Reveal gene dosage compensation genetic. Medical search. Frequent questions

But it became clear in the past decade that genetic changes cannot fully explain cancer and, indeed, whole genome analyses are revealing surprisingly few shared mutational events in cases that lack genetic instability ( 5, 6 ). (aacrjournals.org)
Here we conducted a large-scale genetic association analysis of educational attainment in a sample of approximately 1.1 million individuals and identify 1,271 independent genome-wide-significant SNPs. (brainworkup.com)
In a separate analysis of the X chromosome, we identify 10 independent genome-wide-significant SNPs and estimate a SNP heritability of around 0.3% in both men and women, consistent with partial dosage compensation. (brainworkup.com)
Genome-Wide Association Meta-Analysis in 269,867 Individuals Identifies New Genetic and Functional Links to Intelligence. (brainworkup.com)
This study establishes a reference sequence for the HeLa genome, along with genetic variations identified in the cell line: valuable resources for the continued use of HeLa cells in biomedical research. (biomedcentral.com)
Given its status as a model species, better understanding the green anole genome could reveal insights into other species. (asu.edu)
Comparative genomics analyses were used to infer additional X-linked loci in the green anole, RNAseq data from male and female samples were anayzed to quantify patterns of sex-biased gene expression across the genome, and the extent of dosage compensation on the anole X chromosome was characterized, providing evidence that the sex chromosomes in the green anole are dosage compensated. (asu.edu)
In addition, X-linked genes have a lower ratio of nonsynonymous to synonymous substitution rates than the autosomes when compared to other Anolis species, and pairwise rates of evolution in genes across the anole genome were analyzed. (asu.edu)
In participating UK research institutions, investigators can publish open access in Genome Research, Genes & Development, RNA, and Learning & Memory without article publication charges and all staff can read the entire renowned Cold Spring Harbor journal collection. (cshlpress.com)
We report here a functionally annotated human gene index placed directly on the genome. (biomedcentral.com)
We describe numerous global features of the genome and examine the relationship of various genetic maps with the assembly. (biomedcentral.com)
The current coverage is, however, sufficient for the Human Genome Project to enter a new phase, in which the entire sequence can be analyzed to identify genes, regulatory regions and other genomic elements and structures. (biomedcentral.com)
However, the challenges in genome annotation remain daunting [ 10 ], and the research community can anticipate years of additional work and manual curation to produce a true gene map of high quality. (biomedcentral.com)
The crosstalk that exists between X chromosomes and autologous genes is a relatively new paradigm that has emerged as a result of the biology of sex differences, and gives rise to the question of how SCD shapes the genome function. (dementiatalkclub.com)
Cantaloupe melon genome reveals 3D chromatin features and structural relationship with the ancestral cucurbitaceae karyotype. (u-psud.fr)

Epistasis between genes is traditionally studied with mutations that eliminate protein activity, but most natural genetic variation is in cis-regulatory DNA and influences gene expression and function quantitatively. (bvsalud.org)
Usurping these processes to deregulate functional pathways is likely simpler than generating mutations or chromosomal aberrations (unless DNA repair is deficient and genetic instability is present). (aacrjournals.org)
Whithout mutations we would know very little about inheritance and the existence of genes. (intechopen.com)
Master thesis or technician position: High-throughput investigation of dosage compensation to heterozygous mutations in mammalian systems. (sirop.org)
Why heterozygous mutations in some genes cause disease while others do not? (sirop.org)
In this project, we aim to investigate the extent to which dosage compensation occurs in respond to heterozygous mutations in mammalian systems using high throughput CRISPR screens coupled to single cell RNA sequencing. (sirop.org)
With two X-chromosomes, women are more prone to inheriting potentially deleterious mutations in X-encoded genes, which, because of Xi, may all be expressed in different cells. (dementiatalkclub.com)
As a monogenic disease, DMD is caused by mutations in the Dystrophin gene located on the X chromosome. (medicaltrend.org)
Due to these mutations, the Dystrophin gene fails to produce a sufficient or functionally intact dystrophin protein, resulting in the gradual replacement of muscle tissue with fat and fibrotic tissue in patients. (medicaltrend.org)
The Dystrophin gene is exceptionally large, with as many as 79 exons, and mutations in different exons can lead to DMD. (medicaltrend.org)

Be it for development, differentiation, stemness, or sex chromosome dosage compensation, stable, cell specific regulation of gene expression is essential for normal function ( 1 ). (aacrjournals.org)
But the researchers say their findings shed light on the evolutionary role of sex chromosome dosage compensation in many species. (scitechdaily.com)
The study sheds light on how organisms have evolved to address such imbalances through a process called sex chromosome dosage compensation, or SCDC. (scitechdaily.com)
Sex chromosome dosage compensation comes into play for individuals who have mismatched sex chromosomes. (scitechdaily.com)
The study represents not only the first such study to analyze sex chromosome dosage compensation in turtles, but the findings also show that remarkably, temperature appears to affect the SCDC process in the turtles. (scitechdaily.com)

Some lineages have evolved dosage compensation, an epigenetic mechanism which restores expression of X or Z specific genes in the heterogametic sex to the same levels observed in the ancestor prior to the evolution of the sex chromosome. (wikipedia.org)
It took a while to recognize that these same processes are intimately involved in the pathophysiology of disease states, but research into epigenetic deregulation is now as commonplace as research into genetic etiology in various medical conditions. (aacrjournals.org)
Alternatively, the presence of multiple layers of epigenetic regulation may in fact protect imprinted genes from such perturbation. (prolekarniky.cz)
We demonstrate that, despite the functional mono-allelicism of imprinted genes and their unique mechanisms of epigenetic dosage control, imprinted genes as a class are neither more susceptible nor protected from expression perturbation induced by maternal undernutrition in either the F1 or the F2 generation compared to other genes. (prolekarniky.cz)
We and others have hypothesised that a compromised in utero environment may impinge upon the epigenetic apparatus with lasting consequences for gene expression and development. (prolekarniky.cz)
Epigenetic control of gene expression lasts through multiple cell divisions without alterations in primary DNA sequence and can occur via mechanisms that include histone modification and DNA methylation. (stanford.edu)
Noncoding RNA sequences can regulate gene expression via interactions with epigenetic and other control mechanisms. (stanford.edu)
In many biological processes the regulation of gene expression involves epigenetic mechanisms. (walterswebs.com)

Dosage compensation is the process by which organisms equalize the expression of genes between members of different biological sexes. (wikipedia.org)
In order to neutralize the large difference in gene dosage produced by differing numbers of sex chromosomes among the sexes, various evolutionary branches have acquired various methods to equalize gene expression among the sexes. (wikipedia.org)
thus organisms instead equalize the expression from each gene. (wikipedia.org)
In this system gene expression of sex-specific loci is reduced in the heterogametic sex i.e. the females in ZZ/ZW systems and males in XX/XY systems. (wikipedia.org)
One logical way to equalize gene expression amongst males and females that follow a XX/XY sex differentiation scheme would be to decrease or altogether eliminate the expression of one of the X chromosomes in an XX, or female, homogametic individual, such that both males and females then express only one X chromosome. (wikipedia.org)
But the idea of stably changing gene expression in vivo has transformative potential in cancer therapy and beyond. (aacrjournals.org)
Cells have built in machinery to turn off and on gene expression permanently. (aacrjournals.org)
Indeed, early cancer research focused on the fact that neoplastic cells have aberrant gene expression and differentiation states, pointing to shared mechanisms between normal development and cancer ( 2 ). (aacrjournals.org)
2) We have discovered a group of oncoproteins that are implicated in long-term maintenance of gene expression through their effects on the state of chromatin. (stanford.edu)
Unbiased investigation of these alternative hypotheses requires assessment of imprinted gene expression in the context of the response of the whole transcriptome to environmental assault. (prolekarniky.cz)
Changes in DNA methylation and histone modifications at putative regulatory regions correlating with the altered expression of genes implicated in phenotypic development have been observed in a number of animal models of early life compromise [3] - [8] . (prolekarniky.cz)
DNA methylation patterns change dynamically during mammalian development and lineage specification, yet scarce information is available about how DNA methylation affects gene expression profiles upon differentiation. (cipsm.de)
This process is mediated by 2 mutually exclusive programs of gene expression: 1) an undifferentiated program supporting proliferation by stem cells within the basal layer and 2) a differentiation program instructing growth arrest and differentiation-associated programmed cell death in suprabasal layers. (stanford.edu)
In species with highly heteromorphic sex chromosomes, the degradation of one of the sex chromosomes can result in unequal gene expression between the sexes (e.g., between XX females and XY males) and between the sex chromosomes and the autosomes. (asu.edu)
Dosage compensation is a process whereby genes on the sex chromosomes achieve equal gene expression which prevents deleterious side effects from having too much or too little expression of genes on sex chromsomes. (asu.edu)
The regulation of gene expression, timing, location, and amount of a given project, ultimately affects the cellular structure and function. (asu.edu)
However, gene expression is not uniform among individuals and varies greatly between genetic males and females. (asu.edu)
Contributing to the sex differences in gene expression between males and females are the sex chromosomes, X and Y. Gene expression differences on the autosomes and the X chromosome between males (46, XY) and females (46, XX) may help inform on the mechanisms of sex differences in human health and disease. (asu.edu)
Characterizing sex-specific gene expression among human tissues will help inform the molecular mechanisms driving sex differences in human health and disease. (asu.edu)
This dissertation covers a range of critical aspects in gene expression. (asu.edu)
In chapter 2, I characterize gene expression in an early formed tissue, the human placenta. (asu.edu)
Fig. 4: Analysis of expression of genes in neoloops. (nature.com)
Dosage compensation implies increased expression levels of the unaffected allele. (sirop.org)
If the target protein expression reaches the upper limit, i.e., essential cellular functions come to a halt when the level of protein exceeds a certain limit, the gene/plasmid copy number must decrease to below the upper limit. (biomedcentral.com)
In gTOW, we thus increase the expression of a protein to a limit by increasing the copy number and then determine the upper limit by measuring the corresponding copy number of the gene. (biomedcentral.com)
The commonly used gene-deletion experiments reduce the expression of a target protein to 0. (biomedcentral.com)
To reduce the expression of a gene/protein, we need to reduce the production rate of the transcript, increase the degradation rate of the transcript, decrease the production rate of the protein, or increase the degradation rate of the protein. (biomedcentral.com)
Epigenetics is an emerging field of science that studies alterations in gene expression caused by factors other than changes in the DNA sequence. (walterswebs.com)
An endless supply of new studies prove that our health is an expression of how we live our lives--that what we eat and think and how we handle daily stress, plus the toxicity of our immediate environment--creates an internal biochemistry that can actually turn genes on or off. (walterswebs.com)
In addition, we found that isolated islets from Chop -/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. (jci.org)
Histones are subject to numerous post-translational modifications that correlate with the state of higher-order chromatin structure and gene expression. (silverchair.com)
However, sex differences in gene expression profiles in the brains of vertebrates are only beginning to be understood. (biomedcentral.com)
In this study we examined whole-brain sex-biased gene expression through RNA-sequencing across four strains of zebrafish. (biomedcentral.com)
Despite differences in morphology, physiology, and behavior, there is limited sex-biased neural gene expression in zebrafish. (biomedcentral.com)
Other traits show sex bias in which they are displayed by both males and females but on average show higher expression in one sex (e.g. some behaviors, context-dependent hormone and gene regulation). (biomedcentral.com)

Because sex chromosomes contain different numbers of genes, different species of organisms have developed different mechanisms to cope with this inequality. (wikipedia.org)
Different lineages have evolved different mechanisms to cope with the differences in gene copy numbers between the sexes that are observed on sex chromosomes. (wikipedia.org)
There are three main mechanisms of achieving dosage compensation which are widely documented in the literature and which are common to most species. (wikipedia.org)
Understanding the diversity of SCDC mechanisms in nature, how they happen and evolve, informs more broadly on how animals and humans compensate for gene dose imbalance, and why the failure to properly compensate for these differences leads to disease states," Valenzuela said. (scitechdaily.com)
But SCDC mechanisms work to upregulate, or increase the level, of protein production from genes in the single Z (or X) chromosomes. (scitechdaily.com)
Since the evolutionary forces driving genetic changes that cause infertility between species are likely also acting within species, the study of hybrid sterility also promises significant insight into mechanisms underlying infertility within species. (elifesciences.org)
In addition to classical gene regulatory networks noted above, we have recently identified a central role for additional biologic mechanisms, namely gene regulation by chromatin regulators and by noncoding RNAs. (stanford.edu)

We are currently pursuing studies of the dominant signaling and gene regulatory networks that control this process, including the Ras/MAPK cascade, which is required for stem cell-mediated self-renewal and the p53 transcription factor family member, p63, which is required for epidermal differentiation. (stanford.edu)
Genomic analyses are crucial for a comprehensive picture of sex chromosome differentiation and dosage compensation, in addition to understanding speciation. (asu.edu)
More broadly, gene regulation is the basis for cellular differentiation and development. (asu.edu)
Despite significant advances in understanding nephron segment patterning, many questions remain about the underlying genes and signaling pathways that orchestrate renal progenitor cell fate choices and regulate differentiation. (mdpi.com)

Thus, human females have the same number of expressed X-linked genes per cell as do human males (XY), both sexes having essentially one X chromosome per cell, from which to transcribe and express genes. (wikipedia.org)
We subsequently conducted systems level analyses by examining gene network dynamics between the sexes using weighted gene coexpression network analysis. (biomedcentral.com)
Intriguingly, comparing intermodule dynamics between the sexes revealed only moderate preservation. (biomedcentral.com)

n = 1m + 1m-sm + 1a + 1a (X). Fluorescence in situ hybridization (FISH) revealed three loci of 18S rDNA on two autosomes and dispersion of H3 histone genes on all autosomes and the X chromosome. (bvsalud.org)
These chromosomes also contain the genetic codes for the production of essential proteins, and the disproportion in chromosomes in XY individuals caused by them carrying only a single X for every pair of non-sex chromosomes (called autosomes) can lead to an imbalance in the production of proteins. (scitechdaily.com)
The researchers then compared the activity of genes from sex chromosomes and from autosomes, broken down by male and female turtles. (scitechdaily.com)

Imprinted genes, a class of functionally mono-allelic genes critical for early growth and metabolic axis development, have been proposed to be uniquely susceptible to environmental change. (prolekarniky.cz)

Genomes exhibit large regions with segmental copy number variation, many of which include entire genes and are multiallelic. (bvsalud.org)
In addition, these findings provide further support for models in which conflicts between different genes in genomes can drive the process of speciation. (elifesciences.org)

123-Chalvin C, Drevensek S, Chollet C, Gilard F, Šolić EM, Dron M, Bendahmane A, Boualem A, Cornille A. (2021) Study of the genetic and phenotypic variation among wild and cultivated clary sages provides interesting avenues for breeding programs of a perfume, medicinal and aromatic plant. (u-psud.fr)
[ 1 ] Significant genetic variation exists between and within racial and ethnic groups, but the issue is confounded by important coexisting economic, cultural, and environmental differences, including geography (place of birth). (medscape.com)

The third documented type of gene dose regulatory mechanism is incomplete compensation without balance (sometimes referred to as incomplete or partial dosage compensation). (wikipedia.org)
The evidence for this mechanism of dosage compensation was discovered prior to scientists' understanding of what its implications were. (wikipedia.org)
Although gene duplicability has been observed to differ by duplication mechanism and evolutionary rate, there is so far no broad characterization of its determinants. (bvsalud.org)
This mechanism also applies to hematopoietic cells transformed by other HOX genes, including CDX2, which is highly expressed in a majority of acute myeloid leukemias, thus providing a molecular approach based on GSK-3 inhibitory strategies to target HOX-associated transcription in a broad spectrum of leukemias. (stanford.edu)
It seemed apparent that per gene regulation was directly related to the circadian clock, but the mechanism was still shrouded in mystery. (genestogenomes.org)
This process of X-chromosome inactivation evolved as a mechanism to regulate gene dosage. (dementiatalkclub.com)
A possible mechanism is through regulating specific brain gene networks. (biomedcentral.com)

However in recent years with the development of epigenesis, genomic imprinting and the horizontal transferences of the genes, Lamarck's ideas have resurfaced. (intechopen.com)
Public attention surrounding completion of the draft human sequence has fostered the impression that we are entering a 'post-genomic' era, and that description of genes and their functions is straightforward. (biomedcentral.com)

The nuclear membrane protein SUN1 stabilizes endothelial cell-cell junctions far from the nucleus via regulation of microtubule dynamics and Rho GEF-H1 signaling, revealing long-range cellular communication important for vascular development and function. (elifesciences.org)
The Z chromosomes contain instructions for some of the proteins normally functioning cells should produce, and having only a single copy of a chromosome can result in a reduced amount of proteins produced, because protein production is often affected by the number of gene copies. (scitechdaily.com)
Rosbash and Hall found that levels of the protein product of the period gene (PER) oscillated throughout the day, peaking in the middle of the night. (genestogenomes.org)
To identify YpdB-regulated genes, we compared the transcriptomes of E. coli cells overproducing either YpdB or a control protein. (cipsm.de)
In this study, we used the TEV protease-mediated induction of protein instability (TIPI) in combination with the genetic Tug-of-War (gTOW) to develop a method to measure the lower limit of protein level. (biomedcentral.com)
TIPI-gTOW is useful for estimating changes in the lower limit of a protein under different conditions, such as different genetic backgrounds and environments. (biomedcentral.com)
For Terry, who had a deletion mutation in exon 1 of the Dystrophin gene, the CRD-TMH-001 therapy utilized a recombinant adeno-associated virus serotype 9 (rAAV9) to deliver a Cas9 variant (dSaCas9) with lost cleavage activity from Staphylococcus aureus and a transcription activation protein VP64. (medicaltrend.org)

TIPI-gTOW is also useful for analyzing genetic interactions of essential genes whose deletion mutants cannot be obtained. (biomedcentral.com)

When evolutionary change of nucleons occurs mainly by mutation and genetic drift, all the measures can be expressed in terms of the product of mutation rate per nucleon and effective population size. (typeset.io)

Valenzuela and her co-authors sampled softshell turtles at various stages of development, including embryos, young hatchlings and adults, and analyzed various tissues to determine which genes were activated. (scitechdaily.com)
We therefore analyse the role of imprinted genes in multiple tissues in two affected generations of an established murine model of the developmental origins of health and disease using microarrays and quantitative RT-PCR. (prolekarniky.cz)
Using this approach, I show that more genes are called as sex differentially expressed in several human adult tissues compared to a default reference alignment. (asu.edu)

We revealed a saturating dose-dependent relationship but also allele-specific idiosyncratic interactions, including between alleles driving a step change in fruit size during domestication. (bvsalud.org)
In addition, it provides further support for models in which genetic conflicts, such as those caused by meiotic drive alleles, can drive speciation. (elifesciences.org)
These new models, which we term Multi-Functional Human Tissue Genetics, allow up to 10 alleles or more to be altered simultaneously, permitting genetic experiments with an unprecedented degree of rapidity and complexity. (stanford.edu)
The dominant theoretical model for the early stages of sex chromosome evolution 3 , 4 , 5 predicts that recombination will be selected against in the region between a sex determining gene and a nearby locus with alleles of sex-specific effect. (nature.com)

We applied NeoLoopFinder in Hi-C data from 50 cancer cell lines and primary tumors and identified tens of recurrent genes associated with enhancer hijacking. (nature.com)
Single-cell transcriptomic analysis of tumor cells from the primary tumors reveals a distinct transcriptional signature that is predictive of metastatic potential and patient survival. (pklab.org)

We are studying the role that normal chromatin structure plays in gene regulation in hematopoietic cells and how its disruption leads to altered development and cancer. (stanford.edu)

Our approach and findings expose an underexplored dimension of epistasis, in which cis-regulatory allelic diversity within gene regulatory networks elicits nonlinear, unpredictable interactions that shape phenotypes. (bvsalud.org)
Epigenetics: The Death of the Genetic Theory of Disease Transmission is the result of decades of research and its findings that could be as critical to our understanding of human health as Pasteur s research in bacteriology. (walterswebs.com)
Laboratory findings revealed elevated liver enzyme levels. (symptoma.com)
CRISPR Gene Editing Treatment Leads to Patient's Death 8 Days Later, NEJM Publishes Autopsy Findings Revealing AAV-Induced Innate Immune Response as the Cause of Death. (medicaltrend.org)
The research team conducted a thorough analysis of the cause of his death, and the autopsy findings revealed severe acute respiratory distress syndrome (ARDS) with diffuse alveolar damage. (medicaltrend.org)

In addition to these basic issues concerning leukemia pathogenesis, we are devising new diagnostic procedures for detecting and monitoring leukemia patients based on molecular genetic abnormalities in the malignant cells. (stanford.edu)

Further research has revealed similar intricate biological clocks tick in all animals, including humans. (genestogenomes.org)
This nexus between nutrition and so-called genetic disease has been observed in both humans and primates, and it is the central theme of Epigenetics. (walterswebs.com)

In mice, the Sry gene is located on the Y chromosome very close to one of the pseudoautosomal regions that pairs with the X chromosome during male meiosis. (quizlet.com)
The best known genes of microbes, mice and men are those that specify enzymes. (typeset.io)

Although most of what follows focuses on situations arising in diploid organisms, it is worth saying that the dosage balance principles hold also for prokaryotes. (biomedcentral.com)
The Plant Systems Biology Lab aims at understanding how green organisms cope with the fluctuating environmental conditions they encounter in nature, i.e. understand what are the genetic/physiological bases of robustness in sessile green organisms. (universityofgalway.ie)

Moreover, in line with the somatic nervous system, pretarget sorting via heterotypic axonal interactions is revealed to play critical roles in patterning extrinsic efferent trajectories to the gut. (jneurosci.org)
We first tested the feasibility of this method using ADE2 as a marker and then analyzed some cell cycle regulators to reveal genetic interactions. (biomedcentral.com)
Using this strain, we studied genetic interactions between cell cycle regulators and CDC20 , and the result was highly consistent with the previously identified interactions. (biomedcentral.com)
Comparison of the experimental data with predictions of a mathematical model revealed some interactions that were not implemented into the current model. (biomedcentral.com)
Cette thèse a comme objectif général d'approfondir notre connaissance des déterminants environnementaux de la fécondité des arbres forestiers et de leurs interactions, en se focalisant sur le chêne vert, une espèce très répandue en milieu méditerranéen. (cnrs.fr)
Our receptor-ligand interaction analysis reveals a highly complex interactive network of the NB microenvironment from which we highlight several interactions that we suggest for future therapeutic studies. (pklab.org)

Visualization with characterized intrinsic markers revealed that visceral sensory, sympathetic, and parasympathetic axons arise from different anatomic locations, project in close association via the gut mesentery, and form distinctive innervation patterns within the gut from embryonic day (E)10.5 to E16.5. (jneurosci.org)

Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)

Surprisingly, only 61 genes (approximately 0.4% of genes analyzed) showed a significant sex effect across all four strains, and 48 of these differences were male-biased. (biomedcentral.com)

Complex topology and dosage sensitivity. (biomedcentral.com)

A normal-visioned woman (with both genes present on each of her two X chromosomes) has a red color-blind son who was shown to have one copy of the green-detecting gene and no copies of the red-detecting gene. (quizlet.com)
Thus, unevenness in the number of copies of genes that work together can lead to developmental, physiological, or other disorders. (scitechdaily.com)

A recent study reported that the number can be even higher (up to 3000 genes) that display signs of haploinsuffeciency (Collins et al, Cell, 2023). (sirop.org)
On September 28, 2023, researchers from the Massachusetts Medical School and Yale University published a study in the New England Journal of Medicine (NEJM) titled "Death after High-Dose rAAV9 Gene Therapy in a Patient with Duchenne's Muscular Dystrophy. (medicaltrend.org)

The B chromosome had a small amount of heterochromatin in the centromeric and telomeric regions of the chromosomal arms and showed two clusters of H3 genes. (bvsalud.org)
In addition, initial sequence analysis reveals highly ordered chromosomal landscapes associated with paralogous gene clusters and distinct functional compartments. (biomedcentral.com)

After salivary gland cells from Drosophila are isolated and cultured in the presence of radioactive thymidylic acid, autoradiography is performed, revealing polytene chromosomes. (quizlet.com)
In Drosophila phosphorylation of histone H3S10 in euchromatic chromatin regions by the JIL-1 tandem kinase has been implicated in counteracting heterochromatization and gene silencing. (silverchair.com)
Our observations reveal that the male germ line of Drosophila shows a characteristic pattern of histone modifications. (biomedcentral.com)

The genes encoding the red- and green-color-detecting proteins of the human eye are located next to one another on the X chromosome and probably evolved from a common ancestral pigment gene. (quizlet.com)

Linkage and genetic association studies can be immediately followed by investigation of candidate regions. (biomedcentral.com)

Genetic differences may alter susceptibility to asthma, as well as responsiveness to asthma medications. (medscape.com)

Oligonucleotides used in gene therapy and silencing are fragile compounds that degrade easily in biological environments. (cipsm.de)
It explains why mapping an organism's genetic code is not enough to determine how it develops or acts and shows how nurture combines with nature to engineer biological diversity. (walterswebs.com)

While it is routine to detect structural viral proteins in vitro for diagnostic purposes, it previously remained impossible to directly and dynamically visualize HIV in living cells without genetic modification of the virus. (cipsm.de)

The (Bateson) Dobzhansky-Muller (BDM) model provided a solution to the paradox of how genetic changes that lead to speciation could be tolerated by natural selection despite decreasing the fitness potential of an organism. (elifesciences.org)

We have developed a computational method GeneToCN that counts the frequencies of gene-specific k-mers in FASTQ files and uses this information to infer copy number of the gene. (bvsalud.org)
The combination of deep learning with whole-brain computational models reveals the low-dimensional representation of neurodegenerative diseases, which emerges from a highly multidimensional brain, providing valuable insight into pathological states' diagnostic, prognosis, and treatment response. (elifesciences.org)
The creation of a comprehensive gene index requires the synthesis of all available computational and experimental evidence. (biomedcentral.com)

Alteration of gene copy numbers are associated with lung cancer and the determination of copy number variations (CNV) is appropriate for the discrimination between tumor and non-tumor tissue in lung cancer. (bvsalud.org)
In retrospect, the fact that cancer was viewed as a genetic disease for so long was likely an artifact of focus and technology: Chromosomal changes began to be detectable before we understood epigenetics at a molecular level, and the early focus on familial cancer and rapidly induced viral tumors favored the discovery of mutational carcinogenesis, which has largely colored our views over the past three decades ( 3, 4 ). (aacrjournals.org)
For example, XX females are more likely to suffer from autoimmune diseases, and genetic XY males are more likely to develop cancer. (asu.edu)
Fig. 3: Cancer-type specificity of neoloop-involved genes. (nature.com)
The list of cancer-related genes was obtained from the Bushman Lab ( http://www.bushmanlab.org/assets/doc/allOnco_May2018.tsv ). (nature.com)
A census of human cancer genes. (nature.com)
In recent years, we have witnessed clinical advancements in CRISPR gene editing for rare genetic diseases, cancer, and cardiovascular disorders, igniting hope for many families facing rare and devastating conditions. (medicaltrend.org)

In summary, NeoLoopFinder enables identification of critical oncogenic regulatory elements that can potentially reveal therapeutic targets. (nature.com)

We validated the copy number predictions for amylase genes (AMY1, AMY2A, AMY2B) using experimental data from digital droplet PCR (ddPCR) on 39 individuals and observed a strong correlation (R = 0.99) between GeneToCN predictions and experimentally determined copy numbers. (bvsalud.org)

Accordingly, he examined the inhibitory effect of comprehensive strategy that includes, whenever possible, the various chemicals on the growth and viability of bacteria and selection of antibacterial agents in dosages sufficient to be directly applied the results to the practice of medicine by bactericidal (13). (cdc.gov)

Laboratory domestication may reduce their genetic diversity and mating behaviour and hence, refreshment with wild genetic material is frequently needed. (bvsalud.org)
Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press announced the release of Genetic Counseling: Clinical Practice and Ethical Considerations, available on its website in Hardcover and Paperback formats. (cshlpress.com)

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