MutagenesisMutagenesis, Site-DirectedDNA Restriction EnzymesCaloric RestrictionPolymorphism, Restriction Fragment LengthMolecular Sequence DataMutagenesis, InsertionalBase SequenceAmino Acid SequenceMutationDeoxyribonucleases, Type II Site-SpecificEscherichia coliPlasmidsBinding SitesCloning, MolecularDNA, BacterialModels, MolecularDNA Transposable ElementsGenes, BacterialDNAPolymerase Chain ReactionFood DeprivationBacterial ProteinsAmino Acid SubstitutionSequence Homology, Amino AcidStructure-Activity RelationshipFetal Growth RetardationRecombinant ProteinsProtein Structure, TertiaryKineticsDNA PrimersCell LineProtein BindingSubstrate SpecificitySequence AlignmentProtein ConformationDeoxyribonuclease EcoRINucleic Acid HybridizationPoint MutationDNA, ViralChromosome MappingCysteineGenesProtein Structure, SecondarySequence Analysis, DNAMutagensPhenotypeBlotting, SouthernCatalysisEthylnitrosoureaDNA Mutational AnalysisAlanineTranscription, GeneticOligodeoxyribonucleotidesSpecies SpecificityGenetic Complementation TestElectrophoresis, Agar GelDNA, RecombinantTransfectionEscherichia coli ProteinsDNA Restriction-Modification EnzymesAllelesConserved SequenceDeoxyribonuclease HindIIICatalytic DomainSOS Response (Genetics)Recombination, GeneticHistidineCrystallography, X-RayPromoter Regions, GeneticGenetic VectorsDeoxyribonuclease BamHIRecombinant Fusion ProteinsGenotypeSequence Homology, Nucleic AcidSequence DeletionSaccharomyces cerevisiaeLongevityProtein EngineeringCricetinaeGenes, ViralEthyl MethanesulfonateTransformation, BacterialDNA-Binding ProteinsDeoxyribonucleases, Type I Site-SpecificRestriction MappingLysineAmino Acid MotifsMutant ProteinsPolymorphism, GeneticPregnancyRNA, MessengerAspartic AcidEnzyme StabilityUltraviolet RaysDNA FingerprintingDirected Molecular EvolutionEnergy IntakeTransformation, GeneticNucleic Acid Conformation