• As a retrovirus, it has a single-stranded, positive sense RNA genome which replicates via a DNA intermediate mediated by a reverse transcriptase. (wikipedia.org)
  • However, this is only possible when the host cell is co-infected with a helper virus which provides functions it needs to be able to replicate which it does not code for in its own genome such as a reverse transcriptase and some major structural proteins. (wikipedia.org)
  • This recombinant virus behaved like the A-MuLV virus from which it was derived: it transformed both fibroblasts and lymphoid cells in vitro. (duke.edu)
  • Human Immunodeficiency Virus Type I (HIV-1) infection is associated with a high incidence of B-cell lymphomas. (biomedcentral.com)
  • Murine models for human AIDS-related B cell lymphomas have been lacking. (biomedcentral.com)
  • In vitro studies have shown that lymphocyte infection produces tumor cell populations comprising three types of cells: stable productive cells, non-productive cells and cells which produced defective virus particles which are not infective. (wikipedia.org)
  • Several chimeric murine retroviruses were constructed to test whether the gag sequence of Abelson murine leukemia virus (A-MuLV) could influence the in vitro specificity of two sarcoma-inducing oncogenes: src of Rous sarcoma virus and fps of Fujinami sarcoma virus. (duke.edu)
  • We previously confirmed that overexpression of in primitive hematopoietic cells provides them a rise benefit in vitro and the capability to generate leukemia in vivo, synergizing with to improve these final results (39). (angiogenesis-blog.com)
  • One candidate focus on is certainly Abelson helper integration site 1 (encodes a distinctive proteins with multiple SH3 binding sites, an SH3 area, and seven WD40 repeats, all known mediators of proteinCprotein connections (38). (angiogenesis-blog.com)
  • Around the same time, and building on the observation that the vitamin folic acid could stimulate acute lymphoblastic leukemia (ALL) cells, Farber used folate analogs such as aminopterin and then amethopterin (methotrexate) to treat ALL, in what is often heralded as the first 'rational' drug development approach [ 4 ]. (biomedcentral.com)
  • The Abelson murine leukemia virus (Ab-MLV or A-MuLV) is a retrovirus (Class VI) used to induce malignant transformation of murine lymphoid cells. (wikipedia.org)
  • Mixture treatment also statistically considerably improved apoptosis of Compact disc34+ leukemic stem/progenitor cells and removed their long-term leukemia-initiating activity in NSG mice. (angiogenesis-blog.com)
  • Human Immunodeficiency Virus Type I (HIV-1) infection is associated with an elevated incidence of B-cell non-Hodgkin's lymphoma (NHL) and in recent years also with Hodgkin's lymphoma [ 1 ]. (biomedcentral.com)
  • Here we describe the phenotypic and molecular characteristics of the B cell leukemia/lymphoma in the Tg mice. (biomedcentral.com)
  • A-MuLV causes a rapidly progressive lymphosarcoma known as Abelson disease in mice, which is a type of leukemia that does not involve the thymus. (wikipedia.org)
  • Serological characterization of C-type retroviruses endogenous to the C57BL/6 mouse and isolated in tumours induced by radiation leukaemia virus (RadLV-Rs). (microbiologyresearch.org)
  • Syncytin-1 also known as enverin is a protein found in humans and other primates that is encoded by the ERVW-1 gene ( endogenous retrovirus group W envelope member 1). (wikipedia.org)
  • Different serotypes of B-tropic murine leukemia viruses and association with endogenous ecotropic viral loci. (microbiologyresearch.org)
  • Serological characterization of B-tropic viruses of C57BL mice: possible origin by recombination of endogenous N-tropic and xenotropic viruses. (microbiologyresearch.org)
  • Radiation-induced murine leukemias and endogenous retroviruses: the time course of viral expression. (microbiologyresearch.org)
  • A selective temperature-sensitive defect in viral RNA expression in cells infected with a ts transformation mutant of murine sarcoma virus. (wikidata.org)
  • 4. In vitro transformation of murine pro-B and pre-B cells by v-mpl, a truncated form of a cytokine receptor. (nih.gov)
  • PMID- 214398 TI - Characterization of an adenosine triphosphatase of the avian myeloblastosis virus and the virus-infected myeloblast. (nih.gov)
  • PMID- 214400 TI - Transmission of Japanese encephalitis virus by Culex bitaeniorhynchus Giles. (nih.gov)
  • PMID- 214405 TI - Long-term T-cell-mediated immunity to Epstein-Barr virus in man. (nih.gov)
  • PMID- 214407 TI - Antibodies to Herpes simplex virus types 1 and 2 in patients with squamous-cell carcinoma of uterine cervix in India. (nih.gov)
  • 16. Viral oncogene expression during differentiation of Abelson virus-infected murine promonocytic leukemia cells. (nih.gov)
  • [15] Syncytin-1 has been shown to interfere with viral infection in-vitro by RDR interference group member spleen necrosis virus. (wikipedia.org)
  • The Abelson murine leukemia virus (Ab-MLV or A-MuLV) is a retrovirus (Class VI) used to induce malignant transformation of murine lymphoid cells. (wikipedia.org)
  • 17. Temperature-sensitive transformation by an Abelson virus mutant encoding an altered SH2 domain. (nih.gov)
  • 19. Abelson virus transformation prevents TRAIL expression by inhibiting FoxO3a and NF-kappaB. (nih.gov)
  • I. Complete regression of virus-induced transformation in cultures of seropositive donor leukocytes. (nih.gov)
  • It causes leukemia directly by interfering with the normal growth and differentiation processes of lymphocytes. (wikipedia.org)
  • 1. A small molecule Abl kinase inhibitor induces differentiation of Abelson virus-transformed pre-B cell lines. (nih.gov)
  • 9. Induction by some protein kinase inhibitors of differentiation of a mouse megakaryoblastic cell line established by coinfection with Abelson murine leukemia virus and recombinant SV40 retrovirus. (nih.gov)
  • X-irradiation of C57BL/6 mice induces thymic lymphosarcomas which sometimes contain retroviruses which upon injection into normal mice mimic the effect of the irradiation. (microbiologyresearch.org)
  • As a retrovirus, it has a single-stranded, positive sense RNA genome which replicates via a DNA intermediate mediated by a reverse transcriptase. (wikipedia.org)
  • However, this is only possible when the host cell is co-infected with a helper virus which provides functions it needs to be able to replicate which it does not code for in its own genome such as a reverse transcriptase and some major structural proteins. (wikipedia.org)
  • 5. Inhibition of Abelson oncogene function by erbstatin analogues. (nih.gov)
  • In vitro studies have shown that lymphocyte infection produces tumor cell populations comprising three types of cells: stable productive cells, non-productive cells and cells which produced defective virus particles which are not infective. (wikipedia.org)
  • 13. Tracing the pre-B to immature B cell transition in human leukemia cells reveals a coordinated sequence of primary and secondary IGK gene rearrangement, IGK deletion, and IGL gene rearrangement. (nih.gov)
  • Antibody-induced modulation of Friend virus cell surface antigens decreases virus production by persistent erythroleukemia cells: influence of the Rfv-3 gene. (microbiologyresearch.org)
  • Structural markers on core protein p30 of murine leukemia virus: functional correlation with Fv-1 tropism. (microbiologyresearch.org)
  • Binding of retrovirus-associated protein kinase and proteins to Staphylococcus aureus. (wikidata.org)
  • 6. Proviral integration of an Abelson-murine leukemia virus deregulates BKLF-expression in the hypermutating pre-B cell line 18-81. (nih.gov)
  • Note that the expression "active in" does not always refer to the source organism of the promoter (e.g. in viruses). (expasy.org)
  • The results strongly suggest that the regression phenomenon is an in vitro expression of long-term T-cell-mediated immunity to EB virus which the large majority, if not all, infected individuals possess. (nih.gov)
  • AB - Antibody activity to Herpes simplex virus type-1 (HSV-1) and type-2 (HSV-2) was measured by the indirect hemagglutination (IHA) test in sera from 124 women with squamous-cell carcinoma of the uterine cervix, 46 women with non-cervical cancer and 116 matched normal women. (nih.gov)
  • 14. Autocrine production of pre-B-cell stimulating activity by a variety of transformed murine pre-B-cell lines. (nih.gov)