Ra) is a member of the interleukin (IL)-1 family that binds to IL-1 receptors without inducing a cellular response, thereby antagonizing the effects of IL-1α and -1β ( 1 ). (diabetesjournals.org)
Asthma1
  • Interleukin (IL)-33 immunobiology in asthma and airway inflammatory diseases. (cdc.gov)
Diagnosis2
  • Rapid diagnosis of rheumatoid arthritis allows for earlier treatment with disease-modifying antirheumatic drugs, which is associated with better outcomes. (aafp.org)
  • RA-ILD and airway disease generally can be found in combination in the same patient, a finding that favors the diagnosis of rheumatoid lung disease. (nih.gov)
DIRA1
Musculoskeletal1
  • J.M.K. was partially supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health under Award Number K08AR063668 for this work. (medscape.com)
Adults1
  • Older adults with rheumatoid arthritis (RA) have a higher risk than those without the disease of developing shingles, a virus related to chickenpox that causes pain and a blistering rash. (arthritis.org)