Responsive hydrogels. Medical search. Frequent questions

Dubbed as "smart hydrogels" or "stimuli-responsive hydrogels", these gels are able to dynamically respond to external or internal stimuli in addition to possessing similar swelling-deswelling properties of traditional hydrogels. (wikipedia.org)
Various examples of external stimuli that have been used to control smart hydrogels in drug delivery systems include temperature, pH, light, ultrasound, and enzymes. (wikipedia.org)
Additional considerations in designing smart hydrogels involve fundamental understanding of bond strength, molecular weight, degree of polymerization, polymer structure, and molecular assembly. (wikipedia.org)
Similar to conventional hydrogels, the polymeric chain (or backbone) of the smart hydrogels is derived from polysaccharides, polypeptides, and polynucleotides. (wikipedia.org)
A series of smart hydrogels based on dual stimuli responsive star-block copolymers responding to pH and temperature were prepared via atom transfer radical polymerization (ATRP) employing the core-first method. (uni-bayreuth.de)
The hydrogels could increase the temperature-responsive of smart hydrogels, enhance solar modulation and have high luminous transmission. (ias.ac.in)

Inspired by the hierarchical structure of fluorescent proteins in jellyfish and biomembranes in nature, herein, a facile and universal all-in-one strategy is demonstrated to construct fluorescent, electrically responsive and ultratough self-healing hydrogels via aqueous self-assembly of polyelectrolyte-surfactant micelles with hierarchical structures and functionality. (polymer.cn)
The fundamental studies for such self-healing hydrogels would give us useful insights towards the material design for a specific application. (onepetro.org)

Ultrasound-triggered drug delivery using stimuli-responsive hydrogels refers to the process of using ultrasound energy for inducing drug release from hydrogels that are sensitive to acoustic stimuli. (wikipedia.org)
This method of approach is one of many stimuli-responsive drug delivery-based systems that has gained traction in recent years due to its demonstration of localization and specificity of disease treatment. (wikipedia.org)
Hydrogels are generally classified based on the following characteristics: material, crosslinking mechanism, physical structure, electric charge, and response to stimuli. (wikipedia.org)
Self-immolative polymers (SIPs) are molecules that depolymerize in a controlled manner due to the cleavage of stimuli-responsive end groups. (uwo.ca)
Preparation of synthetic polypeptide-polyHIPE hydrogels with stimuli-responsive behavior. (ki.si)
Enhancement of oral insulin bioavailability: in vitro and in vivo assessment of nanoporous stimuli-responsive hydrogel microparticles. (bvsalud.org)

In this work, the behavior of biocompatible and biodegradable hydrogels made with Fmoc-diphenylalanine (Fmoc-FF) (Fmoc = fluorenylmethoxycarbonyl) and Fmoc−arginine−glycine− aspartic acid (Fmoc-RGD) short peptides to which MNP were incorporated was studied in detail with physicochemical, mechanical, and biological methods. (ugr.es)
Gelation temperatures and rheological behavior depended on the MC concentration and type and concentration of salt used in hydrogel preparation. (polimi.it)
A continuous cell layer (cell sheet) was allowed to grow and then detached from the hydrogel surface without the use of enzymes, thanks to the thermo-responsive behavior of the MC hydrogel. (polimi.it)
Polyester polymers such as Polylactide (PLA) are able to undergo stereocomplexation process, leading to the production of a biodegradable hydrogel matrix Additionally, the elucidation of hydrogel formation mechanism and factors that influence mechanical behavior can be utilized in design optimization of the system. (memphis.edu)
Intrinsic properties of a hydrogel, such as elastic modulus, phase transition temperature, and rate of gel formation are directly influenced by the crosslinking behavior. (memphis.edu)
Plasma polymerization resembles free-radical polymerization in which various active components of plasma, such as reactive species or radicals, play an important role in controlling for instance chemical and mechanical properties that determine the shrinking and swelling behavior of the obtained hydrogels. (materialstoday.com)

The resulting hybrid hydrogels showed enhance mechanical properties and withstood injection without phase disruption. (ugr.es)

Synthesis of hydrogels are developed from a combination or isolated forms of natural and synthetic polymers. (wikipedia.org)
The plasma-based methodology for hydrogel synthesis includes three consecutive processes: 1. (materialstoday.com)
The PAM-CG composite hydrogels were prepared by a two-step method consisting of the synthesis of PAM-CG polymer via inverse emulsion polymerization followed by the preparation of PAM-CG hydrogel by in-situ mixing. (onepetro.org)
Mohammad-Ali Shahbazi, Tomás Bauleth-Ramos, Hélder A. Santos*, " DNA Hydrogel Assemblies: Bridging Synthesis Principles to Biomedical Applications ", Adv. Ther. (helsinki.fi)
In their review article, researchers from the University of Helsinki first sought to comprehensively discuss physicochemical identifications and key features that can directly affect the design and synthesis of DNA based hydrogels. (helsinki.fi)

This understanding can pave the way for further development of flexible electronics using environmentally responsive hydrogels. (nanowerk.com)

In these efforts, hydrogels - three-dimensional cross-linked polymeric networks - are among the most promising nature-derived materials applied in recent technologies for biomedical engineering, biotechnology, packaging, pharmaceutical science and agriculture. (materialstoday.com)
Ultrasound-responsive polymeric materials had attracted significant attention for several decades. (frontiersin.org)
DNA is a perfect polymeric molecule for interfacing biology with material science to construct hydrogels with fascinating properties for a wide variety of biomedical applications. (helsinki.fi)

DNA-Responsive Polyisocyanopeptide Hydrogels with Stress-Stiffening Capacity. (mpg.de)

Hydrogels are three dimensional structures consisting of hydrophilic polymers (i.e., polymers, colloids, etc.) that form networks through cross-linking processes. (wikipedia.org)
The main examples of natural polymers used to derive hydrogels include polysaccharides, polypeptides, and polynucleotides. (wikipedia.org)
Hydrogels are crosslinked hydrophilic polymers that undergo swelling in water. (uwaterloo.ca)
With their function as biomimetic material, synthetic hydrogels or hydrogel-forming natural polymers (e.g. collagen, alginate or agarose) are utilized to reproduce the filamentous nature and properties of extracellular matrix serving as scaffolds for 3D cell culture, artificial skin, actuators, biosensors, drug delivery vehicles and tissue-engineered products for cell matrices [4] . (materialstoday.com)
To address this issue, researchers have explored various approaches, such as incorporating conductive fillers or dopants, selecting hydrogels made of conductive polymers, and introducing a double-network strategy that combines both conductive and non-conductive elements within the hydrogel structure. (nanowerk.com)

Additionally, magnetic short-peptide hydrogels showed good biocompatibility and the absence of toxicity, which together with their enhanced mechanical stability and excellent injectability make them ideal biomaterials for in vivo biomedical applications with minimally invasive surgery. (ugr.es)

The main safety concerns in formulating hydrogels include bacterial infection and biocompatibility. (wikipedia.org)
The main hurdle in the development of injectable hydrogel for localized gene therapy is the fine balance needed between high mechanical strength and biocompatibility. (memphis.edu)
To produce high modulus hydrogel, relatively toxic chemical crosslinking approaches are often needed, which has a negative effect on the biocompatibility of the system. (memphis.edu)
DNA is an irreplaceable building block for the construction of novel 3D hydrogels, because of its multifunctional tunability, convenient programmability, adequate biocompatibility, biodegradability, capability of precise molecular recognition, and high versatility. (helsinki.fi)

The enormous diversity provided by the design of multifunctional hydrogels is realized by combining hierarchical structuring inspired by nature with the variety of materials available by engineering are of utmost significance for the desired application. (materialstoday.com)
Additionally, the review provides insights into current challenges and future directions for developing multifunctional hydrogel-based flexible electronics, which can enhance the performance and scope of applications in this emerging field. (nanowerk.com)

To overcome these limitations, here, we introduced responsive porous hydrogel microparticles loaded with 5-fluorouracil and metformin for oncotherapy. (bvsalud.org)

thermo-mechanical properties and thermo-reversibility of the MC hydrogels were investigated by rheological analysis. (polimi.it)
The thermal and rheological properties of the composite hydrogels were examined by using thermogravimetric analyzer (TGA), and differential scanning calorimetry (DSC). (onepetro.org)
Rheological properties of hydrogels produced by cellulose derivatives cross-linked with citric acid, succinic acid, and sebacic acid. (usda.gov)

Hydrogels have emerged as a promising candidate for developing bioelectronics, which interface living biological tissues with synthetic electronic systems. (nanowerk.com)

Biomimetic Heterodimerization of Tetrapeptides to Generate Liquid Crystalline Hydrogel in A Two-Component System. (acs.org)
Coordinadora del grup d'investigació "Biomimetic Supramolecular Chemistry and Materials", desenvolupa la seua activitat investigadora en el àmbit dels materials orgànics supramoleculars amb especial interés en els materials biomimetics i en la seua aplicació en biomedicina i en catàlisi. (uji.es)

Additionally, the long-term stability, temperature-related performance, and self-repairing ability of hydrogels need to be improved to meet the functional requirements of data collection and communication. (nanowerk.com)

While adding various content of gelatin and cross-linker, the mechanical properties of hydrogels show from soft and fragile (elastic modulus of 121.18 kPa and work of tension of 218.11 kJ·m−3) to rigid and tough (elastic modulus of 505.15 kPa and work of tension of 969.00 kJ·m−3). (deepdyve.com)

Various examples of hydrogel type designs include nanoparticles, nanogels, and microgels. (wikipedia.org)

Mechanical stimulation led to a significant increase in chondrogenic gene expression, while histological analysis detected sulphated glycosaminoglycans and collagen II only in loaded specimens, confirming MC hydrogel suitability to support load induced MSCs chondrogenesis. (nature.com)

Stereocomplexation is an attractive alternative to chemical crosslinking in the production of an injectable hydrogel with biological relevant mechanical strength. (memphis.edu)
Here, we demonstrate an injectable filamentous hydrogel depot (FM-depot) engineered for low dosage, sustained delivery of anti-inflammatory nanocarriers. (frontiersin.org)

In this study, we report the thermodynamics and kinetic parameters for the water absorption by thermo-elastic and self-healing polyacrylamide-commercial graphene (PAM-CG) composite hydrogels. (onepetro.org)

Methylcellulose (MC), a water-soluble polymer derived from cellulose, was investigated as a possible temporary substrate having thermo-responsive properties favorable for cell culturing. (polimi.it)

Among the investigated compositions, the hydrogel composed of 8 % w/v MC with 0.05 M Na2SO4 had a thermo-reversibility temperature at 37 °C. For that reason, this formulation was thus considered to verify the possibility of inducing in vitro spontaneous detachment of cells previously seeded on the hydrogel surface. (polimi.it)

Hydrogels are cross-linked hydrophilic polymer networks with low optical background and high loading capacity for immobilization of biomolecules. (uwaterloo.ca)

DLS measurements revealed that temperature-responsive gels prepared by ATRP have more homogeneous networks than those by free radical polymerization. (rsc.org)
In addition, the relatively higher temperature of the tumor site and the temperature -responsive shape transition of pNIPAM hydrogel enabled controllable drug release . (bvsalud.org)
We propose a design method of a micro self-rolling up structure using a temperature-responsive hydrogel sheet with rigid plate array. (elsevierpure.com)

The lack of any hydrogel-derived immunoreaction was demonstrated in vivo by mice subcutaneous implantation. (nature.com)

The macromolecules involved in the formation of hydrogels are able to absorb and retain large amounts of water and other aqueous substances. (wikipedia.org)
The crosslinking mechanism of the hydrophilic macromolecules are driven by covalent bonding, resulting in a physical- or chemical-type hydrogel. (wikipedia.org)

proposed gelatin-based hydrogel nanoparticles that were stimulated by magnetic forces. (wikipedia.org)
the IPN hydrogels showed a interpenetrated network of NIPAAm/chitosan has layers with more minute stoma and canals compared to interpenetrated network of NIPAAm/gelatin. (techno-press.org)
The hydrogel is prepared conveniently with hydroxyethyl acrylate, cross-linker, gelatin and photoinitiator, and can be printed into certain 3D patterns with the direct ink write (DIW) 3D printer designed and developed by the research group.Design/methodology/approachIn this paper, the authors designed a composite sensitization initiation system that is suitable for hydrogels. (deepdyve.com)

For the preparation of hydrogels, physical and chemical polymerization and crosslinking methods are traditionally involved. (materialstoday.com)

The calculated free energy (∆G) values are negative and hence the water absorption by the composite hydrogels is spontaneous. (onepetro.org)
The hydrogels have high capacity of water absorption. (deepdyve.com)

Hydrogel size and type are the two main properties considered in designing hydrogels when seeking the optimal delivery route for drug administration. (wikipedia.org)
Further investigation into these hydrogels' physical properties is warranted to understand their potential applications fully. (uwo.ca)
Embedded MNP offer the possibility to modulate the physical properties of the hydrogel remotely and on demand by applying an external magnetic field. (ugr.es)
Moreover, they enable permanent changes in the mechanical properties of the hydrogel, as well as alterations in the micro- and macroporosity of its threedimensional (3D) structure, with the associated potential to induce anisotropy. (ugr.es)
In mice, the hydrogels showed faster and improved self-healing properties compared to their nonmagnetic counterparts. (ugr.es)
This study presents a new approach to improving the physical and mechanical properties of supramolecular hydrogels by incorporating MNP, which confer structural reinforcement and stability, remote actuation by magnetic fields, and better injectability. (ugr.es)
These hydrogels closely mimic the mechanical, chemical, and optical properties of biological tissues, making them ideal for use in flexible electronic devices. (nanowerk.com)
Hydrogels are soft, bendable, stretchable, and possess self-healing properties due to their versatility in mechanical and bio-functional engineering. (nanowerk.com)
In this context, the latest methods for synthesizing functional hydrogels and their applications in various fields have been reviewed in Advanced Materials ( 'Hydrogel-Based Flexible Electronics' ), highlighting the relationship between hydrogel properties and device performance. (nanowerk.com)
Fan, Jun 2021-06-04 00:00:00 This paper aims to show a series of hydrogels with adjustable mechanical properties, which can be cured quickly with visible light. (deepdyve.com)
With the DIW 3D printer, pre-gel hydrogel solution can be printed into objects with certain dimension.Originality/valueIn this work, a composite sensitization initiation system was designed, and fast curing hydrogels with adjustable mechanical properties had been prepared conveniently, which has high equilibrium water content and 3D printability with the DIW 3D printer. (deepdyve.com)
To expand hydrogels' modulation ability of infraredregion, hydrogels with temperature-sensitive properties of polyvinyl alcohol (PVA) and HPC were prepared and applied in thermochromic smart windows areal. (ias.ac.in)

Human Neutrophil Elastase Responsive Delivery from Poly(ethylene glycol) Hydrogels. (anaspec.com)

Physical hydrogels contain reversible matrices of hydrogen and non-covalent bonds, while chemical hydrogels are composed of irreversible matrices that are molecularly held together by covalent bonds. (wikipedia.org)

As a result, hydrogel-based flexible electronics can better conform and interact with biological tissues and organisms than traditional electronic components, which are often rigid, dry, or incompatible with human tissues. (nanowerk.com)
The key design parameters to achieve responsive DNA hydrogels are discussed and challenges of DNA hydrogel fabrication are addressed from biological point of view. (helsinki.fi)

It was found that formulations of higher polymer content produced hydrogels that degraded upon UV light irradiation, showing promise for future applications. (uwo.ca)
In this work, we successfully prepared ultrasonic-responsive Lidocaine@PLGA microcapsule formulations by encapsulating insoluble lidocaine drugs inside the microcapsules through premix membrane emulsion (PME) combined with the water in oil in water (W/O/W) double emulsion method ( Figure 1 ). (frontiersin.org)

Intelligent hydrogels that simultaneously exhibit excellent toughness, self-healing ability and photoelectronic responsiveness are in high demand but are greatly challenging to prepare. (polymer.cn)
In addition, the PAM-CG hydrogels exhibit excellent recyclability upto eight consecutive cycles. (onepetro.org)

In vitro cytotoxicity tests, performed using L929 mouse fibroblasts, showed no toxic release from all the tested hydrogels. (polimi.it)
The use of hybrid self-assembling peptide (EFK8)-carbon nanotube (SWNT) hydrogels for tissue engineering and in vitro 3D cancer spheroid formation is reported. (uwaterloo.ca)

More importantly, Lidocaine@PLGA microcapsules had the function of ultrasonic responsive release, which made the drug release controllable with the effect of on-off administration. (frontiersin.org)

The negative entropy (∆S) ( i.e . decrease in degree of freedom), values are in line with absorption phenomenon of water molecules by the composite hydrogels. (onepetro.org)

The review provides a detailed overview of hydrogels, approaches to boost hydrogen functionality, and applications of hydrogel-based flexible electronics such as sensors, energy harvesting and storage devices, actuators, transistors, electromagnetic shielding, touch creens, and devices for controlled drug release. (nanowerk.com)

From the obtained kinetic curves, the hydrogel can absorb water upto 16,000% at 25°C and reaches the saturation in 30 h. (onepetro.org)

Another challenge is the mechanical weakness of hydrogels, which can limit their durability and performance in flexible electronics. (nanowerk.com)

Since its discovery in 1960, hydrogels have become a crucial component in biomedical research and applications. (wikipedia.org)
We demonstrate a suite of applications, encompassing self-assembling gels and cross-linked hydrogels, which can bind saccharides and modulate a range of chosen responses. (dcu.ie)
Our approach is a potential catalyst for expanding the biomedical applications of supramolecular short-peptide hydrogels. (ugr.es)
Recently, hydrogels have been used for controlled release applications. (uwaterloo.ca)
The Global Market for Hydrogels 2024-2034 provides a comprehensive analysis of the global hydrogel landscape, technologies, companies, and applications across major industry verticals. (researchandmarkets.com)
This study serves as a strategic guide for companies and investors looking to capitalize on the major growth opportunities for hydrogels across a diverse set of high-potential markets and applications. (researchandmarkets.com)
Main features of hydrogels and their applications in flexible electronics. (nanowerk.com)
In addition, potential usages of DNA hydrogels for different biomedical applications are highlighted by giving different examples of efforts intending to bring the molecule of DNA into the realm of bulk materials. (helsinki.fi)

Furthermore, by applying plasma technology, the route of chemical reactions is modified, which enables a high level of functionality as well as the formation of a hierarchical structure of the fabricated hydrogel coating. (materialstoday.com)

Since traditional hydrogels were able to encapsulate and carry materials, research into drug-loaded hydrogels began to expand in the field of drug delivery. (wikipedia.org)
Through the stimulus-responsive trigger, these materials can decompose rapidly in response to triggers, such as UV light irradiation. (uwo.ca)
The inclusion of magnetic nanoparticles (MNP) in a hydrogel matrix to produce magnetic hydrogels has broadened the scope of these materials in biomedical research. (ugr.es)
Compared to other traditional stimulate respondence, such as UV stimulus, thermal stimulus, and pH stimulus, the ultrasound-responsive materials were more applicable because of their efficient drug delivery and targeted treatment via non-invasive means. (frontiersin.org)
Various barrier materials have been studied as potential means of preventing postoperative tendon adhesion, including Seprafilm and other hydrogels. (medscape.com)

Here, we report on the fabrication of hydrogel coatings by using non-thermal gas discharges, referred to as plasma, a gaseous state in which free electrons and ionized atoms exist. (materialstoday.com)

A few examples of hydrogel use include organ regeneration, wound healing, and drug delivery. (wikipedia.org)

HEMA and DEAEMA were selected due to the presence of polymerizable structures (e.g. vinyl groups) and because of their capacities to undergo hydrogen bonding in the plasma-polymerized film leading to inter- and intramolecular cross-linking to maintain the integrity of the hydrogel, in addition to conventional cross-linking reactions during plasma polymerization, resulting in complex networked structures. (materialstoday.com)
Various methods have been investigated for realizing self-healing in hydrogels, which can be categorized under two major approaches: those based on dynamic covalent bonds that can reversibly form and break, and those based on noncovalent bonds, such as hydrogen bonding or ionic interactions. (nanowerk.com)

Cells, proteins, and therapeutic drugs are the main payloads used in hydrogel-based drug delivery platforms. (wikipedia.org)

Other variables considered in hydrogel design include safety, biodegradability, drug loading capacity, and on-demand control of drug release [23]. (wikipedia.org)

Overview of hydrogels and approaches to boost their functions for hydrogel-based flexible electronics. (nanowerk.com)

Anatomy3

Chemicals and Drugs26

Analytical, Diagnostic and Therapeutic Techniques and Equipment11

Phenomena and Processes11

Disciplines and Occupations2

Technology, Industry, Agriculture13

Smart hydrogels6

Self-healing h2

Stimuli6

Behavior6

Hybrid hydrogels1

Synthesis5

Environmentally responsive hydrogels1

Polymeric3

Polyisocyanopeptide Hydrogels1

Polymers5

Biomaterials1

Biocompatibility4

Multifunctional2

Microparticles1

Rheological3

Synthetic1

Biomimetic2

Additionally1

Elastic modulus1

Microgels1

Collagen1

Injectable2

Polyacrylamide1

Methylcellulose1

Thermo-reversibility1

Polymer networks1

Temperature-responsive3

Vivo1

Macromolecules2

Gelatin3

Preparation1

Water absorption2

Properties12

Poly1

Physical1

Biological2

Formulations2

Exhibit excellent2

Vitro2

Controllable1

Composite1

Sensors1

Absorb1

Durability1

Applications8

Hierarchical1

Materials5

Fabrication1

Wound1

Hydrogen2

Cells1

Design1

Approaches1