• Malondialdehyde (MDA), an index of lipid peroxidation), and urine N-acetyl-beta-d-glucosaminidase (NAG), a marker of renal tubular damage were used as markers of oxidative stress-induced renal impairment. (greenmedinfo.com)
  • Aim: The aim of this study was to compare the tissue levels of antioxidant Super oxide dismutase (SOD) and lipid peroxidation marker Malondialdehyde (MDA) in established cases of OLP and healthy individuals. (medicopublication.com)
  • Oxidative stress ErbB4/HER4 Source causes lipid peroxidation, resulting in protein carbonylation, typically known as "carbonyl strain," that's predominantly associated with chronic ailments (76). (namptinhibitor.com)
  • Mutations to SLC40A1 that change the amino acid sequence can result in loss of function or gain of function for the resulting ferroportin protein. (wikipedia.org)
  • The results obtained showed the there was an increase in the weight of wet liver, lipid peroxidation and plasma protein concentration. (ajol.info)
  • The patients' oxidative (lipid, protein, and DNA oxidation) and antioxidative (antioxidant enzyme activities and compounds) profiles were examined before and after the treatment period. (nih.gov)
  • Significant differences were found in pre-post change between the EVOO and ROO groups for protein carbonyls, lipid peroxidation, and FIQ and MCS-12 scores. (nih.gov)
  • Chronic ER stress promotes apoptosis, at least in part through the UPR-induced transcription factor C/EBP homologous protein (CHOP). (jci.org)
  • These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)
  • TCDD for every step of the mechanism described for 2,3,7,8-TCDD carcinogenesis in humans including receptor binding, gene expression, protein activity changes, cellular replication, oxidative stress, promotion in initiation-promotion studies and complete carcinogenesis in laboratory animals. (who.int)
  • Microsomal glutathione transferase 1 (MGST1) is an antioxidant enzyme located predominantly in the mitochondrial outer membrane and endoplasmic reticulum and has been shown to protect cells from lipid peroxidation induced by a variety of cytostatic drugs and pro-oxidant stimuli. (cdc.gov)
  • The results indicated that TFs significantly alleviate H/R injury, which include inhibiting apoptosis and enhancing antioxidant capacity. (hindawi.com)
  • Sparstolonin B was showed to alleviate joint swelling in RA rats, inhibited inflammatory cell infiltration and the release of ROS, reduced damage caused by oxidative stress, and suppressed the rate of apoptosis in synovial cells. (hindawi.com)
  • In this study, we examined the cytoprotective effects of cyanidin-3-glucoside (C3G) isolated from mulberry fruit against pancreatic β-cell apoptosis caused by hydrogen peroxide (H2O2)-induced oxidative stress. (spandidos-publications.com)
  • The MIN6 pancreatic β-cells were used to investigate the cytoprotective effects of C3G on the oxidative stress-induced apoptosis of cells. (spandidos-publications.com)
  • Taken together, our results suggest that C3G isolated from mulberry fruit has potential for use as a phytotherapeutic agent for the prevention of diabetes by preventing oxidative stress-induced β-cell apoptosis. (spandidos-publications.com)
  • Estimations of blood lead levels are more useful for diagnosing acute lead poisoning, whereas the extent of past lead exposure can be estimated by determining the body burden of lead on the basis of results from the edetate (EDTA) calcium disodium (CaNa 2 EDTA) lead mobilization test. (medscape.com)
  • Effect of maternal exposure of fluoride on biometals and oxidative stress parameters in developing CNS of rat. (fluoridealert.org)
  • Effect of chronic exposure to prometryne on oxidative stress and antioxidant response in early life stages of common carp (Cyprinus carpio L. (nel.edu)
  • Neurological studies have demonstrated that chronic stress exposure induces neurodegeneration of important neuronal structures and destabilization of the mesocortical dopaminergic pathway. (spandidos-publications.com)
  • Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. (who.int)
  • Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. (who.int)
  • In this study, the increase in MDA levels of renal tissue and in urine NAG and also the decrease in renal SOD, CAT, GSH-Px activities demonstrated the role of oxidative mechanism induced by 900-MHz mobile phone exposure, and melatonin, via its free radical scavenging and antioxidant properties, ameliorated oxidative tissue injury in rat kidney. (greenmedinfo.com)
  • Corneal oxidative damage was induced by exposure to UVB radiation at 560 μW/cm 2 . (molvis.org)
  • These results provide support to previously reported data on sub-lethal effects following exposure to cyanobacterial biomass containing MCs in birds and mortality occurring only in birds under combined action with other stressors. (nel.edu)
  • The principal component analysis of antioxidant/oxidative stress parameters (glutathione reductase, lipid peroxidation, and ferric reducing antioxidant power) in tissues (liver, kidney, heart, brain, lungs, gonads, and pectoralis major muscle) clearly separated the triple group (P+B+M) from all single and double exposure groups and the control and indicated thus marked joint effects in the overall pattern of antioxidant/oxidative stress responses of this group. (nel.edu)
  • Following exposure to radioactive strontium compounds, the most severe non carcinogenic effects seen are the result of incorporation of radioactive strontium, an emitter of beta radiation, into the skeleton, with subsequent irradiation of surrounding tissues (ATSDR 2001e). (cdc.gov)
  • Studies have also shown correlations between VNA exposure and lipid peroxidation and oxidative stress (insulin-resistance and inflammation), chronic diseases (diabetes), and neurodegenerative diseases, such as Alzheimer's. (cdc.gov)
  • Previous mouse studies suggest that electronic cigarette exposure plus a Western diet triggers oxidative stress leading to increased lipid peroxidation and hepatic steatosis, according to Dr. Theodore Friedman of Charles R. Drew University of Medicine & Science in Los Angeles. (medscape.com)
  • In liver samples, they observed that e-cigarette exposure led to hepatic lipid accumulation and oxidative stress, as well as a significant increase in hepatic expression of p53, a known inducer of insulin resistance and NAFLD. (medscape.com)
  • These exposures, however, are with exposure, proceeding through operational and ana- expected to be acute in nature due to its intended use, which tomical changes, and resulting in toxicity. (cdc.gov)
  • mtROS also causes oxidation of lipids and proteins identified in bleomycininduced mouse models of pulmonary fibrosis and in sufferers with IPF (80, 81). (namptinhibitor.com)
  • Lead blocks the activity of 5-aminolevulinic acid dehydratase and leads to hemoglobin oxidation, which along with the lipid peroxidation can result in red cell hemolysis. (medscape.com)
  • On the basis of the results was assessed the effect on the hematological profile, oxidative stress parameters, and antioxidants biomarkers in tissues, in another acute test. (nel.edu)
  • The hematological profile well oxidative stress parameters and antioxidant defensive systems provide important information about the internal environment of organisms. (nel.edu)
  • These results suggest that there was a negative alteration of the biochemical parameters examined which could have been induced by the contaminated feed they consumed. (ajol.info)
  • The aim of this study was to investigate the effect of olive oil on oxidative stress and health-related parameters in FM. (nih.gov)
  • Group responses were compared using standard plasma biochemistry and antioxidant/oxidative stress parameters in tissues. (nel.edu)
  • Distraction of these elements in central nervous system (CNS) have been demonstrated in many neurological disorders, which are vital in generating free radicals, causing oxidative stress, and contributing to neuronal maladies. (fluoridealert.org)
  • On this course of free radicals take electrons from the lipids (usually in cell membranes), resulting in cell hurt. (biorag.org)
  • Free radicals in the body exploit the instability of PUFAs to trigger chain reactions that drive LPO and the resulting degradation of these vital PUFAs. (globenewswire.com)
  • Oxidative stress occurs when the intracellular concentration of free radicals increases over the physiologic value. (bvsalud.org)
  • We have reported that oxidative stress may play a role in the pathophysiology of FM. (nih.gov)
  • This group was retested to confirm important role in the pathophysiology of their blood lipid status before participating several vascular diseases, including athero- in the study. (who.int)
  • The attenuation of metal/peroxide oxidative chemistry, as well as lipid peroxidation, appears to be the major chemical mechanisms by which NO may limit oxidative injury to mammalian cells. (researchgate.net)
  • Numerous markers of oxidative activity are present in persons with asthma. (namptinhibitor.com)
  • On 21st postnatal day, the concentration of fluoride, biometals, and oxidative stress markers were determined in discrete regions of CNS. (fluoridealert.org)
  • The correlation coefficient values among oxidative stress markers and biometals were either positive or negative and showed less significance during correlation. (fluoridealert.org)
  • This study was designed to determine whether red-cell oxidative stress status and antioxidant enzyme levels can serve as markers in patients predisposed to in-stent stenosis. (vitality101.com)
  • TBARS content was correlated with the percentage of granulomas in liver (R2=0.9439, y=0.003x-0.1242) denoting the involvement of an imbalance oxidative status in the appearance of granulomas. (stir.ac.uk)
  • CRP in three out of six studies that measured CRP following training in mindfulness-based stress reduction (MBSR), but inconsistent or null findings on other circulating immune biomarkers. (humankinetics.com)
  • Change in oxidative stress biomarkers levels: lipid peroxidation index, nitric oxide metabolites, hydrogen peroxide (H2O2), superoxide anion radical (O2-), and glutation (GSH), catalasis(CAT) and superoxid dismutasis(SOD). (who.int)
  • The cellular redox imbalance results in inflammatory infiltration and cell damage and can cause severe asthma and reduction of the corticosteroid response (879). (namptinhibitor.com)
  • As the disease progresses, iron may accumulate in the tissues of affected individuals over time, potentially resulting in organ damage. (wikipedia.org)
  • The damage is largely due to iron-catalyzed oxidative reactions. (wikipedia.org)
  • This can lead to oxidative stress, lipid peroxidation, and DNA damage, which may result in cell death. (wikipedia.org)
  • The increase in oxidative stress leads to cell membrane damage due to lipid peroxidation. (medscape.com)
  • The results confirm that the fluoride provoked oxidative stress and biometal deformations are synergistic that successively governs the neuronal damage and developing CNS no longer prevents exacerbations of fluoride. (fluoridealert.org)
  • However, the excessive generation of ROS, such as super oxide anions (O 2 − ) and hydrogen peroxide (H 2 O 2 ) due to environmental stress results in significant oxidative damage to cell structures, such as DNA, the mitochondria and cell membranes ( 3 , 4 ). (spandidos-publications.com)
  • Differences between groups approached statistical significance for oxidative DNA damage and levels of the antioxidant compound zinc. (nih.gov)
  • 15 Castilho R.F., Meinicke A.R., Alemida A.M., Hermes-Lima M., Vercesi A.E. Oxidative damage of mitochondria induced by Fe(II)citrate is potentiated by Ca 2+ and includes lipid peroxidation and alterations in membrane proteins. (thieme-connect.de)
  • Oxidative damage in the kidney induced by 900-MHz-emitted mobile phone: protection by melatonin. (greenmedinfo.com)
  • The purpose of this study was to investigate the protective effects of Dunaliella salina ( D. salina ) on UVB radiation-induced corneal oxidative damage in male imprinting control region (ICR) mice. (molvis.org)
  • The studies demonstrate that D. salina exhibits potent protective effects on UVB radiation-induced corneal oxidative damage in mice, likely due to both the increase of antioxidant enzyme activity and the inhibition of lipid peroxidation. (molvis.org)
  • This causes oxidative stress, a process that if not countered by the body's antioxidant defenses, will over time result in cell, tissue and DNA damage. (irondisorders.org)
  • Conclusion: The current study suggests that oxidative damage is one of the major causes for the pathogenesis of OLP. (medicopublication.com)
  • In addition, we found that isolated islets from Chop -/- mice displayed increased expression of UPR and oxidative stress response genes and reduced levels of oxidative damage. (jci.org)
  • Research on this topic may be of great procedures were approved by the Eth- Results interest since oxidative damage has ics Review Committee of the National been proposed as a pathogenic mecha- Research Centre. (who.int)
  • Although CNC exposures are associated with pulmonary inflammation and damage as well as oxidative stress responses and genotoxicity in vivo, studies evaluating cell transformation or tumorigenic potential of CNC's were not previously conducted. (cdc.gov)
  • The a lot more serious symptoms in allergic problems happen to be linked with mitochondrial defects around complexes I and III, which are accountable for the majority of mtROS production as a result of electron leakage (85). (namptinhibitor.com)
  • To analyze the effect of homeopathic Arnica on mitochondrial oxidative stress induced by Ca 2+ plus inorganic phosphate and/or Fe 2+ -citrate-mediated lipid peroxidation through changes in oxygen consumption rates. (thieme-connect.de)
  • In the presence of antimycin-A, electron transport chain inhibitor, as evidenced by antimycin-A insensitive O 2 consumption, Arnica inhibited lipid peroxidation of mitochondrial membranes. (thieme-connect.de)
  • In oxidative stress conditions, in the presence of Ca 2+ and inorganic phosphate, animals receiving Arnica 30cH had a significant decrease in mitochondrial O 2 consumption compared to control animals. (thieme-connect.de)
  • These data suggest that MDMA-induced toxicity of dopamine neurones in mice results from free radical formation which in turn induces an oxidative stress process. (erowid.org)
  • RESULTS- We found that changes of gut microbiota induced by an antibiotic treatment reduced metabolic endotoxemia and the cecal content of LPS in both high-fat-fed and ob/ob mice. (diabetesjournals.org)
  • Functional analysis showed that cholesterol biosynthesis pathways and the cytochrome 450 family of proteins (specifically Cyp4A10 that is associated with oxidative stress and lipid peroxidation leading to hepatocyte injury) were increased in mice exposed to e-cigarette aerosol. (medscape.com)
  • Iron toxicity results when circulating iron exceeds the capacity of transferrin available to bind it. (irondisorders.org)
  • Lipid peroxidation refers again to the oxidative degradation of lipids. (biorag.org)
  • In addition to these chemical and biochemical properties, NO can modulate cellular and physiological processes to limit oxidative injury, limiting processes such as leukocyte adhesion. (researchgate.net)
  • We believe that there is promise in the potential of modifying the course of PSP by mitigating the oxidative stress and cellular degeneration that is caused by pathogenic LPO. (globenewswire.com)
  • This platform is designed to combat the oxidative stress and cellular degeneration that arises from lipid peroxidation (LPO). (globenewswire.com)
  • The Abu-Remaileh Lab is interested in identifying novel pathways that enable cellular and organismal adaptation to metabolic stress and changes in environmental conditions. (stanford.edu)
  • The separation was driven by the modification of the ferric reducing antioxidant power levels in heart and brain and the cardiac lipid peroxidation level, in particular. (nel.edu)
  • This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
  • The aim of the study was to investigate effects of the triazine herbicide prometryne on early life stages of common carp Cyprinus carpio as indicated by oxidative stress and antioxidant indices. (nel.edu)
  • The aim of the present study was to investigate the oxidative stress occurrence during canine distemper (CD) virus infection in dog. (revmedvet.com)
  • This leads to an increase in blood sugar levels and a decrease in the energy transfer to other organs, which results in various secondary complications ( 2 ). (spandidos-publications.com)
  • Under experimental stress, there is increased masseter activity, which returns to baseline levels upon relaxation ( 12 ). (spandidos-publications.com)
  • Patients with temporomandibular disorders (TMD) exhibit higher levels of anxiety ( 17 ), while TMD symptoms worsen whenever a person is under stress ( 18 , 19 ). (spandidos-publications.com)
  • RESULTS: In the EMR-exposed group, while tissue MDA and urine NAG levels increased, SOD, CAT, and GSH-Px activities were reduced. (greenmedinfo.com)
  • The present results show that high levels of vitamin C (1,200-3,200 mg kg-1C) and low stock density (3.20 kg m-3) favours the growth of juvenile meagre, reducing the lipid peroxidation indicators and decreasing the incidence of granulomas, which confirms that this pathology is mostly triggered by deficiency of antioxidant nutrients, particularly vitamin C. (stir.ac.uk)
  • ing high levels of oxidative stress [1]. (who.int)
  • The occurrence of disinfection by-products (DBPs) of health concern in drinking water: results of a nationwide DBP occurrence study. (who.int)
  • miRNAs have been implicated as transcriptional regulators in a wide range of biological processes determining cell fate, stress response, proliferation, or death [ 5 ]. (hindawi.com)
  • HFs extending from the skin surface to the dermis or subcutaneous tissue with direct connection to the sebaceous gland are called pilosebaceous units that, together with sweat glands, create a unique lipid‐rich hydrophobic niche, making the scalp a highly favorable environment for the growth of microorganisms. (cosmeticsdesign.com)
  • Sparstolonin B improved inflammatory responses and oxidative stress by inhibiting the NLRP3 inflammasome, inhibiting the expression of FucT-V and downregulating the TLR4/MYD88/NF-𝜅B signaling pathway in order to rescue RA. (hindawi.com)
  • Conclusions: These findings indicate that HBO treatment may result in abatement of the development of EBI after SAH, possibly through suppression of TLR4/NF-κ B signaling pathway. (karger.com)
  • Reported results for all assays meet the Division of Environmental Health Laboratory Sciences quality control and quality assurance performance criteria for accuracy and precision, similar to the Westgard rules (Caudill et al. (cdc.gov)
  • We evaluated the induction of cytotoxicity and oxidative stress by TiO2, CeO2, SiO2, and ZnO in the human MCF-7 cell line with or without overexpression of MGST1. (cdc.gov)
  • The data point toward a role of lipid peroxidation in SiO2 nanoparticle -induced cell death. (cdc.gov)
  • Ninety percent of glutathione in the cell exists in reduced form and 10% in oxidative form, and it typically acts as an antioxidant defense mechanism. (medscape.com)
  • Results: LED produced in vitro increases of cell growth of 140-200% in mouse-derived fibroblasts, rat-derived osteoblasts, and rat-derived skeletal muscle cells, and increases in growth of 155-171% of normal human epithelial cells. (researchgate.net)
  • New devices have demonstrated significant results for the treatment of medical conditions, including mild-to-moderate acne vulgaris, wound healing, psoriasis, squamous cell carcinoma in situ (Bowen's disease), basal cell carcinoma, actinic keratosis, and cosmetic applications. (researchgate.net)
  • The results of this study revealed the nism of atherosclerosis, cell ageing, following data. (who.int)
  • Among adults with a history of chronic stress , 300 mg ashwagandha extract reduces cortisol and anxiety and improves resistance to additional stress. (marksdailyapple.com)
  • CONCLUSIONS: These results show that melatonin may exhibit a protective effect on mobile phone-induced renal impairment in rats. (greenmedinfo.com)
  • Oxidative anxiety also plays a crucial role in allergic IL-23 Storage & Stability airway disorders. (namptinhibitor.com)
  • Finally, the positive effects of individualized supplementation are discussed in the context of diminishing anxiety and oxidative stress, neuroprotection and in the reversal of neurodegeneration, and also in alleviating/reducing neuromuscular symptoms. (spandidos-publications.com)
  • By virtue of this stress-reducing effect, ashwagandha may help improve or mitigate other stress-related conditions, like insomnia, lack of libido/erection, and anxiety. (marksdailyapple.com)
  • Taken together, our results show that tARPC are able to counteract cisplatin-induced nephrotoxicity via CYP1B1 release through EV. (bvsalud.org)
  • The effect of the homeopathic remedies Arnica montana and Bellis perennis on mild postpartum bleeding - a randomized, double-blind, placebo-controlled study - preliminary results. (thieme-connect.de)
  • Since the neuropathology typical of AD is observed very early in the life of persons with DS, the study of this condition in persons with DS could result in knowledge that could also be useful for individuals without DS. (medscape.com)
  • We hypothesized that MGST1 may also protect against nanomaterial -induced cytotoxicity through a specific effect on lipid peroxidation. (cdc.gov)
  • This review will address these aspects of the chemical biology of this multifaceted free radical and explore the beneficial effect of NO against oxidative stress. (researchgate.net)
  • 6 Seeley B.M., Denton A.B., Ahn M.S., Maas C.S. Effect of homeopathic Arnica montana on bruising in face-lifts: results of a randomized, double-blind, placebo-controlled clinical trial. (thieme-connect.de)
  • MDMA administration increased lipid peroxidation in striatal synaptosomes, an effect reduced by approximately 60% by GBR 12909 pre- treatment. (erowid.org)
  • Stress has been well‑documented to have a significant role in the etiopathogenesis of bruxism. (spandidos-publications.com)
  • Results in group B patients were intermediate between those of groups A and C with significant decreases in glutathione peroxidase versus controls. (vitality101.com)
  • Last week, I made the case for the inclusion of chill-out, relaxing, and otherwise anti-stress teas and herbs , particularly for the stress-wracked among us (and who doesn't deal with significant amounts of stress? (marksdailyapple.com)
  • The protective effects of TFs resulted in higher expression of miR-21 in H/R-induced H9c2 cells than that of controls, which in turn upregulated Akt signaling activity via suppressing the expression of PTEN together with decreasing the ratio of Bax/Bcl-2, caspase3, and cleaved-caspase3 expression in H/R-induced H9c2 cells. (hindawi.com)
  • Emotional stress is associated with an increase in head and muscle tonicity, as well as an increase in non-functional muscle activity ( 7 , 8 ). (spandidos-publications.com)
  • Hypercholesterolaemia is frequently sayed on the same day for the determination associated with enhanced lipid peroxida- of glutathione peroxidase activity and lipid tion [3]. (who.int)