AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
AutoimmunityAutoimmune DiseasesAutoantibodiesAutoantigensDiabetes Mellitus, Type 1Mercuric ChlorideLupus Erythematosus, SystemicT-LymphocytesAntibodies, AntinuclearSelf ToleranceT-Lymphocytes, RegulatoryMice, Inbred C57BLImmune ToleranceThyroiditis, AutoimmuneMice, Inbred NODLymphocyte ActivationB-LymphocytesMice, Inbred MRL lprMice, Inbred NZBMice, TransgenicEncephalomyelitis, Autoimmune, ExperimentalAutoimmune Diseases of the Nervous SystemGlutamate DecarboxylaseMice, KnockoutCD4-Positive T-LymphocytesAdoptive TransferInterleukin-17Islets of LangerhansImmunoglobulin GModels, ImmunologicalForkhead Transcription FactorsT-Lymphocyte SubsetsDendritic CellsMice, Inbred BALB CPolyendocrinopathies, AutoimmuneDisease Models, AnimalSpleenInsulin AntibodiesThyroid GlandTh17 CellsLupus VulgarisB-Cell Activating FactorThymus GlandProtein Tyrosine Phosphatase, Non-Receptor Type 22T-Lymphocytes, Helper-InducerHashimoto DiseaseReceptors, Antigen, T-CellVitiligoFlow CytometryMolecular MimicryCytokinesThyroglobulinB-Lymphocyte SubsetsCTLA-4 AntigenIodide PeroxidaseLymphopeniaMultiple SclerosisThyroid DiseasesHLA-DQ AntigensInflammationTh1 CellsInterferon-gammaB-Lymphocytes, RegulatoryGenetic Predisposition to DiseaseMice, Inbred StrainsHLA-DQ beta-ChainsCD8-Positive T-LymphocytesSplenomegalySignal TransductionCollagen Type VAntigens, CDGraves DiseasePeripheral ToleranceAntigen PresentationImmunity, InnateEnzyme-Linked Immunosorbent AssayMice, CongenicLupus NephritisCell DifferentiationArthritis, RheumatoidMice, Mutant StrainsCells, CulturedMyelin-Oligodendrocyte GlycoproteinInterleukin-2 Receptor alpha SubunitSjogren's SyndromeHypergammaglobulinemiaHistocompatibility Antigens Class IIImmunotherapyReceptor-Like Protein Tyrosine Phosphatases, Class 8Myelin Basic ProteinImmunomodulationImmune SystemUveitisImmunizationCell ProliferationAntibody FormationThymectomyThyroiditisAntigen-Presenting CellsStiff-Person Syndrome
ImmunologyDrug-induced autoimmunityAutoimmunePosed by isletIslet2023ToxicologyMechanismsImmunityInflammatoryViral infectionsGeneticallySusceptibilitySystematic reviewThyroidInfectionInfectious diseasesVaccinationOutcomes2021PublicationPathologyRespiratorySevere infectionsChronicAdversePeer reviewDiabetesImmune systemHighlightsTypeStressCancerResponsesAutoantibodiesHealthSummarizesMedicallySearchCellsArticleRoleMethodsDiscoveryStudiesJournalPatientsStudyHumanClinicalCell
Immunology1
  • Finally, there is a literature project, where you will write a review about a specific topic in immunology and present it during a seminar. (lu.se)
Drug-induced autoimmunity1
Autoimmune4
  • Here, we review some of the recent advances and studies that highlight the roles of these changes as well as antigen presentation and stress response pathways in beta cells in the onset and propagation of the autoimmune process in type 1 diabetes. (springer.com)
  • In order to examine the experimental evidence reported in the literature regarding zinc levels in the body of patients with autoimmune disorders compared to control individuals, a systematic review and meta-analysis were performed. (covid19criticalcare.com)
  • Autoimmune Reviews. (home-remedies-for-you.com)
  • A recent review by Casanova and Anderson concluded that inherited and autoimmune deficiencies of type I interferon (IFN) immunity together account for 15%-20% of critical COVID-19 pneumonia in unvaccinated individuals. (cdc.gov)
Posed by islet1
  • We advance the hypothesis that antigen presentation by beta cells, their stress responses and functional heterogeneity are critical factors that will provide clues towards solving the enigma posed by islet autoimmunity in type 1 diabetes. (springer.com)
Islet11
  • Type 1 diabetes results from the poorly understood process of islet autoimmunity, which ultimately leads to the loss of functional pancreatic beta cells. (springer.com)
  • Mounting evidence supports the notion that the activation and evolution of islet autoimmunity in genetically susceptible people is contingent upon early life exposures affecting the islets, especially beta cells. (springer.com)
  • While the role of islet autoimmunity remains unquestioned, the role of the islets as active participants has only recently become accepted [ 1 ]. (springer.com)
  • Notwithstanding this achievement, we are still far from a nuanced understanding of how islet autoimmunity originates and propagates during the development of type 1 diabetes and why it is so heterogeneous among individuals. (springer.com)
  • Here, we draw upon studies that have shed light on the initiation and progression of islet autoimmunity from the point of view of the beta cell. (springer.com)
  • How is islet autoimmunity initiated? (springer.com)
  • Central to solving the puzzle as to how type 1 diabetes occurs will be to identify the elusive cause(s) of initial islet autoimmunity. (springer.com)
  • The concept that islet autoimmunity results from genetic susceptibility combined with an environmental trigger, first theorised by Eisenbarth [ 10 ], is now generally accepted [ 11 ]. (springer.com)
  • The predisposition of the high-risk HLA DR-DQ genotype and as yet unknown environmental triggers lead to autoimmunity and the onset of T1D, which is preceded by islet beta-cell autoantibodies acting as markers for ongoing autoimmunity. (lu.se)
  • A low-fiber diet has been associated with other inflammatory associated islet autoimmunity. (lu.se)
  • This work was supported in part by the NIH/National soluble fiber is not associated with islet autoimmunity or T1D in Center for Advancing Translational Sciences Clinical and Translational Sci- early life. (lu.se)
20232
Toxicology1
  • All of our content is reviewed by medical doctors and doctoral-level experts in pharmacology, toxicology, and chemistry. (consumerlab.com)
Mechanisms6
  • However, this section lacks a review or balanced discussion of the various mechanisms of autoimmunity and proof of causation. (cdc.gov)
  • This is the first peer-reviewed publication to describe an agonist monoclonal antibody, which triggers pro-resolutive mechanisms in macrophages and neutrophils in chronic inflammatory condition. (pharmiweb.com)
  • In this brief review, a detailed account of the putative mechanisms by which the normal physiology of T cells are disturbed and why regulatory T cells fail to alleviate proinflammatory response in SLE will be discussed. (hindawi.com)
  • It explored the possibility that autoimmunity and autoinflammation, typically thought of as mutually exclusive mechanisms of disease, may both coexist in acute pericarditis. (medscape.com)
  • Therefore, this review summarizes some immune mechanisms involved in periodontal disease. (bvsalud.org)
  • The course covers innate and acquired immunity, infection biology and host-pathogen interactions, mechanisms behind autoimmunity and allergy, vaccination, and evolution of animal immune systems. (lu.se)
Immunity1
  • This review will recount the path to discovering the importance of resident memory CD8 T cells as they pertain to cancer immunity. (frontiersin.org)
Inflammatory2
  • However, TGF-beta also drives the development of other T cells (regulatory T cells) that dampen the inflammatory response and help prevent autoimmunity. (nih.gov)
  • This review summarizes some immunological factors involved in the development and control of this oral disease, such as: the participation of inflammatory cells in local inflammation, the synthesis of chemotaxis proteins with activation of the complement system and a range of antimicrobial peptides, such as defensins, cathelicidin and saposins. (bvsalud.org)
Viral infections1
  • Sachdeva M, Taneja S, Sachdeva N. Stem cell-like memory T cells: Role in viral infections and autoimmunity. (wjgnet.com)
Genetically1
  • Autoimmunity occur in genetically predispose persons with familial connections. (scialert.net)
Susceptibility1
  • As of 2022, 485 different types of PI had been described, affecting different components of the immune system and resulting in a variety of disorders, including increased susceptibility to severe infections and autoimmunity. (cdc.gov)
Systematic review3
  • Zinc status and autoimmunity: A systematic review and meta-analysis. (covid19criticalcare.com)
  • Dr Peter Kovacs summarizes a systematic review that compared available treatments for unexplained infertility, including expectant management, IVF, and others. (medscape.com)
  • In our recent systematic review of 68 studies, we calculated an overall 9% case fatality rate, 49% hospitalization rate, and 29% oxygen supplementation rate in the 459 people with PI and COVID-19. (cdc.gov)
Thyroid5
Infection4
Infectious diseases1
Vaccination1
  • Vaccination and autoimmunity-'vaccinosis': a dangerous liaison? (nih.gov)
Outcomes1
  • Reviews that compiled results of multiple, smaller studies have found some types of PI to be a potential risk factor for severe COVID-19 outcomes. (cdc.gov)
20211
Publication2
  • Mnemo: OSE) announced the first peer-reviewed publication on OSE-230, a novel and innovative approach in the management of the resolution of chronic and severe inflammation, in Science Advances . (pharmiweb.com)
  • Accepted for publication after peer review and revision. (elifesciences.org)
Pathology1
  • Indeed, it is likely that the chronic pathology of autoimmunity is mediated in part by otherwise innocent bystander cells, augmented by inflammasomes. (blogspot.com)
Respiratory1
  • Adjusting sunlight exposure, D3 intake, and co-factors to maintain vitamin D levels in the 40-60 ng/mL range is associated with lower risk of autoimmunity, respiratory disease, and other illnesses. (greenmedinfo.com)
Severe infections2
  • We undertook this study to investigate the occurrence of and risk factors for severe infections in off-trial patients using data from the AutoImmunity and Rituximab (AIR) registry. (nih.gov)
  • The charts of patients with severe infections were reviewed. (nih.gov)
Chronic1
  • Your hosts, Drs. Brent and Tiffany Caplan and Dr. Tom O'Bryan, have spent months gathering the right experts, information and protocols to help you understand and address autoimmunity and other chronic conditions by looking at food sensitivities and intolerances and using nutrition as an essential component of treatment. (bodyecology.com)
Adverse1
  • Autoimmunity is an adverse relation of immune system against non- foreign substances leaving behind either alters the normal function or destroying the tissue involved. (scialert.net)
Peer review1
Diabetes2
  • Type 1 diabetes results from organ-specific autoimmunity, which eliminates most of the insulin-producing pancreatic beta cells. (springer.com)
  • Undoubtedly, sustained efforts by the global type 1 diabetes research community to understand the basis of T cell-driven autoimmunity in type 1 diabetes have paid dividends. (springer.com)
Immune system2
Highlights1
  • NIH Research Matters is a weekly update of NIH research highlights reviewed by NIH's experts. (nih.gov)
Type1
Stress1
Cancer2
  • Dr Peter Kovacs reviews a case-control study that evaluated the association between ERT and specific subtypes of ovarian cancer in menopausal women. (medscape.com)
  • In this way, it plays a role in fighting cancer, developing autoimmunity , and rejecting transplanted organs. (cdc.gov)
Responses1
  • Informed by studies in infectious disease models, and instructed by a clear role for T RM cells in autoimmunity, we will discuss strategies for therapeutically promoting T RM responses in settings where they don't naturally occur. (frontiersin.org)
Autoantibodies1
  • A reduction in neutrophil counts primarily in boys and children with the HLA-DR3-DQ2/DR4-DQ8 genotype, and a reduction of red blood cell counts, hemoglobin, and hematocrit primarily in girls and in children with HLA-DR3-DQ2/DR4-DQ8 were inversely associated with autoimmunity and the number of beta-cell autoantibodies. (lu.se)
Health1
  • For her, health communication is not just writing complicated reviews for professionals but making medical knowledge understandable and available to the general public as well. (news-medical.net)
Summarizes5
  • Little Evidence to Show Benefits of Add-on Fertility Treatments Dr Kovacs summarizes an opinion paper that reviewed the scientific evidence behind treatments that fertility treatments often offer as part of IVF procedures. (medscape.com)
  • The Best Treatments for Genitourinary Syndrome of Menopause Dr Kovacs summarizes a review paper on options for treating a common syndrome of menopause. (medscape.com)
  • Dr Kovacs summarizes a review paper that paper that reviewed the risk for CVD and VTE with hormonal contraceptive methods. (medscape.com)
  • Dr Kovacs summarizes a review paper that examined fertility-sparing options for women undergoing chemotherapy. (medscape.com)
  • Dr Peter Kovacs summarizes a meta-analysis that reviewed the evidence on how salpingectomy may affect ovarian response to stimulation in patients undergoing IVF. (medscape.com)
Medically1
  • We continually update and medically review our information to keep our content trustworthy, accurate, and reliable. (consumerlab.com)
Search2
  • Method: A literature search was performed and reviewed using the narrative approach. (lu.se)
  • For this article a literature review was undertaken, consulting available publications through an automated search in PubMed, Scopus, and Embase databases. (bvsalud.org)
Cells2
  • review the heterogeneity of the current models for memory T cells generation and maintenance in humans and mice. (scielo.br)
  • In a very interesting review, P. MARRACK & J. KAPPLER focus on naïve, activated, and memory T cells survival separately, and discuss experiments done in vitro and in mice lacking or containing normal populations of lymphocytes. (scielo.br)
Article1
  • This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. (wjgnet.com)
Role1
  • Role of neutrophil extracellular la NETosis en las enfermedades infecciosas pulmonares. (bvsalud.org)
Methods1
  • you may login or review methods of obtaining more access . (hstalks.com)
Discovery2
  • Mackay, IR 2010, ' Travels and travails of autoimmunity: A historical journey from discovery to rediscovery ', Autoimmunity Reviews , vol. 9, pp. 1 - 8. (monash.edu)
  • The discovery of IL-23 as a driving force in Th17 development points to potential new targets for therapies against autoimmunity. (nih.gov)
Studies2
  • So, during 1915-1945, autoimmunity underwent a long eclipse despite, during this time, some potentially telling studies relating to brain, kidney and other diseases. (monash.edu)
  • These sources include peer-reviewed studies and information from agencies such as the FDA and USDA, and the National Academy of Medicine. (consumerlab.com)
Journal2
Patients2
  • Why Lifestyle Advice Should Be Part of Fertility Counseling Dr Kovacs reviews the latest committee opinion from the American Society for Reproductive Medicine on how to counsel patients who are trying to conceive. (medscape.com)
  • One study included in the review found that mutations in TLR3 and IRF7 and genes in related pathways were more common in patients with severe COVID-19, compared to patients with mild or asymptomatic COVID-19. (cdc.gov)
Study5
  • Last month, a new study was published in Autoimmunity Reviews that peaked interest in acute pericarditis. (medscape.com)
  • How Pain Relievers May Affect Time to Pregnancy Dr Kovacs reviews a study that looked at whether women who regularly use aspirin or NSAID take longer to conceive than women who don't use pain relievers. (medscape.com)
  • What DNA Fragmentation May Tell Us About Recurrent Miscarriage Dr Kovacs reviews a study that evaluated the degree of DNA fragmentation in men in couples with recurrent miscarriages, as compared with infertile and fertile men. (medscape.com)
  • Dr Peter Kovacs reviews a study that evaluated a new time-lapse algorithm for embryo selection. (medscape.com)
  • Dr Peter Kovacs reviews a study that evaluated whether ovary-sparing hysterectomy has an impact on ovarian reserve based on measures of anti-Müllerian hormone levels. (medscape.com)
Human2
  • CIENCIASMEDICASNEWS: Inflammasomes and human autoimmunity: A comprehensive review. (blogspot.com)
  • Because of the mended for previously unvaccinated males age 22-26 years greater use of 4vHPV in the United States, the objective of this who are immunocompromised, test positive for human immu- paper is to review post-licensure 4vHPV safety data published nodeficiency virus (HIV), or have sex with men. (cdc.gov)
Clinical1
  • From 2003 to 2014 most of my research effort was through the NIH Autoimmunity Centers of Excellence (ACE) as a member of the steering committee and as the Clinical Director for the Rochester ACE. (rochester.edu)
Cell2
  • Since the mid-1990's I became interested in investigator-initiated trials of new agents for immune-mediated diseases, most notably one of the very first trials of B cell targeted therapy for autoimmunity (anti-CD20 for SLE). (rochester.edu)
  • Peripheral blood biomarkers of cell-specific autoimmunity. (lu.se)