• These suggested that mPEG-PLA polymeric micelle nanoparticles had great potential as nanocarriers for effective solubilization of poorly soluble ethaselen and further reducing side effects and toxicities of the drug. (springer.com)
  • Gold nanoparticles also have high electron stability, conductivity, and solubility. (libero.it)
  • Recently, new drug-loaded nanoparticles (NPs) - diblock copolymer D-α-tocopheryl polyethylene glycol 1000 succinate-b-poly(ε-caprolactone-ran-glycolide) (PLGA-TPGS) - have received special attention for their reduced toxicity, and increased effectiveness of drug has also been reported. (dovepress.com)
  • Methods: We constructed nanoparticles to fully encapsulate the therapeutic drug (ginsenoside Rg1), which can be transferred into brain tissue via the receptor-mediated transfer of drug-encapsulated nanoparticles. (cbinsights.com)
  • Iron oxide nanoparticles have high stability, good dispersion, simple preparation and good biocompatibility. (selfgrowth.com)
  • Relevant research results titled Hypoxia-Triggered Self-Assembly of Ultrasmall Iron Oxide Nanoparticles to Amplify the Imaging Signal of a Tumor are available on Journal of the American Chemical Society. (selfgrowth.com)
  • Strategies have been advised that nanoparticles can be used to deliver drug/gene to targeted tissues [ 4 ]. (hindawi.com)
  • It covers areas such as solubility, pharmacokinetics and drug delivery. (wikipedia.org)
  • Nevertheless, several factors, including poor solubility, low dissolution rate, stability, and bioavailability of many dugs remain a constant challenge in achieving the desired therapeutic targets. (mdpi.com)
  • Lipid-based drug delivery systems are one of the emerging technologies designed to address challenges such as the solubility and bioavailability of poorly water-soluble drugs. (mdpi.com)
  • Conjugation of hydrophilic polymers with small molecule drugs to produce polymer-drug conjugate systems has been demonstrated to be a viable formulation strategy for utilizing hydrophobic drugs in a water-soluble manner, which may offer advantages over the corresponding parent drugs, including fewer side effects, improved solubility, passive tumor targeting, an improved pharmacokinetic profile, and lower plasma concentrations. (dovepress.com)
  • However, these antifungal drugs have several defects in clinical practice, such as low efficacy and serious adverse drug reactions (ADRs) and even the emergence of resistant strains. (dovepress.com)
  • The difference between effectiveness and efficacy of antimalarial drugs in Kenya. (ajtmh.org)
  • Likewise, medical professionals expect prescribed products to comply with efficacy, safety and stability requirements. (pharmamanufacturing.com)
  • pH Sensitive Drug Delivery Systems (PSDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. (scialert.net)
  • Due to its notable efficiency of penetration and accumulation inside a hypoxic tumor, the hypoxia imaging probe could also be considered as a potential candidate as a versatile platform for hypoxia-targeted drug delivery, and meanwhile its hypoxia-related therapeutic efficacy can be monitored. (selfgrowth.com)
  • Because your methods, facilities, or controls for manufacturing, processing, packing, or holding do not conform to CGMP, your API are adulterated within the meaning of section 501(a)(2)(B) of the Federal Food, Drug, and Cosmetic Act (FD&C Act), 21 U.S.C. 351(a)(2)(B). (fda.gov)
  • Multivariate methods could help to capture much larger effects between FNC stability and children's behavior. (futurity.org)
  • Background: The radiation sterilization is one of the best methods for sterilizing vulnerable degradation drugs like cefozopran hydrochloride. (bvsalud.org)
  • Results: Chemical stability of radiosterylized cefozopran hydrochloride, was confirmed by spectrophotometric and chromatographic methods. (bvsalud.org)
  • The results of experimental methods show excellent agreement with predicted results, highlighting the importance of design of experiments in method optimization. (ijpsonline.com)
  • The Bristol MRC Hub for Trials Methodology Research is developing methods to define "intervention stability," informed by work within two surgical RCTs (the By-Band study and the ROMIO study ). (bmj.com)
  • The stability between helical conformations of homopeptides of alanine, glycine, and aminoisobutyric acid has been studied by means of quantum-mechanical methods. (ub.edu)
  • In 1940, phenytoin (PHT) was found to be an effective drug for the treatment of epilepsy, and since then it has become a major first-line antiepileptic drug (AED) in the treatment of partial and secondarily generalized seizures. (medscape.com)
  • Pearls of antiepileptic drug use and management. (medscape.com)
  • Electronically monitored antiepileptic drug adherence and seizure outcome data were collected. (medscape.com)
  • Growth on the control medium is compared to the growth on the drug-containing medium to determine susceptibility or resistance. (cdc.gov)
  • Antimalarial drug resistance and combination chemotherapy. (ajtmh.org)
  • Antimalarial drug resistance. (ajtmh.org)
  • Drug resistance is a main obstacle for curative cancer chemotherapy. (hindawi.com)
  • Besides this, acquired drug resistance may arise via changes in gene expression. (u-szeged.hu)
  • Drug resistance represents one of the greatest challenges in cancer treatment. (bvsalud.org)
  • Cancer stem cells (CSCs) are thought to be the major cause of failure in cancer therapy due to their considerable resistance to most chemotherapeutic agents, resulting in tumor recurrence and eventually metastasis. (bvsalud.org)
  • Selective PPARγ agonist Pio reversed drug resistance to Dox by significantly down-regulating the expression of stemness markers and P-glycoprotein (P-gp) in osteosarcoma cells. (bvsalud.org)
  • It is important to understand the mechanisms of action and the pharmacokinetics of antiepileptic drugs (AEDs) so that these agents can be used effectively in clinical practice, especially in multidrug regimens (see the image below). (medscape.com)
  • Medically reviewed by Drugs.com on Oct 25, 2023. (drugs.com)
  • It emphasis on the physical characteristics and actions of the drug delivery system before the same is given to the patient. (wikipedia.org)
  • AMB-NPs were prepared with a modified nanoprecipitation method and then characterized in terms of physical characteristics, in vitro drug release, stability, drug-encapsulation efficiency, and toxicity. (dovepress.com)
  • By employing state-of-the-art computational fluid dynamics (CFD) simulations, designers can optimize the keel's hydrodynamic characteristics to reduce drag and increase lift generation. (naval-architects.org)
  • By employing cutting-edge technologies and materials, designers can optimize hydrodynamic characteristics, resulting in increased speed, improved stability, enhanced maneuverability, and ultimately ensuring a safer sailing experience. (naval-architects.org)
  • RESULTS: A review of the current understanding of thyroid oncogenesis at a molecular level is presented and characteristics of advanced thyroid cancer are defined. (bvsalud.org)
  • Adverseeffects were simultaneously assessed.Results:There was no significant difference in the baseline characteristics between the three groups. (bvsalud.org)
  • Microencapsulation technology has also been used to improve the stability of drugs. (tutorialspoint.com)
  • The multi-year grant will fund research by Isis to improve the stability and tissue distribution of RNAi drugs. (news-medical.net)
  • In vivo results further confirm that our hypoxic imaging probe can display a prompt MRI signal for the tumor interior region, and its signal enhancement performs a long-term effective feature and gradually reaches 3.69 times amplification. (selfgrowth.com)
  • Pembrolizumab is a humanized antibody directed against the programmed death-1 receptor on the cell surface, resulting in a T-cell-mediated immune response against tumor cells that can be complicated by immune-related adverse events. (bvsalud.org)
  • Col was encapsulated in the thermosensitive gel to preferentially degrade tumor extracellular matrix (ECM), ensuring subsequent drug penetration, while Mps with Pio and Dox were co-delivered to synergistically inhibit tumor growth and metastasis. (bvsalud.org)
  • Our results showed that the Gel-Mps dyad functions as a highly biodegradable, extremely efficient, and low-toxic reservoir for sustained drug release, displaying potent inhibition of tumor proliferation and subsequent lung metastasis. (bvsalud.org)
  • Twenty-four hours later, the patient showed clinical stability, major improvement of respiratory status, and no fever. (cdc.gov)
  • Drug resistant falciparum malaria: clinical consequences and strategies for prevention. (ajtmh.org)
  • Additionally, neuroprotectants could mitigate the ischemia/reperfusion injury, including edaravone and fingolimod, 3 but their clinical effects cannot achieve the desired condition, primarily due to the rigid blood-brain barrier (BBB) that limits drug delivery to the ischemic regions. (cbinsights.com)
  • Some currently-available drugs as well as approaches undergoing testing in pre-clinical models of radiation injury have shown great promise as mitigators/treatments, improving survival and enhancing other indicators such as levels of immune and other blood cells. (nih.gov)
  • Optimal clinical outcome cannot be achieved if drug plasma concentrations are constant. (scialert.net)
  • Although, significant progress has been made in the controlled drug delivery area, more advances are yet to be made for treating many clinical disorders, such as diabetes and rhythmic heart disorders. (scialert.net)
  • Its effectiveness in reducing bone resorption has been proven in comparative clinical studies after a period of 24 months administering the drug 6-7 . (bvsalud.org)
  • This manuscript describes the significant disease modifying benefits associated with daily dosing of SMT022357, a second-generation compound in this drug series with improved physicochemical properties and a more robust metabolism profile. (drugdiscoverynews.com)
  • The crystal structure can influence the drug's properties, such as stability and dissolution rates, as well as impact the formulation and processing conditions. (news-medical.net)
  • As a result, a very high concentration is required (typically ca. 150 mg/ml), which introduces unique stability issues related to aggregation, viscosity and thermal volatility. (pharmamanufacturing.com)
  • To mitigate viscosity issues, it might become necessary to reduce the concentration of the drug, leading to a larger volume. (pharmamanufacturing.com)
  • therefore, variations both in a disease state and in drug plasma concentration need to be taken into consideration in developing drug delivery systems intended for the treatment of disease with adequate dose. (scialert.net)
  • We demonstrate the possible effects of increasing drug concentration, and characterize the possible bifurcation sequences. (u-szeged.hu)
  • The action mechanism of bisphosphonates like risedronate, consists of it binding to the minerals of the bone matrix and, as the latter is reabsorbed, the drug is slowly released causing an increased concentration in the middle of the osteoclasts where their main job is to render them inactive 2 . (bvsalud.org)
  • Enclosing drugs within a shell material protects them from environmental factors such as moisture, heat, and light, which can degrade the drug. (tutorialspoint.com)
  • Considering stability, biopharmaceutical manufacturers need to know that as a product sits on a shelf, it won't lose its effectiveness or degrade into something dangerous to consume. (pharmamanufacturing.com)
  • Ultrasonic drug and gene delivery from nanocarriers have tremendous potential because of the wide variety of drugs and genes that could be delivered to targeted tissues by fairly noninvasive means [ 7 ]. (hindawi.com)
  • Antiepileptic drugs (AEDs) are the primary treatment modality for most patients with epilepsy, and the overall goal of treatment is no seizures, no side effects and best quality of life (Glauser, 2002). (medscape.com)
  • In previous work, our group has prepared micellar ethaselen formulation employing PLA-based copolymers and characterized its drug loading contents and stability (data not shown), which have demonstrated the compatibility between the core of micelles and the ethaselen molecules. (springer.com)
  • however, the stability of emerging analogs has not been elucidated, and therefore, assuming equivalent storage stability can be erroneous. (ojp.gov)
  • 5 This oil-in-water composition demonstrates skin-freshening and softening effects and has good skin permeability and storage stability. (cosmeticsandtoiletries.com)
  • The technology has gained a lot of attention over the years due to its numerous benefits, including controlled release, increased shelf life, targeted delivery, and improved product stability. (tutorialspoint.com)
  • For finished product stability testing, a product is stored in controlled conditions and then periodically removed from those conditions and examined to ensure it adheres to standards. (pharmamanufacturing.com)
  • 1975. Drug-biomolecule interations: Drug toxicity and vitamin coenzyme depletion. (cdc.gov)
  • The AMB-PLGA-TPGS NP system significantly improves the AMB bioavailability by improving its antifungal activities and reducing its toxicity, and thus, these NPs may become a good drug carrier for antifungal treatment. (dovepress.com)
  • Here the authors used MsbA (an adenosine triphosphate binding cassette transporter), CorA (a Mg(++) channel), and CpxA (a histidine kinase) as model proteins and show that DSLS is not sensitive to the presence of detergents or protein hydrophobicity and can be used to monitor thermodenaturation of membrane proteins, assess their stability, and detect ligand binding in a 384-well format. (nih.gov)
  • Upon modulation of utrophin protein with the second-generation utrophin modulator SMT022357, in-vivo models of DMD showed significantly improved muscle stability and a marked reduction of the muscle regeneration, necrosis and fibrosis that are at the core of DMD pathology. (drugdiscoverynews.com)
  • In addition, the controlled drug delivery area needs further development of techniques for delivery of peptide and protein drugs. (scialert.net)
  • The goal of the present investigation is to examine the effects of missense mutations in the MERS-CoV S protein on protein stability and binding affinity with DPP4 to provide insight that is useful in developing vaccines to prevent coronavirus infection. (frontiersin.org)
  • We investigated the effects of MERS-CoV S protein viral mutations on protein stability and binding affinity. (frontiersin.org)
  • In addition, we studied all DPP4 mutations and found the functional substitution R336T weakens both DPP4 protein stability and S-DPP4 binding affinity. (frontiersin.org)
  • On the other hand, dermal/transdermal drug delivery candidates have increased in recent years in response to the development of new and optimized approaches to improve local and systemic drug delivery. (mdpi.com)
  • The American Society of Hematology defines it as an isolated thrombocytopenia with clinically no apparent associated conditions or no other cause of thrombocytopenia, such as HIV infection, systemic lupus erythematosus, lymphoproliferative disorders, myelodysplasia, agammaglobulinaemia or hypogammaglobulinaemia, drug-induced thrombocytopenia, alloimmune thrombocytopenia or congenital/hereditary non-immune thrombocytopenia [7]. (who.int)
  • Treatment with SMT022357 resulted in significant increases in utrophin expression in both the heart and diaphragm. (drugdiscoverynews.com)
  • Repositioning the knee (recurvatum) increases knee mechanical stability, but at the cost of increased contact forces and shock generation. (medscape.com)
  • CYB5R3 gene mutations that cause autosomal recessive congenital methemoglobinemia type I typically reduce enzyme activity or stability. (medlineplus.gov)
  • Mutations that cause autosomal recessive congenital methemoglobinemia type II usually result in a complete loss of enzyme activity. (medlineplus.gov)
  • The biodistribution of drug carriers is monitored by imaging, so that the optimal timing for the application of external stimuli can be achieved [ 2 ]. (hindawi.com)
  • It also serves as a basis for the understanding of drug absorptions, distributions, metabolism, and eliminations that happen during the course of drug treatment. (wikipedia.org)
  • It forms the basis for design, manufacture, and distribution of drug products and serves as the foundation for the stable and proper use of medical drugs. (wikipedia.org)
  • Biopharmaceutical companies want a highly stable biologic that can be stored for long periods of time in ambient conditions so viable quantities of the drug can be delivered and stored by medical professionals and patients. (pharmamanufacturing.com)
  • Results Hierarchical linear modeling results for overall barriers remained stable over 2 years. (medscape.com)
  • They have been applied in a wide range of biological systems ranging from drug delivery to tissue engineering. (springer.com)
  • Nanomaterials have demonstrated a wide range of applications and recently, novel biomedical studies are devoted to improving the functionality and effectivity of traditional and unmodified systems, either drug carriers and common scaffolds for tissue engineering or advanced hydrogels for wound healing purposes. (researchgate.net)
  • These effects may induce transient membrane permeabilization (sonoporation) on a single cell level, cell death, and disruption of tissue structure, ensuring noninvasive, targeted, and efficient drug/gene delivery and therapy. (hindawi.com)
  • Thus, drug release from devices made from these polymers will display release rates that are pH sensitive. (scialert.net)
  • Postural stability assessment during task performance. (cdc.gov)
  • In response to this letter, provide a risk assessment for all drugs within their re-test date manufactured and distributed within the United States. (fda.gov)
  • Provide a risk assessment for any drugs within their re-test date manufactured using inappropriate equipment and distributed within the United States. (fda.gov)
  • In this paper, the authors describe their assessment of stability for each analyte, their preparation of samples in drug-free urine at three different pHs and stored at three different temperatures, and analysis utilizing the Lin-Zhi International Cannabinoids Enzyme Immunoassay cannabinoid screening kit calibrated at the 25 ng/mL cut-off. (ojp.gov)
  • As a result, many nursing competency assessment tools were developed but only a few of these were evaluated for reliability (Wu et al. (scielo.org.za)
  • When performed properly, this method allows a quantitation of the proportion of mutants resistant to a drug and can detect the 1% proportion of drug- resistant mutants above which therapeutic failure is likely. (cdc.gov)
  • To reduce the development of drug-resistant bacteria and maintain the effectiveness of Vibramycin® and other antibacterial drugs, Vibramycin should be used only to treat or prevent infections that are proven or strongly suspected to be caused by bacteria. (rxlist.com)
  • Up to 44 percent of strains of Streptococcus pyogenes and 74 percent of Streptococcus faecalis have been found to be resistant to tetracycline drugs. (rxlist.com)
  • 4 On the other hand, a large number of neurons cause irreversible degeneration and necrosis in ischemic regions, which results from ischemia/reperfusion injury. (cbinsights.com)
  • This results in improved sarcolemmal stability and prevents dystrophic pathology through a significant reduction of regeneration, necrosis and fibrosis. (drugdiscoverynews.com)
  • This addressed the primary cause of fiber degeneration and increased muscle stability in hind-limb muscles of the mdx mouse, which resulted in reduced regeneration and necrosis, enhanced protection of the muscle against contraction-induced damage and improved muscle function. (drugdiscoverynews.com)
  • They conclude that time, storage temperature, and pH of urine specimens may affect the screening results of specimens collected for cannabinoid drug screening. (ojp.gov)
  • To accelerate the stability testing process, scientists put the substance in stress conditions such as high humidity and temperature to highlight stability issues sooner. (pharmamanufacturing.com)
  • Biologics can exhibit narrow thermal stability profiles, meaning they can easily become unstable and denature (lose their biologic activity) unless they are maintained at a specific temperature range. (pharmamanufacturing.com)
  • even if the drug is stored in this temperature range. (bvsalud.org)
  • The technology has been used to improve the effectiveness and safety of drugs through controlled release and targeted delivery. (tutorialspoint.com)
  • Anticonvulsant mood stabilizers are drugs that have certain therapeutic effects on epilepsy, bipolar disorder, and other diseases ( 1 ). (frontiersin.org)
  • This isoform is necessary for many chemical reactions, including the breakdown and formation of fatty acids, the formation of cholesterol, and the breakdown of various molecules and drugs. (medlineplus.gov)
  • The harmful effects of chemicals and the side effects of chemical drugs on human health have a widely focused global attention on herbal drugs and medicinal plants. (researchgate.net)
  • The influence of peptide length on the relative stability between helical conformations has also been analyzed by means of systematic studies for peptides of size up to 11 residues. (ub.edu)
  • These approvals have paved the way for use of these already-stockpiled drugs, without the need for an Emergency Use Authorization (EUA), and has elevated their use to an expected standard of care in a mass casualty, radiation public health emergency. (nih.gov)
  • In those GLP studies, both growth factor-based drugs improved survival when administered 24 hours after radiation exposure. (nih.gov)
  • The NIAID's focus on product development makes the kinds of studies that resulted in these licensures available to companies and/or academic investigators who are developing drugs for a radiation indication. (nih.gov)
  • Results of indirect fluorescent antibody assays were nonreactive for R. conorii IgG but positive (titer 1:64) for R. typhi IgG. (cdc.gov)
  • Screening assays are usually the first step in urine drug testing. (ojp.gov)
  • With the development of nanotechnology, nanocarriers have been increasingly used for curative drug/gene delivery. (hindawi.com)
  • As a novel theranostic system, nanocarriers hold great promise for ultrasound molecular imaging, targeted drug/gene delivery, and therapy. (hindawi.com)
  • Nanocarriers can pass through blood capillary walls and cell membrane walls to deliver drugs. (hindawi.com)
  • In this review, we explore the research progress and application of ultrasound-mediated local drug/gene delivery with nanocarriers. (hindawi.com)
  • Furthermore, as targeted delivery carriers, gene/drug-loaded nanocarriers can release their associated payload upon insonation. (hindawi.com)
  • Besides, nanocarriers decorated with targeting moiety can adhere to targeted tissues, which can promote intracellular uptake of drug delivery vehicles. (hindawi.com)
  • Although the system of ultrasound-mediated drug delivery with nanocarriers has many advantages, there are still many challenges. (hindawi.com)
  • Based the dual action of OA in metabolic regulation and mitochondrial dynamics, further results revealed that mitochondrial functional status and spare respiratory capacity (SRC) of cancer cells had a close correlation with mitochondrial metabolic plasticity, and played important roles in the susceptibility to cancer therapy aiming at glucose restriction. (bvsalud.org)
  • Our results suggested that the rs1083801 within the GRM7 (glutamate receptor, metabotropic 7) gene was associated to early response under a recessive model (GG genotype observed in 14.34% of early responders vs 5.25% of late responders, OR=0.33, 95% CI=0.21-0.54, p=6.41e-06. (nih.gov)
  • They have shown a wide range of application prospects in the fields of sensor detection, disease diagnosis, gene therapy vectors, and targeted drug delivery. (selfgrowth.com)
  • Nanoparticle, used as a drug/gene delivery vehicle, can not only target specific cells and tissues, but also retain the biological activity of the drug/gene during transport. (hindawi.com)
  • Therefore, the development of novel visible ultrasonic responsive nanosized drug/gene carriers is necessary. (hindawi.com)
  • The shell material releases the drug when it reaches the target area, increasing the effectiveness of the drug and reducing its side effects. (tutorialspoint.com)
  • Our Vibramycin (doxycycline hyclate) for Injection Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
  • Antiepileptic drugs should be used carefully, with consideration of medication interactions and potential side effects. (medscape.com)
  • If the insomnia is related to medication or drug abuse, the offending medication or drug must be slowly tapered and withdrawn. (medscape.com)
  • Objective To determine the stability and influence of adherence barriers on medication adherence and seizure control in pediatric epilepsy. (medscape.com)
  • After 7 days of antimicrobial drug treatment, he was discharged with complete resolution of symptoms. (cdc.gov)
  • The U.S. Food and Drug Administration (FDA) inspected your drug manufacturing facility, Malladi Drugs & Pharmaceuticals Limited, Unit 1, at 67 SIPCOT Industrial Complex, Ranipet, Vellore District, Tamil Nadu, from September 4 to 8, 2017. (fda.gov)
  • 2017). The psychometric evaluation of these tools helps in the reduction of measurement error and improvement of authentic assessments (Vitoratou & Pickles 2017) that will produce accurate findings or results (Souza, Alexandre & Guirardello 2017). (scielo.org.za)
  • Results of therapeutic effects during the course of the treatment. (wikipedia.org)
  • Results indicated that in the standard sprouting test, the 1000 grain weight had significant effects on growth traits such as length and weight of dry seedling, yet it had no significant effect on sprouting percentage. (researchgate.net)
  • Effects of substance abuse on housing stability of homeless mentally Ill persons in supported housing , by MS Hurlburt, RL Hough and PA Wood. (theincidentaleconomist.com)
  • This meta-analysis was performed using Revman 5.4, Stata 14.0, and R4.1.0, and effect size pooling was performed in fixed- or random-effects models based on the results of I 2 and Q-test, and the surface under the cumulative ranking curve (SUCRA) was used for analysis to assess the cumulative probability of drug-induced PCOS. (frontiersin.org)
  • A balance between knee stability and shock absorption is achieved by eccentric quadriceps contractions during loading response. (medscape.com)
  • Smart materials that can be triggered by external stimuli are seen with high potential for innovative treatments and improved drug delivery systems by regulatory agencies like the FDA and EMA. (researchgate.net)
  • PSDDS wherein the drug release is controlled primarily by the delivery system, stimuli induced PSDDS in which release is controlled by the stimuli, such as the pH present in the intestinal tract. (scialert.net)
  • The pH range of fluids in various segments of the gastrointestinal tract may provide environmental stimuli for responsive drug release. (scialert.net)
  • As a result, trials of innovative procedures are often criticised because of disagreements about the way the interventions were delivered and concerns that the results represent the "learning curve. (bmj.com)
  • Ideally, as in a drug trial, it would represent the point at which surgical interventions are identical to each other and delivered in a uniform way. (bmj.com)
  • Conclusions Assessing for specific adherence barriers over time may lead to identification of interventions that result in improved adherence and care. (medscape.com)
  • To solve these problems, an amphiphilic polymer-drug conjugate was prepared by attachment of low molecular weight (ie, 2 kDa) methoxy poly(ethylene glycol) methyl ether (mPEG) to gambogic acid (GA-mPEG 2000 ) through an ester linkage and characterized by 1H nuclear magnetic resonance. (dovepress.com)
  • If they have standardized technology, practices and data to support an integrated approach to stability testing and analytics, they may also use virtual models. (pharmamanufacturing.com)
  • Right analytics at right time" plays significant role in drug product development cycle and is expected to strengthen by implementation of analytical quality by design (AQbD). (ijpsonline.com)
  • Physical pharmacy deals with the science that works on the following aspects which are related to the development of a drug product. (wikipedia.org)
  • Physical stability and appeal of the drug. (wikipedia.org)
  • Tetracyclines are not the drugs of choice in the treatment of any type of staphylococcal infections. (rxlist.com)
  • Dermal/transdermal delivery of drugs represents an effective method to deliver drugs directly to the site of action or to enhance treatment activity noninvasively. (mdpi.com)
  • Isis Pharmaceuticals, Inc. has announced that it has been awarded a multi-year Phase 2 Small Business Innovation Research (SBIR) grant by the National Institutes of Health (NIH) for up to $1.5 million to design oligonucleotide drugs that can exploit the RNA interference (RNAi) antisense mechanism for disease treatment. (news-medical.net)
  • Ethosuximide has been used since 1958 as a first-choice drug for the treatment of absence seizures without generalized tonic-clonic seizures. (medscape.com)
  • It became the drug of choice in primary generalized epilepsies and in the mid 1990s was approved for treatment of partial seizures. (medscape.com)
  • OXFORD, U.K.- Summit Therapeutics plc , a drug discovery and development company advancing therapies for Duchenne muscular dystrophy (DMD) and C. difficile infection, recently announced the publication of preclinical data on the disease-modifying potential of utrophin modulation in the treatment of DMD. (drugdiscoverynews.com)
  • Significantly, utrophin expression is localized along the length of the muscle fiber, not just at the synapse, and is fiber-type independent, suggesting that drug treatment is modulating utrophin transcription in extra-synaptic myonuclei. (drugdiscoverynews.com)
  • In the reported study, SMT022357 treatment for five weeks resulted in increased utrophin expression, localized along the entire length of the muscle fiber membrane in both slow- and fast-twitch muscles. (drugdiscoverynews.com)
  • Notably SMT022357 treatment resulted in reduced fibrosis in the diaphragm, a significant observation due to the disease pathology in the diaphragm of the mdx model closely resembling that of DMD patients. (drugdiscoverynews.com)
  • Unlike drug studies, long term follow ups show that reduction of symptoms is permanent with brain wave biofeedback . (selfgrowth.com)
  • There are studies by Monastra that show that children on stimulant medications can stop taking their drugs without a resurgence of symptoms after EEG biofeedback training. (selfgrowth.com)
  • If symptoms of a disease display circadian variation, drug release should also vary over time. (scialert.net)
  • Identifying factors of plaque stability is necessary to design drugs to prevent plaque rupture and symptoms. (lu.se)
  • Nanoporous complexes can increase the efficiency with which drugs can penetrate the blood-brain barrier and reach target organs. (cbinsights.com)
  • Microbubbles are commonly used as intravascular ultrasound imaging probes and are becoming increasingly popular tools for targeted drug delivery. (hindawi.com)
  • Ultrasound is a noninvasive and visual theranostic modality that can be used to track drug carriers, trigger drug release, and improve local drug sediment with high spatial precision [ 5 , 6 ]. (hindawi.com)
  • Antiepileptic drugs can be grouped according to their major mechanism of action. (medscape.com)
  • Some antiepileptic drugs work by acting on combination of channels or through some unknown mechanism of action. (medscape.com)
  • Such a system would require coupling of the drug delivery rate with the physiological need by means of some feedback mechanism. (scialert.net)
  • Controlled drug delivery systems, which are intended to deliver drugs at predetermined rates for predefined periods of time, have been used to overcome the shortcomings of conventional drug formulations. (scialert.net)
  • Include an evaluation of all (b)(4) , drug intermediates, and drugs potentially contaminated by vermin. (fda.gov)
  • This detailed evaluation of the SMT C1100 drug series strongly endorses the therapeutic potential of utrophin modulation as a disease-modifying therapeutic strategy for all DMD patients irrespective of their dystrophin mutation. (drugdiscoverynews.com)
  • It addresses important aspects of the results of the biennial evaluation which should be brought to the attention of the Regional Committee. (who.int)