• Hypersplenism
  • Quantitative changes in platelet counts associated with infection may result from decreased marrow production, hypersplenism, consumption due to widespread endothelial damage or disseminated intravascular coagulation, as well as immune-mediated platelet destruction. (ispub.com)
  • disorders
  • Due to its special mode of action (see below) and its price, Arwin has never been used as 'normal' anticoagulant such as heparin, but only for the symptomatic treatment of moderate to severe forms of peripheral arterial circulatory disorders such as those resulting from years of heavy smoking and/or arteriosclerosis. (wikipedia.org)
  • gastrointestinal
  • Absence of LT-α leads to the disruption of gastrointestinal development, prevents Peyer's patch development, and results in a disorganized spleen. (wikipedia.org)
  • During medical imaging, accessory spleens may be confused for enlarged lymph nodes or neoplastic growth in the tail of the pancreas, gastrointestinal tract, adrenal glands or gonads. (wikipedia.org)
  • pregnancy
  • The risk of passing the abnormal gene from affected parent to offspring is 50% for each pregnancy regardless of the sex of the resulting child. (rarediseases.org)
  • It can occur in adults as the result of injuries and other similar conditions that cause the ligaments to weaken, such as connective tissue disease or pregnancy. (wikipedia.org)
  • cerebral
  • Rapid incapacitation can be achieved indirectly by cerebral hypoxemia resulting from massive bleeding from the heart, the thoracic aorta, or the pulmonary artery. (wikipedia.org)
  • concentrations
  • In hereditary hemolytic anemias, the underlying molecular defect affects and determines red blood cell vesiculation, resulting in shedding microvesicles of different compositions and concentrations. (frontiersin.org)
  • mutation
  • The abnormal gene can be inherited from either parent, or can be the result of a new mutation (gene change) in the affected individual. (rarediseases.org)
  • Recently, new DNA scanning techniques using whole-exome sequencing identified 5 missense somatic clonal mutations, including a heterozygous mutation in BRAF that results in the BRAF V600E variant protein, which is oncogenic for other tumors as well, was identified in all hairy cell leukemia patients and may be responsible for the pathogenesis, diagnosis, and targeted therapy of hairy cell leukemia. (medscape.com)
  • found
  • Though not a genetic disease, wandering spleen is often found at birth. (wikipedia.org)
  • Accessory spleens are found in approximately 10 percent of the population and are typically around 1 centimeter in diameter. (wikipedia.org)
  • cause
  • Sickle-cell disease can cause a functional asplenia (or autosplenectomy) by causing infarctions of the spleen during repeated sickle-cell crises. (wikipedia.org)
  • activation
  • One of the cleavage fibrinogen products, termed 'desAA-Fibrin', acts as cofactor for the tPA-induced plasminogen activation and an increased fibrinolysis results in return (profibrinolytic activity of ancrod). (wikipedia.org)
  • We reconcile this discrepancy by demonstrating that activation within spleen results in intermediate induction of homing potential to the intestinal mucosa. (pubmedcentralcanada.ca)
  • otherwise
  • A spleen easily palpable below the costal margin in any child over the age of 3-4 years should be considered abnormal until proven otherwise. (wikipedia.org)