• pigment
  • Diagnosis is also difficult in dogs with coats of dilute color because lack of pigment in the choroid of these animals can be confused with choroidal hypoplasia. (wikipedia.org)
  • Also, because of the lack of choroidal pigment, mild choroidal hypoplasia is difficult to see, and therefore cases of CEA may be missed. (wikipedia.org)
  • Classically recognized white dot syndromes include: Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) Birdshot chorioretinopathy Multiple evanescent white dot syndrome (MEWDS) Acute zonal occult outer retinopathy (AZOOR) Multifocal choroiditis and panuveitis (MCP) Punctate inner choroiditis (PIC) Serpiginous choroiditis Specific characteristics regarding the white dots and predicted etiology are presented of selected diseases. (wikipedia.org)
  • The white dots are small and located in the posterior pole at the level of the retinal pigment epithelium (RPE). (wikipedia.org)
  • Outer nuclear layer - cell bodies of rods and cones External limiting membrane - layer that separates the inner segment portions of the photoreceptors from their cell nucleus Layer of rods and cones - layer of rod cells and cone cells Retinal pigment epithelium - single layer of cuboidal cells (with extrusions not shown in diagram). (wikipedia.org)
  • sclera
  • Folds are best imaged with SD-OCT. The patterns of retinal and choroidal folds are the products of a complex interplay between the degree of papilledema and anterior deformation of the load-bearing structures (sclera and possibly the lamina cribrosa), both modulated by structural geometry and material properties of the optic nerve head. (arvojournals.org)
  • A graph-based multistage segmentation approach was used to identify the choroid, defined as the layer between the outer border of the RPE band and the choroid-sclera junction. (arvojournals.org)
  • The algorithm-defined position of the outer RPE border and choroid-sclera junction was consistent with the manual delineation, resulting in highly correlated choroidal thickness values with r = 0.91 to 0.93 for the healthy subjects and 0.94 for patients with non-neovascular AMD. (arvojournals.org)
  • and for the choroid-sclera junction was −3.90 ± 15.93 μm and 21.39 ± 10.71 μm. (arvojournals.org)
  • Iridectomy - Removal of the affected piece of the iris Choroidectomy - Removal of the choroid layer (the vascular tissue sandwiched between the sclera and the retina) Iridocyclectomy - Removal of the iris plus the ciliary body muscle. (wikipedia.org)
  • vasculature
  • 2 Improvements to existing SD-OCT, such as frame averaging, despeckling, and enhanced image contrast, have provided even better definition of deeper intraocular structures, such as the choroidal stroma and choroidal vasculature structures. (arvojournals.org)
  • Causes of hyperfluorescence: window/transmission (filling) defects leaking defects (i.e. capillary leakage, aneurysm, neovascularization) pooling defects staining abnormal vasculature Causes of hypofluorescence: blocking defect (i.e. blood) filling defect (capillary nonperfusion/blockage) Fluorescein angiography is used by physicians specializing in the treatment of eye diseases (ophthalmologists) to evaluate the vasculature of the retina, choroid, optic disc, and iris. (wikipedia.org)
  • ciliary
  • Melanomas (choroidal, ciliary body and uveal) - In the early stages there may be no symptoms (the person does not know there is a tumor until an ophthalmologist or optometrist looks into the eye with an ophthalmoscope during a routine test). (wikipedia.org)
  • ophthalmic
  • Through joint research with Santen, one of the leading companies in the ophthalmic technologies, it is hopeful that such collaboration will result in new approaches for the treatment of various back of the eye diseases. (businesswire.com)
  • patients
  • SD-OCT revealed morphologically intact choroid in STGD patients with ICGA-imaged dark atrophy. (arvojournals.org)
  • Morphological patterns of Paneth cells are a prognostic biomarker in Western Crohn's disease (CD) patients, and are associated with autophagy-associated ATG16L1 and NOD2 variants. (jci.org)
  • fluorescein
  • To evaluate differences in fluorescein angiography (FA) and indocyanine green angiography (ICGA), findings between subjects affected by Stargardt disease (STGD) and atrophic AMD. (arvojournals.org)
  • Fluorescein angiography (FA) and indocyanine green angiography (ICGA) are important tools for diagnostic and pathogenetic evaluation of the two diseases. (arvojournals.org)
  • 9 In fact, fluorescein angiography allows accurate imaging of the retinal circulation, but evaluation of the choroidal circulation is limited mainly because of rapid leakage of the dye from fenestrated choriocapillaris that obscures choroidal vessels. (arvojournals.org)
  • A series of black-and-white or digital photographs are taken of the retina before and after the fluorescein reaches the retinal circulation (approximately 10 seconds after injection). (wikipedia.org)
  • tissues
  • Vogt-Koyanagi-Harada disease ( VKH ), also known as Vogt-Koyanagi-Harada syndrome , uveomeningitis syndrome and uveomeningoencephalitic syndrome , is a multisystem disease of presumed autoimmune cause, that affects pigmented tissues, which have melanin . (wikipedia.org)
  • The early images allow for the recognition of autofluorescence of the retinal tissues. (wikipedia.org)
  • occur
  • The lesion may occur within the choroid, between Bruch's membrane and RPE, or between the RPE and photoreceptors. (wikipedia.org)
  • central
  • STGD is one of the most common inherited retinal dystrophies, while AMD is the most important cause of central visual acuity loss in western countries. (arvojournals.org)
  • layer
  • The purpose of this study was to adapt the graph search algorithm to semiautomatically identify the choroidal layer in spectral-domain optical coherence tomography (SD-OCT) volume scans and compare its performance to manual delineation. (arvojournals.org)
  • The choroid is a major vascular layer of the eye and provides oxygen and nourishment to the outer layers of the retina. (arvojournals.org)
  • treatment
  • Santen is committed to discovering and developing innovative therapies for the treatment of retinal disease. (businesswire.com)
  • The collaboration with Santen prepares an avenue to develop state-of-the art medications for the critical treatment of sight-threatening disease. (businesswire.com)
  • It is not approved by the Food and Drug Administration, in the U.S. while UDCA is approved in the United States for the treatment of primary biliary cirrhosis Ongoing research is finding TUDCA has diminishing apoptotic effects, helping with cardiac function, Huntington's disease, Parkinson's disease, and stroke. (wikipedia.org)
  • The findings of the study are elucidating optimized conditions for RP treatment A study done at the Department of Ophthalmology at Seoul National University College of Medicine, examined the effects of TUDCA and UDCA on laser-treated choroids of rat models. (wikipedia.org)
  • stages
  • White dots appear early in the disease stages of PIC and MEWDS. (wikipedia.org)
  • Benezra has theorized that a large amount of CD8+ T suppressor cells are observed in the later stages of the disease in order to down regulate the inflammatory immune reaction. (wikipedia.org)
  • cones
  • A study examined the effects of TUDCA on cones, in relation to retinitis pigmentosa (RP), a disease in which retinal rods and cones undergo apoptosis. (wikipedia.org)
  • early
  • Eyes with ICGA-imaged dark atrophy, both in STGD and in atrophic AMD groups, did not show early obscuration of the choroidal vessels by FA. (arvojournals.org)
  • S. Early retinal development in the zebrafish, Danio rerio Light and electron microscopic analyses. (luxbar-starway.ru)
  • Genetic
  • Some suggest a genetic predisposition to the disease, while others postulate an abnormal immune response to a virus. (wikipedia.org)
  • area
  • A typical camera views 30 to 50° of retinal area, with a magnification of 2.5x, and allows some modification of this relationship through zoom or auxiliary lenses from 15°, which provides 5x magnification, to 140° with a wide angle lens, which minifies the image by half. (wikipedia.org)
  • Occlusion of a short or long PCA will produce a smaller choroidal infarct within the larger area supplied by the specific parent PCA. (wikipedia.org)
  • cause
  • Theories regarding the cause include an exogenous pathogen sensitizing an individual to antigens within photoreceptors, RPE, or choroid. (wikipedia.org)
  • species
  • H02.6) Xanthelasma of eyelid (H03.0*) Parasitic infestation of eyelid in diseases classified elsewhere Dermatitis of eyelid due to Demodex species ( B88.0+ ) Parasitic infestation of eyelid in: leishmaniasis ( B55. (wikipedia.org)
  • particular
  • 8 Also, ICGA may provide useful information, in particular about the alterations of the choroid and the choriocapillaris. (arvojournals.org)
  • Consequently, sudden occlusion of any PCA will produce an infarct in the region of the choroid supplied by that particular PCA. (wikipedia.org)
  • Trauma
  • Although there is sometimes a preceding viral infection, or skin or eye trauma, the exact underlying initiator of VKH disease remains unknown. (wikipedia.org)
  • normal
  • Excellent agreement was observed between the algorithm and manual choroidal segmentation in both normal eyes and those with non-neovascular AMD. (arvojournals.org)
  • Check photographs, normal healthy eyes would have the red eye reflex, but a white/yellow dot instead of the red eye reflex can indicate a tumor or some other kind of eye disease. (wikipedia.org)
  • evidence
  • This finding, along with SD-OCT evidence of intact choroid, suggests a possible selective damage of the choriocapillaris in STGD. (arvojournals.org)
  • Some veterinarians advocate only breeding dogs with no evidence of disease, but this would eliminate a large portion of potential breeding stock. (wikipedia.org)
  • Light
  • Several important features of visual perception can be traced to the retinal encoding and processing of light. (wikipedia.org)