• ovarian
  • In females, FSH insensitivity results in diminished development of ovarian follicles and granulosa cells and low to normal estrogen levels, elevated to very elevated gonadotropin levels, and low inhibin B levels, whereas males present with diminished Sertoli cell proliferation and moderately elevated FSH levels, normal to slightly elevated LH levels, normal testosterone levels, and reduced inhibin B levels. (wikipedia.org)
  • and 2) ovarian dysgenesis or failure, resulting in primary or secondary amenorrhea, infertility, and normal sized to slightly enlarged ovaries. (wikipedia.org)
  • This results in an inability of the granulosa cells in ovarian follicles to respond to FSH in females, in turn resulting in diminished estrogen production by the ovaries and loss of menstrual cycles, and an inability of Sertoli cells in the seminiferous tubules of the testicles to respond to FSH in males, which in turn results in impaired spermatogenesis. (wikipedia.org)
  • androgen
  • Due in part to elevated LH levels, which stimulate androgen production by theca cells in the ovaries, and due in part to FSH insensitivity, resulting in a lack of aromatase in nearby granulosa cells that normally convert androgens into estrogens, it could be expected that females with FSH insensitivity might present with symptoms of hyperandrogenism at puberty. (wikipedia.org)
  • Hence, in females, FSH insensitivity may not only result in deficiencies in estrogen production by granulosa cells, but in diminished androgen synthesis by both theca and granulosa cells as well, which could potentially explain why hyperandrogenism does not occur. (wikipedia.org)
  • gonads
  • The insertion and subsequent expression of hobo-like sequences results in the loss of germ cells in the gonads of developing flies. (wikipedia.org)
  • The expression of Sry and Sox9 genes in gonads of XY Cbx2-knockout mice is reduced, suggesting that Cbx2 is required for the expression of Sry in gonadal development. (wikipedia.org)
  • FSH is subject to oestrogen feed-back from the gonads via the hypothalamic pituitary gonadal axis. (wikipedia.org)
  • hormonal
  • Identification of 45,X/46,XY karyotype has significant clinical implications due to known effects on growth, hormonal balance, gonadal development and histology. (wikipedia.org)
  • partial
  • Typical sexual development is the result of numerous genes, and mutation in any of these genes can result in partial or complete failure of sex differentiation. (wordpress.com)
  • female
  • Also, the lack of testosterone means that no dihydrotestosterone is formed and consequently the external genitalia fail to virilize, resulting in normal female genitalia. (wikipedia.org)
  • If one male zygote and one female zygote fuse, a hermaphroditic individual may result. (wikipedia.org)
  • germ cells
  • Neoplastic transformation may result from unprotected germ cells and abnormally high and prolonged gonadotropin stimulation with the risk exceeding 50% as the third decade is approached. (radiopaedia.org)
  • cause
  • The Hobo transposons in Drosophila have been extensively studied due to their ability to cause gonadal dysgenesis. (wikipedia.org)
  • The sharp increase in estradiol production by the dominant follicle (possibly along with a decrease in gonadotrophin surge-attenuating factor) cause a positive effect on the hypothalamus and pituitary and rapid GnRH pulses occur and an LH surge results. (wikipedia.org)
  • true
  • Although fertility is possible in true hermaphrodites, there has yet to be a documented case where both gonadal tissues function, contrary to the misconception that hermaphrodites can impregnate themselves. (wikipedia.org)
  • Function
  • Results showed that intraperitoneal injection of M1 improved liver function, ameliorated liver injury and finally raised the survival rate in D-galactosamine/lipopolysaccharide (GalN/LPS)-treated mice. (readbyqxmd.com)
  • individuals
  • Disruption of typical development may result in the development of both, or neither, duct system, which may produce morphologically intersex individuals. (wikipedia.org)