• Multiscale Blood Vessel Segmentation in Retinal Fundus Images. (fliphtml5.com)
  • The approach results are better than the other state of the art methods used for vessel segmentation. (peerj.com)
  • Anonymous Reviewer ( 2018 ) Peer Review #1 of 'Optimizing the trainable B-COSFIRE filter for retinal blood vessel segmentation (v0.3)' . (peerj.com)
  • The paper presents a method of optimizing trainable B_COSFIRE filter for the retinal blood vessel segmentation. (peerj.com)
  • In this study, we investigate a novel pipeline that generalizes the retinal vessel segmentation across color fundus photography and OCT angiography images. (mlr.press)
  • Automated segmentation of retinal vessel is in fundus important step to identify the retinal disease region. (tmu.edu.tw)
  • Retinal vessel detection is one such area of application of deep learning, for improving the accuracy of detection and segmentation and the quality of patient care. (tmu.edu.tw)
  • Automatic segmentation of blood vessels from retinal images is the initial step of the computer based assessment for blood vessel anomalies. (jist.ir)
  • An ensemble classification-based approach applied to retinal blood vessel segmentation,' Biomedical Engineering, IEEE Transactions on, vol. 59, pp. 2538-2548, 2012. (jist.ir)
  • 11] F. Zana and J.-C. Klein, 'Segmentation of vessel-like patterns using mathematical morphology and curvature evaluation,' Image Processing, IEEE Transactions on, vol. 10, pp. 1010-1019, 2001. (jist.ir)
  • 13] A. M. Mendonca and A. Campilho, 'Segmentation of retinal blood vessels by combining the detection of centerlines and morphological reconstruction,'Medical Imaging, IEEE Transactions on, vol. 25, pp. 1200-1213, 2006. (jist.ir)
  • This paper addresses the issue of improving the retinal image quality and vessel segmentation through retinal image restoration. (deepai.org)
  • A modified UNet is used for retinal vessel segmentation for the restored retinal images (CBAM-UNet). (deepai.org)
  • The retinal vessel segmentation model uses downsampling, bottlenecking, and upsampling layers to generate segmented images. (deepai.org)
  • The retinal vessel segmentation performance was compared with the ground-truth fundus images. (deepai.org)
  • Experimental results show the effectiveness of the proposed method for retinal image restoration and vessel segmentation. (deepai.org)
  • However, due to the poor fundus image quality and domain shifts between datasets, retinal vessel segmentation has long been regarded as a problematic machine-learning task. (nottingham.edu.cn)
  • An automatic retinal vessel segmentation method is proposed for quick and accurate segmentation of eye vessels. (edu.au)
  • A retinal fundus image contains varying low contrasts, which undermine the performance of the segmentation process. (edu.au)
  • Lastly, morphological post-processing is applied to eliminate exudates which are detected as blood vessels. (jist.ir)
  • 3] S. W. Franklin and S. E. Rajan, 'Diagnosis of diabetic retinopathy by employing image processing technique to detect exudates in retinal images,' IET Image Processing, vol. 8, pp. 1-9, 2014. (jist.ir)
  • Occasionally, the eye becomes inflamed and hazy and exudates form along the retinal vessels with engorgement and tortuosity of the posterior pole vessels. (medscape.com)
  • Retinal hemorrhages in 4 patients with rhages and exudates were found on Patients 2 and 3 were known to have dengue fever. (cdc.gov)
  • Funduscopic examination may reveal tortuous aneurysms of the retinal vessels, exudates on the fundus, and subretinal yellowish spots. (medscape.com)
  • Serum leakage from these vessels and hemangiomas leads to retinal exudates. (medscape.com)
  • Yarmohammadi A, Zangwill LM, Diniz-Filho A et al (2017) Peripapillary and macular vessel density in patients with glaucoma and single-hemifield visual field defect. (springer.com)
  • Hou H, Moghimi S, Zangwill LM et al (2019) Macula vessel density and thickness in early primary open-angle glaucoma. (springer.com)
  • A decrease in N1-P1 amplitude was observed in glaucomatous eyes in relation to a reduction in macular vessel density in the deep retinal layer, which suggests that ischemia-induced bipolar cell dysfunction may be involved in the intermediate retinal dysfunction associated with glaucoma. (arvojournals.org)
  • Intermediate retinal dysfunction in glaucoma is related to the changes in deep retinal microvasculature. (arvojournals.org)
  • The first theory suggests that high intraocular pressure causes mechanical damage to the retinal nerve fiber layer at the level of the lamina cribrosa, leading to the development of glaucoma (mechanical theory). (arvojournals.org)
  • The second theory suggests that insufficient ocular blood supply, including retinal and choroidal circulation, leads to the development of glaucoma (vascular theory). (arvojournals.org)
  • Studies on glaucoma using optical coherence tomography angiography (OCTA) have shown changes in the vascular structure of the optic nerve head, including optic disc vessel density (VD), 7 , 8 superficial peripapillary VD, 9 , 10 and peripapillary deep choroidal VD. (arvojournals.org)
  • It's not common, but sometimes after glaucoma , retinal or cataract surgery , you can get macular edema. (aao.org)
  • Sometimes these abnormal blood vessels bleed or cause a painful type of glaucoma (called neovascular glaucoma). (msdmanuals.com)
  • Basically, the Retinal Vessel Analyzer measures the diameters of small arteries (arterioles) and vein (venules) in the posterior segment of the eye. (wikipedia.org)
  • Sports Medicine Researchers from the Institute of Exercise and Health Sciences at the University of Basel demonstrated that cardiovascular fitness and body composition affect retinal vessel diameters which in turn give an indication of a person's cardiovascular health. (wikipedia.org)
  • Given the bias from central light reflex, they recommended that future studies use vessel diameters adjusted for central light reflex for the most accurate estimates when assessing the relationship between retinal vessel caliber and ophthalmic or systemic disease. (reviewofoptometry.com)
  • Dynamic Changes in Retinal Vessel Diameters and Arteriovenous Ratio within 10 Days of Birth. (bvsalud.org)
  • Finally, each group's retinal vessel diameters and AVR were compared separately to show their dynamic changes. (bvsalud.org)
  • Association between blood pressure and retinal vessel diameters among police officers in the US Northeast. (cdc.gov)
  • Variations in vessel caliber are associated with increased mortality risk, which we attributed to the likelihood that morphologic changes of retinal arterioles and venules reflect life-threatening changes in cerebral and coronary vessels. (entokey.com)
  • The results of these studies show that vascular changes of retinal vessels are reflected in systemic vessel changes, respectively vascular diseases. (touchophthalmology.com)
  • Retinal vessel analysis is conducted mainly by ophthalmologists, cardiologists, neurologists and other medical specialities dealing with vascular diseases. (wikipedia.org)
  • Quantitative information about the vascular network can facilitate clinical diagnosis of retinal diseases [1]. (columbia.edu)
  • One property, vessel caliber, is thought to be a potential biomarker for pathologies such as atherosclerosis, coronary heart disease and some neurological diseases. (reviewofoptometry.com)
  • Such a relationship with retinal vascular disease is thought to be the basis for the association between CS and death, supported by the fact that abnormal CS is also related to systemic diseases characterized by microvascular disease. (entokey.com)
  • Dynamic vessel analysis is the key technology for the early detection of vascular dysfunctions, which again play an important role in the field of retinal and systemic vascular diseases. (touchophthalmology.com)
  • With blood vessel diseases like RVO, veins in the retina become blocked. (aao.org)
  • She focuses on retinal vascular diseases, macular degeneration, and surgical repair of retinal detachments, macular pathology, and complications from cataract surgery. (stanford.edu)
  • In contrast, we show here that neovascularization can be accomplished by nonangiogenic expansion of preexisting vessels. (nature.com)
  • If your eye doctor notices new blood vessels growing in your retina (neovascularization) or you develop macular edema, treatment is usually needed. (medlineplus.gov)
  • The widely accepted pathogenesis for sickle cell retinopathy is vasoocclusion that leads to retinal hypoxia, ischemia, infarction, neovascularization, and fibrovascularization. (medscape.com)
  • On the other hand, they observed no differences in any quadrant of total retinal thickness, subfoveal choroidal thickness and choriocapillaris flow voids. (reviewofoptometry.com)
  • There are two variants of retinal vessel analysis which are based on a special fundus camera, the Retinal Vessel Analyzer which was developed by Imedos, a medical engineering company in Jena, Germany. (wikipedia.org)
  • We use only 4 image features and consider vessels inside zone B (802 vessels from 70 fundus camera images) and in an extended zone (1,207 vessels, 70 fundus camera images). (sinapse.ac.uk)
  • They investigated potential bias from central light reflex and retinal vessel caliber agreement between two modalities, fundus camera and scanning laser ophthalmoscope, and reported that the two aren't interchangeable. (reviewofoptometry.com)
  • Retinal photograph showing a white intraretinal lesion on the macula and a hemorrhage above the fovea. (medscape.com)
  • Fu L, Fung FK, Lo AC et al (2018) Transcorneal electrical stimulation inhibits retinal microglial activation and enhances retinal ganglion cell survival after acute ocular hypertensive injury. (springer.com)
  • They also noted in their paper that "retinal microvascular insult may precede its structural change and that the retina may be a better candidate to predict the onset of retinochoroidal microvascular changes than the choroid in the early stages of childhood obesity, which may help to characterize the underlying pathophysiology of obesity and enable early detection and prevention of obesity-related ocular complications. (reviewofoptometry.com)
  • Correlations among the ocular parameters, macular vessel density, and multifocal electroretinographic parameters were evaluated using a mixed model. (arvojournals.org)
  • The morphology of the retinal vascular structure in fundus images is of great importance for ocular disease diagnosis. (nottingham.edu.cn)
  • In this study, we investigated relationships between vessel caliber indices and various measures of visual function (best-corrected visual acuity [BCVA], VF, and CS) among participants in the Longitudinal Study of the Ocular Complications of AIDS (LSOCA). (entokey.com)
  • Identification of the axis of the retinal vascular arcades can serve as a direct and accessory means to provide additional pertinent information regarding ocular cyclorotations. (bmj.com)
  • VHL disease is characterized by retinal capillary hemangiomas (also called benign vascular hamartomas). (medscape.com)
  • Retinal capillary hemangiomas, usually supplied by large dilated feeder vessels, may occur in any part of the retina. (medscape.com)
  • One promising approach is retinal imaging , as there is homology between retinal & cerebral vasculature. (ed.ac.uk)
  • Multiple studies have shown increased mortality in patients with retinal arterial emboli. (medscape.com)
  • [ 15 ] A10-fold increase in the annual rate of stroke in patients with retinal emboli compared with controls after a follow-up period of 3.4 years was demonstrated in another study. (medscape.com)
  • A case series reported that 15% of patients with retinal emboli died within 1 year, and a mortality rate of 54% was shown within 7 years. (medscape.com)
  • Antinuclear antithrombin, protein C, protein S or pres- antibodies were investigated with standard- ence of antiphospholipid antibodies, are ized enzyme-linked immunosorbent assay common in patients with retinal vein occlu- sions and may contribute to the etiology of (ELISA). (who.int)
  • To investigate the changes and evaluate the diagnosis value of circumpapillary vessel density (VD) in cases of acute primary angle closure (APAC). (springer.com)
  • Moghimi S, SafiZadeh M, Xu BY et al (2020) Vessel density and retinal nerve fibre layer thickness following acute primary angle closure. (springer.com)
  • Moghimi S, SafiZadeh M, Fard MA et al (2019) Changes in optic nerve head vessel density after acute primary angle closure episode. (springer.com)
  • Wang X, Jiang C, Kong X, Yu X, Sun X, Oho AUID (2017) Peripapillary retinal vessel density in eyes with acute primary angle closure: an optical coherence tomography angiography study. (springer.com)
  • Compared with children of a healthy weight, those with obesity in this study had a lower vessel density despite a recent diagnosis within the last three years. (reviewofoptometry.com)
  • The researchers reported in their paper in BMC Ophthalmology that newly obese children "had lower vessel density in the inferior parafovea, nasal parafovea and temporal perifovea of the deep vascular complex (DVC), higher vessel density in the fovea of the superficial vascular complex and the fovea of the DVC and smaller foveal avascular zone when compared with controls. (reviewofoptometry.com)
  • There were no significant correlations for macular vessel density in the superficial retinal layer. (arvojournals.org)
  • Vagge A, Nucci P, Desideri LF, et al, Evaluation of macular vessel density changes after strabismus surgery using optical coherence tomography angiography . (ophthalmologyadvisor.com)
  • Exploratory meta‐analyses revealed a significant increase in the foveal avascular zone area & a significant decrease in superficial parafoveal & whole vessel density in AD, although there was significant heterogeneity between studies. (ed.ac.uk)
  • The limitations of this study include the lack of detection of blood flow in the intermediate retinal plexus by the SS-OCT-A, including patients who underwent varying procedures, such as recession, resection, and transposition of eye musculature, and the small sample size. (ophthalmologyadvisor.com)
  • From a clinical perspective, the devices are "sufficiently interchangeable," but the researchers noted that "nevertheless, color fundus images are likely to be more informative for assessing the central light reflex, whereas vessel diameter measurements derived from scanning laser ophthalmoscope images are less affected by the confounding effect of the central light reflex. (reviewofoptometry.com)
  • From an epidemiological perspective," they added, "our results suggest that the effect of cardiovascular disease on retinal vessel caliber is likely to be underestimated, because the central light reflex makes arteriolar calibers appear wider in color fundus images. (reviewofoptometry.com)
  • We have validated both ICA architectures on retinal color fundus images and selected the one that provides improved contrast values. (edu.au)
  • 11 Moreover, other OCTA studies have shown changes in the superficial retinal VD in the macular area, where retinal ganglion cells are distributed. (arvojournals.org)
  • They examined hemodynamic changes in patients' superficial retinal plexus (SCP), DCP, and CCL portions immediately after the procedure (T0), 1 day postoperative (POD1), and 30 days postoperative (POD30). (ophthalmologyadvisor.com)
  • Retinal vessel analysis is a non-invasive method to examine the small arteries and veins in the retina which allows to draw conclusions about the morphology and the function of small vessels elsewhere in the human body. (wikipedia.org)
  • These clots may travel through the body and reach the veins, arteries and blood vessels of the eye. (aao.org)
  • They applied AI to the images to quickly and automatically distinguish between the different types of blood vessels (arteries and veins), and to measure blood vessel width and the extent to which the vessels twist and turn. (independent.co.uk)
  • In a cohort of 10,407 participants, analysing the retinal vessel caliber led to the reclassification of 21% of low-risk women to carrying an intermediate risk. (wikipedia.org)
  • The researchers advocated for a standardized, objective protocol for retinal vessel caliber estimations. (reviewofoptometry.com)
  • Retinal vessel caliber measurement bias in fundus images in the presence of the central light reflex. (reviewofoptometry.com)
  • To evaluate relationships between retinal vessel caliber and tests of visual function among people with AIDS. (entokey.com)
  • We have shown that variations in retinal vessel caliber among people with Acquired Immunodeficiency Syndrome (AIDS) are related to level of immunodeficiency (as manifested by CD4+ T lymphocyte count) and use of highly active antiretroviral drug therapy (HAART). (entokey.com)
  • An association between variations in retinal vessel caliber and visual function has not been shown directly, however. (entokey.com)
  • Retinal nerve fiber layer (RNFL), macular ganglion cell complex (GCC) were measured by spectral-domain optical coherence tomography, while VD was assessed by optical coherence tomography angiography. (springer.com)
  • tion and retinal flourescein angiography. (who.int)
  • Wet AMD is when abnormal blood vessel behind the retina start to grow under the macula, ultimately leading to blood and fluid leakage. (cdc.gov)
  • Macular edema is caused by pockets of fluid (usually leakage from damaged blood vessels) swelling up in the macula . (aao.org)
  • With diabetes, high blood sugar levels damage blood vessels, which leak into the macula. (aao.org)
  • Conditions like uveitis , where the body attacks its own tissues, can damage retinal blood vessels and cause swelling of the macula. (aao.org)
  • The researchers concluded that retinal vessel analysis may represent a new and useful method to non-invasively monitor microvascular abnormalities in heart failure. (wikipedia.org)
  • Endocrinology Hypercholesterolemia is associated with significant retinal microvascular dysfunction as evidenced in a study based on 67 patients with hypercholesterolemia without known cardiovascular disease by a reduction in flicker-induced dilatation of retinal arterioles. (wikipedia.org)
  • For instance, zone B is the standardised region of a retinal image utilised for the measurement of the arteriole to venule width ratio (AVR), a parameter indicative of microvascular health and systemic disease. (sinapse.ac.uk)
  • 8] L. Gang, O. Chutatape, and S. M. Krishnan, 'Detection and measurement of retinal vessels in fundus images using amplitude modified second-order Gaussian filter,' Biomedical Engineering, IEEE Transactions on, vol. 49, pp. 168-172, 2002. (jist.ir)
  • [ 7 ] Retinal vessel development begins at the optic nerve and progresses into the periphery. (medscape.com)
  • [ 8 ] The vessels reach the nasal ora serrata in the third trimester and the temporal periphery by 40 weeks' gestation. (medscape.com)
  • The vessels are fragile and immature with avascular areas at the periphery. (medscape.com)
  • email: [email protected] on amplification of SARS-CoV RNA blood vessels ( 5 ), although the tissues by reverse transcriptase-polymerase of the periphery tended to be spared. (cdc.gov)
  • However, the peripheral retinas demonstrated 360° of abnormal arborization of the peripheral vessels, with small scattered intraretinal hemorrhages and possible nonvascularization in the far periphery (Figure 2). (medscape.com)
  • Retinal photograph of the far periphery, showing scattered intraretinal hemorrhages and abnormal arborization of the peripheral vessels. (medscape.com)
  • Clinical picture of the retina, showing a pair of dilated and tortuous feeder vessels coursing on the surface of the retina from the optic nerve head toward the angioma (which is not seen in this image because it is in the extreme periphery). (medscape.com)
  • Retinal seeding from anterior disease may occur following vitrectomy. (medscape.com)
  • Ping Ji decided to measure and catalogue these differences by taking fundus photographs in children with Down's syndrome and typical children, and analyse the size and shape of the optic disc and the numbers and arrangement of blood vessels. (cardiff.ac.uk)
  • Retinal blood vessels share common guidance signals with ganglion cell axons and are now recognised to follow retinal axonal pathways. (bmj.com)
  • Whether the temporal retinal vessels are affected more often or whether the nasal retinal vessel occlusions are more often undetected is unclear. (medscape.com)
  • In static retinal vessel analysis this is a snapshot, in dynamic vessel analysis (DVA) a 12.5 Hz optoelectric flickering light induces a stimulation of a specific segment of the retina to which the vessels react by a change in their diameter which is quantified by the device. (wikipedia.org)
  • One parameter evaluated in retinal vessel analysis, the mean arteriolar to venular diameter ratio (AVR), correlated with individual fitness and normalized in obese individuals after they underwent a training program and weight reduction. (wikipedia.org)
  • The Vesselmap software enables to determine the arterio-venous ratio and the central arterial and venous vessel diameter equivalent in line with the various epidemiological studies, e.g. the Atherosclerosis Risk in Communities (ARIC) study. (touchophthalmology.com)
  • For retinal vein diameter, there were differences between groups one and two and groups six and seven. (bvsalud.org)
  • Lacunar strokes account for 25% of all ischemic strokes and may represent the cerebral manifestation of a systemic small vessel vasculopathy of unknown etiology. (neurology.org)
  • Second, when reperfusion of the retina occurred, the vessels in the ischemic portions of the eye began to grow abnormally and in an uncontrolled manner. (medscape.com)
  • Retinal vessel dynamics have the potential to serve as a tool for the assessment of risks in other organs since they are thought to reflect the general status of the microvasculature (i.e. the smallest vessels in the human body). (wikipedia.org)
  • This was seen as an indication that regular exercise reverses the subclinical impairment of the retinal microvasculature and thus most likely of small vessels in other organs. (wikipedia.org)
  • Relationships are consistent with the hypothesis that HIV-related retinal vasculopathy is a contributing factor to vision dysfunction among HIV-infected individuals. (entokey.com)
  • Since non-invasive and affordable methods for the early detection of Alzheimer's disease are scarce, the fact that alterations in vessel reaction could be detected in patients not yet clinically diagnosed was considered noteworthy. (wikipedia.org)
  • Then, the retinal central vascular system undergoes similar emergency and adaptive alterations. (bvsalud.org)
  • Digital Retinal Fundus Images helps to detect various ophthalmic disease. (deepai.org)
  • Ultrastructures of retinal vascular tissues were observed under transmission electron microscope, and pathology of retinal capillaries was examined using retinal vascular digest preparations. (nih.gov)
  • Retinal image assessment has been employed by the medical community for diagnosing vascular and non-vascular pathology. (jist.ir)
  • Neurology In 2019, neurologists and ophthalmologists from Milan, Italy, demonstrated that arterial dilation was decreased in patients with manifest Alzheimer's disease and persons with mild cognitive impairment when performing dynamic vessel analysis. (wikipedia.org)
  • Retinal vein occlusions are usually painless, sudden, and unilateral causes of vision loss. (bmj.com)
  • To evaluate the correlation between macular retinal function and the changes in the macular retinal vascular structure in glaucomatous eyes. (arvojournals.org)
  • The best approach to treatment requires addressing the underlying cause of the macular edema, and the related leakage and retinal swelling. (aao.org)
  • When macular edema is caused by inflammation or leaking from blood vessels, steroid medication may be used. (aao.org)
  • This shows whether any blood vessels are leaking and how much leakage there is. (aao.org)
  • patient 1 had the most severe leakage, as well as some spots of leak- disease and required mechanical ven- age at the level of the retinal pigment tilation in an intensive care unit before epithelium. (cdc.gov)
  • There is growing evidence that in particular the dynamic vessel analysis is able to detect blood vessel damage - for instance as a consequence of aging or metabolic disease - in an early stage. (wikipedia.org)
  • This imaging device can be upgraded for static and dynamic vessel analysis. (touchophthalmology.com)
  • The DVA is a dynamic vessel analysis system. (touchophthalmology.com)
  • Clinical hallmarks of VHL disease include the development of retinal and central nervous system (CNS) hemangioblastomas (blood vessel tumors), pheochromocytomas , multiple cysts in the pancreas and kidneys, and an increased risk for malignant transformation of renal cysts into renal cell carcinoma. (medscape.com)
  • Altered retinal vessel fractal dimensions may act as a surrogate marker for diseased cerebral vessels. (neurology.org)
  • Further studies should concentrate on longitudinal associations with other manifestations of cerebral small vessel disease. (neurology.org)
  • Some studies show a close relation between oxidative stress and DR. This study was aimed to investigate the effects of anti-oxidant in DR and expression of vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) from retinal blood vessels in diabetic rats. (nih.gov)
  • The small study found that endothelial function is abnormal in eye blood vessels of patients who have early-stage hypertension, but that treatment with an angiotensin-receptor blocker (ARB) drug improves endothelial function. (news-medical.net)
  • [ 7 ] Retinal endothelial cells give rise to primitive capillaries that further differentiate into mature vessels. (medscape.com)
  • In the 15-day-old rat embryo undifferentiated cells derive from the outer wall of the hyaloid vessel, or the immediate surrounding tissue, and migrate into the peripapillary retina beneath the internal limiting membrane. (arvojournals.org)
  • An examination report allows the medic to determine the current state of these vessels (normal, narrow or wide) and the vascular risk of the microcirculation of the retinal, as well as of the systemic circulation. (touchophthalmology.com)