Loading...
  • BMAA
  • Sacks and Paul Alan Cox subsequently wrote that a local species of flying fox, which is now extinct due to overhunting, had been feeding on cycads and concentrating β-methylamino-L-alanine (BMAA), a known neurotoxin, in its body fat. (wikipedia.org)
  • A study performed in 2015 with vervets (Chlorocebus sabaeus) in St. Kitts, which are homozygous for the apoE4 gene (a condition which in humans is a risk factor for Alzheimer's disease), found that vervets orally administered BMAA developed hallmark histopathology features of Alzheimer's Disease including amyloid beta plaques and neurofibrillary tangle accumulation. (wikipedia.org)
  • Additionally, vervets that were co-administered BMAA with serine were found to have 70% less beta-amyloid plaques and neurofibrillary tangles than those administered BMAA alone, suggesting that serine may be protective against the neurotoxic effects of BMAA. (wikipedia.org)
  • This study also demonstrates that BMAA, an environmental toxin, can trigger neurodegenerative disease as a result of a gene/environment interaction. (wikipedia.org)
  • Most cyanobacteria produce the neurotoxin beta-N-methylamino-l-alanine (BMAA) that has been implicated as a significant environmental risk in the development of neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Amyotrophic Lateral Sclerosis (ALS). (wikipedia.org)
  • concentrations
  • Blooms result in reduced dissolved oxygen concentrations, alterations in aquatic food webs, algal scum lining the shores, the production of compounds that cause distasteful drinking water and fish flesh, and the production of toxins severe enough to poison aquatic as well as terrestrial organisms. (wikipedia.org)
  • Antimicrobial susceptibility testing (AST) can be done on 96-well plates by diluting the antimicrobial agent at varying concentrations in broth inoculated with bacteria and measuring the minimum inhibitory concentration that results in no growth. (wikipedia.org)
  • monomer
  • The structure of alanine racemase from Bacillus stearothermophilus (Geobacillus stearothermophilus) was determined by X-ray crystallography to a resolution of 1.9 A. The alanine racemase monomer is composed of two domains, an eight-stranded alpha/beta barrel at the N terminus, and a C-terminal domain essentially composed of beta-strand. (wikipedia.org)
  • residue
  • Increased activity of an E451A mutant enzyme (where Glu451 is replaced with an alanine residue) after addition of azide is consistent with Glu451 as the acid/base residue. (wikipedia.org)
  • The pyridoxal 5'-phosphate (PLP) cofactor lies in and above the mouth of the alpha/beta barrel and is covalently linked via an aldimine linkage to a lysine residue, which is at the C terminus of the first beta-strand of the alpha/beta barrel. (wikipedia.org)
  • Another problem identified was the need for another basic residue to return Lys39 and Tyr265 back to their protonated and unprotonated forms for L-alanine and vice versa for D-alanine. (wikipedia.org)
  • muscle
  • BCAA Matrix combines the muscle recuperation properties of BCAAs and the performance enhancing ability of Beta-Alanine and Carnitine! (gnc.com)
  • By raising the intake to an average-sized 250-300g portion of turkey a day, the researchers predicted that muscle concentration of beta-alanine might rise by as much as 80% over six months, leading to an even more positive impact on performance. (athleticsweekly.com)
  • This method keeps the body highly sensitive and responsive to insulin resulting in greater lean muscle growth and destruction of fat tissue. (epicsports.com)
  • Incredible Results for Boosting Muscle Mass And Sex Drive. (fav-store.net)
  • Nerves below the head may be compressed where chronic neck and spine problems exist and can be caused by, among other things, muscle cramps that may be a result of clinical anxiety or excessive mental stress,[citation needed] bone disease, poor posture, unsafe heavy lifting practices or physical trauma such as whiplash. (wikipedia.org)
  • sugar
  • In assembling the pieces of the scientific puzzle, N.O. Shotgun was formulated to mimic the insulin response generated by high glycemic (high Gl) carbs (i.e. sugar) to activate beta-cells and stimulate whole body creatine retention! (epicsports.com)
  • deficiency
  • Neurological disorders associated with a deficiency of carnosinase, and the resulting carnosinemia ("carnosine in the blood") are common. (wikipedia.org)
  • Mutations in CNDP1 are responsible for carnosinase deficiency, resulting in carnosinemia. (wikipedia.org)
  • Homocarnosinosis, a neurological disorder resulting in an excess of homocarnosine in the brain, though unaffected by tissue carnosinase, is caused by a deficiency of serum carnosinase in its ability to hydrolyze homocarnosine. (wikipedia.org)
  • A deficiency in this enzyme results in the build-up of non-hydrolyzed mucopolysaccharides in the patient. (wikipedia.org)
  • paraesthesia
  • Most pressure-induced paraesthesia results from awkward posture, such as engaging in cross-legged sitting for prolonged periods of time. (wikipedia.org)
  • metabolic
  • Deficiencies in β-glucuronidase result in the non recessive inherited metabolic disease known as Sly syndrome or Mucopolysaccharidosis VII. (wikipedia.org)
  • found
  • Alanine racemase can be found in some invertebrates. (wikipedia.org)
  • The N-terminal domain is also found in the PROSC (proline synthetase co-transcribed bacterial homolog) family of proteins, which are not known to have alanine racemase activity. (wikipedia.org)
  • These results were relevant to all forms of cataract, mild or severe, although other studies found the most beneficial effect was in relation to early forms of cataract. (wikipedia.org)
  • gene
  • Bacteria can have one (alr gene) or two alanine racemase genes. (wikipedia.org)
  • However, knockout studies have shown that without the alr gene being expressed, the bacteria would need an external source of D-alanine in order to survive. (wikipedia.org)
  • group
  • The Babizhayev group later published a placebo-controlled clinical trial of NAC in 76 human eyes with mild to advanced cataracts and reported similar positive results for NAC. (wikipedia.org)
  • structural
  • Beta-glucuronidase contains several notable structural formations, including a type of beta barrel known as a jelly roll barrel and a TIM barrel. (wikipedia.org)
  • high
  • These blooms occur as the result of nutrient pollution and degraded water quality, and their growth is further stimulated by high temperatures. (wikipedia.org)
  • blooms
  • First, this water tends to be rich in nutrients as a result of agricultural runoff, and thus has a tendency to cause algae blooms and other imbalances. (wikipedia.org)
  • Blooms have been reported throughout the continental United States, and resulting cyanotoxins have been associated with human and animal illness and death in at least 43 states. (wikipedia.org)
  • weeks
  • all you have to do is just work out about 5-7 days a week (what i have been doing) and you will notice results, and what ive been told is that it takes about 3 weeks for it to have a good amount of affect. (bodybuildingweb.net)
  • Subjects were supplemented orally for 4 weeks with 4.8 g/day placebo or beta-alanine. (ugent.be)
  • known
  • Beta-Alanine is also known as 3-aminopropanoic acid. (bodybuildingweb.net)
  • Both dark chocolate and beetroot juice are known to increase nitric oxide, which is the major mechanism we believe is behind these results," Patel said of his findings, published in the Journal of the International Society of Sports Nutrition . (athleticsweekly.com)
  • great
  • We owe a great deal of credit and respect to the scientists who are in the trenches doing the work and publishing the research on beta-alanine. (bodybuilding.com)
  • While there aren't an abundance of great Beta-Alanine products out there I would have to say by far my favorite is H+Blocker by iSatori. (bodybuildingweb.net)
  • Price
  • Get Optimum Nutrition Beta-Alanine,Beta-Alanine By Optimum Nutrition, Fruit Fusion 75 Servings and other OPTIMUM NUTRITION products shipped the same day to USA, Brazil, United Kingdom, Germany, Australia, Japan, India, France and worldwide at the cheapest price online. (samedaysupplements.com)
  • 1,000
  • You might be interested to know that since I started following the recommendations in Vegan for Life my depression has all but cleared up (I think mainly as a result of taking 1,000 IU of vitamin D each day as well as a small DHA/EPA supplement). (jacknorrisrd.com)
  • mixture
  • The reaction of barium hydroxide octahydrate with ammonium chloride or ammonium thiocyanate is often used as a classroom chemistry demonstration, producing temperatures cold enough to freeze water and enough water to dissolve the resulting mixture. (wikipedia.org)
  • liver
  • Our results indicated that shikonin pretreatment attenuates ConA-induced acute liver injury by inhibiting apoptosis and autophagy through the suppression of the JNK pathway. (hindawi.com)
  • barrel
  • The core part of the domain is a 10 stranded beta barrel that is structurally similar to lipocalins and FABP. (wikipedia.org)
  • Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together. (wikipedia.org)
  • severe
  • Absence of cMyBP-C (Mybpc3-targeted knock-out mice) results in severe cardiac hypertrophy, increased heart-weight-to-body-weight-ratios, enlargement of ventricles, increased myofilament Ca2+ sensitivity and depressed diastolic and systolic function. (wikipedia.org)
  • consistent
  • Although these results were consistent with the idea that syntaxin 3 must be restricted to the apical membrane to achieve maximal fidelity of apical cargo transport, it could not be excluded that the observed cargo mistargeting was an indirect effect of microtubule disruption. (rupress.org)
  • enzymes
  • The arylcetonitrile substrates for these particular enzymes consist of phenylpropionitrile and other products that result from glucosinolate metabolism. (wikipedia.org)
  • response
  • Mouse transgenic studies in which the phosphorylation site in α-tropomyosin is mutated to Alanine have shown that phosphorylation may function to modulate tropomyosin polymerization, head-to-tail interactions between adjacent tropomyosin molecules, cooperativity, myosin ATPase activity, and the cardiac response to stress. (wikipedia.org)
  • development
  • During the early stages of fetal development, the number of pancreatic alpha cells outnumbers the number of pancreatic beta cells. (wikipedia.org)
  • The increasing emergence of vancomycin-resistant enterococci has resulted in the development of guidelines for use by the Centers for Disease Control Hospital Infection Control Practices Advisory Committee. (wikipedia.org)
  • long
  • This is due to the fact that the beta oxidation of long chain fatty acids with an odd number of carbons produces propionyl-CoA. (wikipedia.org)
  • study
  • Gregson, D. "Neutron diffraction study of Sr(OH)2(H2O) and beta-Ba(OH)2*(H2O)" Zeitschrift für Kristallographie (1979-2010) 1988, vol. 183, p319-p325. (wikipedia.org)
  • active
  • As a result, the conformational changes synchronised in the pair of subunits facilitates the catalysis despite the reduction of the number of available active sites. (wikipedia.org)