Mupirocin is a naturally occurring antibiotic. (nih.gov)
Inhibits2
Mupirocin inhibits bacterial protein synthesis by reversibly and specifically binding to bacterial isoleucyl transfer-RNA synthetase. (nih.gov)
Methotrexate competetively and reversibly inhibits dihydrofolate reductase (DHFR), an enzyme that is part of the folate synthesis metabolic pathway. (the-medical-dictionary.com)
Ointment15
Each gram of Mupirocin Ointment USP, 2% contains 20 mg mupirocin in a bland water miscible ointment base (polyethylene glycol ointment, N.F.) consisting of polyethylene glycol 400 and polyethylene glycol 3350. (nih.gov)
Application of 14 C-labeled mupirocin ointment to the lower arm of normal male subjects followed by occlusion for 24 hours showed no measurable systemic absorption (less than 1.1 nanogram mupirocin per milliliter of whole blood). (nih.gov)
Mupirocin Ointment USP, 2% is not for ophthalmic use. (nih.gov)
If a reaction suggesting sensitivity or chemical irritation should occur with the use of Mupirocin Ointment USP, 2%, treatment should be discontinued and appropriate alternative therapy for the infection instituted. (nih.gov)
Mupirocin Ointment USP, 2% is not formulated for use on mucosal surfaces. (nih.gov)
Mupirocin ointment is indicated for the topical treatment of impetigo (skin diseases) due to Staphylococcus aureus and Streptococcus pyogenes. (com.bd)
The safety and effectiveness of Mupirocin ointment have been established in the age range of 2 months to 16 years. (com.bd)
No drug interaction has been identified with Mupirocin ointment. (com.bd)
Reproduction studies on Mupirocin ointment in animals have revealed no evidence of harm to the foetus. (com.bd)
As there is no clinical experience on it's use during pregnancy, Mupirocin ointment should only be used in pregnancy when the potential benefits outweigh the possible risks of treatment. (com.bd)
Because many drugs are excreted in human milk, caution should be exercised when Mupirocin ointment is administered to a nursing woman. (com.bd)
Mupirocin ointment is not for ophthalmic or intra-nasal use. (com.bd)
In the event of a sensitization or severe local irritation from Mupirocin ointment, usage should be discontinued and appropriate alternative therapy for the infection instituted. (com.bd)
Mixing of Mupirocin ointment with other preparations causes risk of dilution, resulting in a reduction of the antibacterial activity and potential loss of stability of the Mupirocin in the ointment. (com.bd)
There is currently limited data with overdose of Mupirocin ointment. (com.bd)
Reactions1
The drug is contraindicated in individuals with a history of hypersensitivity reactions to Mupirocin or any of the components of the preparation. (com.bd)
Mode1
Due to this unique mode of action, mupirocin demonstrates no in vitro cross-resistance with other classes of antimicrobial agents. (nih.gov)
Administration of mupirocin1
In a study conducted in 7 healthy adult male subjects, the elimination half-life after intravenous administration of mupirocin was 20 to 40 minutes for mupirocin and 30 to 80 minutes for monic acid. (nih.gov)
INDICATIONS AND USAGE1
Mupirocin has been shown to be active against most strains of S. aureus and Streptococcus pyogenes , both in vitro and in clinical studies (see INDICATIONS AND USAGE ). (nih.gov)
Antibacterial1
Mupirocin 2% (Bactroban®, GlaxoSmithKline) is a topical antibacterial drug structurally unrelated to other agents and acts by inhibiting bacterial protein synthesis. (skintherapyletter.com)
Synthetase1
However, when mupirocin resistance does occur, it appears to result from the production of a modified isoleucyl-tRNA synthetase. (nih.gov)
Gram2
Cream: 20 mg (2% w/w) of mupirocin per gram in 15-gram and 30-gram tubes. (nih.gov)
Mupirocin cream USP, 2% is a white to off white cream that contains 20 mg (2% w/w) of mupirocin per gram in an oil-and water-based emulsion, supplied in 15-gram and 30-gram tubes. (nih.gov)
Irritation1
In the event of a sensitization or severe local irritation from mupirocin cream, usage should be discontinued, and appropriate alternative therapy for the infection instituted. (nih.gov)
Topical treatment1
Mupirocin may be advantageous for topical treatment of staphylococcus-infected burns, especially those colonized with MRSA. (skintherapyletter.com)
Burns1
Experts recommend that mupirocin be used on burns encompassing less than 20% of body surface and for less than 5 days. (skintherapyletter.com)
Patients1
Severe Allergic Reactions: Anaphylaxis, urticaria, angioedema, and generalized rash have been reported in patients treated with formulations of mupirocin, including mupirocin cream. (nih.gov)
Therapy1
Topical therapy with agents, such as fusidic acid and/or mupirocin, can be used as adjuncts to parenteral antibiotics, but they should not be used alone in true cases of staphylococcal scalded skin syndrome (SSSS). (medscape.com)