• pathophysiology
  • Given that the bioactive lipid sphingosine 1-phosphate is involved in cardiovascular pathophysiology, and since lipid accumulation and inflammation are hallmarks of calcific aortic stenosis, the role of sphingosine 1-phosphate on the pro-inflammatory/pro-osteogenic pathways in human interstitial cells from aortic and pulmonary valves was investigated. (jove.com)
  • First we will review some basic concepts about definitions and pathophysiology of IAH and then we will present a detailed analysis of IAH in the setting of AP. (intechopen.com)
  • dysfunction
  • Basing on erectile dysfunction causes, a man can be prescribed different drugs that increase potency . (landacorp.com)
  • The autonomic nervous system's physiological state (see below) leading to loss of consciousness may persist for several minutes, so If sufferers try to sit or stand when they wake up, they may pass out again The person may be nauseated, pale, and sweaty for several minutes or hours Reflex syncope occurs in response to a trigger due to dysfunction of the heart rate and blood pressure regulating mechanism. (wikipedia.org)
  • vasodilation
  • Subsequently, it was suggested that EDHF is a sulfur signal that results in activation of K channels via sulfhydration of a cysteine residue (formation of a cysteine persulfide) (https://doi.org/10.1161/CIRCRESAHA.111.240242) C-type natriuretic peptide (CNP) has been shown to exert a variety of cardiovascular effects including vasodilation and hyperpolarization of arteries through the opening of KCa+-channels. (wikipedia.org)
  • risk
  • Though practical constraints (cost and radiation exposure) limit the routine use of CT scan to estimate individual cardiovascular risk at the population level, this study contributes to the fascinating discussion regarding the potentially causal role of fat abundance around the heart in coronary atherosclerosis. (ahajournals.org)
  • The diagnostics of cardiovascular risk factors in AD are addressed, as are potential therapeutic approaches. (iospress.nl)
  • To date, trials that target major cardiovascular risk factors in the prevention of AD remain inconclusive but have become an important focus of international research as described by contributors of this special volume in their overviews. (iospress.nl)
  • In conclusion, obesity in combination with presence of a parental history of diabetes may be particularly hazardous in men as these two factors were observed to synergistically increase the risk of developing type 2 diabetes in men. (jove.com)
  • Both conditions lead to a decrease in cardiac output which is accompanied by an elevation of central venous pressure that reflects, in an imperfect fashion, the real status of intravascular volume in this scenario [ 5 ].Stasis in deep venous circulation puts the patient in an increased risk for thromboemolism. (intechopen.com)
  • It also includes cardiac conditioning and SECONDARY PREVENTION in patients with elevated cardiovascular risk profile. (bioportfolio.com)
  • Ablation of the estrogen binding site in the PEMT promoter region may increase risk of hepatic steatosis from choline deficiency. (wikipedia.org)
  • This Vaughn-Williams class IC effect increases the risk of conduction disturbance and tachyarrhythmias. (wikipedia.org)
  • interactions
  • The study of interdependent networks is a subfield of network science dealing with phenomena caused by the interactions between complex networks. (wikipedia.org)
  • decreases
  • Activity in this range is associated with the respiratory sinus arrhythmia (RSA), a vagally mediated modulation of heart rate such that it increases during inspiration and decreases during expiration. (wikipedia.org)
  • synthesis
  • In vitro studies have shown that paracrine dialogs between human adipocytes and inflammatory cells present in adipose tissue (ie, macrophage, lymphocytes, and others) promote an increased synthesis of numerous biomolecules, 4 leading to a low-grade inflammatory microenvironment. (ahajournals.org)
  • prevention
  • The aim of this chapter is to review basic pathophysyology and clinical concepts about prevention, diagnosis and medical-surgical management of IAH in the setting of AP. (intechopen.com)
  • Aging
  • This special issue contains both review and original research articles which, when combined together, provide an interesting insight into the current state of basic and applied research in free radical metabolism, exercise, and aging. (hindawi.com)
  • systemic
  • This phenomenon indicates that alternative splicing of TNNT2 pre-mRNA is under the control of a genetically built- in systemic biological clock. (wikipedia.org)
  • Thus
  • The low pKa of taurine's sulfonic acid group ensures this moiety is negatively charged in the pH ranges normally found in the intestinal tract, thus it improves the surfactant properties of the cholic acid conjugate. (wikipedia.org)
  • adaptation
  • Intermittent hypoxic training (IHT), also known as intermittent hypoxic therapy, is a non-invasive, drug-free technique aimed at improving human performance and well-being by way of adaptation to reduced oxygen. (wikipedia.org)
  • and -λογία, -logia), environmental physiology or physiological ecology is a biological discipline that studies the adaptation of an organism's physiology to environmental conditions. (wikipedia.org)
  • effects
  • In conclusion, the impact of changes in GABAergic input is very difficult to predict in these settings, emphasizing the need for experiments performed in conscious animals when aiming at determining the cardiovascular effects of compounds acting on GABAergic neurons. (hindawi.com)
  • A 2007 review of meditative practices that included Transcendental Meditation concluded that the definitive health effects of meditation cannot be determined as the scientific evidence was of poor quality, though the review has been criticized for using an inappropriate method for assessing quality. (wikipedia.org)
  • These protect them from the damaging effects of ice formation and falling rates of enzyme catalysis at low temperatures, and from enzyme denaturation and increased photorespiration at high temperatures. (wikipedia.org)
  • Targeted delivery is believed to improve efficacy while reducing side-effects. (wikipedia.org)
  • Increasing developments to novel treatments requires a controlled microenvironment that is accomplished only through the implementation of therapeutic agents whose side-effects can be avoided with targeted drug delivery. (wikipedia.org)
  • different
  • Among other findings, the reviewed studies showed that inactivity and activity operate on different molecular pathways. (drovers.com)
  • doses
  • Moderate doses of caffeine (around 5 mg/kg) can improve sprint performance, cycling and running time trial performance, endurance (i.e., it delays the onset of muscle fatigue and central fatigue), and cycling power output. (wikipedia.org)
  • membrane
  • Taurine crosses the blood-brain barrier and has been implicated in a wide array of physiological phenomena including inhibitory neurotransmission, long-term potentiation in the striatum/hippocampus, membrane stabilization,[unreliable medical source? (wikipedia.org)
  • receptors
  • Subtypes of γ -aminobutyric acid(A) receptors: classification on the basis of subunit structure and receptor function," Pharmacological Reviews , vol. 50, no. 2, pp. 291-313, 1998. (hindawi.com)
  • systems
  • IAH is caused by persistent elevation in intra-abdominal pressure that is associated with multiple physiological derangements in almost all systems. (intechopen.com)
  • acute
  • However, cell damage produced by acute and unaccustomed exercise, as a result of an enhanced production of free radical species, is a recognised phenomenon. (hindawi.com)
  • IAH increases morbidity and mortality in acute pancreatitis (AP) and has become an issue of concern [ 2 ]. (intechopen.com)
  • role
  • In the present review we discuss the role of inflammatory mediators that increase during sleep loss and their association with general disturbances in peripheral endothelium and epithelium and how those inflammatory mediators may alter the blood-brain barrier. (hindawi.com)
  • peripheral
  • Sleep is a vital phenomenon related to immunomodulation at the central and peripheral level. (hindawi.com)
  • Here, we will review (1) the inflammatory mediators that increase during periods of sleep loss and their association with general disturbances in peripheral endothelium and epithelium and (2) how those inflammatory mediators might alter the blood-brain barrier during sleep loss. (hindawi.com)
  • blood
  • With the evidence presented in this review, we propose a hypothetical mechanism by which sleep restriction could induce blood-brain barrier disruption, emphasizing the effect of inflammatory molecules on tight junction maintenance. (hindawi.com)
  • Another review did find a reduction in diastolic and systolic blood pressure in those who practiced TM compared to controls. (wikipedia.org)