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Angioplasty, BalloonAngioplasty, Balloon, CoronaryCatheterizationCoronary RestenosisCoronary VesselsAngioplastyEquipment DesignSwineStentsRecurrenceCoronary AngiographyConstriction, PathologicCoronary DiseaseAngioplasty, LaserTreatment OutcomeFollow-Up StudiesGraft Occlusion, VascularBalloon OcclusionTunica IntimaAtherectomy, CoronaryIliac ArteryIntra-Aortic Balloon PumpingFemoral ArteryArterial Occlusive DiseasesVascular PatencyHyperplasiaBeta ParticlesTime FactorsUltrasonography, InterventionalMyocardial InfarctionGastric BalloonRetreatmentDrug-Eluting StentsPopliteal ArteryCarotid Artery InjuriesCarotid StenosisAngiographyProspective StudiesCoronary StenosisAngioplasty, Balloon, Laser-AssistedBrachytherapyAngina PectorisSirolimusAtherectomyMuscle, Smooth, VascularCoronary Artery BypassNeointimaRetrospective StudiesAortic CoarctationCoronary Artery DiseaseEndarterectomy, CarotidIridium RadioisotopesCarotid ArteriesCoronary ThrombosisUltrasonography, Doppler, DuplexCardiovascular AgentsCoated Materials, BiocompatiblePlatelet Aggregation InhibitorsBalloon ValvuloplastyRenal Artery ObstructionAlloysProsthesis DesignReoperationRisk FactorsArteriosclerosisPostoperative ComplicationsMitral Valve StenosisIschemiaThrombolytic TherapyCardiac CatheterizationThrombosisBlood Vessel Prosthesis ImplantationPulmonary Valve StenosisSaphenous VeinVascular Access DevicesMyocardial RevascularizationCoronary CirculationPaclitaxelIntermittent ClaudicationFeasibility StudiesTreatment FailureCineangiographyFibromuscular DysplasiaEndarterectomyDrug ImplantsAngioscopyAngina, UnstableLegPeripheral Vascular DiseasesIntracranial ArteriosclerosisRabbitsCarotid Artery, InternalRisk AssessmentBlood Vessel ProsthesisLimb SalvageMetalsCardiac CathetersSwine, MiniatureSeverity of Illness IndexAspirin
Compared with Heparin DuringStentsPercutaneous coronary intLesionsTrying to prevent restenosisPTCAReduce the risk of restenosisImplantationHigh risk of restenosisDrug-coated balloonCatheterFemoropoplitealStentingPatientsCathetersVesselArterialRevascularizationPeripheralDilatationBlockageOutcomesOcclusionAtherosclerosisCoronary arteriesStudy InvestigatorsStent placementLesionTransluminalArtery diseaseNeointimal hyperplasiaVascularProcedureBlockagesInterventionalInserted into the arteryScar tissueSymptomaticMechanismsSirolimusBlood vesselsClinicalExpandsConventionalInflationInflateArteries
Compared with Heparin During1
Stents14
  • Cutting balloon angioplasty, compared with conventional balloon angioplasty, in patients undergoing γ-brachytherapy for in-stent restenosis is associated with less requirement for new stents (11% vs 22%, p = 0.02) but similar target vessel revascularization (35.1% vs 29.8%, p = 0.4) at follow-up. (illinois.edu)
  • Thus new improvements to balloons and stents are always necessary to achieve the best results from percutaneous coronary intervention (PCI). (scirp.org)
  • 1987) Intravascular Stents to Prevent Occlusion and Restenosis after Transluminal Angioplasty. (scirp.org)
  • Stents are the mesh tubes that prevent arterial collapse after balloon angioplasty, the principal treatment for atherosclerosis: A balloon is inserted into an artery to clear away plaque and is removed. (technologyreview.com)
  • Stents revolutionized the treatment of atherosclerosis in coronary and peripheral arteries, but they did little to address one of the chief problems with balloon angioplasty. (technologyreview.com)
  • Stents reduced the restenosis rate slightly, but it was still high. (technologyreview.com)
  • Stents work on a simple principle: a balloon expands the stent to support the arterial wall and is then deflated and removed. (technologyreview.com)
  • Sono-Tek is the world leader in ultrasonic spraying systems for depositing uniform thin films of anti-restenosis drugs onto implantable devices such a cardiac and peripheral stents. (sono-tek.com)
  • Dr. Zamboni is treating MS patients with a modified balloon angioplasty procedure he calls "The Liberation Procedure", and another physician at Stanford University, Dr. Michael Dake, is opening up the blocked veins of MS patients using stents. (wheelchairkamikaze.com)
  • The NC Emerge OTW and NC Emerge MR PTCA Dilatation Catheters (balloon models 2.00- 5.00 mm) are also indicated for the post-delivery expansion of balloon expandable stents (bare metal and drug-eluting). (bostonscientific.com)
  • Note: Bench testing was conducted with NC Emerge OTW and NC Emerge MR PTCA Dilatation Catheters and marketed Boston Scientific balloon expandable stents. (bostonscientific.com)
  • Stents and balloon catheters provide a less invasive treatment, for example. (bbraun.co.uk)
  • The focus of angioplasty is to widen narrowed blood vessels with stents and balloon catheters, which provide minimally invasive treatment. (bbraun.co.uk)
  • DCBs are also used to treat in-stent restenosis due to scar tissue proliferation inside stents, which can cause a vessel to occlude. (researchandmarkets.com)
Percutaneous coronary int5
Lesions11
  • In-stent restenosis lesions were divided into 2 groups according to the use of cutting balloon (n = 76) or conventional balloon angioplasty (n = 407) before γ-brachytherapy. (illinois.edu)
  • PCB angioplasty is performed mainly to ISR lesions and in small vessel disease. (asiaintervention.org)
  • Background Research has shown that the prognosis of in-stent restenosis (ISR) lesions after drug-coated balloon (DCB) angioplasty can differ in relation to in-stent neointimal characteristics. (elsevierpure.com)
  • Uses of balloon catheters or BMS for the treatment of coronary artery lesions shows good short-term results but long-term follow up revealed restenosis in up to 20%-30% of patients. (scirp.org)
  • For those with complex lesions, PTCRA may provide some benefit in comparison to balloon angioplasty. (cochrane.org)
  • Whereas CMV DNA was detected in 11 of 24 restenoses after angioplasty, none was detected in 11 primary lesions. (bmj.com)
  • A total of 87 de novo lesions were treated by IVL with the following indications: 25 before attempting other balloon-based devices (primary IVL), 51 after the failure of non-compliant balloon dilatation (secondary IVL), and 11 after stent implantation because of stent under expansion (bailout IVL). (frontiersin.org)
  • In 23 lesions, IVL was used for the treatment of in-stent restenosis (ISR). (frontiersin.org)
  • Revascularization procedures, including balloon angioplasty with or without stenting, are often used for the treatment of steno-occlusive lesions 6 , 7 , 8 . (jrheum.org)
  • Patients were enrolled if they had de novo lesions with a visual estimation of lumen DS of 50-70% and without revascularization (balloon angioplasty and/or stent implantation) after IVUS examination. (hindawi.com)
  • The drug helps prevent neointimal hyperplasia (scar tissue growth) caused by trauma when the vessel segment is treated for atherosclerotic lesions with balloon angioplasty. (researchandmarkets.com)
Trying to prevent restenosis1
  • Companies had tinkered with stent designs, trying to prevent restenosis, but with little success. (technologyreview.com)
PTCA6
  • Compared to angioplasty alone, PTCRA/PTCA did not result in a higher incidence of major adverse cardiac events, but patients were more likely to experience vascular spasm, perforation and transient vessel occlusion. (cochrane.org)
  • 95% CI 0.95 to 1.55) in those receiving PTCRA with adjunctive balloon angioplasty (PTCA) (PTCRA/PTCA) compared to those receiving PTCA alone. (cochrane.org)
  • The NC Emerge OTW and NC Emerge MR PTCA Dilatation Catheters are indicated for the balloon catheter dilatation of the stenotic portion of a native coronary artery or bypass graft stenosis for the purpose of improving myocardial perfusion in patients with atherosclerosis. (bostonscientific.com)
  • The safety and effectiveness of this PTCA balloon catheter for the treatment of in-stent restenosis (ISR) has not been established. (bostonscientific.com)
  • Example of an intravascular ultrasound (IVUS) image in percutaneous transluminal coronary angioplasty (PTCA). (medscape.com)
  • Percutaneous coronary interventions (PCI) include percutaneous transluminal coronary angioplasty (PTCA) with or without stent insertion. (msdmanuals.com)
Reduce the risk of restenosis2
  • DES have a thin surface of medication to reduce the risk of restenosis. (vitalheartandvein.com)
  • everolimus , ridaforolimus, zotarolimus) bonded to the metal that limit neointimal proliferation to reduce the risk of restenosis. (msdmanuals.com)
Implantation3
High risk of restenosis2
  • However, previous studies on vascular interventions in patients with TA have shown inconsistent results, ranging from a high risk of restenosis to good longterm efficacy and patency, although open revascularization resulted in superior patency rates compared with endovascular intervention 4 , 6 , 9 , 10 , 11 . (jrheum.org)
  • The new balloons broadened physicians' treatment options for peripheral artery disease (PAD) patients with a high risk of restenosis and expand the Stellarex portfolio. (researchandmarkets.com)
Drug-coated balloon3
  • Stellarex drug-coated balloon featuring EnduraCoat technology comprising hybrid coating, Polyethylene glycol (PEG) excipient and 2µg/mm² low drug dose. (philips.hu)
  • For instance, in October 2019, Koninklijke Philips N.V., a health technology company, launched two new Stellarex Drug-Coated Balloon Sizes. (researchandmarkets.com)
  • Royal Philips introduced two new balloons to its Stellarex 0.035" low-dose drug-coated balloon (DCB) portfolio. (researchandmarkets.com)
Catheter18
  • These devices differ from each other with respect to composition (eg, stainless steel, cobalt chromium alloy, nickel chromium alloy), architectural design, and delivery system (ie, a balloon catheter that delivers the stent, self-expanding, or balloon expandable). (medscape.com)
  • The MediCoat BCC300 is a balloon catheter coating system designed to coat balloons up to 300 mm in length. (sono-tek.com)
  • The balloon catheter cassette assembly can be removed for coating other medical devices, making the MediCoat BCC a flexible R&D development system for a variety of medical device coatings. (sono-tek.com)
  • A rotational motor rotates the catheter and balloon 360 degrees while a precision clamping device securely holds the catheter tail in place. (sono-tek.com)
  • Reliable, repeatable, controllable balloon catheter coatings. (sono-tek.com)
  • A PTA Peripheral DCB Catheter is a drug-coated percutaneous transluminal angioplasty (PTA) balloon intended to prevent restenosis, or restenosis of the peripheral arteries. (medicaldevice-network.com)
  • Do not advance or retract the catheter unless the balloon is fully deflated under vacuum. (bostonscientific.com)
  • Before withdrawing the balloon catheter, visually confirm complete balloon deflation by fluoroscopy. (bostonscientific.com)
  • Balloon catheter retrieval methods (use of additional wires, snares, and/or forceps) may result in trauma to the treated vessel and/or the vascular access site. (bostonscientific.com)
  • The balloon catheter should be used only by physicians trained in the performance of percutaneous transluminal coronary angioplasty. (bostonscientific.com)
  • Before insertion of the balloon catheter, administer appropriate anticoagulant and coronary vasodilator therapy. (bostonscientific.com)
  • Instead, the doctor can place and inflate the drug-coated SeQuent® Please NEO balloon catheter along the vascular occlusion, another innovation by B. Braun, along the vascular occlusion. (bbraun.co.uk)
  • Balloon angioplasty is a procedure in which a small balloon at the tip of the catheter is inserted near the blocked or narrowed area of the coronary artery. (vitalheartandvein.com)
  • A balloon catheter, placed over a guidewire, is used to insert the stent into the narrowed artery. (vitalheartandvein.com)
  • The cutting balloon catheter has a balloon tip with small blades. (vitalheartandvein.com)
  • A balloon-tipped catheter, guided by fluoroscopy or intravascular ultrasonography, is aligned within the stenosis, then inflated to disrupt the atherosclerotic plaque and dilate the artery. (msdmanuals.com)
  • Another catheter with a very small balloon on the end will be pushed over this wire and into the blockage. (medlineplus.gov)
  • The stent is inserted at the same time as the balloon catheter. (medlineplus.gov)
Femoropopliteal1
  • Drug-coated balloons worked better than plain balloon angioplasty in femoropopliteal in-stent restenosis , although durability beyond the 1-year outcomes examined remains an open question, according to a meta-analysis in Circulation: Cardiovascular Interventions . (medpagetoday.com)
Stenting12
  • Because it destroys rather than compresses the plaque, the combination technique will have a lower restenosis rate, or re-narrowing of the artery, compared to balloon angioplasty or stenting. (scienceblog.com)
  • In most cases, balloon angioplasty is performed in combination with the stenting procedure. (vitalheartandvein.com)
  • Angioplasty with stenting is most commonly recommended for patients who have a blockage in one or two coronary arteries. (vitalheartandvein.com)
  • Restenosis after balloon angioplasty and stenting is exacerbated by low flow. (edu.au)
  • Flow-dependent restenosis after angioplasty but not stenting is prevented by the antioxidant pyrrolidine dithiocarbamate (PDTC). (edu.au)
  • Carotid arteries of cholesterol fed rabbits underwent stenting or balloon injury in the presence of low or normal flow. (edu.au)
  • Treatment of underlying reversible pathologies coupled with transcatheter balloon angioplasty and stenting for persistent severe stenoses are established approaches. (bvsalud.org)
  • Two independent reviewers screened for studies in which BA or stenting was performed for PVS with reporting of restenosis outcomes, and data were independently extracted. (bvsalud.org)
  • For restenosis rates, 4 studies treated a total of 340 patients with 579 pulmonary vein interventions (225 with BA and 354 with stenting, mean follow-up 13-69 months). (bvsalud.org)
  • Restenosis requiring repeat intervention was reported in 3 studies, including 301 patients with 495 pulmonary vein interventions (157 with BA and 338 with stenting). (bvsalud.org)
  • Carotid artery angioplasty and stenting (CAS) is done using a small surgical cut. (medlineplus.gov)
  • Carotid artery angioplasty and stenting may help lower your chance of having a stroke. (medlineplus.gov)
Patients7
  • Bown's team tried a laser-based therapy in seven patients who needed a second balloon angioplasty. (newscientist.com)
  • A bigger study with patients who are having their first angioplasty will start in the autumn. (newscientist.com)
  • The phenotypic transformation of proliferation and migration in vascular smooth muscle cells (VSMCs) from media to intima is the basic pathology of neointimal hyperplasia after angioplasty in hypertensive patients. (hindawi.com)
  • PON2 may be a potential therapeutic target to reduce arterial remodeling after angioplasty in hypertensive patients. (hindawi.com)
  • Today, restenosis in coronary arteries afflicts less than 10 percent of patients thanks to the development of the drug-eluting stent (DES), which slowly releases a drug that inhibits the growth of scar tissue. (technologyreview.com)
  • It was important to do this review as it is not known whether or not PTCRA provides greater benefits to patients compared to balloon angioplasty. (cochrane.org)
  • The review also showed that patients receiving PTCRA were more likely to have perforations during the procedure compared to patients receiving balloon angioplasty. (cochrane.org)
Catheters10
  • Standalone coating system for applying ultra-thin layers of anti-restenosis drug polymer+plasticizer coatings onto implantable balloon catheters. (sono-tek.com)
  • Designed for spraying anti-restenosis solutions containing drug + plasticizers onto catheters mounted with cardiac angioplasty or other drug coated medical balloons. (sono-tek.com)
  • The MediCoat BCC was developed specifically for coating implantable medical balloon catheters. (sono-tek.com)
  • Read an in-depth article titled " Texturing Prospective with Ultrasonically Coated Balloon Catheters ", written by one of our Application Engineers regarding the efficacy of ultrasonic balloon coating and the specific process considerations for optimal coating characteristics using ultrasonic spray. (sono-tek.com)
  • Highly uniform thin film coatings onto cardiac or other balloon catheters for homogenous drug transfer at lesion. (sono-tek.com)
  • The PTA (percutaneous transluminal angioplasty) Balloons Catheters market includes Standard Balloon Catheters and PTA Peripheral DCB Catheters. (medicaldevice-network.com)
  • GlobalData uses proprietary data and analytics to provide a comprehensive report on the pta balloon catheters market in the Netherlands. (medicaldevice-network.com)
  • PTA standard balloon catheters are used to open up the arteries that are blocked by plaque build-up (atherosclerosis). (medicaldevice-network.com)
  • The pta balloon catheters market in the Netherlands can expand or contract due to a variety of reasons including population demographics, disease incidence and prevalence, macroeconomic issues, and geopolitical considerations. (medicaldevice-network.com)
  • The surgeon then removes the balloon and catheters. (medlineplus.gov)
Vessel10
  • To reduce the potential for vessel damage, the inflated diameter of the balloon should approximate the diameter of the vessel just proximal and distal to the stenosis. (bostonscientific.com)
  • Do not expand the balloon if it is not properly positioned in the vessel. (bostonscientific.com)
  • A total of five (4.5%) IVL balloons ruptured during treatment with subsequent vessel perforation in 1 case. (frontiersin.org)
  • When the balloon is inflated, the fatty plaque or blockage is compressed against the artery walls and the diameter of the blood vessel is widened (dilated) to increase blood flow to the heart. (vitalheartandvein.com)
  • This procedure is sometimes complicated by vessel recoil and restenosis. (vitalheartandvein.com)
  • Background For endovascular rescue therapy (ERT) of cerebral vasospasm (CVS) due to spontaneous subarachnoid haemorrhage (sSAH), non-compliant (NCB) and compliant (CB) balloons are used with both balloon types bearing the risk of vessel injury due to specific mechanical properties. (bmj.com)
  • There are two different balloon types used in connection with ERT for CVS: compliant balloons (CB) can be more easily implemented and are assumed to produce stronger dilative pressure in adjacent vessel parts because of variations in the final inflation diameter with expansion into the section of the artery with a larger calibre and potentially have a higher risk of edge dissections than non-compliant balloons (NCB). (bmj.com)
  • Drug eluting balloons are angioplasty balloons that are coated with an anti-proliferative drug, which is eluted in vessel walls during the inflation of balloon, usually at nominal pressure with a specific minimal inflation time. (researchandmarkets.com)
  • The active substance coated on the drug eluting balloon should be lipophilic in nature to have a high absorption rate through the vessel wall. (researchandmarkets.com)
  • Mostly paclitaxel is used as active ingredient due to its high pharmacokinetic transfer rate into the vessel wall and it is actively used in drug eluting balloons in the U.S. market and has been already approved for use in Europe. (researchandmarkets.com)
Arterial5
  • Angiotensin II (AngII) stimulates oxidative stress in VSMC, inducing VSMC proliferation and migration, which is a critical factor in both developments of hypertension and angioplasty-induced arterial restenosis. (hindawi.com)
  • Then, the balloon compresses the fatty matter into the arterial wall. (vitalheartandvein.com)
  • Although severe delayed arterial narrowing after transluminal balloon angioplasty (TBA) for CVS has sporadically been described, valid data concerning incidence and relevance are missing. (bmj.com)
  • For endovascular rescue therapy (ERT), the intra-arterial (IA) administration of vasodilators and the use of transluminal balloon angioplasty (TBA) are proven techniques to treat severe and refractory CVS. (bmj.com)
  • Percutaneous transluminal angioplasty (PTA) Peripheral arterial disease (PAD) is atherosclerosis of the extremities (virtually always lower) causing ischemia. (msdmanuals.com)
Revascularization1
  • Percutaneous revascularization with techniques such as percutaneous transluminal angioplasty (PTA), a less invasive option in the management of peripheral vascular disease (PVD), has been furthered by the work of pioneers such as Dotter and Gruntzig. (medscape.com)
Peripheral1
  • Drug-coated balloons (DCB), also referred to as drug-eluting balloons (DEB), were created as a way to reduce very high restenosis rates in peripheral vessels. (researchandmarkets.com)
Dilatation1
Blockage2
  • The process, an inflammatory response to the clearing of the blockage, is called restenosis. (newscientist.com)
  • This blockage can't be addressed in the usual ways, with balloon venoplasty or with a stent, so further options are being explored. (wheelchairkamikaze.com)
Outcomes1
  • This review sought to determine whether PTCRA leads to improved patient outcomes compared to balloon angioplasty. (cochrane.org)
Occlusion3
Atherosclerosis1
  • Atherosclerosis, a buildup of plaque, can lead to heart disease, artery disease, and chronic kidney disease and is traditionally treated by inserting and inflating a balloon to expand the artery. (scienceblog.com)
Coronary arteries1
Study Investigators2
Stent placement2
Lesion1
  • Larger studies with longer follow-up and stratification of lesion morphology are warranted to define its role relative to balloon angioplasty. (lu.se)
Transluminal1
Artery disease1
Neointimal hyperplasia3
Vascular1
  • Therefore, despite the existing anti-RAAS medicines, finding a novel downstream molecule exclusively targeting to inhibit neointimal formation and vascular remodeling may be a promising strategy for the treatment of vascular restenosis after angioplasty in hypertension. (hindawi.com)
Procedure1
  • Many physicians felt the report only reflected and gave approval to a procedure that was in their minds an important evidence based adjunct to balloon angioplasty: it reflected what they believed to be an improvement in good clinical practice at the individual patient level. (bmj.com)
Blockages2
  • The most commonly used method for clearing blockages is balloon angioplasty, in which a small balloon is inflated inside the artery. (newscientist.com)
  • This type of balloon may be used to treat the buildup of plaque within a previously placed stent (restenosis) or other types of blockages. (vitalheartandvein.com)
Interventional3
  • [ 5 ] Cesar Gianturco, a radiologist, and Gary Roubin, an interventional cardiologist, designed this bare-metal coronary stent, which was manufactured and sold by Cook Inc. The Gianturco-Roubin stent was a balloon-expandable and coil-type stent manufactured using a flat 316 L stainless steel wire coil attached to a single longitudinal strut. (medscape.com)
  • Dr. Jeffrey Brinker directs the cardiac pacemaker service and is an expert in interventional cardiology including pacemakers and implantable cardio defibrillators (ICDs), angioplasty, heart catheterization and lead extraction. (hopkinsmedicine.org)
  • Over the years, B. Braun has established itself as one of the leading European manufacturers of products for interventional angioplasty. (bbraun.co.uk)
Inserted into the artery2
  • Immediately after angioplasty, a thin optical fibre inserted into the artery delivered low-power red laser light to the site, killing the smooth muscle cells. (newscientist.com)
  • Then a stent containing another balloon is inserted into the artery. (technologyreview.com)
Scar tissue1
  • In about 30 percent of cases, scar tissue formed around the site of the injury, causing the artery to close again, a setback called restenosis. (technologyreview.com)
Symptomatic1
  • During follow-up one symptomatic aortic restenosis occurred and was successfully restented. (lu.se)
Mechanisms1
  • 1996) Patterns and Mechanisms of In-Stent Restenosis. (scirp.org)
Sirolimus1
  • This product provides a controlled release of the drug sirolimus in order to prevent restenosis. (bbraun.co.uk)
Blood vessels1
  • The stent itself offers no guarantee that it will keep blood vessels open and the blood flowing, and it can even cause the blood vessels to narrow - a restenosis. (bbraun.co.uk)
Clinical2
  • HTA groups such as NICE and ANAES (Agence Nationale d'Accreditation et d'Evaluation en Sante) in France are seen as being much more influential since they impact on clinical practice and reimbursement. (bmj.com)
  • They also have been investigated in clinical trials to prevent coronary artery in-stent restenosis. (researchandmarkets.com)
Expands2
Conventional1
  • In conventional laser angioplasty, a high laser power is required for the entire cavitation process, whereas in our technology, a lower laser power is only required for initiating the cavitation process," said Singh. (scienceblog.com)
Inflation2
Inflate1
Arteries1