• disorders
  • Due to its special mode of action (see below) and its price, Arwin has never been used as 'normal' anticoagulant such as heparin, but only for the symptomatic treatment of moderate to severe forms of peripheral arterial circulatory disorders such as those resulting from years of heavy smoking and/or arteriosclerosis. (wikipedia.org)
  • concentrations
  • About one third of the circulating platelets are in the spleen at all times and the production of antiplatelet antibody in the spleen subjects these platelets to high antibody concentrations. (scripps.edu)
  • In hereditary hemolytic anemias, the underlying molecular defect affects and determines red blood cell vesiculation, resulting in shedding microvesicles of different compositions and concentrations. (frontiersin.org)
  • injuries
  • It can occur in adults as the result of injuries and other similar conditions that cause the ligaments to weaken, such as connective tissue disease or pregnancy. (wikipedia.org)
  • found
  • Though not a genetic disease, wandering spleen is often found at birth. (wikipedia.org)
  • Accessory spleens are found in approximately 10 percent of the population and are typically around 1 centimeter in diameter. (wikipedia.org)
  • large
  • Fish are exposed to large oxygen fluctuations in their aquatic environment since the inherent properties of water can result in marked spatial and temporal differences in the concentration of oxygen (see oxygenation and underwater). (wikipedia.org)
  • cause
  • Sickle-cell disease can cause a functional asplenia (or autosplenectomy) by causing infarctions of the spleen during repeated sickle-cell crises. (wikipedia.org)
  • patients
  • In patients who have no spleen, the antibody is produced mostly in the bone marrow, and the antibody-sensitized platelets are destroyed in either the bone marrow or liver. (scripps.edu)
  • Recently, new DNA scanning techniques using whole-exome sequencing identified 5 missense somatic clonal mutations, including a heterozygous mutation in BRAF that results in the BRAF V600E variant protein, which is oncogenic for other tumors as well, was identified in all hairy cell leukemia patients and may be responsible for the pathogenesis, diagnosis, and targeted therapy of hairy cell leukemia. (medscape.com)
  • cell
  • Hairy cell leukemia is recognized as a clonal B-cell malignancy, as identified by immunoglobulin gene rearrangements that result in a phenotype B-cell expression of surface antigens. (medscape.com)
  • This results in monocyte sequestration in the spleen through apoptotic cell clearance mechanisms. (wikipedia.org)
  • activation
  • One of the cleavage fibrinogen products, termed 'desAA-Fibrin', acts as cofactor for the tPA-induced plasminogen activation and an increased fibrinolysis results in return (profibrinolytic activity of ancrod). (wikipedia.org)
  • We reconcile this discrepancy by demonstrating that activation within spleen results in intermediate induction of homing potential to the intestinal mucosa. (pubmedcentralcanada.ca)
  • otherwise
  • A spleen easily palpable below the costal margin in any child over the age of 3-4 years should be considered abnormal until proven otherwise. (wikipedia.org)
  • mostly
  • Wilf was an ex-convict with an extensive criminal record, mostly as a result of his tendency to take part in scams, a trait that many members of his family had inherited. (wikipedia.org)
  • Despite
  • This action lead to Blanche Hunt (Maggie Jones) and Deirdre Barlow (Anne Kirkbride) believing he was dead - with the former arranging her own wake, despite still being alive, as a result. (wikipedia.org)
  • thus
  • In contrast, unregulated expression of LT-α can result in a constantly active signaling pathway, thus leading to uncontrolled cellular growth and creation of tumors. (wikipedia.org)