• Rehermann and Stephan Rosshart, M.D., the study's lead author and NIDDK postdoctoral fellow, have long sought to improve animal models of complex diseases in humans. (sciencedaily.com)
  • We always strive for effective ways to shorten the gap between early lab findings and health advances in people, and the wildling model has the potential to do just that," said NIDDK Director Griffin P. Rodgers, M.D. "By helping to predict immune responses of humans, the wildling model could lead to important discoveries to help treat and prevent disease, and ultimately, improve human health. (sciencedaily.com)
  • Clinical disease is restricted mainly to humans, but the virus can infect a wide range of animal species ( 2 ). (cdc.gov)
  • The history of Neisseria research has involved the use of a wide variety of vertebrate and invertebrate animal models, from insects to humans. (cabi.org)
  • Cases of LD in humans are a result of several factors (e.g., vectors and reservoir hosts) that facilitate the transmission of the causative bacterium ( Borrelia burgdorferi ) to humans. (health.mil)
  • Substantial decreases in plasma levels are observed in acute and chronic infection and injury in both animal models and in humans. (wikipedia.org)
  • Extrapolating these results to humans means blind people owing to AMD would have an acuity of 20/80 when using the implant. (healthnews.com)
  • In the cardiovascular system, mercury induces hypertension in humans and animals that has wide-ranging consequences, including alterations in endothelial function. (hindawi.com)
  • Exposure to mercury brought harmful effects to health of humans, but changes resulting from human exposure to mercury only called the attention of the scientific society after the accidents in Japan and Iraq [ 3 ]. (hindawi.com)
  • The strong, quantitative agreement of results in the two models underlines the value of ERG testing as an early detection technique for DR in humans. (arvojournals.org)
  • Since 1938, the FDA has required that all new drugs be tested on animals before being administered to humans in a clinical trial. (theearthawards.org)
  • In defense of animal testing, it's commonly cited that animals share many anatomical and physiological similarities with humans. (theearthawards.org)
  • Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAELs) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
  • In humans, açai supplementation indicated positive results in increasing exhaustion time to 90% of VO and increasing intensity at the anaerobic threshold. (bvsalud.org)
  • To assess CCHFV exposure spatial distribution, we analyzed serum from 2,440 sheep and goats by using a double-antigen ELISA and modeled exposure probability with environmental predictors by using generalized linear mixed models. (cdc.gov)
  • The best-fitted statistical model indicated that the most significant predictors of virus exposure risk were cattle/horse density and the normalized difference vegetation index. (cdc.gov)
  • To map CCHFV exposure risk, we projected the model at a 1 × 1-km spatial resolution. (cdc.gov)
  • Approximately twelve million serological test results for canine exposure to Ehrlichia spp. (capcvet.org)
  • 2005. A physiologically based toxicokinetic model of inhalation exposure to xylenes in Caucasian men. (cdc.gov)
  • The results described in this paper indicate that mercury exposure, even at low doses, affects endothelial and cardiovascular function. (hindawi.com)
  • This class of laser only causes damage if the exposure time exceeds 0.25 s, which approximately corresponds to the time lag of the natural blink reflex (according to DIN EN 60825 1). (aerzteblatt.de)
  • The results found that one-time exposure to cannabinoids early in a pregnancy can cause growth issues in a developing embryo. (kpax.com)
  • Avoid: A p-value of 0.05 means the probability that these results were due to random chance is five percent. (nih.gov)
  • Periodontal disease is an inflammatory disease process resulting from the interaction of a bacterial attack and host inflammatory response. (ijp-online.com)
  • Beneficial Effects of Inflammatory Cytokine-Targeting Aptamers in an Animal Model of Chronic Prostatitis. (iasp-pain.org)
  • These results suggest that ICTA provides protection against local carrageenan-induced enhanced pain sensitivity, and that the neutralization of proinflammatory cytokines may result in inflammatory cell apoptosis. (iasp-pain.org)
  • In this study, we assessed the status of OS in the brain of type 1 and type 2 diabetic animal models. (nature.com)
  • Similar results were obtained in the type-2 diabetic BBZDR/Wor model and the STZ-treated type-1 diabetic model. (arvojournals.org)
  • Moreover, we found that leaf extract from A. trifoliatus significantly exhibited acute antianxiety effects in animal models by the single oral administration at the concentration of 500 mg/kg body weight [ 6 ]. (hindawi.com)
  • Find out how beta-blocker eye drops show promising results for acute migraine relief. (medhelp.org)
  • Testicular torsion , also termed torsion of the spermatic cord, is a relatively common and potentially devastating acute condition resulting from obstruction of the arterial blood supply to the testis. (medscape.com)
  • A wide variety of species are used in animal testing. (caringconsumer.com)
  • Not all animal species are used equally in animal testing. (caringconsumer.com)
  • The remaining percentage of animal tests and clinical trials are split relatively evenly among the above animal species. (caringconsumer.com)
  • Twelve different animal species occurred and nine various imaging. (lu.se)
  • Twelve different animal species occurred and nine various imaging modalities were used, with two-thirds of the studies being longitudinal. (lu.se)
  • The results showed that the most prevalent species was Candida albicans followed by Candida famata (second most prevalent in unexposed to HIV and HIV carriers)) and Candida parapsilosis (second most prevalent in exposed to HIV group). (bvsalud.org)
  • Vertebrate and invertebrate animal and new in vitro models for studying Neisseria biology. (cabi.org)
  • Relating in vitro to in vivo exposures with physiologically based tissue dosimetry and tissue response models. (cdc.gov)
  • [ 6 , 7 ] We don't know whether the animal and physiology models translate to actual patient care, and therefore we still don't know whether APRV is the right choice for our critical care patients. (medscape.com)
  • Earlier this year, our Model Animal Welfare Act book became available on our website for purchase . (worldanimal.net)
  • We are proud to announce that the Model Animal Welfare Act , released earlier this year for viewing and download on our website, is now available as a paperback book! (worldanimal.net)
  • Together with WAN co-founders Wim de Kok and Janice Cox, and Model Animal Welfare Act co-author Dr. iur. (worldanimal.net)
  • In the interview she discusses our recent Model Animal Welfare Act , advocacy at the UN, and her dreams for animals in the future. (worldanimal.net)
  • The Animal Welfare Act provides limited protection by requiring laboratories to comply with standards of care for test animals. (theearthawards.org)
  • Here, we found that the major inhibitor of the myelin growth signaling pathway PI3K/Akt/mTOR, phosphatase and tensin homolog (PTEN) is increased in abundance in CMT1A and decreased in HNPP rodent models. (biorxiv.org)
  • Several groups, including those headed by Stanford University's Vittorio Sebastiano, the Salk Institute's Juan Carlos Izpisúa Belmonte and Harvard Medical School's David Sinclair (See Table), have shown that partial reprogramming can dramatically reverse age-related characteristics in the eye, muscle and other tissues in cultured mammalian cells and even rodent models by countering epigenetic changes associated with aging. (scientificamerican.com)
  • In conclusion, CS hydrogels were able to stimulate tissue ingrowth and accelerate the process of cartilage repair in animal studies. (bvsalud.org)
  • At the large American congress ACR Convergence on rheumatological diseases held in 2021, results from a large study were presented indicating that the diabetes medication metformin can reduce the risk of osteoarthritis. (lu.se)
  • Here we show OS involvement in brain damage in a diabetic animal model that is at least partially mediated through an AD-pathology-independent mechanism apart from amyloid-β accumulation. (nature.com)
  • In both human disease and animal models, electroretinography (ERG) can detect functional losses resulting from diabetic eye complications. (arvojournals.org)
  • Our results pave the way to a systematic understanding of ERG changes due to hyperglycemia alone as well as other mechanisms common to both types of diabetic disease. (arvojournals.org)
  • The drug also improved the body weight of diabetic animals. (ijp-online.com)
  • She completed her M.S. in Animals and Public Policy from Tufts University and internships with Humane Society International, Animal Protection of New Mexico, and the New England Anti-Vivisection Society before arriving at World Animal Net. (worldanimal.net)
  • As Humane Society International highlights, for example, over 12 million animals are experimented on within Europe every year, particularly for medical research. (caringconsumer.com)
  • Researchers developed a new mouse model that could improve the translation of research in mice into advances in human health. (sciencedaily.com)
  • The mouse model, which the scientists called 'wildling,' acquired the microbes and pathogens of wild mice, while maintaining the laboratory mice's genetics that make them more useful for research. (sciencedaily.com)
  • In the present study, we evaluated whether BD suppresses growth and breast-to lung cancer metastasis in an orthotopic model of human breast cancer cells implanted in mice. (spandidos-publications.com)
  • In the present study, we evaluated toxicity and anti-cancer activities of BD in an animal model of breast-to-lung cancer metastasis with triple-negative highly invasive humane breast cancer cells MDA-MB-231 implanted in the mammary pad of nude mice. (spandidos-publications.com)
  • Literature was reviewed on animal models in which in vivo imaging was used to detect and assess lung lesions that resembled pathological changes found in DIILD, such as inflammation and fibrosis. (lu.se)
  • Lymphangioleiomyomatosis (LAM) is a rare lung disease, resulting from proliferation in the lung, kidney, and axial lymphatics of abnormal smooth muscle-like cells (LAM cells) that exhibit features of neoplasia and neural crest origin. (medscape.com)
  • Results between conditions and catheters were compared to describe lung behavior. (medscape.com)
  • Electrical impedance tomography in diseased lungs (animal or human) showed evidence of volume shift from nondependent to dependent areas of the lung (pendelluft) during spontaneous breaths. (medscape.com)
  • The authors have modeled pendelluft in the past, [ 2 ] and regional variations in pleural pressure are well described in the diseased lung. (medscape.com)
  • [ 7 ] Animal models suggest that estrogen may promote the metastasis of TSC2-deficient cells to the lungs. (medscape.com)
  • Results of search for 'su:{Models, Animal. (who.int)
  • Your search returned 19 results. (who.int)
  • Would you like email updates of new search results? (nih.gov)
  • Table representation of search results timeline featuring number of search results per year. (nih.gov)
  • CCHFV infections in animals are mainly asymptomatic, which complicates detection of the virus and increases the risk for human infection. (cdc.gov)
  • Retroviruses of human A.I.D.S. and related animal diseases : 7e Colloque des "cent gardes", 26-27-28 octobre 1992, Marnes-la-Coquette, Paris, France / edited by Marc Girard, Louis Valette. (who.int)
  • Nonhuman primate models for human diseases / editor, W. Richard Dukelow. (who.int)
  • Supplementation therapies with recombinant human pGSN have been shown effective in more than 20 animal models. (wikipedia.org)
  • For example, do these results agree with those in animal models and different human populations? (nih.gov)
  • The ALS Therapy Development Institute, which studies the motor-neuron disease amyotrophic lateral sclerosis, has concluded - through its own animal studies - that several compounds that failed clinical trials entered human testing on the basis of poorly conducted or poorly designed preclinical experiments. (bioedonline.org)
  • Researchers believe the results on mouse fetuses would be similar to human fetuses. (kpax.com)
  • Those in favor of animal testing would say that it's done for the greater good of human well-being, as we would be the end-users of the drugs involved. (theearthawards.org)
  • Although many animals have varied and elaborated communication systems, human communicability allows an array of almost infinite construction of oral sound phrases and meanings, not only to share needs and desires but also to establish an even more complex personal relationship (Werker & Hensch, 2015). (bvsalud.org)
  • This scoping review aimed to map evidence on açai supplementation combined with exercise in animal and/or human experimental studies. (bvsalud.org)
  • 11 (5 with animal and 6 with human models) were eligible. (bvsalud.org)
  • The fitted model and factor extrapolations were then used to forecast the regional seroprevalence for 2016. (capcvet.org)
  • Obstruction of lymphatics may result in lymphangioleiomyomas, chylothorax, and chylous ascites. (medscape.com)
  • Animal test alternatives: Refinement, reduction, replacement. (cdc.gov)
  • The authors suggest that the stability and resilience of wildlings, if the model is used widely, could improve the validity and reproducibility of biomedical studies. (sciencedaily.com)
  • Results of these studies may increase the need for identification of high-risk areas within the reservation and the surrounding area. (health.mil)
  • The current studies using animal models show promising results. (healthnews.com)
  • The evidence on retinal implants has mounted significantly over the past two decades, even though the majority of it is derived from animal studies. (healthnews.com)
  • Statistics show that 92% of drugs that pass animal studies will fail at the clinical stage. (theearthawards.org)
  • The majority of studies reported other biomarkers and/or histological confirmation of the imaging results. (lu.se)
  • Regarding animal models in ASD, many studies focus on gene expression, cortical neuronal migration and cell maturation, and neural network deficits. (bvsalud.org)
  • However, very few studies directly link animal oral communication and gene expression in cortical areas of language. (bvsalud.org)
  • The object of our study aimed to review and to correlate genes involved in ASD and those related to ultrasonic communication in animal model studies of language-based social behavior at the PubMed database. (bvsalud.org)
  • The results are interesting as they confirm previous studies, including animal models. (lu.se)
  • If you're not already fed up with how cruel-and potentially wasteful -animal testing is, keep reading. (caringconsumer.com)
  • In this article we will build a Fluffy Animal Detector, where I will show you a way to leverage a pre-trained Convolutional Neural Network (CNN) model like MobileNet. (codeproject.com)
  • In Japan, a serious accident occurred resulting from the deposition of industrial waste with large quantities of mercury in the Minamata Bay. (hindawi.com)
  • Data from animal (livestock) trials are intricate and influenced by environmental factors, as well as by individual animal biology. (mdpi.com)
  • Having received a B.S. in biology with minors in chemistry and anthropology from the University of New Mexico, she combines a scientific background with a passion for animal protection. (worldanimal.net)
  • This study compared the long-term consequences of two common forms of bariatric surgery: one-anastomosis gastric bypass (OAGB) and Roux-en-Y Gastric Bypass (RYGB) in a preclinical rat model. (nature.com)
  • In conclusion, RYGB results in a better long-term outcome than OAGB, as chronic signs of biliary reflux or reactional gastritis were reported post-OAGB even after reducing the BPL length in a preclinical rat model. (nature.com)
  • Animal testing occurs in the preclinical stage. (theearthawards.org)
  • The correlation between the observed and model-estimated county-by-county Ehrlichia seroprevalence for the five-year period 2011-2015 is 0.842, demonstrating reasonable model accuracy. (capcvet.org)
  • Review and update of ultrasonic vocalization in animals: Correlation with autism spectrum disorder experimental models? (bvsalud.org)
  • This study investigated effects of the aqueous extract of its leaves (ATL) on cognitive and emotional deficits using an olfactory bulbectomized mouse (OBX) model. (hindawi.com)
  • In this study, to obtain a better understanding of the potential availability of A. trifoliatus for the treatment of cognitive and emotional dysfunction, we elucidated the antidementia and antidepressive effects of A. trifoliatus using an animal model of olfaction deficits. (hindawi.com)
  • The wildling model could help us better understand what causes diseases, and what can protect us from them, thus benefitting many areas of biomedical research. (sciencedaily.com)
  • The Armadillo as an experimental model in biomedical research : proceedings of a workshop held at the Pan American Center for Research and Training in Leprosy and Tropical Diseases, Caracas, Venezuela, 23-27 May 1977. (who.int)
  • We placed the coronary stent INC-1 on a rabbit and dog models so we can evaluate efficacy and security of the device in relationship to its biomechanical properties including navigation capacity, traceability, symmetric expansion, and safety, as well as endothelial attachment, thrombogenicity, and lack of involvement of secondary branches in these models. (scielo.org.mx)
  • In animals, açai supplementation and exercise led to benefits in exercise tolerance and improvements in several hemodynamic parameters, as well as significant improvements in liver markers and glucose metabolism. (bvsalud.org)
  • When animals initiated breaths, PL was twice as high according to the intrapleural vs the esophageal catheter. (medscape.com)
  • When animals were paralyzed, the opposite occurred: PL was higher via the esophageal catheter. (medscape.com)
  • They often cite that when drugs are tested on laboratory animals, the procedures involved are a form of cruelty to other living beings. (theearthawards.org)
  • But there's no ambiguity about the suffering that laboratory animals go through in the name of research. (caringconsumer.com)
  • Man and mouse : animals in medical research / William Paton. (who.int)
  • Thus, simplified biological systems have become an inherent component of animal experimental research. (mdpi.com)
  • Consumers are fed up with animal testing, the gruesome practice of testing products with animal research for medical experiments, makeup testing, chemical testing, and more. (caringconsumer.com)
  • By standard, animal research involves removing animals from their natural environment. (caringconsumer.com)
  • In the sections below I've highlighted some startling statistics about the use of animals in scientific research. (caringconsumer.com)
  • Some are more regularly used in animal research than others. (caringconsumer.com)
  • According to the American Anti-Vivisection Society , guinea pigs are the most common research animals, representing 22% of all animal experiments. (caringconsumer.com)
  • We wanted to create a mouse model that better resembles a mouse you'd find in the wild," said Barbara Rehermann, M.D., chief of the Immunology Section in NIDDK's Liver Diseases Branch and senior author on the study. (sciencedaily.com)
  • When a press release or article claims results to be statistically significant, it usually means researchers used a certain procedure to calculate a p-value, and that number was smaller than 0.05. (nih.gov)
  • If so, low standards for launching clinical trials in the United States could result in ineffective drugs being approved, while also decreasing incentives. (bioedonline.org)
  • Volunteers in clinical trials may lose their lives due to substances that seemed safe in animal testing. (theearthawards.org)
  • These results have spurred interest in translating insights from animal models into anti-aging interventions. (scientificamerican.com)
  • We all have differences in our genes, family background, environment, lifestyle, and social influences that can yield markedly different results in our responses to medical interventions. (theearthawards.org)
  • 2017: A Year of ACTion for Animals! (worldanimal.net)
  • As we set our sights on our goals and resolutions for 2017, we have a unique opportunity to assess our advocacy for animals and incorporate a fresh approach to our strategies in the coming year. (worldanimal.net)
  • 1990. Chromosome aberration and sister chromatid exchange test results with 42 chemicals. (cdc.gov)
  • Complementarily, a duplication on chromosome 17 results in the overexpression of PMP22 and causes Charcot-Marie-Tooth disease type 1A (CMT1A) 12 - 15 . (biorxiv.org)
  • Having the same results across animal models reinforces our findings. (kpax.com)
  • Climate change and landscape transformations have affected the abundance and spatial range of CCHFV animal hosts and vectors ( 6 ), strongly influencing CCHFV transmission dynamics ( 7 ) and modifying the likelihood of disease emergence and re-emergence ( 4 ). (cdc.gov)
  • To identify probable areas where West Point cadets as well as active duty service members stationed at West Point and their families might contract Lyme disease, this study used Geographic Information System mapping methods and remote sensing data to replicate an established spatial model to identify the likely habitat of a key host animal-the white-tailed deer. (health.mil)
  • The IITV exposures, which lasted for 8 hday, 5 daysweek for 3 weeks, were designed to model some of the essential features of an industrial workweek. (cdc.gov)
  • For IITV exposures at an equivalent energy and kurtosis, the temporal variations in level did not alter trauma and in some cases the IITV exposures produced results similar to those found for the 5 day continuous exposures. (cdc.gov)
  • These results suggest that the equal energy hypothesis is an acceptable approach to evaluating noise exposures for hearing conservation purposes provided that the kurtosis of the amplitude distribution is taken into consideration. (cdc.gov)
  • Summary of radiotracers and examples of imaging biomarkers were summarized, and the types of animal models and the most used imaging modalities and applications are discussed in this review. (lu.se)
  • The TSC mutations that occur in LAM result in abnormal signaling through the mammalian target of rapamycin (mTOR) pathway. (medscape.com)
  • Better, but probably not worth it: If only random chance were at work here, and if many technical details about the data collection and analysis are accurate, then results at least as extreme as those found in this study would happen only one time out of 20. (nih.gov)
  • In this paper, we describe our coronary stent (INC-1) design and development, the way that we found the specific characteristics needed for our device including biophysics aspects, design, finite element testing, manufacturing, and mechanic trials, we submitted and animal models experiences. (scielo.org.mx)
  • A total of 5749 articles were found, and, based on inclusion criteria, 284 papers were selected for final data extraction, resulting in 182 out of the 284 papers, based on eligibility. (lu.se)
  • In addition, 2 recently commissioned Second Lieutenants have been discharged from the Army because of medical issues as a result of chronic LD. (health.mil)
  • The symptoms resulting from Lyme disease and possible PTLDS may render service members non-deployable and may result in medical separations from service. (health.mil)
  • To address this, we studied spontaneous type-2 and induced type-1 models to establish systematic alterations of ERG parameters by diabetes. (arvojournals.org)
  • Local carrageenan administration resulted in a reduction of the tactile threshold. (iasp-pain.org)
  • In this program, you'll study animals in their natural habitats to better understand how we can protect their future. (edu.au)
  • This study aimed to review the literature to examine the effects of CS hydrogels on cartilage repair in experimental animal models . (bvsalud.org)
  • In such a study (a so-called randomized clinical trial), the risk of other factors affecting the results is reduced. (lu.se)
  • Diagnostic results could be obtained within two to four hours. (who.int)
  • Data were statistically analyzed to identify factors related to antibody prevalence via a Bayesian spatio-temporal conditional autoregressive (CAR) model. (capcvet.org)
  • Finally, a forecast of future Ehrlichia seroprevalence was constructed based on the proposed model using county-level data on five predictive factors identified at a workshop hosted by the Companion Animal Parasite Council and published in 2014: annual temperature, percentage forest coverage,percentage surface water coverage, population density and median household income. (capcvet.org)
  • That we use p-values to alert us to surprising data results, not to give a final answer on anything. (nih.gov)
  • In one, Bial had data for a different marketed drug showing it was more effective than Bial's drug at relieving pain in animals, but did not include that information in a summary figure. (bioedonline.org)
  • RESULTS: Endpoints could be calculated for 169 participants with follow-up data. (who.int)
  • The Undergraduate Certificate in Animal Ecology provides a direct pathway (subject to meeting all other entry criteria) to the Bachelor of Animal Ecology. (edu.au)