• cardiac
  • As shown, heart failure may be viewed as a progressive disorder that is initiated after an "index event" either damages the heart muscle, with a resultant loss of functioning cardiac myocytes, or alternatively disrupts the ability of the myocardium to generate force, thereby preventing the heart from contracting normally. (ahajournals.org)
  • 11 Beyond contraction and fibrosis of myocardial scar, progressive ventricular remodeling of nonischemic myocardium can further reduce cardiac function in the weeks to months after the initial event. (ahajournals.org)
  • Cardiac magnetic resonance: The most frequently used MR contrast agents based on Gd-chelates accumulate in the extracellular space which is increased in scarred myocardium. (wikipedia.org)
  • Clinical situations of stunned myocardium are: acute myocardial infarction (AMI) after percutaneous transluminal coronary angioplasty (PTCA) after cardiac surgery 'neurogenic' stunned myocardium following an acute cerebrovascular event such as a subarachnoid hemorrhage Myocardial Stunning at the US National Library of Medicine Medical Subject Headings (MeSH) Grund F (February 2001). (wikipedia.org)
  • Blocking this channel reduces cardiac pacemaker activity, selectively slowing the heart rate and allowing more time for blood to flow to the myocardium. (wikipedia.org)
  • Pediatric cardiology - Heart - Chordae tendinae - Right atrium - Right ventricle - Tricuspid valve - Left atrium - Left ventricle - Mitral valve - Endocardium - Myocardium - Pericardial cavity - Transverse pericardial sinus - Pericardium - The cardiac physical exam focuses on portions of the physical exam that elucidate information about diseases and disorders outlined below. (wikipedia.org)
  • The reduction of these latter three factors decreases the contractile force that the myocardium must exert in order to achieve the same level of cardiac output. (wikipedia.org)
  • supplementation
  • In two female siblings with mental retardation who had brain creatine deficiency that was reversible by means of oral creatine supplementation and had low urinary guanidinoacetate concentrations, AGAT deficiency was identified as a new genetic defect in creatine metabolism. (wikipedia.org)
  • mechanism
  • LCAD is regulated by a reversible acetylation mechanism by SIRT3, in which the active form of the enzyme is deacetylated, and hyperacetylation reduces the enzymatic activity. (wikipedia.org)
  • the likely mechanism of action is the increase of cAMP in the myocardium, in effect bypassing the β-adrenergic second messenger system. (wikipedia.org)