Abnormalities, MultipleChromosome AberrationsCongenital AbnormalitiesChromosome DisordersEye AbnormalitiesKaryotypingMagnetic Resonance ImagingBrainDisease Models, AnimalPhenotypeMutationCardiovascular AbnormalitiesCraniofacial AbnormalitiesPregnancySyndromeTime FactorsSkin AbnormalitiesMice, Inbred C57BLUrogenital AbnormalitiesTrisomyMusculoskeletal AbnormalitiesMice, TransgenicIn Situ Hybridization, FluorescenceMice, KnockoutTooth AbnormalitiesRats, Sprague-DawleyElectrocardiographyTranslocation, GeneticInfant, NewbornAneuploidyCells, CulturedSex Chromosome AberrationsRetrospective StudiesProspective StudiesMice, Mutant StrainsAbnormalities, Drug-InducedCase-Control StudiesSignal TransductionFetal DiseasesAnalysis of VarianceSchizophreniaPedigreeCytogenetic AnalysisBrain DiseasesTomography, X-Ray ComputedRNA, MessengerEchocardiographyFollow-Up StudiesUltrasonography, PrenatalBehavior, AnimalChromosome DeletionHeart Defects, CongenitalSensitivity and SpecificityAgingMolecular Sequence DataImage Processing, Computer-AssistedReference ValuesDose-Response Relationship, DrugChromosome BandingCytogeneticsPrenatal DiagnosisHeartBase SequenceNervous System MalformationsImmunohistochemistryPrognosisHomozygoteBody WeightRisk FactorsAtrophyHeterozygoteElectroencephalographyIntellectual DisabilityChromosomes, Human, Pair 13KidneyMyocardiumTreatment OutcomeLiverCerebral CortexBiopsyPredictive Value of TestsGene DeletionGene ExpressionNeuronsGene Expression RegulationAgenesis of Corpus CallosumDown SyndromeDisease ProgressionInsulinHippocampusTranscription FactorsDigestive System AbnormalitiesAnimals, NewbornCardiomyopathiesBlood PressureLungCell LineApoptosisReverse Transcriptase Polymerase Chain ReactionRats, Wistar