• Methods
  • Sensitive psychophysical examinations, such as contrast sensitivity 4- 6 and colour vision, 7, 8 and also electrophysiological methods including electroretinography (ERG) 9- 11 and visual evoked potentials (VEP), 12- 15 clearly show early abnormalities to be a potential primary consequence of hyperglycaemia before the onset of the retinopathy. (bmj.com)
  • RESEARCH DESIGN AND METHODS Twenty patients with type 1 diabetes with no or mild diabetic retinopathy were included in this open parallel-group study, and 20 healthy age- and sex-matched subjects were included as control subjects. (diabetesjournals.org)
  • Results from the various studies are often not directly comparable because of their different assessment methods in the various sections of the ocular vasculature and differences in the study population concerning the patient disease type, duration, and stage. (diabetesjournals.org)
  • Methods: This study examined 1324 patients (784 males and 540 females) with type 2 diabetes mellitus. (scirp.org)
  • Methods of treating diabetes in mammals, particularly humans, by blocking or inhibiting VEGF-mediated activity. (patents.com)
  • Several registers have reported improved glycaemic control over time, 4 , 5 and it has been proposed that benchmarking activity, consisting of actively identifying problems and adopting systematic improvement methods (including reporting of results by centre), has contributed to improving patient outcomes. (mja.com.au)
  • This comparison reveals attracting analogies from different standpoints (methods employed, age, gender, lack of obesity, duration and control of diabetes, biochemical - total urinary protein excretion, serum creatinine and clearance of creatinine - and microscopic analysis). (uninet.edu)
  • Several recent reports have examined methods that may facilitate optimal delivery of this type of care. (acpjc.org)
  • severe
  • Also, poor glycaemia control does not always lead to retinopathy in younger onset patients, while still others develop severe retinopathy that is resistant to retinal photocoagulation. (bmj.com)
  • These facts suggest that the risk factors for diabetes and retinopathy are not necessarily the same, and that the development of severe retinopathy may be influenced by genetic factors. (bmj.com)
  • Patients who maintain rigorous control of their diabetes are less likely to develop severe and extensive periodontal disease. (pharmacytimes.com)
  • citation needed] People (usually with type 1 DM) may also experience episodes of diabetic ketoacidosis, a metabolic disturbance characterized by nausea, vomiting and abdominal pain, the smell of acetone on the breath, deep breathing known as Kussmaul breathing, and in severe cases a decreased level of consciousness. (wikipedia.org)
  • A rare but equally severe possibility is hyperosmolar hyperglycemic state, which is more common in type 2 DM and is mainly the result of dehydration. (wikipedia.org)
  • glycaemic control
  • To assess glycaemic control, anthropometry and insulin regimens in a national sample of Australian children and adolescents with type 1 diabetes. (mja.com.au)
  • The known International diabetes registries report that many young people with type 1 diabetes do not meet recommended targets for glycaemic control. (mja.com.au)
  • The new 73% of Australian children and adolescents with type 1 diabetes do not meet the recommended target for glycaemic control. (mja.com.au)
  • The implications Strategies for improving glycaemic control in young people with diabetes are urgently needed to prevent the acute and chronic complications of this disorder. (mja.com.au)
  • Furthermore, most previous studies have not taken into consideration the background of glycaemic control or the duration of the diabetes. (bmj.com)
  • peripheral
  • Ischaemia, reduced protein synthesis, depleted myoinositol, and high sorbitol levels have been demonstrated in patients with diabetes and may result in nerve fibre loss in peripheral nerves. (bmj.com)
  • pathological
  • The initial pathological changes in diabetic retinopathy (DR) are presumed to occur in small vessels, and involve endothelial cell and pericyte loss. (bmj.com)
  • The microvascular injury in DR has been linked to upregulation of several cytokines such as IL-6, IL1- β , and VEGF and pathological overexpression of adhesion molecules (ICAM-1 and VCAM-1) [ 8 - 10 ]. (hindawi.com)
  • Although periodontal disease is primarily associated with dental plaque, and although there are other factors leading to it (Table 2), periodontal disease is affected by pathological events related to diabetes. (pharmacytimes.com)
  • 1998
  • Se comunica una comparaci n hecha entre datos reportados por Kanauchi et al (1998) en pacientes con una rara divergencia (neuropat a avanzada sin retinopat a) y otros obtenidos en una l nea similar de ratas (eSS), aceptada como modelo general para el estudio de la diabetes tipo 2. (uninet.edu)
  • In 1998, neuropilin 1 and neuropilin 2 were shown to act as VEGF receptors. (wikipedia.org)
  • proximal
  • So that it appears the presence of the DQA1*03:DQB1*04 is of West Pacific Rim origins in Japanese and proximal Siberians, but unfortunately there is no current typing of these haplotypes in the Taiwan aboriginal population. (wikipedia.org)