• patients
  • Moreover, these studies support the idea that NPR2 agonists can be potential candidates for treating retinal edema in diabetic patients. (aspetjournals.org)
  • proteins
  • This comes not directly from the visual cycle but from several retinal pools of retinal binding proteins which are connected to each other by the transportation and reaction steps of the visual cycle. (wikipedia.org)
  • This study examines whether retinal secretions, alone or in collaboration with basal factors, alter the expression of claudins, proteins that determine the properties of tight junctional strands. (arvojournals.org)
  • Retinal pigment epithelial (RPE) cells apically polarize proteins that are basolateral in other epithelia. (rupress.org)
  • atrophy
  • Eventually, however, an oval-shaped atrophy with a horizontal major axis appears in the retinal pigment epithelium, and has the appearance of beaten bronze, along with sparing of the area surrounding the optic disc (peripapillary sparing). (wikipedia.org)
  • retinol
  • 1985;27:225-45 Biesalski HK, Nohr D New aspects in vitamin a metabolism: the role of retinyl esters as systemic and local sources for retinol in mucous epithelia. (wikipedia.org)
  • The other enzymes of the visual cycle complete the reactions necessary to oxidize and esterify all-trans-retinol to a retinyl ester (RPE65's substrate) and to oxidize 11-cis-retinol to 11-cis-retinal (the required photoactive visual pigment component). (wikipedia.org)
  • metabolic
  • This framework for understanding metabolic relationships in the vertebrate retina provides new insights into the underlying causes of retinal disease and age-related vision loss. (elifesciences.org)
  • regulates
  • Such non-cell autonomous defects strongly suggest that CRX regulates photoreceptor-expressed factors required for RPE and retinal vasculature maintenance and yet to be identified. (arvojournals.org)
  • peak
  • The action spectrum of light-sensitive retinal ganglion cells was found to peak at approximately 450 nm, a range with lower damage potential, yet not completely outside the damaging range. (wikipedia.org)
  • damage
  • A 2014 study found that LEDs cause retinal damage even in settings where they are used indirectly, such as household light bulbs. (wikipedia.org)
  • diseases
  • August 25, 1933 - August 28, 2012) was an Israeli ophthalmologist specializing in the diagnosis and treatment of retinal and genetic eye diseases. (wikipedia.org)
  • light
  • In the transition from darkness to light suddenly, large amount of 11-cis retinal is required. (wikipedia.org)
  • Light and electron microscopic analysis was used to examine retinal ultrastructure. (jneurosci.org)
  • Blue-light hazard is defined as the potential for a photochemically-induced retinal injury resulting from electromagnetic radiation exposure at wavelengths primarily between 400 and 450 nm. (wikipedia.org)