AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesAnthropology, Education, Sociology and Social PhenomenaInformation Science
GammaretrovirusXenotropic murine leukemia virus-related virusRetroviridae InfectionsPhascolarctidaeWhale, KillerEndogenous RetrovirusesLeukemia Virus, MurineDNA ContaminationRetroviridaeTumor Virus InfectionsTerminal Repeat SequencesLeukemia Virus, FelineFatigue Syndrome, ChronicReceptors, VirusMolecular Sequence DataGene Products, envGenetic VectorsDNA, ViralCell LinePhylogenyAmino Acid SequenceMoloney murine leukemia virusVirus IntegrationProstatic NeoplasmsGene Transfer TechniquesGenetic TherapyBase SequenceProvirusesTransfection
Murine leukemia viruXMRVEndogenousVectorsRetrovirusesMoloneyLentivirusGeneLeukemia virusSpeciesSequencesBatsProteinAssociationCellRangeMammalianClosely related to exogenous gammaretrovirusesLentivirusGenusExogenousGamma retroviralAnother endogenousMurine gammaretrovirusesGene therapyVectorGeneraPrimateProteinsOncogenicGenesInfectionPathogenesisReplication-competentSequenceKoRVMRNAsRetroviridaeGenomeEnvelopeReceptorDiversityEvolutionSpreadClassCell linesResearchImportantFormPresentOriginal
Murine leukemia viru4
XMRV3
  • Neither in the 76 specimens homozygous for the QQ allele, nor in any of the other samples could XMRV or a related gammaretrovirus be detected. (biomedcentral.com)
  • Detection of a novel Gammaretrovirus, Xenotropic Murine leukaemia virus-Related Virus (XMRV) has been reported in peripheral blood mononuclear cells of patients with chronic fatigue syndrome, and in prostate cancer tissue. (biomedcentral.com)
  • As Multiple Sclerosis (MS) is a disease with retroviral association (human endogenous retroviruses (HERVs)), we investigated whether XMRV could be contributing to MS aetiology by testing a well defined cohort of Danish MS patients for the presence of XMRV sequences. (biomedcentral.com)
Endogenous5
  • Many endogenous retroviruses, closely related to exogenous gammaretroviruses, are present in the DNA of mammals (including humans), birds, reptiles and amphibians. (wikipedia.org)
  • This gammaretrovirus called Tursiops truncates endogenous retrovirus, was thought to be from extant mammalian endogenous gammaretroviruses. (wikipedia.org)
  • The Tursiops truncates endogenous retrovirus original invasion dates back to approximately 10-19 million years ago, and was identified in killer whale endogenous gammaretrovirus which invaded over 3 million years ago. (wikipedia.org)
  • In 2009, another endogenous gammaretroviruses were detected in a species of killer whale, as well as nine other cetacean genomes. (wikipedia.org)
  • The evolution of endogenous retroviral envelope genes in bats and their potential contribution to host biology. (ox.ac.uk)
Vectors4
  • Gammaretroviruses are very popular retroviral vectors in laboratory studies. (wikipedia.org)
  • Outcomes We produced retroviral vectors pseudotyped with different gamma and lentiviral Envs on MLV-B and -NB CAs formulated with a green neon proteins (GFP) news reporter. (siamtech.net)
  • These vectors contained strong enhancers as part of the long terminal repeat (LTR) of the Moloney murine leukemia virus (MLV) retroviral backbone. (europeanhealthjournal.com)
  • Retroviral (primarily gamma-retroviral) and adenoviral vectors were among the first cell modifying vectors and have generated a 30-year history to date. (cellculturedish.com)
Retroviruses2
  • Gammaretroviruses are similar to other retroviruses and reverse transcribe a positive single strand RNA into double stranded DNA. (wikipedia.org)
  • Therefore, our research project aims at characterizing in detail the major epitranscriptomic modifications of viral RNAs of different retroviruses, assessing their implication on viral replication, and comparing the epitranscriptomic strategies used among the different retroviral genera. (unil.ch)
Moloney1
Lentivirus1
  • Much less than a 10 years after Fv1 was cloned in 1996, the tripartite theme (Cut) family members of meats had been suggested as a factor in species-specific limitation of inbound retroviral CAs, originally known to as the lentivirus limitation element or Lv1 [13-15]. (siamtech.net)
Gene5
  • As a potential vector for gene therapy, gammaretroviruses have some advantages over HIV as a lentiviral vector. (wikipedia.org)
  • Background 'Intrinsic' level of resistance to retroviral infection was 1st recognised with the Friend computer virus susceptibility gene (Fv1), which determines susceptibility to murine leukaemia computer virus (MLV) infection in different murine species. (siamtech.net)
  • Retroviral proteins, often glycosylated, coded by the envelope (env) gene. (lookformedical.com)
  • Proteins coded by the retroviral gag gene. (lookformedical.com)
  • Neural stem cells as engraftable packaging lines can mediate gene delivery to microglia: evidence from studying retroviral env-related neurodegeneration. (omeka.net)
Leukemia virus1
  • We will concentrate at first on m6A and m5C post-transcriptional modifications, and on three retroviral genera: lentiviruses (HIV and SIV, human and simian immunodeficiency viruses), the oncogenic deltaretroviruses (HTLV and BLV, human T-lymphotropic virus and bovine leukemia virus), and the oncogenic gammaretrovirus (MLV, mouse leukemia virus). (unil.ch)
Species3
  • Researchers also looked into several different types of bat species to solidify the claim that bats are the main reservoir for gammaretroviruses. (wikipedia.org)
  • So gammaretrovirus genomes are present in both aquatic and terrestrial mammal species. (wikipedia.org)
  • Species of GAMMARETROVIRUS , containing many well-defined strains, producing leukemia in mice. (lookformedical.com)
Sequences2
  • In this study, we screened all publicly available bat genomes from six bat families within which we have identified several envelope sequences of retroviral origin (gammaretroviruses). (ox.ac.uk)
  • DNA sequences that form the coding region for retroviral enzymes including reverse transcriptase, protease, and endonuclease/integrase. (lookformedical.com)
Bats2
  • However, bats are the primary reservoir for many gammaretroviruses. (wikipedia.org)
  • So, it is possible for bats to harbor not only one, but several types of gammaretroviruses. (wikipedia.org)
Protein1
  • Over-expression, incorporation near oncogenic loci, or the website hosts' response to the protein encoded by retroviral genetics determine the type of disease demonstrated [1]. (siamtech.net)
Association1
  • ME/CFS requires as strong a response from the NIH as AIDS did, especially in light of recent research indicating a retroviral association. (cfscentral.com)
Cell1
  • There have also been claimed discoveries of murine gammaretroviruses in lung cancer cell lines. (wikipedia.org)
Range1
  • Gammaretroviruses have a wide range of implications for animals. (wikipedia.org)
Mammalian4
  • This gammaretrovirus called Tursiops truncates endogenous retrovirus, was thought to be from extant mammalian endogenous gammaretroviruses. (wikipedia.org)
  • We demonstrate a history of frequent horizontal interorder transmissions from a rodent reservoir and suggest that rats may have acted as important overlooked facilitators of gammaretrovirus spread across diverse mammalian hosts. (scilifelab.se)
  • Endogenous retrovirus-like sequences (ERVs) are fossils of ancient retroviral integrations into the mammalian germline. (biomedcentral.com)
  • [13] [14] This receptor places syncytin-1 in a large viral interference group called retroviral mammalian type D receptor (RDR) interference group. (wikipedia.org)
Closely related to exogenous gammaretroviruses1
Lentivirus3
  • Like the primate lentivirus Nef and the gammaretrovirus glycoGag, the accessory protein from EIAV is an example of a retroviral virulence determinant that independently evolved SERINC5-antagonizing activity. (unitn.it)
  • Current retroviral vector systems produced from lentivirus (LV), foamy trojan (FV) and gammaretrovirus (GV) Celecoxib manufacturer are replication-incompetent, Celecoxib manufacturer and also have been constructed with several basic safety features. (pkc-inhibitor.com)
  • 8. Unique integration profiles in a canine model of long-term repopulating cells transduced with gammaretrovirus, lentivirus, or foamy virus. (nih.gov)
Genus4
  • Gammaretrovirus is a genus in the Retroviridae family. (wikipedia.org)
  • In 2000, 20 years after its identification in the early '80s as the first member of the deltaretrovirus genus, we have discovered that the Human T-cell Leukemia Virus (HTLV), and its simian STLV counterparts, have an Env structurally related to that of gammaretroviruses, although remotely related to the latter viruses (Kim, JBC 2000). (cnrs.fr)
  • Starting with nearly 90,000 ERVs from 60 vertebrate host genomes, we construct phylogenetic hypotheses and draw inferences regarding the designation, host distribution, origin, and transmission of the Gammaretrovirus genus and associated class I ERVs. (scilifelab.se)
  • KoRV is a member of the gammaretrovirus genus. (biomedcentral.com)
Exogenous1
  • Among the retroviruses of vertebrates, the gammaretroviruses are the most widely spread in mammals, whether as exogenous infectious agents or as bona fide host genes (Endogenous RetroViruses, ERV). (cnrs.fr)
Gamma retroviral1
  • Some people who have received gamma retroviral gene therapies have later developed leukemia, which scientists suspect is due to the vector causing activation of genes that control cell growth. (nih.gov)
Another endogenous1
  • In 2009, another endogenous gammaretroviruses were detected in a species of killer whale, as well as nine other cetacean genomes. (wikipedia.org)
Murine gammaretroviruses2
  • There have also been claimed discoveries of murine gammaretroviruses in lung cancer cell lines. (wikipedia.org)
  • Prostate cancer cell lines appear to have a propensity for infection with murine gammaretroviruses, and we propose that this may be in part due to cell line establishment by xenograft passage in immunocompromised mice. (edu.au)
Gene therapy7
  • As a potential vector for gene therapy, gammaretroviruses have some advantages over HIV as a lentiviral vector. (wikipedia.org)
  • Early trials have got confirmed the efficacy of anti-HIV transgenes delivered by retroviral gene therapy. (pkc-inhibitor.com)
  • 1. Dynamics of gene-modified progenitor cells analyzed by tracking retroviral integration sites in a human SCID-X1 gene therapy trial. (nih.gov)
  • 4. Retroviral integration and human gene therapy. (nih.gov)
  • 5. Murine leukemias with retroviral insertions at Lmo2 are predictive of the leukemias induced in SCID-X1 patients following retroviral gene therapy. (nih.gov)
  • 7. Genotoxicity of retroviral hematopoietic stem cell gene therapy. (nih.gov)
  • 13. Cytoreductive conditioning intensity predicts clonal diversity in ADA-SCID retroviral gene therapy patients. (nih.gov)
Vector6
  • One specific gammaretrovirus that is commonly used as a retroviral vector is the Moloney murine leukemia virus. (wikipedia.org)
  • Until the occurrence of these adverse events was related to an integrating retroviral vector, the risk of insertional mutagenesis was estimated as only 10 −6 -10 −8 per integration event. (medscape.com)
  • by transduction using a retroviral vector. (pkc-inhibitor.com)
  • During Celecoxib manufacturer vector creation the viral helper features are in physical form separated in the retroviral vector and supplied on split helper plasmids. (pkc-inhibitor.com)
  • 6. Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo. (nih.gov)
  • 15. Recurrent retroviral vector integration at the Mds1/Evi1 locus in nonhuman primate hematopoietic cells. (nih.gov)
Genera1
  • We will concentrate at first on m6A and m5C post-transcriptional modifications, and on three retroviral genera: lentiviruses (HIV and SIV, human and simian immunodeficiency viruses), the oncogenic deltaretroviruses (HTLV and BLV, human T-lymphotropic virus and bovine leukemia virus), and the oncogenic gammaretrovirus (MLV, mouse leukemia virus). (unil.ch)
Primate2
  • Therefore, it appears that primate APOBEC3 proteins were capable of targeting ancient primate gammaretroviruses. (rockefeller.edu)
  • The gene encoding this protein is an endogenous retroviral element that is the remnant of an ancient retroviral infection integrated into the primate germ line. (wikipedia.org)
Proteins3
  • There appear to be several different modes of interaction between retroviral proteins and nucleic acids, each with important functional consequences for viral replication. (nih.gov)
  • Retroviral proteins that have the ability to transform cells. (lookformedical.com)
  • Not all retroviral proteins are oncogenic. (lookformedical.com)
Oncogenic1
  • [ 135 ] Significantly, more lentiviral integrations are necessary to result in a similar oncogenic risk as gammaretroviruses. (medscape.com)
Genes1
  • Reciprocally, activity against CERV1 and CERV2 would suggest that archaic gammaretroviruses contributed to the positive selection observed in TRIM5 and APOBEC3 genes. (rockefeller.edu)
Infection1
  • While this result could be explained by viral clearance over time, it fails to support a sustained retroviral infection in human cells. (meassociation.org.uk)
Pathogenesis2
  • A better understanding of viral epitranscriptomics will provide additional knowledge on retroviral life cycle and pathogenesis, as well as potentially identify novel therapeutic strategies. (unil.ch)
  • The goal of the research efforts in the Retroviral Assembly Section is to extend our understanding of basic mechanisms in retroviral replication and pathogenesis. (nih.gov)
Replication-competent1
  • We have identified gammaretroviruses in two additional prostate cancer cell lines: LAPC4 and VCaP, and show that these viruses are replication competent. (edu.au)
Sequence3
  • S2 shares no sequence homology with other retroviral factors known to counteract SERINC5. (unitn.it)
  • Our results uncover remarkable depths in retroviral sequence diversity, supported within a phylogenetic context. (scilifelab.se)
  • The haptoglobin gene cluster has been expanded and contracted during the evolution of primates, this evidence was associated with gene conversion events and mutations induced by retroviral and other sequence insertions ( McEvoy and Maeda 1988 ). (gydb.org)
KoRV1
  • As for many other gammaretroviruses, the KoRV genome can potentially encode an alternate form of Gag protein, glyco-gag. (biomedcentral.com)
MRNAs1
  • 8. Clémenceau B, Lalain S, Martignat L, Saï P. Porcine endogenous retroviral mRNAs in pancreas and a panel of tissues from specific pathogen-free pigs. (koreamed.org)
Retroviridae1
Genome1
Envelope2
  • We are interested in retroviral envelope glycoproteins ( Env ) that use nutrient transporters from the solute carrier ( SLC ) family as receptors. (cnrs.fr)
  • We then identified the envelope glycoprotein of EIAV as a determinant that also modulates retroviral susceptibility to SERINC5, indicating that EIAV has a bimodal ability to counteract the host factor. (unitn.it)
Receptor1
  • All Env from gammaretroviruses and deltaretroviruses, and some members of the alpha- and beta-retroviral generae, for which a fusion or entry receptor has been identified, have been shown to specifically bind SLC members through their aminoterminal RBD. (cnrs.fr)
Diversity1
  • Together, these results demonstrate the promise of the methodology used here to analyze large ERV datasets and improve understanding of retroviral evolution and diversity for utilization in wider applications. (scilifelab.se)
Evolution1
  • In conjunction with broad-scale in silico screening of vertebrate genomes, this resource offers an opportunity to complement data on the evolution and frequency of past retroviral spread and so evaluate future risks and limitations for horizontal transmission between different host species. (scilifelab.se)
Spread1
  • The gammaretroviruses can be spread horizontally, animal to animal, or vertically from parent to offspring. (wikipedia.org)
Class1
  • For the first time, we formally describe the characteristics of this ERV class and its classification relative to other recognised ERV and retroviral classes. (biomedcentral.com)
Cell lines1
  • Importantly, our results suggest a need for regular screening of cancer cell lines for retroviral "contamination", much like routine mycoplasma testing. (edu.au)
Research1
  • To summarize, the present research project aims in a multidisciplinary approach to decipher the post- transcriptional modifications of retroviral RNAs. (unil.ch)
Important1
  • Au cours des 12 dernières années, le laboratoire du Dr Langlois s'est concentré sur l'étude des défenses immunitaires intrinsèques de l'hôte qui jouent un rôle important dans la limitation des infections rétrovirales, comme le VIH, et des zoonoses. (uottawa.ca)
Form1
  • We and others have shown that many gammaretroviruses encode an alternate form of Gag polyprotein, glycosylated Gag or glyco-gag [ 8 - 10 ]. (biomedcentral.com)
Present1
Original1
  • The Tursiops truncates endogenous retrovirus original invasion dates back to approximately 10-19 million years ago, and was identified in killer whale endogenous gammaretrovirus which invaded over 3 million years ago. (wikipedia.org)