Results gene frequency. Medical search. Frequent questions

Is this resistance the result of bacteria evolving new genes in response to the presence of antibiotics, or are antibiotic-resistant bacteria selected for in the environment by possessing antibiotic resistance genes beforehand? (icr.org)
The increase in resistance among these organisms clearly indicates a change in the frequency of antibiotic resistance genes. (icr.org)
The group also looked at the number of antibiotic resistance genes across the samples. (news-medical.net)
Overall, the immature compost samples have the highest abundance of antibiotic resistance genes, indicating that the high heat during composting may degrade some of these genes,' Mao said. (news-medical.net)
We also want to look at what composting conditions work best to remove these pathogens and the antibiotic resistance genes,' said Helen Nguyen (IGOH), Ivan Racheff Professor in Civil and Environmental Engineering. (news-medical.net)
2021) Quantification of pathogens and antibiotic resistance genes in backyard and commercial composts. (news-medical.net)
9. Komijani M, Bouzari M, Rahimi F. Detection of TEM, SHV and CTX-M Antibiotic Resistance Genes in Escherichia coli Isolates from Infected Wounds. (ac.ir)

The allele frequencies were similar for Val (0.455) and Ile (0.545). (geneticsmr.com)
Joaçaba and Concórdia had the highest mutant allele frequencies (0.825 and 0.685, respectively). (geneticsmr.com)
Genetically, this phenomenon is characterized by an increase in allele frequencies in a population as a direct result of the selection effects caused by pesticides ( Braga and Valle, 2007a ). (geneticsmr.com)
The allele frequencies in the -491 site of the promoter region were 0.845 for the A allele and 0.155 for the T allele. (wayne.edu)
Allele frequencies and their distribution in genes and pathways were analyzed with single variant and SKAT-O tests. (figshare.com)
Selection for recombinants that acquired the trait, followed by genome-wide profiling of donor-specific allele frequencies, we can rapidly identify the relevant genes. (drexel.edu)

We examined the association of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme gene, of the M235T polymorphism of the angiotensinogen gene, and of the A1166C polymorphism of the angiotensin II type 1 receptor gene with NAION. (molvis.org)
NAION occurrence was not associated with the M235T polymorphism of the angiotensinogen gene and the A1166C polymorphism of the angiotensin II, type 1 receptor gene. (molvis.org)
The renin-angiotensin system genes exhibit three common polymorphisms: the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme ( ACE ) gene, the M235T polymorphism of the angiotensinogen gene ( AGT ), and the A1166C polymorphism of the angiotensin II type 1 receptor gene ( AT1-receptor ). (molvis.org)
After attributing a regional and/or continental ancestry to each individual using genome-wide polymorphism data, we are able to capture the effect of different environmental exposures on gene expression and health-related traits, while simultaneously controlling for genetic relatedness and migration. (nature.com)
The current study aimed to use Coagulase gene polymorphism to identify methicillin-resistant Staphylococcus aureus (MRSA) subtypes isolated from nasal carriers in Minia governorate, Egypt, evaluate the efficiency of these methods in discriminating variable strains, and compare these subtypes with antibiotypes. (hindawi.com)
The aim of this study was to use coa gene polymorphism to identify MRSA subtypes isolated from nasal carriers in Minia governorate, Upper Egypt, evaluate the efficiency of these typing methods in discriminating variable strains, and compare these subtypes with antibiotypes. (hindawi.com)
The Q353 allele of the factor VII gene polymorphism is associated with decreased factor VII and could be protective against cardiovascular disease. (who.int)
The -491A/T polymorphism of the promoter region of the APOE gene was also examined. (wayne.edu)
To analyse for the MBL códon 54 gene polymorphism and for IL1-Ra, buccal cells were obtained with a cotton swabs and shipped to New York at ambient temperature. (usp.br)
T gene polymorphism. (bvsalud.org)

Quinolone resistance among Enterobacteriaceae originally occurred due to chromosomal mutations in the quinolone-resistance-determining regions (QRDRs) of the gyrA and gyrB genes, which encode the gyrase A and B subunits, respectively and the parC and parE genes, which encode topoisomerase IV subunits (Hernández et al. (scielo.br)
Many possess genes that encode proteins to neutralize the affects of antibiotics and prevent attacks on their cell machinery. (icr.org)
In particular, they analyzed a region of chromosome 6 known as the major histocompatibility complex (MHC), a polymorphic DNA segment with some 130 genes that encode many of the molecules involved in innate and acquired immune responses. (indiatimes.com)
10% transformation frequency), which reside in genes undergoing strong diversifying selection that encode large membrane proteins, likely as an immune invasion tactic. (drexel.edu)
The majority of mammalian genes encode multiple transcript isoforms that result from differential promoter use, changes in exonic splicing, and alternative 3' end choice. (bvsalud.org)

In this study, we investigated the presence of plasmid-mediated quinolone resistance (PMQR) genes among 101 ciprofloxacin-resistant urinary Escherichia coli isolates and searched for mutations in the quinolone-resistance-determining regions (QRDRs) of the DNA gyrase and topoisomerase IV genes in PMQR-carrying isolates. (scielo.br)
Mutations in the BLM gene cause Bloom syndrome. (medlineplus.gov)
BLM gene mutations result in the absence of functional BLM protein. (medlineplus.gov)
Exchange of DNA between chromosomes derived from the individual's mother and father are also increased in people with BLM gene mutations. (medlineplus.gov)
Large populations are therefore a reservoir of new mutations and their size hardly slows down the propagation of good genes. (amren.com)
Through genomic analysis of tumor samples, the researchers identified somatic mutations in EGFR, KRAS, and other target genes. (dana-farber.org)
Using the genomic and ancestry data, the researchers assessed the associations of somatic mutations in target genes and global ancestry groups within a single admixed population. (dana-farber.org)
After adjusting for a variety of factors, including self-reported smoking status and sample-specific tumor mutational burden, the researchers found that global Native American ancestry was positively correlated with mutations in the EGFR gene. (dana-farber.org)
Further, the researchers found that Native American ancestry was predominantly associated with oncogenic mutations in the EGFR gene, but not with non-oncogenic mutations. (dana-farber.org)
Meyerson and colleagues then stratified patients by their self-reported smoking status and evaluated the association between global ancestry and mutations in target genes. (dana-farber.org)
In both never smokers and smokers, global Native American ancestry was associated with mutations in the EGFR gene, suggesting that the genomic differences associated with Native American ancestry are independent of smoking status. (dana-farber.org)
These mutations in MUC22 are technically termed 'missense' variants, DNA changes that result in different amino acids being encoded at particular positions in the resulting proteins. (indiatimes.com)
Moreover, the allele frequency of gene mutations in cytological specimens showed a correlation with tissue specimens. (eurekalert.org)
Exploring mutations in AVR among M. oryzae isolates from rice-production fields could aid assessment of the efficacy and durability of R genes. (researchsquare.com)
Recognize that the frequencies of a gene's disease-causing mutations can vary widely between ethnic populations. (case.edu)
20 000 protein coding genes (Parsons mutations. (who.int)

Since NAION may occur when compromised watershed microcirculation is combined with insufficient autoregulation of systematic circulation, polymorphisms of genes involved in systematic circulation, such as the RAAS genes, may be associated with NAION occurrence. (molvis.org)
ABSTRACT Factor VII gene polymorphisms may contribute to elevations in factor VII coagulant (FVIIc) levels that have been associated with cardiovascular risk. (who.int)
The impor- objectives of determining the frequencies tance of FVII in normal haemostasis is il- of these gene polymorphisms in the popula- lustrated by the severe bleeding diathesis tion and clarifying the genotype association associated with low plasma levels of the of the R353Q and 0/10 bp insertion poly- protein [ 3 ]. (who.int)
The aim of this study was to assess the correlation between polymorphisms in the genes coding for mannose-binding lectin (MBL) and interleukin-1 receptor antagonist (IL1-Ra) and RVCC in women from São Paulo, Brazil. (usp.br)
Nevertheless, the effects of the RAN and RANBP2 gene polymorphisms on the tumorigenesis of Wilms tumor remain unclarified. (jcancer.org)
Our results indicated that RAN and RANBP2 polymorphisms were associated with Wilms tumor susceptibility in Chinese children. (jcancer.org)
Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)

The rates of spontaneous gene duplication and deletion are extraordinarily high and speak to the enormous potential of these structural variants for generating new adaptive variability [ 5 - 10 ]. (biomedcentral.com)
In this study, we seek to determine if gene copy-number changes are a common class of genetic change during adaptation and what role, if any, natural selection plays in the maintenance and frequency increase of copy-number variants (CNVs henceforth) in experimental populations. (biomedcentral.com)
2011). Over the last several years, different PMQR gene variants have been described in different locations worldwide. (scielo.br)
G variants of solute carrier family 26, member 4 ( SLC26A4 ) gene play a critical role in the development of large vestibular aqueduct syndrome (LVAS). (springeropen.com)
In this study, we developed a rapid genotyping method for discriminating LVAS-associated high-frequency variants in SLC26A4 gene. (springeropen.com)
2017 ). It is well known that the solute carrier family 26, member 4 ( SLC26A4 ) gene plays a critical role in the development of LVAS, and about 90% of LVAS is closely attributed to SLC26A4 gene variants (Nishio et al. (springeropen.com)
To date, more than 100 of SLC26A4 gene variants have been identified and described as causally related to hereditary hearing impairment ( https://hereditaryhearingloss.org/ ). (springeropen.com)
G high-frequency variants and explore strategies for clinical genetic diagnosis. (springeropen.com)
The results have demonstrated that many new variants of the coa gene are present in Minia, Egypt, different from those reported in the previous studies. (hindawi.com)
Variants on genes belonging to the reward pathway have been shown to account for part of this heritability. (figshare.com)
Exome sequencing was performed, and variants with a strong functional impact in brain-expressed genes were selected. (figshare.com)
The 10 most associated variants, genes, and pathways were retained for replication in the Parkinson's progression markers initiative (PPMI) cohort. (figshare.com)
The first was that the frequency of variants of the gene MUC22 was twice as high in the mild Covid-19 group as in severe patients, and higher still in resilient super-agers. (indiatimes.com)
Computational techniques were used to (1) study the enrichment of PSC-risk variants within regulatory elements, (2) correlate risk genotype with differences in regulatory element activity, and (3) identify regulatory elements differentially active and genes differentially expressed between PSC patients and controls. (bvsalud.org)
RESULTS: Noncoding PSC-risk variants are strongly enriched within immune-specific enhancers, particularly ones involved in T-cell response to antigenic stimulation. (bvsalud.org)
This model was developed using data collected from molecular epidemiology studies of allergic asthma that examined variants in 16 susceptibility genes. (cdc.gov)
In light of this, a multiplicative gene-gene interaction model was developed to allow for estimating the combinatorial contribution of multiple genetic variants to disease risk. (cdc.gov)

Forward genetics has generated many alleles of frq resulting in strains whose circadian clocks vary in period length. (wikipedia.org)
We evaluated the frequency of these alleles in A. aegypti in west Santa Catarina. (geneticsmr.com)
Genetic variation is essential for natural selection to operate since natural selection can only increase or decrease frequency of alleles already in the population. (berkeley.edu)
also called allele frequency) Proportion of genes/alleles in a population that are of a particular type. (berkeley.edu)
Gene conversion can be biased, tending to favor some alleles over others. (berkeley.edu)
Genetic drift is a change in the frequency of a population's genes and alleles over time, often by founder effects (when a small group of individuals relocate) or bottlenecking (when a large population is decimated, leaving a smaller group to repopulate). (visionlearning.com)
Our analysis of frequency of the ApoE alleles in 38 patients with AD, 21 patients with FTD and 29 normal controls indicates an association of both AD and FTD with an increased frequency of the epsi4 allele and in AD also with homozygosity for epsi4. (lu.se)
We studied the probable molecular-evolutionary patterns of AVR-Pib alleles by assaying their DNA-sequence diversification and examining their avirulence to the corresponding Pib resistance gene under natural conditions in China. (researchsquare.com)
PCRs detected results from M. oryzae genomic DNA revealed that 162 out of 366 isolates collected from Yunnan Province contained AVR-Pib alleles. (researchsquare.com)
Our results revealed that AVR-Pib alleles suffered neutral evolution and divergences that led to overcome specific resistant Pib alleles under field conditions. (researchsquare.com)

Eight isolates harboured the qnr and aac(6')-Ib-cr genes (3 qnrS1, 1 qnrB19 and 4 aac(6')-Ib-cr). (scielo.br)
Therefore, in this study, we investigated the presence of the qnrA , qnrB , qnrS and aac(6-)-Ib-cr genes in a sample of ciprofloxacin-resistant E. coli isolates from women with CA-UTIs. (scielo.br)
These results indicate that qac resistance genes are common and that linkage between resistance to disinfectants and penicillin resistance occurs frequently in clinical isolates in Norway. (nofima.no)
The identified isolates were tested by Coagulase gene RFLP typing. (hindawi.com)
Furthermore, 36 (28.6%) out of 126 isolates had a transposable element (TE) insertion in AVR-Pib , which resulted in altered virulence. (researchsquare.com)
To evaluate frequency of SHV, TEM, and CTX-M genes in the isolates, the PCR method was used. (ac.ir)
Of 49 isolates, 89.8% had SHV gene, 89.8% had CTX-M gene, and 100% had TEM gene. (ac.ir)
We concluded that one of the reasons of increasing multi drug resistance in nosocomial isolates of UTI in Rasht may be an increase in horizontal transfer of plasmid genes between these isolates. (ac.ir)
The frequency of ermA, ermB and ermC genes in S. aureus isolates were 5%, 7.5% and 10% respectively. (alliedacademies.org)

Antibodies to Pgp3 (plasmid gene product 3) have been shown to have high sensitivity 1,2 and remain positive for an extended time period. (cdc.gov)
Molecular and genetic studies indicated different structural arrangements of blaZ and qacA/B, including variable intergenic distances and transcriptional directions of the two genes on the same plasmid within the strains. (nofima.no)
Different types of antibiotic resistance mechanisms have been found in S. aureus that beta-lactamase producing is the most common which associated gene with enzyme production is located on the plasmid. (alliedacademies.org)
Resistance to nafcillin by mecA gene which is located on chromosome, resistance to vancomycin (vancomycin and nafcillin resistance genes exist in these strains) and plasmid resistance to tetracycline, erythromycin and aminoglycosides are the types of resistance mechanisms [ 5 , 6 ]. (alliedacademies.org)

Gene copy-number variation (CNVs), which provides the raw material for the evolution of novel genes, is widespread in natural populations. (biomedcentral.com)
The frequencies of CNVs in these populations were analyzed by oligonucleotide array comparative genome hybridization, quantitative PCR, PCR, DNA sequencing across breakpoints, and single-worm PCR. (biomedcentral.com)
Multiple duplications and deletions rose to intermediate or high frequencies in independent populations. (biomedcentral.com)
Several lines of evidence suggest that these changes were adaptive: (i) copy-number changes reached high frequency or were fixed in a short time, (ii) many independent populations harbored CNVs spanning the same genes, and (iii) larger average size of CNVs in adapting populations relative to spontaneous CNVs. (biomedcentral.com)
Due to the high rates of origin of spontaneous duplications and deletions, copy-number changes containing the same genes arose readily in independent populations. (biomedcentral.com)
Duplications that reached high frequencies in these adapting populations were significantly larger in span. (biomedcentral.com)
In contrast, natural selection for increased gene expression may represent an important mechanism by which duplicate gene copies are maintained in populations [ 14 ]. (biomedcentral.com)
To investigate the gene frequency of the T235 allele and its relationship with hypertension in two Japanese populations. (lww.com)
The São Miguel do Oeste and Chapecó populations had similar frequencies of Val and Ile and were not in Hardy-Weinberg equilibrium, suggesting that a selection pressure or other evolutionary force has occurred. (geneticsmr.com)
In conclusion, the observed frequency of Ile/Ile homozygous individuals in the region studied requires attention, because the implementation of controls using pyrethroid may increase the frequency of the mutant allele through the selection of resistant populations. (geneticsmr.com)
The movement of genes between populations. (berkeley.edu)
Most annotations are related to variant frequencies in different populations. (lu.se)

Conclusion: Our results suggest that genes implicated in the signaling pathways linked to G protein-coupled receptors participate to genetic susceptibility to ICDs in PD. (figshare.com)
These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)

Using an amplicon-based high-sensitivity next generation sequencing panel test capable of measuring eight druggable genes (EGFR, BRAF, KRAS, ERBB2, ALK, ROS1, MET, RET), Dr. Morikawa prospectively enrolled consecutive patients who underwent diagnostic procedures from May 2020 to January 2022. (eurekalert.org)
111 cases (68.1%) had gene mutation, including 58 cases (35.6%) of EGFR, 25 cases (15.3%) of KRAS, 9 cases (5.5%) of MET Ex14 skipping, 6 cases (3.7%) of ALK fusion, 6 cases (3.7%) of BRAF, 4 cases (2.5%) of ERBB2, 2 cases (1.2%) of ROS1 fusion and 1 case (0.6%) of RET fusion. (eurekalert.org)

Distribution of quinolone resistance gene (qnr) in ESBL-producing Escherichia coli and Klebsiella spp. (ac.ir)

The involvement of chromosome 19 in AD has been associated with apoliprotein E (ApoE) and the epsi4 gene frequency has been related to increased risk and early onset of AD. (lu.se)
We are now using advanced optical mapping technology to reproduce these maps in the absence of genetic variation, in order to disentangle the role of chromosome structure from the potential for genetic incompatibilities ("speciation genes") skewing our results. (drexel.edu)

Previous studies revealed that SLC26A4 gene variant has obvious racial specificity, LVAS patients from different races with unique variant spectra and different variant frequencies (Berrettini et al. (springeropen.com)

This happens as a result of sampling error - some genotypes just happen to reproduce more than other genotypes, not because they are "better," but just because they got lucky. (berkeley.edu)
Results shown that RAN rs7132224 AG/GG genotypes significantly increased Wilms tumor risk when compared to AA genotype (adjusted OR=1.40, 95% CI=1.01-1.95, P =0.047). (jcancer.org)

As more clinically relevant cancer genes are identified, comprehensive diagnostic approaches are needed to match patients to therapies, raising the challenge of optimization and analytical validation of assays that interrogate millions of bases of cancer genomes altered by multiple mechanisms. (nih.gov)
2] Kanamycin, an antibiotic used in the 1950s, has become clinically useless as a result of the prevalence of kanamycin-resistant bacteria. (icr.org)
Statistically significant and clinically meaningful efficacy results were achieved across key MDS subgroups irrespective of ring sideroblast (RS) status, baseline transfusion burden and IPSS risk category. (businesswire.com)

The frequency (frq) gene encodes the protein frequency (FRQ) that functions in the Neurospora crassa circadian clock. (wikipedia.org)
Reflecting its role as a core clock protein, deletion of the frq gene results in arrhythmicity, and in Neurospora, the only function of FRQ is in the circadian clock. (wikipedia.org)
The choice of which protein is made is the result of temperature-dependent splicing of the primary transcript such that it includes or excludes the ATG start codon for lFRQ. (wikipedia.org)
Aida Andrés at University College London, UK, Felix Key at the Max Planck Institute for Evolutionary Anthropology in Leipzig and their colleagues studied the gene for a protein called TRPM8, which is known to activate in cold temperatures. (newscientist.com)
The gene for the protein comes in two flavours. (newscientist.com)
The BLM gene provides instructions for making a member of a protein family called RecQ helicases. (medlineplus.gov)
Without the BLM protein, the cell is less able to repair DNA damage caused by ultraviolet light, which results in increased sun sensitivity. (medlineplus.gov)

furthermore, when strains of Neurospora were engineered in which frq expression could be driven from a region distinct from the resident wild type gene, it was found that FRQ repressed its own expression and that no level of constant expression could support a circadian clock. (wikipedia.org)
Moreover, the higher frequency of antibiotic resistance among BC-resistant strains indicates that the presence of either resistance determinant selects for the other during antimicrobial therapy and disinfection in hospitals. (nofima.no)
The aim of this study was to evaluate the frequency of SHV, TEM and CTX-M genes in Escherichia Coli and Klebsiella Pneumoniae strains isolated from UTI in children in 17 Shahrivar hospital from Rasht city, Iran. (ac.ir)
10. Jena J, Sahoo RK, Debata NK, Subudhi E. Prevalence of TEM, SHV, and CTX-M genes of extended-spectrum β-lactamase-producing Escherichia coli strains isolated from urinary tract infections in adults. (ac.ir)

In mammals, mutation of proteins involved in the nuclear architecture (lamins and lamin associated proteins) results in diseases associated with genomic instability. (cea.fr)
4] Failure of DNA to properly separate during these processes results in a bacterium not being able to divide normally or produce functional proteins. (icr.org)

Effect of the angiotensinogen gene Met235$Thr variant on blo. (lww.com)

In Europe, the European Center for Disease Prevention and Control (ECDC) estimates that 33,000 people die each year as a direct result of resistant bacteria. (pasteur.fr)
Bacteria can become resistant to antibiotics either through mutation or by acquiring resistance genes that confers resistance to one or more antibiotics. (pasteur.fr)
These exchanges are especially problematic when it comes to genes making the bacteria resistant. (pasteur.fr)
The frequencies of resistance to a range of antibiotics were significantly higher among BC-resistant staphylococci than among BC-sensitive staphylococci. (nofima.no)
A brief look at an example of penicillin resistance reveals the increase in the frequency of antibiotic-resistant organisms since the time when antibiotic use became common. (icr.org)
Application of rice varieties with multiple resistant genes is the most important method governing the disease by an economical, environmentally and friendly manner. (researchsquare.com)
In recent years, because of overuse of antibiotics and transition of resistance genes, frequency of resistant staphylococcal infections, are increasing. (alliedacademies.org)

Sickle-cell anaemia (also known as sickle-cell disorder or sickle-cell disease) is a common genetic condition due to a haemoglobin disorder - inheritance of mutant haemoglobin genes from both parents. (who.int)
Globally, there are more carriers (i.e. healthy people who have inherited only one mutant gene from one parent) of thalassaemia than of sickle-cell anaemia, but the high frequency of the sickle-cell gene in certain areas leads to a high rate of affected newborns. (who.int)
This distribution reflects the fact that sickle-cell trait confers a survival advantage against malaria and that selection pressure due to malaria has resulted in high frequencies of the mutant gene especially in areas of high malarial transmission. (who.int)
Frequencies of the carrier state determine the prevalence of sickle-cell anaemia at birth. (who.int)
For example, in Nigeria, by far the most populous country in the subregion, 24% of the population are carriers of the mutant gene and the prevalence of sickle-cell anaemia is about 20 per 1000 births. (who.int)
The sickle-cell gene has become common in Africa because the sickle-cell trait confers some resistance to falciparum malaria during a critical period of early childhood, favouring survival of the host and subsequent transmission of the abnormal haemoglobin gene. (who.int)
Although a single abnormal gene may protect against malaria, inheritance of two abnormal genes leads to sickle-cell anaemia and confers no such protection, and malaria is a major cause of ill-health and death in children with sickle-cell anaemia. (who.int)
Our data showed that the frequency of sickle cell mutational gene is second to β-thalassemia, α-thalassemia is the third one. (ijbc.ir)

Air pollution impacts gene expression and pathways affecting cardio-metabolic and respiratory traits, when controlling for genetic ancestry. (nature.com)
HR comprises different pathways: gene conversion (GC) that accurately repair the lesion by copying the homologous sequence, single strand annealing (SSA) or break induced replication (BIR) that can both lead to loss of genetic information. (cea.fr)

This pathway, called "natural transformation," is a major mechanism of gene transfer across bacteria and has a profound effect on genome evolution, including spreading antibiotic resistances and other virulence determinants. (drexel.edu)
We are applying a variety of genomic methods to identifying putative virulence genes, including machine learning and phylogenetic correlated evolution methods. (drexel.edu)

Since bacteria have very long DNA sequences, the study focused on genetic markers-;genes that are unique to each organism. (news-medical.net)
The set of genes an organism has. (berkeley.edu)

Taking antibiotics disrupts our microbiome and contributes to an increase in our reservoir of resistance genes. (pasteur.fr)
An increase in the frequency of antibiotic resistance in bacteria since the 1950s has been observed for all major classes of antibiotics used to treat a wide variety of respiratory illnesses, skin disorders, and sexually transmitted diseases. (icr.org)
In Staphylococcus resistance to these antibiotics is create by methylation of target site on ribosome that mostly related to methylase gene erm (rRNA) [ 12 ]. (alliedacademies.org)

Bacteria are capable of exchanging genes. (pasteur.fr)
While the acquisition of resistance through mutation is extremely rare - occurring in approximately one in every hundred million bacteria - resistance genes can be acquired between bacteria much more frequently, by as many as one bacterium in every hundred. (pasteur.fr)
The friendly, non-pathogenic bacteria that colonize us and make up our microbiome and are essential to our health can also develop resistance, creating a reservoir of resistance genes that can then spread to pathogenic bacteria. (pasteur.fr)
To answer these questions a discussion of several factors involved in antibiotic resistance will show that resistance is a designed feature of pre-existing genes enabling bacteria to compete with the antibiotic producers in their environment. (icr.org)
We have developed a novel method for mapping genes in bacteria, exploiting natural transformation in combination with genome-wide deep sequencing. (drexel.edu)
This disease results from an inflammatory cascade generated by the interaction between periodontopathogenic bacteria and the host immune response, which includes a complex network of cytokines, reactive oxygen species, and proteolytic enzymes 1,2 . (bvsalud.org)

Gene and genome duplications are the primary source of new genes and have played a pivotal role in the evolution of genomic and organismal complexity [ 1 - 4 ]. (biomedcentral.com)

We implemented a practical validation strategy with reference samples of pooled cell lines that model key determinants of accuracy, including mutant allele frequency, indel length and amplitude of copy change. (nih.gov)

These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)

Here we describe a test based on massively parallel DNA sequencing to characterize base substitutions, short insertions and deletions (indels), copy number alterations and selected fusions across 287 cancer-related genes from routine formalin-fixed and paraffin-embedded (FFPE) clinical specimens. (nih.gov)

Sequence analysis temporally or geographically with established or emerg- was performed by using Sequencher version 4.8/5.0 (Gene- ing tickborne pathogens and their vectors. (cdc.gov)

The APOE frequencies found in this study differ significantly from those obtained in earlier Norwegian APOE phenotypings. (wayne.edu)
A significantly higher epsi2 frequency in our FTD material compared to AD and normals might also indicate a connection with the distribution of cortical degeneration. (lu.se)
Results: In the individuals evaluated in this study, periodontitis was significantly associated with a low educational level (p = 0.024) and clinical variables, such as gingival bleeding (p = 0.019) and tooth mobility (p = 0.001). (bvsalud.org)

We have previously established that the spontaneous, genome-wide rate of gene duplication in C. elegans is two orders of magnitude higher than the point mutation rate [ 8 ]. (biomedcentral.com)

The researchers next developed a local Native American ancestry risk score to evaluate the association of ancestry with EGFR mutation frequency across multiple distinct sites in the genome. (dana-farber.org)
They found that the correlation between ancestry and increased mutation frequency in the EGFR gene was stronger at the local genome level than the global genome level. (dana-farber.org)

METHODS: Culture-dependent and -independent (16S rRNA gene clone libraries were constructed) methods were used to determine the composition of LAB in fermented cabbage. (who.int)
RESULTS: Ninety LAB isolated from fermented cabbage were identified as species of Lactobacillus and Leuconostoc, whereas 115 clones of the 16S rRNA gene sequence from fermented cabbage DNA were identified as Lactobacillus, Weissella, Pediococcus and Leuconostoc. (who.int)

Attending the Laboratory's weekly abnormal meeting and discussing abnormal patient results, both cytogenetic and molecular. (case.edu)

Our results might indicate that ApoE epsi4 is an important. (lu.se)
Our results might indicate that ApoE epsi4 is an important aggravating and pathoplastic factor in the presence of genetic and other determinants for the development of AD or FTD. (lu.se)

For instance, aberrant splicing of WT1 , a pivotal cancer suppressor gene, increased the risk of Wilms tumor [ 8 ]. (jcancer.org)

Nevertheless, few studies of PMQR genes have been conducted in Brazil. (scielo.br)
T in the IL1A gene and periodontitis in subjects from Vitória da Conquista, Bahia, Brazil. (bvsalud.org)

Before the clinical application of gene diagnosis, the imageological examination was the only way of LVAS diagnosis and had stated clearly that LVAS is the most common inner ear malformation (Connor et al. (springeropen.com)
To address this, Dr. Morikawa and colleagues evaluated the feasibility of performing gene panel tests using cytological specimens including transbronchial brushing, transbronchial needle aspiration, and pleural effusion in clinical practice. (eurekalert.org)
The conference will cover a wide range of disciplines and unveil several research studies and clinical trial results. (eurekalert.org)
Treatment with imetelstat vs. placebo led to greater reduction in variant allele frequency (VAF) in multiple genes associated with lower risk MDS, which correlated with clinical endpoints of TI response, longer TI duration and increase in hemoglobin levels, suggesting the potential of imetelstat to modify the disease. (businesswire.com)
Based on results from the IMerge Phase 3 clinical trial, Geron submitted a New Drug Application for imetelstat in lower risk MDS that was accepted for review by the FDA and assigned a Prescription Drug User Fee Act (PDUFA) action date of June 16, 2024. (businesswire.com)
Recognize how results from cytogenetics and molecular genetics diagnostic tests and from prenatal screening tests can be integrated with results from pathology and laboratory medicine to provide the referring physician a more comprehensive clinical picture of the patient. (case.edu)

These alterations can result in the wide range of somatic and reproductive effects described in greater detail in Chapter 3. (cdc.gov)

Avaliação da frequência do polimorfismo nos genes que codificam a lecitina ligadora. (usp.br)
Para a análise dos polimorfismos nos genes que codificam para a MBL e o IL1-Ra realizou-se coleta de células bucais que foram enviadas para Division of Immunology and Infectious Diseases of Weill Medical College of Cornell University Resultados: Mulheres com candidíase vulvovaginal recorrente apresentaram maior frequência de polimorfismo no códon 54 do gene que codifica a MBL quando comparadas a mulheres saudáveis. (usp.br)

We found a correlation between frequency [of the gene] and latitude," says Key. (newscientist.com)
The correlation coefficient of the gene allele ratio in 61 cases compared with the tissue sample was 0.717, showing a high correlation. (eurekalert.org)

Ohno [ 1 ] theorized that newly duplicated genes were freed from the constraints of natural selection, implicating a dominant role of genetic drift in their early evolutionary dynamics. (biomedcentral.com)

About 5% of the world's population carries genes responsible for haemoglobinopathies. (who.int)
This process causes gene frequencies in a population to drift around over time. (berkeley.edu)
Some genes may even "drift out" of a population (i.e., just by chance, some gene may reach a frequency of zero). (berkeley.edu)
All of the genes in a population. (berkeley.edu)
Simulation results were compared to genetic analyses and matched estimates of the real population very well. (ufz.de)
They arrived at three very important results, two of which were made possible only by the use of samples from a population that is highly mixed in terms of ethnicity and ancestry. (indiatimes.com)
Based on the product of single gene variant odds ratios, the risk of developing asthma was assigned to genotype profiles, and the frequency of each profile was estimated for the general population. (cdc.gov)

Our hypothesis was that gene editing is a more efficient method than conventional breeding for decreasing the horned allele frequency in Jersey cattle, while keeping inbreeding at acceptable levels and maintaining genetic progress. (usda.gov)
These results confirm our hypothesis that gene editing of the polled locus could be used to effectively address dairy producers' economic concerns, while also alleviating consumers' animal welfare concerns. (usda.gov)
In the principal hypothesis of the arms-race, the mutation of R genes and AVR genes is derived by directional selection. (researchsquare.com)

3) However, sexual selection is usually described as the product of genetic models, particularly 'linkage disequilibrium ' (8) in which a 'gene for' a trait is located near a presumed 'gene for an attraction to' that same trait. (behavior.net)
However, sensory mechanisms could reduce or eliminate the role of a 'gene for an attraction to' whatever trait is under consideration. (behavior.net)

The data suggest that exo + polymerase-mediated 3′ terminal phosphorothioate-modified primer extension is reliable in the identification of SLC26A4 gene high-frequency variant prior to high-resolution CT scan. (springeropen.com)
However, researchers lead by Kei Morikawa, St. Marianna University School of Medicine, Japan today reported data that the success rate of gene analysis using cytological specimens was extremely high, and the yield and quality of the extracted nucleic acid were also sufficient for panel analysis. (eurekalert.org)
The success rate of gene analysis using cytological specimens was extremely high, and the yield and quality of the extracted nucleic acid were also sufficient for panel analysis," Dr. Morikawa reported. (eurekalert.org)

Characterization of frequency-dependent responses of sensory nerve function to repetitive vibration. (cdc.gov)
This is probably the first time [the adaptation of] a sensory gene has been tied to environment. (newscientist.com)

Further, in order to capture gene-by-environment interactions through eQTL analyses, we combine whole-transcriptome RNA-Sequencing profiles with whole-genome genotyping and extensive fine-scale environmental exposure data. (nature.com)

The ermA, ermB and ermC are types of erm gene which discovered in Staphylococcus [ 12 , 13 ]. (alliedacademies.org)

The team screened databases of genetic data taken from people across the world, to see how common each gene variant was in Europe, Africa and South East Asia. (newscientist.com)
CEST) -- Personalized medicine for lung cancer using molecular-targeted drugs is common but there have been no prospective validation studies done on the usefulness of lung cancer gene panel testing using cytology samples. (eurekalert.org)

Migration raised the frequency of the gene in the American continent. (who.int)

In a four-year period (2000-2004), 93 voluntary couples from Khuzestan province (mostly Ahvaz area) who were proved to be carrier for alpha thalassemia, beta thalassemia, or other hemoglobinapathies underwent PND and detection of causative mutational genes by chorionic villus sampling {CVS) plus direct or indirect DNA analysis at first trimester of pregnancy. (ijbc.ir)

Anatomy1

Diseases1

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment10

Psychiatry and Psychology1

Phenomena and Processes25

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena2

Information Science3

Named Groups5

Health Care2

Geographicals1

Antibiotic resistance genes7

Allele frequencies6

Polymorphism10

Encode5

Mutations16

Polymorphisms7

Variants17

Alleles10

Isolates9

Plasmid4

Populations12

Susceptibility2

KRAS2

Quinolone resistance1

Chromosome2

Variant frequencies1

Genotypes2

Clinically3

Protein7

Strains4

Proteins2

Angiotensinogen gene1

Resistant7

Sickle-cell8

Pathways2

Virulence2

Organism2

Antibiotics3

Bacteria6

Genomic1

Mutant1

Phenotypes1

Fusions1

Pathogens1

Significantly3

Genome-wide1

EGFR2

RRNA2

Abnormal1

APOE2

Pivotal1

Brazil2

Clinical6

Somatic1

Polimorfismo2

Correlation2

Genetic drift1

Population7

Hypothesis3

Trait2

High3

Sensory2

Analyses1

Staphylococcus1

Common2

Migration1

Carrier1