4. Overlapped differentially expressed genes between acute lymphoblastic leukemia and chronic lymphocytic leukemia revealed potential key genes and pathways involved in leukemia. (nih.gov)
The aim of the present study was to investigate the mRNA levels of several genes that have been implicated in inflammatory response in AMs and lung tissue at various time points after intratracheal instillation of DEPs in rats, and to correlate these findings with cytokine production in AMs and cultured lung fibroblasts exposed in vitro to DEPs. (nih.gov)
Genetics is the study of genes and heredity. (sigmaearth.com)
Genetics is the study of genes to understand the goal of understanding what they are and how they function. (sigmaearth.com)
MRNA5
Atomic force microscopy used in in vitro studies have shown that circular eukaryotic polysomes can be formed by free polyadenylated mRNA in the presence of initiation factor eIF4E bound to the 5' cap and PABP bound to the 3'-poly(A) tail. (wikipedia.org)
It has been found that topologically circular polyribosomes can be successfully formed in the translational system with mRNA with no cap and no poly(A) tail as well as a capped mRNA without a 3'-poly(A) tail. (wikipedia.org)
Several peaks corresponding to mRNA are revealed by the measurement of total protein across the gradient. (wikipedia.org)
The presence of mRNA across the gradient reveals the translation of the mRNA. (wikipedia.org)
8. Studying Isoform-Specific mRNA Recruitment to Polyribosomes with Frac-seq. (nih.gov)
Electron microscopy2
Furosemide-induced (400mg/kg ip) hepatotoxicity progressing to centrilobular necrosis was studied by light and electron microscopy in Swiss white mice. (nih.gov)
Electron microscopy revealed disaggregation of polyribosomes, vesiculation of endoplasmic reticulum, an endocytic origin for the vacuolation, and a definite sequence in the development of congestion. (nih.gov)
Polysome analysis revealed a repressive effect of exon 2 on TFPIβ translation but not on TFPIα. (nih.gov)
Protein4
Furthermore, eEF2K inhibition alleviated AD-associated defects in dendritic spine morphology, post-synaptic density formation, protein synthesis, and dendritic polyribosome assembly. (nih.gov)
However, recent studies demonstrate that the repeat also elicits production of a toxic polyglycine protein, FMRpolyG, via repeat-associated non-AUG (RAN)-initiated translation. (sdbonline.org)
17. Global DNA methylation profiling reveals new insights into epigenetically deregulated protein coding and long noncoding RNAs in CLL. (nih.gov)
Warm exposure (from 0 to 5°C) of the Antarctic zoarcid revealed a capacity for thermal acclimation indicated by a reduction in protein synthesis capacities associated with lower RNA:protein ratios. (silverchair.com)
Translational2
Our results may offer critical therapeutic implications for AD, and the proof-of-principle study indicates translational implication of inhibiting eEF2K for AD and related dementia syndromes. (nih.gov)
Conclusions: Our study reveals multiple regulatory events associated with metabolic and translational machinery adaptation during an epithelial mesenchymal-like transition process. (lu.se)
Fluorescence2
This dense packing can determine their function as regulators of translation, with 3-D polyribosomes being found in sarcoma cells using fluorescence microscopy. (wikipedia.org)
Fluorescence angiographic and histopathological study. (nih.gov)
Vitro3
This FOA issued by the National Institute on Aging (NIA) invites applications for the study of factors regulating neuroplasticity with a particular emphasis on the age-dependent changes in the functions of dendrites, spines and synapses of key cell types in regions of brain especially vulnerable in Alzheimers disease (AD), and in models ( in vitro and in vivo ) of aging and of AD. (nih.gov)
In vitro studies in AMs and cultured lung fibroblasts showed that lung fibroblasts are a significant source of IL-6 and MCP-1 in the lung. (nih.gov)
In this study, a convenient assay for assessing KoRV infectivity in vitro was employed: the use of DERSE cells (initially developed to search for infectious xenotropic murine leukemia-like viruses). (biomedcentral.com)
Eukaryotes2
The origin of eukaryotes is one of the hardest and most intriguing problems in the study of the evolution of life, and arguably, in the whole of biology. (catsboard.com)
Molecular phylogenetics and phylogenomics revealed fundamental aspects of the origin of eukaryotes. (catsboard.com)
Bilateral1
Pharmacological study of a bilateral case. (nih.gov)
Therapeutic2
It is imperative to develop novel therapeutic strategies for Alzheimer's disease (AD) and related dementia syndromes based on solid mechanistic studies. (nih.gov)
In this study, we investigated the therapeutic potential of miR-129 modified with 5-fluorouracil (5-FU) in NSCLC. (bvsalud.org)
Gene expression1
We studied gene expression at 1, 7, and 30 days postexposure in cells obtained by bronchoalveolar lavage (BAL) and in lung tissue. (nih.gov)
Demonstrates2
This study demonstrates that the CGG repeat expansion responsible for the neurodegenerative disorder FXTAS is capable of interacting genetically with modulators of UPS function in Drosophila and of inducing UPS impairment in human cell lines. (sdbonline.org)
SIGNIFICANCE STATEMENT Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter, in nucleus accumbens (NAc) in depression and stress susceptibility. (jneurosci.org)
Cells3
For example, polysomal profiling was used in a study to investigate the effect of vesicular stomatitis virus (VSV) in mammalian cells. (wikipedia.org)
To gain insight into this process, we studied the transition undergone by MCF7-derived cells, which is driven by the constitutive nuclear expression of a MKL1 variant devoid of the actin-binding domain (MKL1 ΔN200). (lu.se)
letter: studies on the radiosensitizing effect of oxygen in chinese hamster cells. (liverpool.ac.uk)
Results2
Patients in this study are given a presence of fungi, but results were negative. (cdc.gov)
Results: Our results reveal the expression profiles of a luminal to basal-like state in accordance with an epithelial to mesenchymal transition. (lu.se)
Findings1
Taken together with previous studies, these findings suggest a model where CGG repeat expansions in FMR1 elicit neuronal proteostasis via RAN translation and contribute to FXTAS pathogenesis (Oh, 2015). (sdbonline.org)
Insights1
Understanding the genetic basis of psychiatric and neurological In this review, we describe recent progress in disorders eventually will lead to insights into how the brain func- the study of one of these disorders, fragile X tions differently in these diseases. (2medicalcare.com)
Levels1
Several studies established that the β-cell gene expressions are regulated at transcriptional and posttranscriptional levels. (frontiersin.org)
Structure1
Polyribosome structure differs between prokaryotic polysomes, eukaryotic polysomes, and membrane bound polysomes. (wikipedia.org)
Found2
2. phenylalanyl-trna synthetase activity is found with the 60s subunit, 80s monoribosome and individual polyribosomes. (liverpool.ac.uk)
3. lysyl-trna synthetase activity is found in a form of about 20s and associated with ribosomal subunits and polyribosomes. (liverpool.ac.uk)
Role1
Nanopore direct RNA sequencing reveals a global role of URT1 in shaping poly(A) tail length, notably by preventing the accumulation of excessively deadenylated mRNAs. (cnrs.fr)
Function1
These studies have proven that polyribonucleotides can function as templates for the synthesis of specific ,o0ly peptides and further have yielded much informa- tion on how such templates may function and be synthesized. (nih.gov)
Recent studies1
Hundreds of recent studies suggest circRNAs are associated with disease development and progression, including cancer, cardiovascular disease, rheumatoid arthritis, Alzheimer's, and diabetes ( Szabo and Salzman, 2016 ). (frontiersin.org)
Shown2
in situ (in cell) studies have shown that eukaryotic polysomes exhibit linear configurations. (wikipedia.org)
This excess can be corrected by reducing signaling by Gp1 mGluRs, andnumerous studies have shown that inhibition of mGluR5, in particular,can ameliorate multiple mutant phenotypes in animal models of FXS. (2medicalcare.com)
Data2
Our data revealed that treatment with eEF2K inhibitors improved AD-associated synaptic plasticity impairments and cognitive dysfunction, without altering brain amyloid β (Aβ) and tau pathology. (nih.gov)
13. Mining Arabidopsis thaliana RNA-seq data with Integrated Genome Browser reveals stress-induced alternative splicing of the putative splicing regulator SR45a. (nih.gov)
Body1
High dietary flavonoid intake has strongly been suggested to reduce the risk of numerous cancer entities in a large body of epidemiological studies. (biomedcentral.com)
Cell1
To test this hypothesis, this study used Drosophila - and cell-based models of CGG-repeat-associated toxicity. (sdbonline.org)
Long1
His laboratory conducted research on how the lung's airspaces become fluid filled (mechanisms of pulmonary edema), how airspace fluid is cleared under both physiologic (fetal lung liquid at birth) and pathophysiologic (pulmonary edema) conditions and population-based studies to discover genetic influences on the development of bronchopulmonary dysplasia and the long term outcomes of neonatal lung disease. (stanford.edu)
Treatment1
In this study, we developed a treatment strategy by modifying tumor suppressor miRNAs, hsa-miRNA-15a (miR-15a) and hsa-miRNA-194-1 (miR-194), with the nucleoside analog chemotherapeutic gemcitabine (Gem) to create Gem-modified mimics of miR-15a (Gem-miR-15a) and miR-194 (Gem-miR-194). (bvsalud.org)
Light2
Experimental paracetamol-induced hepatic necrosis: a light- and electron-microscope, and histochemical study. (nih.gov)
studies in the diabetic chinese hamster: light microscopy and autoradiography of pancreatic islets. (liverpool.ac.uk)