• Differential gene expression from exposures to both extracts were largely parallel although more pronounced for RM 6.5W. When compared to the gene expression associated with individual chemical exposures, PSD extracts produced some gene signatures parallel to PAHs but were more closely matched by oxygenated-PAHs. (pnnl.gov)
  • If omics-based assays were applied with appropriate study designs, thorough validation of the markers, and careful interpretation of study results then a bioinformatics database could be built of the human response to different chemical exposures and associated chronic diseases. (who.int)
  • This database could be useful in many ways for evaluating the risk posed by chemical exposures. (who.int)
  • By subjecting DEGs to gene ontology enrichment analysis, pathway analysis, or functional annotation, we gain insights into the biological processes, molecular functions, and pathways associated with the observed gene expression changes. (pharmiweb.com)
  • Unraveling the underlying molecular pathways enhances our comprehension of stress responses and enables the development of strategies to mitigate their impact. (pharmiweb.com)
  • The aim of this study was to identify the genes and pathways underlying the growth of the mouse sclera during postnatal development. (molvis.org)
  • We hypothesized that dust particles exert their effects by activating not only the pro-inflammatory signaling pathways but might also have an effect on the activation of development of genes important in altering DNA damage within cells. (emerging-researchers.org)
  • Conclusions The study was explorative and no a priori knowledge on gene expression pathways was considered. (bmj.com)
  • Surges of stress hormones during labor progress development of essential pathways that will enable the infant to survive outside the womb, thus implicating changes in the genome in response to stress. (biomedcentral.com)
  • We will have five integrative environmental science and engineering and biomedical research projects that will investigate toxic mechanisms, exposure pathways, biomarkers and strategies to prevent exposures and improve public health outcomes," said Runge-Morris. (eurekalert.org)
  • In zebrafish embryo model also transcriptomic analysis of the changes in the expression of genes involved in the pathways of DNA damage response, hormone metabolism, cell proliferation, apoptosis, sexual development and function, hypothalamic-pituitary-gonadal axis, growth and developmental neurotoxicity will be performed. (nib.si)
  • To investigate these effects, scientists will explore the molecular pathways that are affected in response to environmental exposure among reproductive organs. (illinois.edu)
  • There are mechanisms by which environmental exposures induces epigenetic changes by affecting regulation and gene expression. (wikipedia.org)
  • By unraveling the molecular mechanisms underpinning drug response, we can optimize treatment strategies, expedite drug discovery, and develop personalized therapies tailored to individual patients. (pharmiweb.com)
  • Organisms living in fluctuating environments or entering novel environments must possess mechanisms to cope with environmental changes. (nature.com)
  • Alternatively, organisms may develop homeostatic mechanisms to cushion the effect of environmental fluctuations without changing their phenotypes. (nature.com)
  • The dynamics of genetic variation (variance across different genotypes) and environmental variation (variance across different environments) may be controlled by different mechanisms. (nature.com)
  • Thus, there is a crucial need for an improved understanding of the molecular mechanisms underlying sexually dimorphic responses in utero, in order to effectively prevent, diagnose and treat the effects of prenatal toxicant exposure. (biomedcentral.com)
  • Epigenetic mechanisms include DNA methylation, histone modifications, and non-coding RNA molecules, all of which contribute to the regulation of gene expression. (alliedacademies.org)
  • We use molecular biology, microscopy (light, fluorescence, ultrastructural), analytical chemistry and immunocytochemistry techniques to investigate the mechanisms underlying the pathologic and functional responses to these environmental exposures. (gulfbase.org)
  • My research focuses on fish and other aquatic invertebrates and has ranged from investigating the mechanisms of toxicity of environmental chemicals using (epi)genomics approaches to understanding disease susceptibility within aquaculture. (exeter.ac.uk)
  • However, these simultaneous exposures do not elucidate the effects of Hx pre-exposure in the absence of other stimuli on macrophage priming, nor the underlying molecular mechanisms contributing to long-term effects. (frontiersin.org)
  • Comparison of PS and AS indicated that ETS exposure and active smoking in pregnancy partly employ the same molecular mechanisms. (nih.gov)
  • Since genomic plasticity in response to environmental cues is also determined by changes in gene expression mediated by epigenomic mechanisms, the genome-epigenome relationship across generations will also be uncovered. (illinois.edu)
  • However, we showed that genetics play a role in the respiratory response of asthmatic children to air pollution by potentially regulating oxidant/anti-oxidant cellular mechanisms and inflammation. (rug.nl)
  • Here, epigenetics refers to mechanisms of gene regulation that determine the state of a cell and that are heritable through cell divisions but that do not involve changes in DNA sequence. (wiringthebrain.com)
  • It is obviously true that molecular mechanisms of gene regulation effect (as in mediate) the development of an organism. (wiringthebrain.com)
  • Epigenetic mechanisms make the profiles of gene expression that define a particular cell type more stable, with different sets of genes held in active or inactive chromatin conformations. (wiringthebrain.com)
  • Importantly, such mechanisms may provide one means whereby environmental factors or particular experiences can have long-lasting effects on an organism, by changing patterns of gene expression in particular cells in a stable manner. (wiringthebrain.com)
  • Studies on the mechanisms that regulate UGT genes, in a temporal and tissue-specific manner, should contribute significantly to understanding the basis for these differences. (aspetjournals.org)
  • Genetics, infection, autoimmune mechanisms, environmental factors and psychological elements are intertwined as part of the scenario in most IBD cases. (goldbergtenerclinic.com)
  • 2007). Meanwhile, new research in the field of genetics has shown that there may be other relevant mechanisms, besides melatonin production, which are also controlled by the genes involved in maintaining the circadian rhythm (Stevens et al. (cdc.gov)
  • These results suggested that the resistance of C. albicans biofilms to azoles or polyenes was due not to the activation of specific mechanisms in response to exposure to these antifungals but rather to the intrinsic properties of the mature biofilms. (who.int)
  • MAINZ, GERMANY - An updated evidence review strengthens the concept that exposure to environmental noise from road traffic and aircraft may increase the risk for heart disease and gets at the potential underlying pathophysiologic mechanisms. (medscape.com)
  • This paper makes an important contribution to our understanding of the mechanisms of cardiovascular damage resulting from noise exposure. (medscape.com)
  • A recent focus has been on the relationship between in utero exposure to these pollutants and subsequent potentiation of atherosclerotic and allergic responses. (gulfbase.org)
  • however, the exact ways pollutants have these effects and the roles of genes related to immune function and stress response are not fully understood. (sciencedaily.com)
  • By supporting research in Precision Environmental chemicals, metals, pesticides and herbicides, air pollutants, and Health, the National Institute of Environmental Health biologically derived toxins (hazardous substances made from Sciences (NIEHS) plans to identify those who are plants, animals, and microorganisms). (medlineplus.gov)
  • My expertise lies in answering questions about how environmental pollutants interact and affect organisms. (lu.se)
  • My lab group tries to identify pollutants of concern and how exposure changes signaling systems inside organisms. (lu.se)
  • My expertise lies in answering questions about how environmental pollutants interact with organisms on a molecular level. (lu.se)
  • The main objective of research in my laboratory is to understand how environmental pollutants interfere with and change biological processes in organisms from natural, wild populations. (lu.se)
  • Our lab tries to identify which genes are affected by pollutants and how exposure changes their function. (lu.se)
  • DGE analysis elucidates how genes respond to environmental stimuli, such as heat stress, chemical exposure, or pathogen infection. (pharmiweb.com)
  • This alignment process enables the determination of the origin of each read, allowing us to associate it with specific genes or genomic regions. (pharmiweb.com)
  • My research is oriented around measuring and manipulating interactions between genes and their cellular, genomic, environmental, and community contexts giving rise to microbial population behaviours such as antibiotic resistance. (exeter.ac.uk)
  • By comparing gene expression patterns during embryogenesis or tissue differentiation, we unravel the molecular events that shape organisms, advancing our understanding of developmental biology. (pharmiweb.com)
  • Based on these results and prior studies, increased AQP9 expression may lead to increased arsenic transport in the female fetal placenta, which in turn may alter the expression patterns of key developmental genes that we have previously shown to be associated with arsenic exposure. (biomedcentral.com)
  • In the context of adipogenesis, DNA methylation patterns are dynamically regulated, leading to changes in gene expression that impact fat cell development[ 1 ]. (alliedacademies.org)
  • Studies have shown that changes in DNA methylation patterns can affect the expression of genes involved in adipocyte differentiation and lipid metabolism. (alliedacademies.org)
  • Altered histone acetylation patterns in response to dietary changes or environmental factors can disrupt the balance between appetite-stimulating and appetite-suppressing signals, potentially contributing to overeating and obesity[ 2 ]. (alliedacademies.org)
  • Using Illumina Expression Beadchip with 24,526 transcript probes, gene expression patterns were assayed in placentas from PS (N=25) exposed to environmental tobacco smoke (ETS) throughout pregnancy and non-exposed (NS) counterparts (N=35), and in cord blood cells from their newborns. (nih.gov)
  • The results showed that nine ZmCAMTA genes showed highly diversified gene structures and tissue-specific expression patterns. (frontiersin.org)
  • Accumulating evidence demonstrates that many of the 17 human UGTs characterized to date exhibit tissue-specific patterns of expression. (aspetjournals.org)
  • Using whole-genome quantitative gene expression as a model, here we study how the genetic architecture of regulatory variation in gene expression changed in a population of fully sequenced inbred Drosophila melanogaster strains when flies developed in different environments (25 °C and 18 °C). We find a substantial fraction of the transcriptome exhibited genotype by environment interaction, implicating environmentally plastic genetic architecture of gene expression. (nature.com)
  • Exploitation of germplasm resources and functional genes of Macrobrachium nipponense based on whole genome sequencing. (enaca.org)
  • In this study, we first identified all the CAMTA homologous genes in the whole genome of maize. (frontiersin.org)
  • In the present study, we investigated the molecular basis for these sex-specific responses to arsenic. (biomedcentral.com)
  • My group uses a number of biophysical approaches to elicit growth responses from fungal hyphae at the molecular and whole-cell levels. (exeter.ac.uk)
  • 2017). Molecular cloning, characterization and expression analysis of caspase-3 from the oriental river prawn, Macrobrachium nipponense when exposed to acute hypoxia and reoxygenation . (enaca.org)
  • 2015). Molecular characterization of insulin-like androgenic gland hormone-binding protein gene from the oriental river prawn Macrobrachium nipponense and investigation of its transcriptional relationship with the insulin-like androgenic gland hormone gene . (enaca.org)
  • We took advantage of a study designed to evaluate the short-term association between PM exposure in working environment and biological molecular targets to assess the correlation between PM10 exposure and gene expressions of 44 genes. (bmj.com)
  • The aims are to identify linkages between the transcriptomic profiles, concentrations, and adverse outcomes, and to identify molecular biomarkers of exposure and effects of specific group TKIs that will serve as diagnostic markers for these types of pharmaceutical exposure. (nib.si)
  • To extend our knowledge on molecular effects of tobacco smoke exposure in pregnancy, we analyzed transcriptome alterations in passive smokers (PS) and compared them to those in active smokers (AS). (nih.gov)
  • Such studies should also aid in the design of molecular probes to assess the capacity of individuals to metabolize specific drugs and toxins, before exposure to these agents. (aspetjournals.org)
  • Gene Ontology analysis in both species, for the genes that exhibited inverse transcriptomic coordination during aging pointed to alterations in the perception of smell, a known impairment occurring during aging. (nsf.gov)
  • To increase our understanding of these differentially expressed unigenes, we performed Gene ontology and KEGG pathway enrichment analyses. (biomedcentral.com)
  • Gene ontology analyses highlighted some important biological processes that might be associated with placental insufficiency and fetal growth restriction in PS, such as fatty acid catabolism, coagulation, regulation of growth, and response to steroid hormone stimulus. (nih.gov)
  • I am an environmental biologist investigating how environmental stressors affect living organisms in aquatic systems, both within natural environments and in aquaculture. (exeter.ac.uk)
  • PhD studentship (with the Salmon and Trout Association) - Endocrine disrupting chemicals (EDCs) and the sustainability of brown trout populations in the UK: relative impact of EDCs compared with other environmental stressors. (exeter.ac.uk)
  • Physician-scientist Runge-Morris is the director of the Institute of Environmental Health Sciences/Center for Urban Responses to Environmental Stressors (IEHS/CURES) at Wayne State University. (eurekalert.org)
  • These include responses to maternal care, to various kinds of stressors, including that caused by early maternal separation and to other experiences, notably drug exposure . (wiringthebrain.com)
  • He hopes politicians create laws to protect people from environmental stressors and "take into account in particular the new findings concerning noise pollution and cardiovascular disease and to acknowledge noise as a cardiovascular risk factor," he said. (medscape.com)
  • The differentiation of preadipocytes into mature adipocytes involves a series of epigenetic changes that control the expression of genes responsible for fat storage and metabolism. (alliedacademies.org)
  • 2018). Integrated metabolomic and transcriptomic analysis of brain energy metabolism in the male Oriental river prawn ( Macrobrachium nipponense ) in response to hypoxia and reoxygenation . (enaca.org)
  • 2018). Based on the metabolomic approach the energy metabolism responses of oriental river prawn Macrobrachium nipponense hepatopancreas to acute hypoxia and reoxygenation . (enaca.org)
  • In P. leucopus, alterations in genes related to cholesterol metabolism were also identified. (nsf.gov)
  • Our results suggest that cold temperature significantly affects genes related to protein translation and cellular metabolism in this chilling sensitive species. (biomedcentral.com)
  • Conclusions There is significant and sex-specific natural genetic variation in the transcriptional response to developmental exposure to ethanol in Drosophila that comprises networks of genes affecting nervous system development and ethanol metabolism as well as networks of regulatory non-coding RNAs. (clemson.edu)
  • The signals that are maintained beyond the F2/F3 generation are referred to as transgenerational epigenetic inheritance (TEI), because initial environmental stimuli resulted in inheritance of epigenetic modifications. (wikipedia.org)
  • The calmodulin-binding transcription activators (CAMTA) play critical roles in plant growth and responses to environmental stimuli. (frontiersin.org)
  • In the plants being exposed to environmental stresses, ion channels are likely activated to convert these external stimuli into intracellular signals. (globalsciencebooks.info)
  • When Ca2+ channels are activated in response to a variety stimuli, a drastic increase in the [Ca2+]c is induced and the entered free Ca2+ binds to the sets of Ca2+-regulated proteins such as calmodulin and calcium dependent protein kinases to modify the activities or affinities of these proteins in binding to specific targets. (globalsciencebooks.info)
  • In genetics and genomics research, gene expression refers to the process by which information encoded in a gene's DNA sequence is converted into functional proteins or RNA molecules. (pharmiweb.com)
  • Instead, it involves modifications to the structure of DNA and associated proteins, which can silence or activate genes. (alliedacademies.org)
  • We investigated the role of genes encoding proteins involved in epithelial integrity, chronic airway inflammation and airway remodeling in asthma. (rug.nl)
  • The types of gene expression affected (e.g., genes involved in cell cycle arrest, apoptosis and stress responses, heat-shock proteins) are consistent with the findings that EMF causes genetic damages. (saferemr.com)
  • Another important finding is the expression of heat shock proteins, particularly HSP70, which is an important protein involved in protein misfolding and protecting cells from environmental stress. (saferemr.com)
  • The UGT1 family constitutes a complex gene locus on human chromosome 2q37 and comprises 13 first exons that encode the unique N-terminal domains of the UGT1A proteins and exons 2 to 5 that encode the C-terminal domain, which is identical in all UGT1A family members ( Owens and Ritter, 1992 ). (aspetjournals.org)
  • Although, the number of omic techniques is ever expanding, the most developed omics technologies are high throughput DNA sequencing, transcriptomics (focused on gene expression), epigenomics (focused on epigenetic regulation of gene expression), proteomics (focused on large sets of proteins, the proteome) and metabolomics (focused on large sets of metabolites, the metabolome). (who.int)
  • There, I visited Dr. Mark Hahn's lab and performed functional analyses of the Atlantic salmon AHR genes and their expressed proteins in order to find out more about their role in the mediation of toxicity from dioxin exposure. (lu.se)
  • In all of these instances, some environmental trigger or experience induces a response in an animal. (wiringthebrain.com)
  • 2013). Transcriptome analysis of androgenic gland for discovery of novel genes from the oriental river prawn, Macrobrachium nipponense , using Illumina Hiseq 2000 . (enaca.org)
  • Abstract Background Genes that belong to the same network are frequently co-expressed, but collectively, how the coordination of the whole transcriptome is perturbed during aging remains unclear. (nsf.gov)
  • To explore this, we calculated the correlation of each gene in the transcriptome with every other, in the brain of young and older outbred deer mice (P. leucopus and P. maniculatus). (nsf.gov)
  • . pilosum and a de novo assembled transcriptome, which can be used to characterize genes related to diverse biological processes. (biomedcentral.com)
  • Modulation of the Drosophila transcriptome by developmental exposure t" by Vijay Shankar, Tatiana V. Morozova et al. (clemson.edu)
  • In addition, the authors say a transcriptome analysis of aortic tissues from animals exposed to aircraft noise revealed changes in the expression of genes responsible for the regulation of vascular function, vascular remodeling, and cell death. (medscape.com)
  • Differential Gene Expression analysis is a fundamental tool for identifying genes whose expression levels significantly differ between experimental conditions or biological samples. (pharmiweb.com)
  • 6 ], the transforming growth factor beta 1 ( Tgfβ1 ) gene and several collagen genes were significantly downregulated in 8-week-old B6 mice scleras when compared with 3-week-old B6 mice scleras. (molvis.org)
  • A total of 196 genes were significantly deregulated in placentas of PS compared to NS. (nih.gov)
  • But even that level of exposure, reported DMS graduate student Courtney Kozul, affects the expression of genes involved in the immune response in mice. (dartmouth.edu)
  • Resistance to white spot syndrome virus in the European shore crab is associated with suppressed virion trafficking and heightened immune responses. (exeter.ac.uk)
  • The CLEAR team hypothesizes that VOC exposure through vapor intrusion early in life incites inflammatory responses in maternal tissues as well in the developing offspring that reprogram the developing immune system and other critical systems, setting the stage for preterm birth and/or associated adverse health outcomes. (eurekalert.org)
  • The gene Nrf2 is known to affect immune function and stress response in adults, but research on the effects of this gene in infants and children has been explored less. (sciencedaily.com)
  • The researchers also analyzed lung and liver tissue from the offpsring to measure differences in certain immune markers and expression of genes related to oxidative stress response. (sciencedaily.com)
  • This highlights a need for further research into the roles of genes on immune and stress response and how those genes interact with environmental factors. (sciencedaily.com)
  • 2019). Evaluating expression of autophagy-related genes in oriental river prawn Macrobrachium nipponense as potential biomarkers for hypoxia exposure . (enaca.org)
  • The aims of the proposed project are to evaluate the consumption and predict environmental occurrence of TKIs that are currently registered for cancer therapy in Slovenia and to explore their genotoxic and endocrine disrupting potential. (nib.si)
  • Our research interests are focused on various contaminants, including endocrine disrupters derived from plastics, and exposure effects from chemicals used in urban environments. (lu.se)
  • Furthermore, de Silva is working with Ralph Baric 's group to characterize vaccine responses. (unc.edu)
  • To characterize that risk, it is necessary to understand the ecological factors that determine the exposure chances of birds to treated seeds. (bvsalud.org)
  • OBJECTIVE: Our purpose was to characterize the exposure-response relationship with a focus on the effects of timing of exposure and exposure cessation. (cdc.gov)
  • Epigenetic gene regulation is a proposed mechanism by which early life exposures affect later health outcomes. (biomedcentral.com)
  • The Center will be dedicated to understanding and mitigating adverse birth outcomes and serious developmental health problems that have been associated with urban environmental exposure to volatile organic chemcials (VOCs), a special class of pollutant found in the subsurface of post-industrial cities like Detroit. (eurekalert.org)
  • CLEAR will provide new methods for assessment, testing and mitigation to help reduce toxic exposures and improve health outcomes. (eurekalert.org)
  • We will apply advanced analysis methods and tools to determine the impact of VOC exposures on preterm birth and other adverse health outcomes. (eurekalert.org)
  • The study demonstrated positive associations between VOC exposures and adverse birth outcomes which have been noted in other studies in the United States, Canada, France, Brazil and Spain. (eurekalert.org)
  • By leveraging combinations of resources that are unique to Illinois, EIRH will address critical gaps in knowledge about the impact of exposure to EDCs, high fat diets, and stress on pregnancy outcomes and reproductive health. (illinois.edu)
  • In the hypothalamus, histone modifications have been linked to the regulation of genes involved in appetite control and energy homeostasis. (alliedacademies.org)
  • Genetic variance in expression increases at 18 °C relative to 25 °C for most genes that have a change in genetic variance. (nature.com)
  • Finally, although genotype by environment interaction in gene expression could potentially disrupt genetic networks, the co-expression networks are highly conserved across environments. (nature.com)
  • In addition to environmental factors, phenotypes can also respond to genetic perturbations in a plastic or homeostatic manner, which characterizes the potential of an organism to express phenotypes when genes mutate. (nature.com)
  • Importantly, the state of plasticity or homeostasis, with respect to either genetic or environmental variation, is not necessarily static and can be modified by both genetic and environmental factors. (nature.com)
  • Change in genetic variation across environments is one of the many forms of genotype by environment interaction (G×E). G×E can be interpreted equivalently either as variable genetic architecture across environments or as variable environmental plasticity across genotypes, depending on what factor is chosen as the context. (nature.com)
  • To accomplish the complex tasks, the project consortium comprises partners with complementary expertise in the fields of aquatic and genetic toxicology, and genomics with bioinformatics (NIB), toxicology, pharmacology and in silico predictive models (FFA) and environmental occurrence predictions based on consumption and use of these drugs (IO). (nib.si)
  • However, these relationships are not well established from past clinical studies that have had limited capacity to control for the effects of variable genetic predisposition and early environmental exposures. (nih.gov)
  • Notably, a large number of stress-related elements present in the promoter regions of some ZmCAMTA genes, indicating a genetic basis of stress expression regulation of these genes. (frontiersin.org)
  • Genetic effects of EMF depend on various factors, including field parameters and characteristics (frequency, intensity, wave-shape), cell type, and exposure duration. (saferemr.com)
  • Other data, such as adaptive effects and mitotic spindle aberrations after EMF exposure, further support the notion that EMF causes genetic effects in living organisms. (saferemr.com)
  • Identifying genetic risk alleles for FASD is challenging since time, dose, and frequency of exposure are often unknown, and manifestations of FASD are diverse and evident long after exposure. (clemson.edu)
  • Drosophila melanogaster is an excellent model to study the genetic basis of the effects of developmental alcohol exposure since many individuals of the same genotype can be reared under controlled environmental conditions. (clemson.edu)
  • We found substantial genetic variation in gene expression in response to ethanol with extensive sexual dimorphism. (clemson.edu)
  • We constructed sex-specific genetic networks associated with alcohol-dependent modulation of gene expression that include protein-coding genes, Novel Transcribed Regions (NTRs, postulated to encode long non-coding RNAs) and female-specific coordinated regulation of snoRNAs that regulate pseudouridylation of ribosomal RNA. (clemson.edu)
  • The first phase of TaRGET and drugs, how an individual's genetic makeup interacts focused on how environmental exposures affect epigenetic with the environment, and how those affect their health. (medlineplus.gov)
  • Our research is also focused on genetic biodiversity and if specific allelic variants can be linked to observed responses. (lu.se)
  • Although the majority of expression quantitative trait loci (eQTLs) for the gene expression traits in the two environments are shared and have similar effects, analysis of the environment-specific eQTLs reveals enrichment of binding sites for two transcription factors. (nature.com)
  • 2018). Validation and evaluation of reference genes for Quantitative real-time PCR in Macrobrachium nipponense . (enaca.org)
  • Quantitative real-time PCR was used to test the expression of ZmCAMTA genes under several abiotic stresses (drought, salt, and cold), various stress-related hormones [abscisic acid, auxin, salicylic acid (SA), and jasmonic acid] and biotic stress [rice black-streaked dwarf virus (RBSDV) infection]. (frontiersin.org)
  • In particular, exposure to CAS resulted in the upregulation of hypha-specific genes known to play a role in biofilm formation, such as ALS3 and HWP1. (who.int)
  • CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
  • By identifying target genes for where toxic responses originate we can make better predictions about resulting effects both on a short and long term scale. (lu.se)
  • The peroxisome proliferator- activated receptor gamma coactivator 1-alpha ( Ppargc1a ) gene was found to be involved in the networks generated using Ingenuity Pathway Studio (IPA) from the differentially expressed transcript cluster lists of week 2 versus 1, week 3 versus 2, week 6 versus 3, and week 8 versus 6. (molvis.org)
  • For instance, hypermethylation of the promoter region of the Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) gene, a master regulator of adipogenesis, can suppress its expression, impairing fat cell formation. (alliedacademies.org)
  • Additionally, collaborative studies will utilize bioengineering tools to direct cell clusters towards in vitro formation of complex, three-dimensional (3D) organoids to explore the impact of environmental factors on reproductive function. (illinois.edu)
  • The most interesting results are the expression of genes related to stress response both in vitro and in vivo in plans and animals. (saferemr.com)
  • The activity of antioxidant enzymes was not altered by benoxacor exposure. (cdc.gov)
  • Using NanoString technology, we further analyzed the fetal placenta samples from the NHBCS for the expression of genes encoding arsenic transporters and metabolic enzymes. (biomedcentral.com)
  • Unlike other plants, the genes encoding enzymes CDPS, KS and KO were reported to be present in duplicate functional forms in Stevia . (scialert.net)
  • By analyzing the expression levels of thousands of genes simultaneously, researchers can identify genes that are upregulated (higher expression) or downregulated (lower expression) in one condition compared to another. (pharmiweb.com)
  • Statistical methods are employed to identify genes that exhibit significant changes in expression between experimental conditions. (pharmiweb.com)
  • When studying gene expression, researchers often compare gene expression profiles between different biological samples or experimental conditions, such as healthy and diseased tissues, treated and untreated cells, or different developmental stages. (pharmiweb.com)
  • In general, mRNA levels of ECM and collagen genes have been found to be downregulated in both the adult mouse sclera [ 6 ] and cornea [ 7 ] when compared with samples from an earlier developmental stage. (molvis.org)
  • In a previous report using the resources of the New Hampshire Birth Cohort Study (NHBCS), we found that low-to-moderate i n utero exposure to arsenic, a highly toxic and widespread pollutant, was associated with altered expression of several key developmental genes in the fetal portion of the placenta. (biomedcentral.com)
  • Multivariable linear regression analysis was used to examine their relationship with arsenic exposure and with key developmental genes, after stratification by fetal sex. (biomedcentral.com)
  • Passive Sampling device (PSD) extracts paired with developmental toxicity assays in Danio Rerio (zebrafish) are excellent sensors for whole mixture toxicity associated with the bioavailable non-polar organics at environmental sites. (pnnl.gov)
  • We reared DGRP lines which showed extreme upregulation or downregulation of snoRNA expression during developmental alcohol exposure on standard or ethanol supplemented medium and demonstrated that developmental exposure to ethanol has genotype-specific effects on adult locomotor activity and sleep. (clemson.edu)
  • Environmental Pollution, Vol. 243, pp. 1154-1165. (enaca.org)
  • Environmental Science and Pollution Research. (monash.edu)
  • Environmental Pollution. (monash.edu)
  • We further focused on the susceptibility of asthmatic children to ambient air pollution, an unavoidable environmental exposure of the modern world. (rug.nl)
  • We showed associations of long-term air pollution (carbon monoxide and nitrogen dioxide) exposure with severity of airflow obstruction and airway hyper-responsiveness in children with asthma. (rug.nl)
  • Veterinary drugs are of concern in terms of potential environmental pollution and their negative impacts on avian scavengers. (bvsalud.org)
  • Exposure to pollution during pregnancy can have many adverse effects in infants and children that can even extend into adulthood. (sciencedaily.com)
  • For example, air pollution exposure is associated with increased risk of low birth weight, preterm birth and risk for developing asthma later in life. (sciencedaily.com)
  • Natalie Johnson, PhD, associate professor at the Texas A&M School of Public Health, along with Carmen Lau, DVM, Jonathan Behlen and others exposed animal models modified to lack the Nrf2 gene and unmodified animal models to particulate pollution like that found in diesel exhaust. (sciencedaily.com)
  • Exposure to pollution had no notable effects in unmodified animal models, which may indicate Nrf2 playing some protective role during pregnancy. (sciencedaily.com)
  • Although more work lies ahead, this study demonstrates that the absence of a functioning Nrf2 gene affects prenatal growth of animal models, especially when exposed to ultrafine particulate air pollution in utero. (sciencedaily.com)
  • Surprisingly, however, the majority of primed genes were not enriched for H3K4me3 acutely following hypoxia exposure. (frontiersin.org)
  • These two usages thus relate to very different levels - one refers to the profile of gene expression of individual cell types and the other to the emergence of the phenotype of the organism. (wiringthebrain.com)
  • Now, clearly, the phenotype of an organism depends largely (though by no means completely) on the profile of gene expression of its constituent cells. (wiringthebrain.com)
  • And there are indeed a number of examples where the behavioural phenotype of an organism has been linked to the epigenetic state of particular genes in cells in particular brain regions. (wiringthebrain.com)
  • For their research, the team applied a technique called luciferase reporting, which involves exploiting an enzyme that produces bioluminescence, to allow the researchers to visualize how active a gene is inside an organism. (genengnews.com)
  • For example, histone H3K4 trimethylation (H34me3) and a network of lipid metabolic genes interact to increase the transcription response to TEI obesogenic effects. (wikipedia.org)
  • On the other hand, hypomethylation of genes associated with lipid storage and adipocyte development can promote adipogenesis. (alliedacademies.org)
  • Thus, it is critically important to understand how exposure to EDCs affects fertility and establishment of pregnancy. (illinois.edu)
  • In a study published in the journal Antioxidants , researchers from Texas A&M University and the University of Florida worked to clarify how a gene related to oxidant response known as Nrf2 affects fetal development in an experimental model. (sciencedaily.com)
  • These findings provide evidence that hypoxia pre-exposure could lead to persistent and aberrant inflammatory responses in the context of CNS disorders. (frontiersin.org)
  • suggesting a mechanism whereby Hx could have long-term effects on microglial inflammatory responses. (frontiersin.org)
  • T cells mediate the inflammatory responses observed in asthma among genetically susceptible individuals and have been suspected to be prone to epigenetic regulation. (nih.gov)
  • The present study provides in vivo evidence that a GSH mediated pathway underlies asthma-like eosinophilic inflammatory responses to respiratory tract isocyanate exposure. (cdc.gov)
  • Together, the data support a possible thiol mediated transcarbamoylating mechanism linking MDI exposure to pathogenic eosinophilic inflammatory responses. (cdc.gov)
  • The dosage and exposure levels can affect the extent of the environmental factors' influence over the epigenome and its effect on later generations. (wikipedia.org)
  • After identifying Differentially Expressed Genes (DEGs), we delve deeper into their functional significance. (pharmiweb.com)
  • Presence of two functional copies of these genes has suggested their efficient role in steviol glycoside biosynthesis pathway as well. (scialert.net)
  • Penn A, Rouse R, Horohov D, Paulsen D., Lomax L and Kearney, M. In utero exposure to environmental tobacco smoke potentiates adult responses to allergen in Balb/c mice. (gulfbase.org)
  • Regulatory T cell (Treg) and effector T cell (Teff) subsets were assessed for levels of cellular function, protein expression, gene expression and CpG methylation within Forkhead box P3 (FOXP3) and interferon gamma-γ (IFNγ) loci. (nih.gov)
  • Scientific and policy developments regarding the health effects of electromagnetic radiation exposure from cell phones, cell towers, Wi-Fi, Smart Meters, and other wireless technology including 5G, the fifth generation of cellular technology. (saferemr.com)
  • The UGT content of cells and tissues is a major determinant of our response to those chemicals that are primarily eliminated by conjugation with glucuronic acid. (aspetjournals.org)
  • Study on the function and interaction of four sex-related genes in Macrobrachium nipponense . (enaca.org)
  • 5, 5-9, 10-19, and 20 y prior to death/reference date, and we evaluated the interaction of cumulative exposure across time windows under additive and multiplicative forms for the joint association. (cdc.gov)
  • Thus, this study suggests that AQP9 may play a role in the sex-specific effects of in utero arsenic exposure. (biomedcentral.com)
  • Humans can be exposed to these environmental contaminants through inhalation of airborne particulate matter (PM) that may provoke respiratory diseases and other adverse effects. (emerging-researchers.org)
  • Their presence in the environment may lead to systemic environmental effects, while in exposed humans increased cancer incidence and reproductive defects may occur. (nib.si)
  • In zebrafish embryos we will determine lethal and sublethal effects of the selected TKIs to obtain parameters (lethal concentration (LC)50, no adverse effect concentration (NOAEC)) needed for environmental and human health risk assessment. (nib.si)
  • Environmental exposures, particularly during pregnancy, can have long-lasting and devastating health impacts and exert long-ranging effects on maternal and child health. (illinois.edu)
  • Gas exchange was monitored every 10 days, and at harvest, bioaccumulation of Ce and Zn in tissues was determined by ICP-OES/MS. The effects of NPs exposure on nutrient concentration and distribution in ears were also evaluated by ICP-OES and μ-XRF. (acs.org)
  • Many studies reported effects in cells and animals after exposure to EMF at intensities similar to those in the public and occupational environments. (saferemr.com)
  • Given the sensitivity of -omic analyses, low- dose adverse effects could also be observed and distinguished from high dose phenomena, and if exposures were accurately assessed, dose-response data could be incorporated into risk assessments. (who.int)
  • Because of the risk for severe autoimmune adverse effects, it is reserved for use in patients who have an inadequate response to two or more other drugs for MS. (medscape.com)
  • The genetics of phenotypic responses to changing environments remains elusive. (nature.com)
  • Introduction The association of gene expressions with exposure to ambient particulate matter (PM) concentrations is still mainly explorative. (bmj.com)
  • Several parties submitted comments, both written and verbal, in response to the Agency for Toxic Substances and Disease Registry's (ATSDR) Public Health Response Plan (PHRP) for the Midlothian site. (cdc.gov)
  • These overlapping splicing events impacted multiple genes involved in phototransduction and neuronal function. (nsf.gov)
  • Cord blood of newborns of PS displayed differential expression of 116 genes encoding mainly neuronal factors, regulators of immunologic response, and protooncogenes. (nih.gov)
  • The ICE1-CBF-COR transcriptional cascade (inducer of CBF expression 1 and C-repeat binding factor transcriptional cascade) is the best characterized pathway for gene regulation under cold conditions in many species [ 8 ]. (biomedcentral.com)
  • In present study, we analyzed the effect of varying sucrose (1, 3 and 5%) concentrations on the genes involved in steviol glycoside biosynthesis pathway and content of steviol glycosides. (scialert.net)
  • Present work thus suggests that sucrose might be acting as an enhancer of transcriptional trigger to the genes of steviol glycoside biosynthesis pathway that could positively manipulate the production of steviol glycosides. (scialert.net)
  • The circadian rhythm is a pattern of approximately 24 hours with characteristic physiologic and metabolic cycles of, among many other attributes, body temperature, hormone secretion, sleep/wake cycle, alertness, and gene expression (Takahashi et al. (cdc.gov)
  • Conclusions There sults suggest that aging is associated with more stringent retention of expression profiles for some genes and more abrupt changes in others, while more subtle but widespread changes in gene expression appear protective. (nsf.gov)
  • At the core of his interest are multi-drug efflux pumps and gene expression programmes that mediate bacterial survival and adaptation to antibiotic exposure. (exeter.ac.uk)
  • RNAseq analysis identified 163 hepatic genes affected by benoxacor exposure. (cdc.gov)
  • Hypermethylation of specific CpG sites in the promoter regions of genes can silence their expression, while hypomethylation can activate gene transcription. (alliedacademies.org)
  • We then surveyed the distribution of stress-related cis -regulatory elements in the −1.5 kb promoter regions of ZmCAMTA genes. (frontiersin.org)
  • The gene expression of Ppargc1a varied during scleral growth from week 1 to 2, week 2 to 3, week 3 to 6, and week 6 to 8 and was found to interact with a different set of genes at different scleral growth stages. (molvis.org)
  • We found that maternal arsenic exposure was strongly associated with expression of the AQP9 gene, encoding an aquaglyceroporin transporter, in female but not male fetal placenta. (biomedcentral.com)
  • Expression of distinct maternal and somatic 5.8S, 18S, and 28S rRNA types during zebrafish development. (uva.nl)
  • The ETS exposure was evaluated by questionnaire disclosure and cotinine measurement in maternal and cord bloods. (nih.gov)
  • Exposure to tobacco smoke was further evaluated by measurement of plasma cotinine levels in maternal peripheral blood and newborn cord blood using radioimmunoassay. (nih.gov)
  • Hypoxia Gill remodelling Respiration Phenotypic plasticity Mangrove rivulus Kryptolebias marmoratus National Sciences and Engineering Research Council of Canada Spatial and temporal environmental heterogeneity creates a fundamental. (silverchair.com)
  • Rouse R, Boudreaux M and Penn A. In utero environmental tobacco smoke (ETS) exposure alters gene expression in lungs of adult Balb/c mice. (gulfbase.org)
  • Our results highlight the need to incorporate field ecology into the characterization of pesticide exposure to improve the efficacy of environmental risk assessment. (bvsalud.org)
  • Based on an extensive historical exposure assessment, we estimated respirable elemental carbon (REC), an index of diesel exposure, for each cohort member. (cdc.gov)
  • Improving the regulatory environmental risk assessment of human pharmaceuticals: Required changes in the new legislation. (janusinfo.se)
  • Sex-specific factors play a major role in human health and disease, including responses to environmental stresses such as toxicant exposure. (biomedcentral.com)
  • However, how CAMTAs function in responses to abiotic and biotic stresses in maize ( Zea mays L.) is largely unknown. (frontiersin.org)
  • The expression of most ZmCAMTA genes responded to both abiotic and biotic stresses. (frontiersin.org)
  • The data will help us to understand the roles of CAMTA-mediated Ca 2+ signaling in maize tolerance to environmental stresses. (frontiersin.org)
  • Perturbations in environmental fields can induce changes in organisms informed by those fields. (blogs.com)
  • Abstract Background Prenatal exposure to ethanol can cause fetal alcohol spectrum disorder (FASD), a prevalent, preventable pediatric disorder. (clemson.edu)
  • In conclusion we found an association of PM10 exposure with NFKB1 expression in a occupational context of high ambient concentrations. (bmj.com)
  • A significant increase of the bpm in adults exposed to high concentrations of smoked CB leachate was observed after 48 h of exposure. (easychair.org)
  • This analysis enables us to pinpoint genes that play pivotal roles in phenotypic variation, disease development, or response to treatments. (pharmiweb.com)
  • A classic example is the heat shock protein system, particularly Hsp90 , whose expression is environmentally plastic and increases under thermal stress, but buffers phenotypic changes induced by mutations to maintain homeostasis 2 , a process termed canalization 3 . (nature.com)
  • In particular, he is interested in deciphering bacterial responses towards antibiotics that are enabled by phenotypic heterogeneity in otherwise clonal populations. (exeter.ac.uk)
  • We incorporate diverse approaches in experimental evolution, mathematics, systems microbiology, engineering and instrumentation to understand how interactions between cells shape bacterial community behaviours, the value of environmental sensing and phenotypic variation in fluctuating environments, and how phenotypes broadly respond to mutation. (exeter.ac.uk)
  • 2015). Transciptomic and histological analysis of hepatopancreas, muscle and gill tissues of oriental river prawn ( Macrobrachium nipponense ) in response to chronic hypoxia . (enaca.org)
  • I think there is no doubt anymore that chronic noise exposure, in particular nighttime noise, can cause coronary disease, heart failure, stroke, and arterial hypertension. (medscape.com)
  • Genes encode and express themselves via light and radio waves, or acoustical holography (see " Quantum Bioholography", Miller, Miller and Webb, JNLRMI , 2002 ). (blogs.com)
  • Researchers can use ENCODE data-- are associated with epigenetic changes that may lead to which has been combined with other data, such as cancer, cardiovascular diseases, autoimmune diseases, environmental information--to better understand diseases and neurological disorders. (medlineplus.gov)