Results drug eluting stents. Medical search. Frequent questions

Of note, the TLR rate was lower in the Firehawk ® stent group and the stent thrombosis rate was the same for both Firehawk ® and Xience family stents. (microport.com)
Additionally, the primary safety measure of major adverse cardiovascular events (MACE), including death, reinfarction, stent thrombosis and stroke established the superiority of drug-eluting stents with respect to safety through one year. (dotmed.com)
The other is the formation of clots inside the stent, called stent thrombosis. (harvard.edu)
As a result, blood clots could form on the stent (stent thrombosis). (harvard.edu)
Stent thrombosis can happen at any time, but most clots form within the first month of receiving a stent. (harvard.edu)
Skipping or stopping the anti-clotting medications is the biggest risk factor for stent thrombosis. (harvard.edu)
Stent thrombosis in the modern era: a pooled analysis of multicenter coronary stent clinical trials. (jamanetwork.com)
Safety and efficacy of only 2 weeks of ticlopidine therapy in patients at increased risk of coronary stent thrombosis: results from the Antiplatelet Therapy alone versus Lovenox plus Antiplatelet therapy in patients at increased risk of Stent Thrombosis (ATLAST) trial. (jamanetwork.com)
Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents. (jamanetwork.com)
During extended clinical follow-up, 2 patients suffered from very late stent thrombosis showing a high degree of malapposition, protrusion, and coronary evaginations at the time of OCT investigation. (eur.nl)
however, considerable concerns have emerged regarding the safety of DES due to an increased risk of sudden stent occlusion by platelet aggregates (or thrombosis). (ca.gov)
The concern of stent thrombosis still an issue and dual antiplatlets therapy (DAPT) is mandatory for variable time ranging from one month to one year. (scirp.org)
64-slice multidetector CT (MDCT) coronary angiography has been shown to detect poststent complications such as instent stenosis, thrombosis, stent migration and stent fractures. (hindawi.com)
We report a case of stent fracture in a patient who underwent RCA stenting with associated RCA perforation and almost complete thrombosis of the RCA and peristent fibrinoid collection. (hindawi.com)
Long stenting was associated with a higher risk of early stent thrombosis (log-rank p=0.001), but not with that of late stent thrombosis (log-rank p=0.887). (pcronline.com)
In the contemporary second-generation DES era, stenting longer than 40 mm continues to be associated with less favourable clinical outcomes such as TLF and stent thrombosis. (pcronline.com)
The use of this product carries the same risks associated with coronary artery stent implantation procedures, which include subacute and late vessel thrombosis, vascular complications and/or bleeding events. (medtronic.com)
Stent thrombosis is a low-frequency event that is frequently associated with MI or death. (medtronic.com)
At a median follow-up of 3.8 years, cobalt-chromium everolimus-eluting stents (EES) were associated with lower rates of mortality, definite stent thrombosis (ST), and myocardial infarction than BMS, paclitaxel-eluting stents (PES), and sirolimus-eluting stents (SES) and less ST than BES. (ox.ac.uk)
Laura Mauri, MD, of the Harvard Clinical Research Institute, said DAPT should provide the evidence needed to confirm whether the current guideline recommendation of 12 months of dual antiplatelet therapy with clopidogrel (Plavix) or prasugrel (Effient) plus aspirin is long enough to reduce the risk of very late stent thrombosis. (medpagetoday.com)
The trial, which officially kicked off on Oct. 2, has been in the planning stages since concerns about long-term safety of drug-eluting stents reached a fever pitch in 2006, when registry data and meta-analyses suggested that drug-eluting stents were associated with a significant risk of stent thrombosis a year or longer after implantation. (medpagetoday.com)
The co-primary endpoints for the study are incidence of death, MI, or stroke between 12 and 33 months after a stent is implanted and the incidence of stent thrombosis between 12 and 33 months. (medpagetoday.com)
Background: The risk of device thrombosis and device-oriented clinical outcomes with bioresorbable vascular scaffold (BVS) was reported to be significantly higher than with contemporary drug-eluting stents (DESs). (koreamed.org)
Cumulative incidences of cardiac death, target vessel myocardial infarction, and clinically indicated target lesion revascularization and definite stent thrombosis at 5 years were similar in patients treated with ultrathin-strut BP-SES and thin-strut DP-EES. (ox.ac.uk)
The primary end point was net adverse clinical and cerebral events (NACCE), with secondary end points being major adverse cardiac events (MACE) and Academic Research Consortium definite or probable stent thrombosis. (acc.org)
However, in patients with coronary artery stents, stopping antiplatelet therapy, whether aspirin or dual antiplatelet therapy, increases the risk of coronary tent thrombosis, which may be fatal. (msdmanuals.com)

While DES reduce restenosis, they cost more than bare metal stents (BMS), and necessitate prolonged dual antiplatelet therapy (DAPT) that increases costs, bleeding risk, and risk of complications if DAPT is prematurely discontinued. (ku.edu)
The study, HORIZONS-AMI (Harmonizing Outcomes with RevascularIZatiON and Stents in Acute Myocardial Infarction), showed that in heart attack patients undergoing angioplasty, the use of paclitaxel-eluting stents reduces rates of target lesion revascularization (TLR) and binary angiographic restenosis when compared to the use of bare-metal stents after one year. (dotmed.com)
The use of paclitaxel-eluting stents also resulted in a significant reduction in binary restenosis after 13 months, which is the rate at which the artery re-narrows at least 50 percent following implantation of the stent, and was the secondary efficacy endpoint of the trial. (dotmed.com)
Long-Term Effectiveness of a Drug-Eluting Stent for Femoropopliteal In-Stent Restenosis: Subanalysis of the Zilver PTX Japan Post-Market Surveillance Study. (bvsalud.org)
To present a subgroup analysis of patients from a large real-world study evaluating the safety and effectiveness of the Zilver PTX drug-eluting stent (DES) for treating femoropopliteal in- stent restenosis (ISR). (bvsalud.org)
One is a gradual renarrowing of the area inside the stent, known as restenosis. (harvard.edu)
Restenosis is most likely to occur during the first three to 12 months of receiving a stent. (harvard.edu)
Stent Anticoagulation Restenosis Study Investigators. (jamanetwork.com)
We report on an approach for validation of an in silico 3D model of in-stent restenosis in porcine coronary arteries and illustrate this approach by comparing the modelling results to in vivo data for 14 and 28 days post-stenting. (springer.com)
This in turn causes a healing response in the vessel wall, which, if it becomes excessive, can cause a new narrowing of the vessel, or in-stent restenosis (ISR). (springer.com)
Uses of balloon catheters or BMS for the treatment of coronary artery lesions shows good short-term results but long-term follow up revealed restenosis in up to 20%-30% of patients. (scirp.org)
DES reduced the incidence of in-stent restenosis. (scirp.org)
1987) Intravascular Stents to Prevent Occlusion and Restenosis after Transluminal Angioplasty. (scirp.org)
1996) Patterns and Mechanisms of In-Stent Restenosis. (scirp.org)
Subsequent stent restenosis or occlusion may require repeat catheter-based treatments (including balloon dilatation) of the arterial segment containing the stent. (medtronic.com)
The chief advantage of drug-eluting stents (DES) over bare-metal stents is that they significantly reduce the risk for restenosis. (jwatch.org)

Following the first generation, the second-generation drug-eluting stents was designed with a thinner strut, better biocompatible polymer with/without bioresorbable coating or even polymer-free struts. (eur.nl)
These findings build on those from other randomized noninferiority trials with relatively smaller sample sizes, which suggested safety and efficacy of short-term dual antiplatelet therapy in patients treated with second-generation drug-eluting stents," the authors said. (acc.org)

Outcomes from prior registry and randomized trials of drug-eluting stents compared with bare-metal stents in heart attack patients have been conflicting. (dotmed.com)

Phosphorylcholine-based zotarolimus-eluting stents had lower rates of definite ST than SES and lower rates of myocardial infarction than BMS and PES. (ox.ac.uk)
Shorter-term dual antiplatelet therapy (DAPT) was noninferior to long-term among patients with stable coronary artery disease or history of low-risk acute coronary syndrome (ACS) undergoing PCI with zotarolimus-eluting stents, according to results from the OPTIMIZE Trial presented on Oct. 31 as part of TCT 2013 and simultaneously published in the Journal of the American Medical Association . (acc.org)

Methods: A total of 88 event-free patients with 1 randomly selected lesion were suitable for final OCT analysis 5 years after drug-eluting stent implantation. (eur.nl)
The ARCTIC- Interruption Trial assessed the impacts of two-year vs. one-year duration of DAPT and found no ischemic benefit of prolongation of DAPT up to 2 years after drug-eluting stent implantation. (acc.org)

Objectives: This study sought to assess stent strut coverage, malapposition, protrusion, and coronary evaginations as markers of healing 5 years after implantation of sirolimus-eluting stents (SES) and paclitaxel-eluting stents (PES), by optical coherence tomography (OCT). Background: Early-generation drug-eluting stents have been shown to delay vascular healing. (eur.nl)
2009) 5-Year Clinical Outcomes after Sirolimus-Eluting Stent Implantation Insights from a Patient-Level Pooled Analysis of 4 Randomized Trials Comparing Sirolimus-Eluting Stents with Bare-Metal Stents. (scirp.org)

OBJECTIVES: In this analysis of 2-year outcomes in the ADAPT-DES (Assessment of Dual AntiPlatelet Therapy with Drug-Eluting Stents) study, the authors sought to examine the independent associations between platelet reactivity to both aspirin and clopidogrel and subsequent outcomes. (duke.edu)
Dual antiplatelet therapy with aspirin plus thienopyridines has become the standard treatment of patients undergoing coronary stenting. (hindawi.com)
The answer to a question with significant clinical and economic implications -- how long should dual antiplatelet therapy continue after placement of a drug eluting stent? (medpagetoday.com)
As a result of those concerns, which were hotly debated during a two-day FDA hearing, the ACC/AHA/SCAI guidelines were changed to recommend 12 months -- rather than six months -- of dual antiplatelet therapy. (medpagetoday.com)
The session, chaired by I. Meredith, is named "Synchronizing polymer absorption and drug elution with the SYNERGY Stent: Implications for healing and dual antiplatelet therapy duration. (salesandmarketingnetwork.com)

The SUPRAFLEX stent system has ultra-thin struts (60 μm) across all stent diameters and a biodegradable polymer coating, enabling 70% of the sirolimus elution within 7 days. (eur.nl)
The Orsiro stent, which is a novel stent platform eluting sirolimus from a biodegradable polymer, demonstrated non-inferiority to the Xience Prime everolimus-eluting stent for the primary angiographic endpoint of in-stent late lumen loss at nine months in the results of an imaging substudy reported at EuroPCR 2013 today. (escardio.org)
Reporting the results, Stephan Windecker, Professor and Chief of Cardiology, Swiss Cardiovascular Center and Clinical Trials Unit Bern, Bern University Hospital, Switzerland, said, "The Orsiro sirolimus-eluting stent with a biodegradable polymer was non-inferior to the Xience Prime everolimus-eluting stent with a durable polymer for the primary angiographic endpoint of in-state late loss at nine months in this prospective, randomised trial. (escardio.org)
The company's DynamX device is a 71-microns thin cobalt-chromium drug-eluting stent with a biodegradable polymer coating that releases novolimus. (drugdeliverybusiness.com)

The remarkably low rates of target lesion revascularization at one year confirm the favorable outcomes associated with the innovative Firehawk ® stent design. (microport.com)
To help validate the observational study results, researchers applied propensity score matching and performed logistic regression to predict DES treatment by 67 patient, procedural, and hospital variables and then analyzed outcomes in 2,952 matched DES and BMS patients with 1,476 in each group. (medicaleconomics.com)
The recent introduction of drug-eluting stents (DESs), together with advances in periprocedural and postprocedural adjunctive pharmacotherapies, has improved outcomes of PCIs of these lesions. (amrita.edu)
Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registry. (jamanetwork.com)
ABSORB Trials Late Outcomes: No Clinical Gains for Bioresorbable Scaffold The everolimus-eluting bioresorbable scaffold did not fare well, clinically or in late lumen loss, against the Xience stent in the 3-year results from ABSORB II and 2-year results from ABSORB China. (medscape.com)
We aimed to understand the association between stent length and clinical outcomes after percutaneous coronary intervention (PCI) using newer-generation drug-eluting stents (DES). (pcronline.com)
When drug-eluting stents (DES) are used outside the specified Indications for Use , patient outcomes may differ from the results observed in the RESOLUTE pivotal clinical trials. (medtronic.com)
In a recent article in Archives of Internal Medicine, researchers performed an analysis of current use of drug-eluting stents (DES) in patients at various levels of risk for target-vessel revascularization (TVR), and estimated the cost and clinical outcomes of using BMS rather than DES in patients at low risk (see News). (jwatch.org)
The session will showcase one-year outcomes in 1,010 all-comer patients treated with the PROMUS Element Everolimus-Eluting Stent System. (salesandmarketingnetwork.com)
The first-in-human results will be presented as a late-breaking clinical trial titled, "Clinical, Angiographic and Intravascular Ultrasound Outcomes of the NG PROMUS Clinical Study Evaluating the Novel Promus PREMIER Everolimus Eluting Platinum Chromium Stent System. (salesandmarketingnetwork.com)
3 mm, respectively) did not stratify according to vessel size and failed to specify the impact of ultrathin-strut thickness on long-term clinical outcomes compared with durable polymer everolimus-eluting stents (DP-EES). (ox.ac.uk)

Drug-eluting stents (DES) were associated with decreased rates of death, myocardial infarction (MI), and revascularization at 3 years of follow up in diabetic patients compared to bare-metal stents (BMS), according to results of a large observational study. (medicaleconomics.com)
and for composite of death or myocardial infarction, the drug-eluting stent with clopidogrel vs drug-eluting stent without clopidogrel comparison was P =.02. (jamanetwork.com)
Angina pectoris is the result of myocardial ischemia caused by an imbalance between myocardial blood supply and oxygen demand. (medscape.com)
The use of drug-eluting stents (DES) in patients with acute myocardial infarction (AMI) has recently generated concern. (jwatch.org)
[ 6 ] Ever since, the spectrum of antianginal strategies has been widened by the introduction of newer drugs such as calcium antagonists, inhibitors of the I F -channel, late inward sodium channel current inhibitors, and modulators of myocardial metabolism. (medscape.com)

The artery can be reopened with a procedure similar to the original stent placement, although doctors sometimes need to use a tiny drill or laser to cut through the obstruction. (harvard.edu)
This procedure is called percutaneous transluminal coronary angioplasty or PTCA, which is usually accompanied by the placement of a metal tube (or stent) at the diseased site to maintain vessel opening. (ca.gov)
1994) A Randomized Comparison of Coronary-Stent Placement and Balloon Angioplasty in the Treatment of Coronary Artery Disease. (scirp.org)
It is hence a rare case of stable RCA perforation following stent placement. (hindawi.com)
However, the patient had recurrent angina within a month of stent placement. (hindawi.com)
Stent placement should only be performed at hospitals where emergency coronary artery bypass graft surgery can be readily performed. (medtronic.com)
Facilitated PCI is defined as the intent to perform a PCI (either conventional balloon angioplasty or coronary stent placement) in the setting of STEMI following treatment with either a full dose or half dose of a fibrinolytic agent. (wikidoc.org)
Primary PCI is defined as the performance of percutaneous coronary intervention (PCI) (either conventional balloon angioplasty or coronary stent placement) in the setting of ST elevation MI (STEMI) without antecedent treatment with a fibrinolytic agent. (wikidoc.org)

Background: Benefits of drug-eluting stents (DES) in percutaneous coronary intervention (PCI) are greatest in those at the highest risk of target vessel revascularization (TVR). (ku.edu)
Thus new improvements to balloons and stents are always necessary to achieve the best results from percutaneous coronary intervention (PCI). (scirp.org)
Percutaneous coronary interventions with drug-eluting stents is currently the preferred revascularization treatment strategy for coronary artery disease. (eur.nl)
Percutaneous coronary intervention (PCI) was then undertaken, which, due to the complex nature of the stenosis, required implantation of two drug-eluting stents (DESs) (Xience V, Abbot, Temecula, Calif, USA) on both bifurcations. (hindawi.com)
Long-Term Effect of Ultrathin-Strut Versus Thin-Strut Drug-Eluting Stents in Patients With Small Vessel Coronary Artery Disease Undergoing Percutaneous Coronary Intervention: A Subgroup Analysis of the BIOSCIENCE Randomized Trial. (ox.ac.uk)
Also the results of bypass surgery were improved by the use of arterial grafts [ 7 ] and percutaneous coronary interventions (PCI) have been made more effective through the introduction of stents, particularly drug-eluting stents. (medscape.com)

TLR, which was the primary efficacy endpoint of the trial, refers to the rate at which a particular lesion re-narrows following stent implantation severely enough to require either a repeat angioplasty or bypass surgery operation. (dotmed.com)
1994) A Comparison of Balloon-Expandable-Stent Implantation with Balloon Angioplasty in Patients with Coronary Artery Disease. (scirp.org)
In a new meta-analysis Dr. Gregg Stone and members of the Drug-Eluting Stent in Primary Angioplasty (DESERT) Cooperation concluded that reduction in target-vessel revascularization (TVR) associated with drug-eluting stents (DES) in primary PCI provided a powerful reason for continued use of DES in primary PCI. (jwatch.org)
In 2003, approximately 84% of the 660,000 hospitalized patients who underwent a coronary angioplasty received a stent, a wire mesh tube inserted during angioplasty to reduce future narrowing of arteries. (cdc.gov)
Black and white angioplasty patients were equally likely to receive a stent. (cdc.gov)

The results show preserved efficacy of DES in diabetic patients, with no increased hazard of death, MI, or revascularization rates. (medicaleconomics.com)
Results from the Intracoronary Stenting and Antithrombotic Regimen--Rapid Early Action for Coronary Treatment 3 (ISAR-REACT 3) trial failed to show any difference between bivalirudin- and UFH-treated patients for the primary quadruple composite end point of death, MI, urgent target vessel revascularization (TVR), or major bleeding within 30 days. (medscape.com)

OBJECTIVES: This study sought to investigate the long-term safety and efficacy of durable polymer-based DES, bioabsorbable polymer-based biolimus-eluting stents (BES), and BMS by means of network meta-analysis. (ox.ac.uk)
This week's topics include studies on biolimus-eluting stents vs. bare-metal stents, risk markers to improve CV event prediction, common carotid intima-media thickness and CV risk prediction, aspirin with alteplase for acute ischemic stroke, and lipid-lowering therapy (and its benefits and harms) in patients with CKD. (jwatch.org)

Incidence of thrombotic stent occlusion during the first three months after sirolimus-eluting stent implantation in 500 consecutive patients. (jamanetwork.com)
Thirty-day incidence and six-month clinical outcome of thrombotic stent occlusion after bare-metal, sirolimus, or paclitaxel stent implantation. (jamanetwork.com)
This sudden occlusion is caused by a concomitant drug inhibition of cells that cover the raw surface of metal stents to prevent platelet aggregation. (ca.gov)
This case also highlights the role of CT coronary angiography (CTCA) in detecting stent fracture and associated coronary occlusion and perforation. (hindawi.com)
A catheter angiography done at that time revealed total occlusion of the RCA stent, with grade III collaterals. (hindawi.com)

New York-Presbyterian Hospital and Columbia University Medical Center, together with the Cardiovascular Research Foundation (CRF), announced that its landmark study comparing the safety and efficacy of drug-eluting stents and bare-metal stents was published in the May 7 New England Journal of Medicine. (dotmed.com)
The paclitaxel-eluting stent had a rate of 10.0 percent and the bare-metal stent had a rate of 22.9 percent. (dotmed.com)
These results now provide definitive evidence that paclitaxel-eluting stents are superior in efficacy to bare-metal stents and have a comparable safety profile at one year," says Dr. Stone. (dotmed.com)
The findings from the HORIZONS-AMI trial will have a major impact on how decisions are made regarding drug-eluting and bare-metal stents in the highest-risk patients, those in the early hours of a heart attack. (dotmed.com)
The HORIZONS-AMI trial, a prospective, open-label, multicenter, controlled study, enrolled 3,602 heart attack patients at 123 centers in 11 countries, 3,006 of whom were randomized to paclitaxel-eluting stents versus otherwise identical bare-metal stents. (dotmed.com)
Originally, stents were made of bare metal. (harvard.edu)
Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: an observational study of drug-eluting versus bare-metal stents [published online ahead of print November 1, 2006]. (jamanetwork.com)
Drug-eluting stents (DES) improved the principles of bare metal stents (BMS) by local drug release to inhibit neointimal growth. (scirp.org)
Long-Term Safety of Drug-Eluting and Bare-Metal Stents: Evidence From a Comprehensive Network Meta-Analysis. (ox.ac.uk)
Most of the 15,000 patients will be randomized to one of the drug-eluting stents, but 5,000 will be treated with bare-metal stents. (medpagetoday.com)
This week's topics include CV risk factors and peripheral artery disease in men, radiofrequency ablation in paroxysmal AF, CPR duration and survival after in-hospital cardiac arrest, an everolimus-eluting stent vs. a bare-metal stent in STEMI, job strain and CHD, and more. (jwatch.org)
This week's topics include studies on the benefits of drug-eluting vs. bare-metal stents, using walking speed and blood pressure measurements to predict mortality in the elderly, stroke and bleeding in AF with chronic kidney disease, and the diagnosis and management of peripheral artery disease. (jwatch.org)
Transitioning from bare-metal stents to drug-eluting stents in the early 2000s brought tremendous benefits for patients. (drugdeliverybusiness.com)

The results of the TARGET AC trial demonstrated that vessels treated with the Firehawk ® Rapamycin Target Eluting Coronary Stent System ("Firehawk ® ") showed non-inferiority results when compared to vessels treated with the Xience family of drug eluting stents. (microport.com)
The primary endpoint of non-inferiority for the Firehawk ® stent compared to the Xience family stent was met with a 12-month TLF rate in the intent-to-treat population of 6.1 percent versus 5.9 percent, respectively (pnon-inferiority = 0.004). (microport.com)
The primary QCA substudy endpoint of non-inferiority for the Firehawk ® stent compared to the Xience family stent was met with an in-stent lumen late loss at 13-months in the per treat population of 0.17 ± 0.05 mm versus 0.11 ± 0.05 mm (P non-inferiority =0.024), respectively. (microport.com)
Patients were randomly assigned to receive either the Orsiro (Biotronik) or the Xience Prime stent (Abbott Vascular). (escardio.org)
The IVUS substudy showed somewhat less neointimal hyperplasia over nine months with the Orsiro stent (0.16) than the Xience stent (0.43, p=0.043) with 100% stent apposition. (escardio.org)
Similarly, neointimal area as assessed by OCT at nine months was somewhat less with the Orsiro stent (0.74+0.38mm2 ) than with the Xience stent (1.00+0.44mm2, p=0.024). (escardio.org)
And the study throws a wide net -- all approved drug-eluting stents, Cypher (sirolimus-eluting), Taxus (paclitaxel-eluting), Endeavor (zotarolimus-eluting), and Xience (everolimus-eluting) are included, with the choice of DES and the choice of antiplatelet agent left to the discretion of physician and patient. (medpagetoday.com)

Among DES patients, 75 percent received sirolimus stents and 25 percent received paclitaxel versions. (medicaleconomics.com)

Only physicians who have received adequate training should perform implantation of the stent. (medtronic.com)

different drug-eluting stents and endpoints were used in the trials. (medscape.com)
Looking to the future, he concluded, "These results will need to be extended to larger randomised trials including more complex patients and powered for clinical endpoints. (escardio.org)
Presented results from the MAJESTIC trial at the 37th Charing Cross International Symposium demonstrating the Eluvia™ Drug-Eluting Vascular Stent System + met its primary safety and effectiveness endpoints, with more than 94 percent of lesions treated remaining open at nine months post implantation. (prnewswire.com)

The Resolute Integrity Zotarolimus-Eluting Coronary Stent System is indicated for improving coronary luminal diameters in patients, including those with diabetes mellitus, with symptomatic ischemic heart disease due to de novo lesions of length ≤ 27 mm in native coronary arteries with reference vessel diameters of 2.25 mm to 4.20 mm. (medtronic.com)

Different components of DES which include the polymers, drugs and the stents underwent progressive evolution, and these led to development of new generations of DES with variable types of drugs and polymers to fully absorbable stents. (scirp.org)
We analysed 9,217 patients who underwent stenting for a single lesion from the GRAND-DES registry, a patient-level pooled registry including five Korean multicentre DES registries. (pcronline.com)

This study removes much of the uncertainty and concern about the efficacy and safety of drug-eluting stents in this clinical setting. (dotmed.com)
Recent studies comparing efficacy and safety of PCIs using drug-eluting stents and CABG revealed comparable results in terms of safety and a lower need for repeat revascularisation for CABG. (amrita.edu)
The DESolve bioresorbable coronary scaffold system achieves good efficacy and safety with low rates of late lumen loss and major coronary adverse events at six months, show first results from the pivotal DESolve Nx trial reported at EuroPCR 2013 today. (escardio.org)
Purpose: Data are limited on the long-term efficacy and safety of drug-coated balloon (DCB) treatment in comparison to drugeluting stent (DES) for de novo coronary lesions. (koreamed.org)
Background and Objectives: The aim of this study was to demonstrate the efficacy and safety of treatment with drug-coated balloon (DCB) in a large real-world population. (koreamed.org)

Ridaforolimus is an mTOR inhibitor being developed by Medinol Ltd for use in drug-eluting stents for patients with coronary artery disease. (wikipedia.org)
A comprehensive analysis published today in The Lancet, one of the world's leading medical journals, from the ABSORB clinical trial demonstrated that Abbott's bioabsorbable drug eluting stent, currently in development, successfully treated coronary artery disease and was absorbed into the walls of treated arteries within two years. (worldpharmanews.com)
Once the catheter reaches the area in the artery narrowed by fatty plaque, the balloon inflates and deploys the stent. (harvard.edu)
The stent holds the artery open, restoring blood flow. (harvard.edu)
A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting. (jamanetwork.com)
This narrowing is often corrected by deploying a stent in the affected artery to keep it open and maintain blood flow. (springer.com)
During the stenting procedure, the narrowed artery is damaged by the stent struts being pressed into the vessel wall, as well as by the expanding balloon which is used to distend the artery and deploy the stent. (springer.com)
The BIOFLOW-II substudy used intravascular ultrasound (IVUS) and optical coherence tomography (OCT) to quantitatively assess neointimal hyperplasia and stent apposition at nine months after treating patients with symptomatic coronary artery disease due to de novo stenotic lesions. (escardio.org)
Entered into an agreement with C. R. Bard, Inc., to distribute the Lutonix® Drug Coated Balloon in the U.S. for the treatment of peripheral artery disease. (prnewswire.com)
When you stent an artery today, you actually cage it and by caging it you are inhibiting the normal pulsatility of the artery and inhibiting its built-in mechanism of adaptive remodeling intended to slow disease progression and clinical events," he explained. (drugdeliverybusiness.com)
Metallic stents stop the artery from doing this, which could potentially accelerate disease progression in the process, Sirhan said. (drugdeliverybusiness.com)

The safety and effectiveness of the Zilver PTX stent for the treatment of femoropopliteal ISR lesions demonstrated that this device provides a favorable treatment option in this difficult-to-treat subgroup. (bvsalud.org)
Despite improvement in stent technology and operator experience, management can be challenging especially in LMCA bifurcation lesions and, therefore, an integrated approach combining advanced devices, tailored techniques, adjunctive support of physiological evaluation, and adjunctive pharmacological agents should be reinforced to improve clinical outcome. (amrita.edu)
Results: OCT analysis was performed at 5 years in 41 SES lesions with 6,380 struts, and in 47 PES lesions with 6,782 struts. (eur.nl)
The results were similar in several key subgroups, including patients with diabetes, history of low-risk ACS, multivessel disease, or bifurcation lesions. (acc.org)

Doctors deliver coronary stents by threading a slender tube (catheter) through a vessel in the wrist or upper thigh all the way up to the heart. (harvard.edu)
This multiscale model includes single-scale models for stent deployment, blood flow and tissue growth in the stented vessel, including smooth muscle cell (SMC) proliferation and extracellular matrix (ECM) production. (springer.com)
The validation procedure uses data from porcine in vivo experiments, by simulating stent deployment using stent geometry obtained from micro computed tomography (micro-CT) of the stented vessel and directly comparing the simulation results of neointimal growth to histological sections taken at the same locations. (springer.com)
For 14 days post-stenting the relative neointimal area, averaged over all vessel sections considered, was 20 ± 3% in vivo and 22 ± 4% in silico . (springer.com)
ISR is associated with excessive damage to the vessel wall and with disturbed flow patterns in the stented vessel, in particular with low values of wall shear stress (WSS). (springer.com)
This disease results from atherosclerosis or fatty deposits in the vessel wall that causes blockage of coronary arteries. (ca.gov)
The in-stent RCA was consequently completely occluded with minimal flow in a short segment of post-stent RCA and in its acute marginal branch vessel. (hindawi.com)
So Sirhan's 65-person company set out to create a device that has the therapeutic benefit of a drug-eluting stent, but also helps the vessel resume its natural healing process. (drugdeliverybusiness.com)
After you open a diseased vessel and allow it to heal, you want a stent to uncage and conform to the vessel anatomy letting nature take over now that the vessel is open and healed, thereby continuing to reduce inflammation and irritation to the vessel wall. (drugdeliverybusiness.com)
But Elixir's DynamX drug-eluting stent, as well as the company's DESolve bioresorbable scaffold, is designed to help the vessel resume adaptive remodeling. (drugdeliverybusiness.com)
RESULTS: Among 2109 patients, 1234 (59%) were treated for small vessel disease. (ox.ac.uk)

Results showed the primary endpoint of in-stent late lumen loss was 0.21mm (+0.34) at six months. (escardio.org)
The primary endpoint results for several trials will be presented, including the NG PROMUS trial, which evaluated our Promus PREMIER Stent System and the EVOLVE study two-year results, which evaluated the SYNERGY Stent System. (salesandmarketingnetwork.com)

This review summarizes the design of the SUPRAFLEX stent, the results of the pivotal clinical trials and outlines the ongoing research programs. (eur.nl)

When I had a heart attack late last year, I got a stent in one of my coronary arteries. (harvard.edu)
Stent induced hemodynamic changes in the coronary arteries are associated with higher risk of adverse clinical outcome. (researchgate.net)
Interventional cardiologists have used stents to keep the heart's coronary arteries open for decades. (drugdeliverybusiness.com)

Scholars@Duke publication: Impact of Aspirin and Clopidogrel Hyporesponsiveness in Patients Treated With Drug-Eluting Stents: 2-Year Results of a Prospective, Multicenter Registry Study. (duke.edu)
As such, it offers insights that complement and extend those of WOEST , the randomized trial that demonstrated that, in the first year after stenting, clopidogrel alone was superior to aspirin and clopidogrel together in patients also on oral anticoagulation. (medscape.com)
Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? (hindawi.com)
We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment. (hindawi.com)

Boston Scientific will host a symposium on its SYNERGY Stent technology featuring a novel bioabsorbable polymer coating. (salesandmarketingnetwork.com)
Segments of the stent are held together by the polymer coating, which is designed to absorb in six months. (drugdeliverybusiness.com)

3 mm) as a surrogate to compare patients treated with ultrathin-strut versus thin-strut drug-eluting stent. (ox.ac.uk)

The proportion of well-apposed struts was similar with the two stents and the proportion of covered struts was slightly higher with the Orsiro stent (98.3% vs. 97.5%, p=0.042). (escardio.org)
For the Biomatrix stent, the adverse effect of thicker struts was mitigated by greater strut spacing, radial cell offset and flow-aligned struts. (researchgate.net)

Results have suggested that there is no difference between the two strategies in terms of mortality, non-fatal MI, and stroke although the rates of additional revascularisation were much higher in the PCI groups. (bmj.com)

Several reports in the literature have focussed on the formulation of the modelling approach applied to highly idealized arterial and stent geometries. (springer.com)
Coronary stent fracture is a known complication of coronary arterial stent placements. (hindawi.com)

On December 14, 2012 the FDA approved ARIAD's leukemia drug Ponatinib for patients with all forms of Ph+ CML or Ph+ acute lymphoblastic leukemia (ALL) who are resistant to or unable to tolerate other tyrosine kinase inhibitors. (wikipedia.org)
In light of recent developments in the field of revascularisation, with the advent of glycoprotein (GP) IIb/IIIa inhibitors, use of stents, and the development of off bypass and minimally invasive surgery, the data available to guide treatment in patients with diabetes are in need of reassessment. (bmj.com)

Findings from a large ongoing registry study provide some reassurance about the long-term safety of new-generation drug-eluting stents (DES) in patients with STEMI who undergo primary PCI. (jwatch.org)

TAXUS DES Trials Results: How Long Should Thienopyridine Be Used After Drug Eluting Stent? (audiomedica.com)
RESULTS: Fifty-one trials that included a total of 52,158 randomized patients with follow-up duration ≥3 years were analyzed. (ox.ac.uk)

He added, " We need to be careful in interpreting the results of a trial set up for an angiographic endpoint but we can speculate that neointimal hyperplasia may be somewhat less with the Orsiro stent platform. (escardio.org)

Anatomy8

Organisms2

Diseases30

Chemicals and Drugs21

Analytical, Diagnostic and Therapeutic Techniques and Equipment49

Phenomena and Processes4

Disciplines and Occupations1

Technology, Industry, Agriculture9

Information Science1

Health Care15

Thrombosis26

Restenosis16

Second-generation drug-elutin2

Compared with bare-metal stents1

Zotarolimus-elutin2

Years after drug-eluting stent impl2

Sirolimus-elutin2

Antiplatelet therapy5

Biodegradable polymer4

Outcomes11

Myocardial5

Placement8

Percutaneous6

Angioplasty5

Revascularization2

Biolimus-elutin2

Occlusion5

Bare13

Xience7

Paclitaxel1

Implantation of the stent1

Endpoints3

Diabetes mellitus1

Underwent2

Efficacy and safety5

Artery11

Lesions4

Vessel11

Primary endpoint2

Clinical trials1

Coronary arteries3

Clopidogrel4

Polymer2

Versus1

Struts2

Mortality1

Arterial2

Inhibitors2

STEMI1

Trials2

Neointimal1