• outcomes
  • Although various psychotherapies, either alone or integrated, are preferred modes of treatment for this group of patients, the effects of psychotherapies on BPD outcomes are small to medium. (frontiersin.org)
  • One augmentation will target stasis outcomes through the addition of specific 'if-then' planning (known as implementation intentions) when setting between-session homework and the other augmentation will target patient drop-out by informing patients about group BA effectiveness and therapy-dose evidence. (clinicaltrials.gov)
  • A one-armed quasi-experimental trial will be used to test the effect of two embedded behavioural activation group (BAG) treatment augmentations on treatment outcomes and to identify a potential outcome mediator for patients with a stasis outcome. (clinicaltrials.gov)
  • Although at first glance the efficacy of all biologicals appears to be the same, in routine practice one might expect there to be differences in effectiveness, safety profiles and specific patient-centered outcomes. (biomedcentral.com)
  • These patient-centered outcomes, as well as safety, deserve further attention in follow-up registries, but also in prospective studies, if we are to optimize patient care. (biomedcentral.com)
  • Biologicals are often compared solely based on their level of efficacy in RA, by measuring Disease Activity Score and American College of Rheumatology (ACR) responses at fixed time points, without considering differences in mechanisms of action, in efficacy and safety profiles, and in administration, or patient preferences and patient reported outcomes. (biomedcentral.com)
  • Our central hypothesis, is that PLWAs can be effective members of the health care team and that their involvement in community-based HIV care will facilitate patient access to services and improve outcomes. (clinicaltrials.gov)
  • In this issue of Clinical Cancer Research , Jain and colleagues ( 1 ) report an analysis of a selection of phase 1 trials at MD Anderson Cancer Center, investigating differences in clinical outcomes as a function of dose, in which patients were categorized as having been treated at low dose [≤25% maximum-tolerated dose (MTD)], medium dose (25-75% MTD), or high dose (≥75% MTD). (aacrjournals.org)
  • Disease and exposure-response models are used to understand the relationship between treatment, biomarker changes and clinical outcomes. (wikipedia.org)
  • treatment
  • However, in the psychiatric group, significantly more patients received anti-depressants before and during treatment with IFN- (P (natap.org)
  • No patient in the psychiatric group had to discontinue treatment because of psychiatric deterioration. (natap.org)
  • In conclusion, our data do not confirm the supposed increased risk for IFN--induced mental side effects and dropouts in psychiatric patients if interdisciplinary care and antidepressant treatment are available. (natap.org)
  • Combination treatment with IFN- and ribavirin has not yet been evaluated in a controlled manner in psychiatric patients and those with a former drug addiction. (natap.org)
  • We studied compliance with treatment, side effects, response rates, and dropout rates during combination treatment of chronic hepatitis C in patients with psychiatric disorders, former drug addiction, or ongoing methadone substitution compared with controls without a psychiatric history or drug addiction. (natap.org)
  • During the 6 months after the end of therapy, 11% (only genotypes 1 and 3) of all patients experienced a relapse without significant differences between treatment groups. (natap.org)
  • When these patients exhibit symptoms such as aggressiveness, impulsivity, intense anxiety, severe depression, self-harm, and suicidal attempts or gestures, diagnosis, and treatment of the BPD becomes challenging for ED doctors. (frontiersin.org)
  • Proper risk management along with developing a positive attitude and empathy toward these patients will help them in normalizing in an emergency setting after which treatment course can be decided. (frontiersin.org)
  • Any articles that reported the patient of borderline personality disorder (BPD), crisis intervention in the Emergency departments (EDs) and beyond in terms of acute and long-term treatment plan. (frontiersin.org)
  • HIV-infected patients taking cenicriviroc had significant reductions in viral load, with the effect persisting up to two weeks after discontinuation of treatment. (wikipedia.org)
  • We established a semimechanistic PK/PD model to better understand the effect of LAN on a surrogate endpoint (serum CgA) and ultimately the clinical endpoint (PFS) in treatment-naive patients with nonfunctioning GEP-NETs. (pubmedcentralcanada.ca)
  • The ideal initial treatment is surgical removal of the tumor, but as many patients have inoperable tumors, medical therapy is required. (pubmedcentralcanada.ca)
  • Combination treatment of afatinib and nimotuzumab demonstrated an acceptable safety profile and encouraging antitumor activity in advanced NSCLC patients with acquired resistance to gefitinib or erlotinib. (aacrjournals.org)
  • Patients are randomized to 1 of 2 treatment arms. (clinicaltrials.gov)
  • After completion of study treatment, patients are followed up every 8 weeks. (clinicaltrials.gov)
  • Objective To investigate the long-term effects of the tight control (TC) and conventional (CT) methotrexate-based strategies of the Computer Assisted Management in Early Rheumatoid Arthritis trial in early rheumatoid arthritis and evaluate the predictive value of an early response to treatment. (bmj.com)
  • The prognostic value of early response to treatment in addition to established predictors was analysed by multiple linear regression analyses. (bmj.com)
  • Multiple regression analysis showed that early response to treatment is an independent predictor of 5-year outcome, irrespective of treatment strategy. (bmj.com)
  • Good-response to treatment independently predicts significantly better 5-year clinical and radiographic outcome. (bmj.com)
  • The purpose of this study is to 1) identify depression stasis prevalence and predictors in an existing evidenced-based group treatment for depression, 2) run a clinical trial to test whether an embedded intervention based on theoretical and clinical practice evidence can help reduce patient depression stasis and drop-out rates and 3) understand what aspect of therapy produces change (or prevents change in stasis). (clinicaltrials.gov)
  • Firstly, an archived anonymised dataset of routine depression measures from patients who have previously received the existing group BA treatment will be analysed. (clinicaltrials.gov)
  • Secondly, the group BA treatment delivered to patients in 2017 will be enhanced with two treatment augmentations. (clinicaltrials.gov)
  • Treatment of patients infected with chronic hepatitis C genotype 2 and 3: More data, more questions? (wiley.com)
  • 1 , 2 Important predictive factors associated with treatment response, irrespective of genotype, include age, gender, weight (body mass index [BMI]), biochemical and histologic characteristics of the patients, and RBV dose. (wiley.com)
  • 3 Therefore, current guidelines recommend a 24-week treatment for patients infected with genotype 2 and 3 in contrast to 48 weeks for patients infected with genotype 1 and 4. (wiley.com)
  • Because of substantial side effects and costs associated with this therapy, several studies have attempted to determine the possibility to further reduce the treatment duration in patients with HCV genotype 2 and 3. (wiley.com)
  • However, differences in study design (fixed versus variable duration treatment strategy), in baseline patient characteristics (e.g., age, BMI), histology (fibrosis) and treatment modalities (RBV dose) have made their collective interpretation difficult (Table 1 ). (wiley.com)
  • To describe the frequency and duration of remission in the Utrecht rheumatoid arthritis cohort of patients followed since diagnosis, and the clinical and treatment characteristics of patients with remission v those without. (bmj.com)
  • Predictors of remission were early response to initial treatment, less pain, rheumatoid factor negativity, and lower joint score at baseline. (bmj.com)
  • A good response to treatment during the first year seems to be independently associated with remission rather than initial treatment alone. (bmj.com)
  • After failing a first tumor necrosis factor blocker, patients have several treatment options - starting a second tumor necrosis factor blocker, or rituximab or abatacept - but no formal randomized studies are available to indicate what is the optimal strategy. (biomedcentral.com)
  • It is clear, however, that every additional targeted therapy creates new opportunities for treatment in many different patient populations. (biomedcentral.com)
  • Compared with the TNF blockers, rituximab has a different treatment schedule (intermittent) and a different response profile, characterized by more gradual onset of beneficial effect, beginning only a few months after infusion. (biomedcentral.com)
  • In this issue of Clinical Cancer Research , Jain and colleagues provide evidence that lower doses may be as effective as maximum-tolerated doses in the treatment of cancer patients. (aacrjournals.org)
  • The results indicate that time to treatment failure and response within 3 to 12 months after starting the trial were similar in patients treated at low, medium, and high dose levels. (aacrjournals.org)
  • Clozapine is an effective treatment for those who respond poorly to other drugs, but it has the potentially serious side effect of agranulocytosis (lowered white blood cell count) in 1-4% of patients. (wikipedia.org)
  • It is normally applied to quantify drug, disease and trial information to aid efficient drug development, regulatory decisions and rational drug treatment in patients. (wikipedia.org)
  • A nocebo effect is said to occur when negative expectations of the patient regarding a treatment cause the treatment to have a more negative effect than it otherwise would have. (wikipedia.org)
  • In the narrowest sense, a nocebo response occurs when a drug-trial subject's symptoms are worsened by the administration of an inert, sham, or dummy (simulator) treatment, called a placebo. (wikipedia.org)
  • Intention to treat analyses are done to avoid the effects of crossover and dropout, which may break the random assignment to the treatment groups in a study. (wikipedia.org)
  • Another approach would be efficacy subset analysis which selects the subset of the patients who received the treatment of interest-regardless of initial randomization-and who have not dropped out for any reason. (wikipedia.org)
  • In one study, poor early management was reported to be a main risk factor for severe CFS (delayed diagnosis, poor response to analgesics, physiotherapy, or alternative medicine), with associated variables including a poor relationship with the GP before and after diagnosis, and the involvement of a psychiatrist in initial treatment. (wikipedia.org)
  • A 2008 Cochrane review of CBT concluded, "CBT is more effective than usual care for reducing fatigue symptoms in adults with CFS, with 40% of participants assigned to CBT showing clinical response at post-treatment, in comparison with 26% assigned to usual care control. (wikipedia.org)
  • however, it also stated that the benefits of CBT in sustaining clinical response at follow up are inconclusive, and there were no conclusive improvements to physical functioning, depression, anxiety or psychological distress at either post treatment or later follow-up. (wikipedia.org)
  • patient's
  • During these treatments, the patient is connected to an extracoporeal machine, and the patient's blood is pumped through the machine. (google.com)
  • That is not to say that the patient's psychologically induced response may not include physiological effects. (wikipedia.org)
  • For example, it may be used help the patient cope with their disability by better management of rest and activity within the boundaries of the energy constraints of the disorder, and does not actively attempt to improve the patient's physical or psychological capacity. (wikipedia.org)
  • chronic
  • In a prospective trial, 81 patients with chronic hepatitis C (positive hepatitis C virus [HCV] RNA and elevated alanine aminotransferase[ALT] level) and psychiatric disorders (n = 16), methadone substitution (n = 21), former drug addiction (n = 21), or controls without a psychiatric history or drug addiction (n = 23) were treated with a combination of IFN--2a 3 MU 3 times weekly and ribavirin (1,000-1,200 mg/d). (natap.org)
  • clinic
  • Methods and analysis This study is designed to assess the effectiveness of a patient-centred computer-based clinic intervention, Health-E You/Salud iTu, on its ability to reduce health disparities in unintended pregnancies among Latina adolescent girls. (bmj.com)
  • Editorial note: a pilot study from Diana Sylvestri at the OASIS clinic in Oakland finds that with extensive support services patients on methadone maintenance can respond well to HCV therapy even if they relapse into drug use. (natap.org)
  • Decrease in patient visits to the clinic from the standard of once per month to every 3 months with home visits monthly. (clinicaltrials.gov)
  • toxicity
  • In the first dose-finding cohort (afatinib 40 mg plus nimotuzumab 100 mg), one patient experienced dose-limiting toxicity (DLT) of grade 3 diarrhea and in the subsequent cohort (afatinib 40 mg plus nimotuzumab 200 mg), two DLTs (grade 3 diarrhea and grade 3 neutropenia) occurred in 2 of 6 patients. (aacrjournals.org)
  • Patients may continue to receive standard chemotherapy with or without erlotinib hydrochloride in the absence of disease progression or unacceptable toxicity. (clinicaltrials.gov)
  • progression
  • The objective of this work was to establish the quantitative relationship between Lanreotide Autogel® (LAN) on serum chromogranin A (CgA) and progression-free survival (PFS) in patients with nonfunctioning gastroenteropancreatic neuroendocrine tumors (GEP-NETs) through an integrated pharmacokinetic/pharmacodynamic (PK/PD) model. (pubmedcentralcanada.ca)
  • To evaluate whether maintenance erlotinib hydrochloride added to standard of care (pemetrexed disodium or docetaxel) chemotherapy in patients with erlotinib hydrochloride-responsive advanced non-small cell lung cancer leads to an improved progression-free survival as compared to standard of care pemetrexed disodium or docetaxel alone. (clinicaltrials.gov)
  • These patients are often treated with low doses of antipsychotic drugs with the goal of reducing their symptoms and preventing progression to frank psychosis. (wikipedia.org)
  • Methods
  • The purpose of this manuscript is to describe patient-centred approaches used both in developing and testing the Health-E You app and to present the research methods used to evaluate its effectiveness in improving intentions to use an effective method of contraception as well as actual contraceptive use. (bmj.com)
  • The present invention relates generally to patient access disconnection systems and methods for medical treatments. (google.com)
  • METHODS Olfaction was assessed by: (1) The University of Pennsylvania smell identification test (UPSIT, which uses microencapsulated odours that are released when scratched with a pencil) in 72 patients with multiple sclerosis and 96 controls, (2) olfactory evoked potentials (OEP) to 20 ppm H 2 S by volume, and 50% CO 2 in air for 45 patients with multiple sclerosis and 47 controls. (bmj.com)
  • Methods and apparatuses for detecting, monitoring and/or controlling blood loss from a patient due to needle dislodgement are also provided. (patentgenius.com)
  • dislodgment
  • 4. The extracorporeal blood system of claim 1 , wherein the controller is configured to assume Z P approaches infinity upon dislodgment of the access device from the patient, such that Z becomes at least substantially equal to Z D . (google.com)
  • More specifically, the present invention relates to the detection of patient access disconnection, such as dislodgment of a patient access device during medical treatments or therapies including dialysis therapy. (google.com)
  • Erlotinib
  • In this phase Ib/II study, we aimed to assess the safety and efficacy of afatinib plus nimotuzumab (N) in advanced non-small cell lung cancer (NSCLC) patients with acquired resistance to gefitinib or erlotinib. (aacrjournals.org)
  • Acquired resistance after initial clinical benefit inevitably occurs in patients with EGFR -mutant non-small cell lung cancer (NSCLC), usually within 1 year of starting gefitinib or erlotinib. (aacrjournals.org)
  • PURPOSE: This randomized phase II trial is studying how well giving pemetrexed disodium or docetaxel together with or without erlotinib hydrochloride works in treating patients with stage IIIB or stage IV non-small cell lung cancer. (clinicaltrials.gov)
  • To evaluate the effect of maintenance erlotinib hydrochloride on the response rate to standard of care (pemetrexed disodium or docetaxel) therapy in patients with erlotinib hydrochloride-responsive advanced non-small cell lung cancer as compared to standard of care (pemetrexed disodium or docetaxel) alone. (clinicaltrials.gov)
  • Arm II: (standard of care plus erlotinib): Patients receive pemetrexed disodium IV over 10 minutes OR docetaxel IV over 60 minutes on day 1 and erlotinib hydrochloride orally (PO) once daily on days 2-19. (clinicaltrials.gov)
  • rates
  • Suicide rates are nearly twice as high in depressed patients as in the general population. (wikipedia.org)
  • Phase IIb data presented at the 20th Conference on Retroviruses and Opportunistic Infections (CROI) in March 2013 showed similar viral suppression rates of 76% for patients taking 100 mg cenicriviroc, 73% with 200 mg cenicriviroc, and 71% with efavirenz. (wikipedia.org)
  • Non-response rates were higher with cenicriviroc, however, largely due to greater drop-out of patients. (wikipedia.org)
  • Remission rates in various studies using the American College of Rheumatology (ACR) remission criteria 1 have been estimated to be 15% during two to six years of follow up in patients with early disease, 2 18% during 1131 patient-years of follow up, 3 20% during five years of follow up in early disease, 4 and 18% at 10 years of follow up. (bmj.com)
  • study
  • Almost half of adult patients suffering an anxiety disorder dropped out of school before completing their education, according to a new study from McMaster University. (mentalhealth.com)
  • Between March and October 2008, a total of 240 patients diagnosed for the first time with anogenital warts in the Sexually Transmitted Infections Unit of the "Andreas Sygros" Hospital for Skin and Venereal Diseases were asked to participate in the study. (springer.com)
  • Editorial note from Jules Levin: although this study is small, it finds individuals on methadone maintenance and individuals with psychiatric problems respond as well as HCV-infected patients without these issues. (natap.org)
  • Patients in this study who were formerly addicted to drugs had a greater dropout rate due to reasons discussed below but these patients still had a good viral response rate. (natap.org)
  • The psychiatric patients in this study received psychiatric evaluation and support services by a multi-disciplinary support team, and medication. (natap.org)
  • Patients will be asked to provide informed consent to agree for their weekly routine outcome scores from enhanced BAG to be used in the study. (clinicaltrials.gov)
  • However, the first study contained only 25 patients with knee OA followed up for just 6 weeks. (bmj.com)
  • 4 The second study was larger (60 patients) but was of just 1 week's duration and contained a mixed population with knee or hip OA. (bmj.com)
  • 6 This compared paracetamol, diclofenac, and placebo over a 12 week period in 82 patients with knee OA but was the first negative study for paracetamol, showing no difference between paracetamol and placebo using Western Ontario McMaster Osteoarthritis Index (WOMAC) assessments. (bmj.com)
  • In a further study 5 using the UPSIT together with a match to sample test, patients with multiple sclerosis scored as high as the controls in both procedures. (bmj.com)
  • Self-selection bias (see also Non-response bias), which is possible whenever the group of people being studied has any form of control over whether to participate (as current standards of human-subject research ethics require for many real-time and some longitudinal forms of study). (wikipedia.org)
  • Excluding subjects who move out of the study area during follow-up is rather equivalent of dropout or nonresponse, a selection bias in that it rather affects the internal validity of the study. (wikipedia.org)
  • The same paper, part of a study funded by the Bill & Melinda Gates Foundation, cited the impact of the Smart Sparrow platform on increasing enrollments and reducing dropouts. (wikipedia.org)
  • characteristics
  • We used the short-form (SF)-36 questionnaire to compare the HRQoL of 91 patients with anogenital warts to 53 control subjects with the same socioeconomic characteristics. (springer.com)
  • The relatively large number of patients is notable, and although the trials were a mixture of single-agent and multi-agent studies, patient characteristics were similar among the high, medium, and low dose groups. (aacrjournals.org)
  • rate among
  • There's little research on the school dropout rate among the general population with which to compare these figures, but Statistics Canada reports that 18% of 20-year-olds have not completed high school. (mentalhealth.com)
  • tumor
  • GEP-NETs secrete endocrine markers such as chromogranin A (CgA), the plasma levels of which are elevated in patients with GEP-NETs, and CgA has been reported to be a sensitive tumor marker for disease monitoring: not only does it reflect tumor load, but it is also an indicator of tumor growth ( 3 , 10 - 13 ). (pubmedcentralcanada.ca)
  • high
  • The high dropout rate. (bmj.com)
  • Patients in the high antibody group had a lower drop out rate and fewer positive cocaine urine results in the last 2 weeks of the trial, but it was not significant versus the low antibody or placebo group. (wikipedia.org)
  • For example, a survey of high school students to measure teenage use of illegal drugs will be a biased sample because it does not include home-schooled students or dropouts. (wikipedia.org)
  • therapy
  • It is cost-effective to provide these services, because if these patients discontinue therapy due to noncompliance and difficulty in tolerating the therapy they will likely receive therapy again. (natap.org)
  • symptoms
  • To meet criteria for a major depressive episode, a patient must have 5 of these 9 symptoms nearly every day for at least 2 weeks. (wikipedia.org)
  • Because this generation of symptoms entails a complex of "subject-internal" activities, in the strictest sense, we can never speak in terms of simulator-centered "nocebo effects," but only in terms of subject-centered "nocebo responses. (wikipedia.org)
  • CBT based on this model attempts to reverse patients' symptoms by altering their interpretation of their symptoms and/or the behaviours they engage in as a result. (wikipedia.org)
  • medication
  • Only 10 to 40 percent of depressed elderly patients are given medication. (wikipedia.org)
  • For example, when a patient anticipates a side effect of a medication, he/she can suffer that effect even if the "medication" is actually an inert substance. (wikipedia.org)
  • disease
  • Atypicals are less likely than haloperidol - the most widely used typical antipsychotic - to cause extrapyramidal motor control disabilities in patients such as unsteady Parkinson's disease-type movements, body rigidity, and involuntary tremors. (wikipedia.org)
  • Pharmacometrics can be defined as that branch of science concerned with mathematical models of biology, pharmacology, disease, and physiology used to describe and quantify interactions between xenobiotics and patients (human and non-human), including beneficial effects and adverse effects. (wikipedia.org)
  • Pharmacometrics uses models based on pharmacology, physiology and disease for quantitative analysis of interactions between drugs and patients. (wikipedia.org)
  • Felitti and Robert Anda from the Centers for Disease Control and Prevention (CDC) went on to survey childhood trauma experiences of over 17,000 Kaiser Permanente patient volunteers. (wikipedia.org)
  • This can result in a spurious negative correlation between diseases: a hospital patient without diabetes is more likely to have another given disease such as cholecystitis, since they must have had some reason to enter the hospital in the first place. (wikipedia.org)
  • data
  • As PFS data were considered informative dropouts, CgA and PFS responses were modeled jointly. (pubmedcentralcanada.ca)
  • Results 5 years of data were available for 205 of 299 patients, with no indication for selective drop-out. (bmj.com)
  • Although current European League Against Rheumatism (EULAR) 1 and American College of Rheumatology (ACR) 2 guidelines both support paracetamol (acetaminophen) as the first line oral analgesic for patients with knee osteoarthritis (OA), until now there has been a paucity of clinical trial data to confirm the efficacy of paracetamol in large joint OA. (bmj.com)
  • Experience with abatacept in RA is growing thanks to open-label extensions of clinical trials [ 11 ], but published data from routine practice and patient registries are currently lacking. (biomedcentral.com)
  • effects
  • Physiologically based pharmacokinetic models Exposure-response models describe the relationship between exposure (or pharmacokinetics), response (or pharmacodynamics) for both desired and undesired effects. (wikipedia.org)
  • It has been shown that, due to the nocebo effect, warning patients about side effects of drugs can contribute to the causation of such effects, whether the drug is real or not. (wikipedia.org)
  • drugs
  • It has been argued that a more nuanced view in which the needs of individual patients are matched to the properties of individual drugs is more appropriate. (wikipedia.org)
  • group
  • It is therefore important to develop specific instruments for the measurement of HRQoL in this group of patients. (springer.com)
  • Five patients in this group also had a history of former drug abuse, and 2 patients with schizophrenic disorders additionally received methadone. (natap.org)
  • This is a 6 week double blind parallel group trial of paracetamol versus placebo in 779 patients with knee OA. (bmj.com)
  • diseases
  • Sexually transmitted diseases (STDs) influence the patients' life. (springer.com)
  • Unlike other diseases, dose-selection for cancer therapeutics is often based on the maximum-tolerated dose in phase 1 studies involving relatively few patients. (aacrjournals.org)
  • However
  • However, the average age of the patients with multiple sclerosis was 47 years, whereas that of the controls was 63 years, and there was a preponderance of women in the multiple sclerosis sample which might have masked some abnormalities in multiple sclerosis. (bmj.com)
  • analyses
  • The Smart Sparrow software tools, known collectively as the Adaptive eLearning Platform, are a web-based suite that develops adaptive learning content and applications, deploys that material to students and analyses how students learn from their responses to the material. (wikipedia.org)