Responders placebos. Medical search. Frequent questions

Disease activity score in 28 joints (DAS28)-C-reactive protein (CRP) was a secondary endpoint and clinically relevant decreases with secukinumab 75-300 mg were reported versus placebo. (bmj.com)
Serum high sensitivity CRP levels at week 16 were significantly reduced with secukinumab 75 mg, 150 mg and 300 mg doses versus placebo. (bmj.com)
Researchers found that when children with nearsightedness used the drops every day for three years, their vision worsened more slowly - and was more likely to stabilize - versus kids given placebo drops. (newsmax.com)
Nearsightedness progression was slower, on average, among kids on 0.01% atropine, versus the placebo. (newsmax.com)
After 5 years, there were no statistically significant differences in AUC C-peptide when comparing those who received ATG/GCSF versus placebo ( P = 0.41). (diabetesjournals.org)
Patients with severe insomnia treated with lemborexant (DAYVIGO) achieved notably greater change in sleep onset latency and wake after sleep onset from baseline versus placebo in a new 12-month, phase 3 trial. (hcplive.com)
Led by Thomas Roth, PhD, director of the Sleep Disorders and Research Center at Henry Ford Hospital, investigators assessed the patient-reported outcomes on ISI in those with reductions of ≥7 points from the phase 3 SUNRISE 2 trial assessing lemborexant versus placebo in adults with insomnia disorder. (hcplive.com)
Investigators assessed for changes from baseline in subjective sleep-onset latency (SOL) and wake after sleep onset (WASO) versus placebo in the full analysis set, as well as in patients with severe insomnia per ISI total scores ≥22. (hcplive.com)
001) versus placebo (-18.0). (hcplive.com)
05) versus placebo (-70.2). (hcplive.com)
Lemborexant generally showed benefit versus placebo. (hcplive.com)
Antidepressants Versus Placebos: Meaningful Advantages Are Lacking , but, Small Effects Are Not Trivial From a Public Health Perspective . (metafilter.com)
8 The authors investigated whether continuous IV infusion of hydrocortisone for 7 days versus placebo would reduce mortality in septic shock. (emra.org)
9 The study looked into 90 day mortality benefit in patients who were given hydrocortisone plus fludrocortisone versus placebo. (emra.org)
The overall sustained virological response (SVR) rates, or continued undetectable HCV viral load 24 weeks after completion of treatment, were 53% for children receiving pegylated interferon plus ribavirin versus 21% for those treated with pegylated interferon plus placebo(results were not reported by HCV genotype). (hivandhepatitis.com)
In terms of pipeline, Synergy has also completed two phase 3 trials of Trulance in irritable bowel syndrome with constipation (IBS-C). In both of these studies, Trulance met its primary endpoint of percentage of patients classified as overall responders versus placebo. (foxbusiness.com)
P = 0.00), respectively, in favor of treatment versus placebo. (medscape.com)

John Haygarth was the first to investigate the efficacy of the placebo effect in the 18th century. (wikipedia.org)
The reduction of harm through an ineffective treatment, the possibility of individualized dosing, the reduction of sample size, and the possible evaluation of the influence of the placebo effect on efficacy outcomes justify this design for a single-centered placebo-controlled investigator-initiated trial of nabilone. (springer.com)
The methodology for this study is entirely different than that used for placebo-controlled clinical efficacy trials. (dr-bob.org)
This global, multi-center, phase 3 clinical trial (AERIFY 2) is a randomized, double-blind, placebo-controlled, parallel-group Phase 3 study to evaluate the efficacy, safety, and tolerability of SAR440340/ REGN3500/ Itepekimab (Anti-IL-33 mAb) in former smokers with moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD). (acaai.org)
Because epoetin alfa has demonstrated efficacy in correcting cancer-related anaemia, the impact of this treatment on quality of life was evaluated in a multinational, randomised, double-blind, placebo-controlled trial in 375 anaemic cancer patients receiving non-platinum-based chemotherapy. (nature.com)
Randomized, placebo-controlled trials (RCTs) are seen as the "gold standard" for assessing the efficacy of a drug treatment, and their results are perceived in society as providing a binary conclusion: either a drug is proven to be effective or it isn't. (madinamerica.com)
This study aims to determine whether a novel, non-invasive form of vagus nerve stimulation (VNS), transcutaneous auricular VNS (taVNS), is acceptable and feasible for use with WTC responders who have PTSD and whether the methodology to test the efficacy of taVNS in reducing PTSD symptoms in a larger trial is acceptable and feasible. (cdc.gov)
Subgroup analysis showed efficacy in patients who were tumor necrosis factor naive, as well as tumor necrosis factor nonresponders or inadequate responders. (medscape.com)
Approval was based on an efficacy study in which patients treated with twice-daily treprostinil improved their median 6-minute walk distance by 23 meters ( P =0.013), as compared with those who received placebo. (medscape.com)

Melatonin 3 mg is better than placebo for migraine prevention, more tolerable than amitriptyline and as effective as amitriptyline 25 mg. (nih.gov)

5R)-5-hydroxytriptolide for HIV immunological non-responders receiving ART: a randomized, double-blinded, placebo-controlled phase II study. (bvsalud.org)
in 2002 conducted a double-blinded, randomized, placebo-controlled trial in France. (emra.org)

A modeling framework based on mean trajectories in C-peptide AUC over 5 years, accounting for differing trends between groups, was applied to recategorize responders ( n = 9) and nonresponders ( n = 7). (diabetesjournals.org)
The mere exposure to milnacipran did not explain our findings because milnacipran responders exhibited increased activity also in comparison to milnacipran nonresponders. (uni-koeln.de)

The IPD in placebo groups will be used to investigate the placebo response according to the minimum clinically important difference (MCID) threshold (e.g. 20 % pain reduction). (nottingham.ac.uk)
Mean headache frequency reduction was 2.7 migraine headache days in the melatonin group, 2.2 for amitriptyline and 1.1 for placebo. (nih.gov)
They then discontinued treatment and were followed up until week 19, when responders, defined as having a reduction in EASI score ≥ 50%, continued follow-up out to week 48. (medscape.com)
The primary endpoint was the proportion of patients who had a reduction of ≥30.0% in average weekly worst abdominal pain and an increase of ≥1 weekly complete spontaneous bowel movement from baseline, both in the same week, for ≥6 of the first 12 treatment weeks (6/12-week combined responder). (lww.com)
Treatment with imetelstat vs. placebo led to greater reduction in variant allele frequency (VAF) in multiple genes associated with lower risk MDS, which correlated with clinical endpoints of TI response, longer TI duration and increase in hemoglobin levels, suggesting the potential of imetelstat to modify the disease. (businesswire.com)
For dichotomous data on responders (patients with ≥ 50% reduction in headache frequency), we calculated odds ratios (ORs) and numbers needed to treat (NNTs). (cochrane.org)
The psychiatric community-and by extension, our society-focuses on a single data point plucked from the RCTs: the difference in "symptom reduction" between drug and placebo groups at the end of the study period (typically six weeks. (madinamerica.com)
Theirs was an analysis that focused on differences in symptom reduction at the end of short-term trials, and even though the researchers concluded that there was a "moderate to high risk of bias" in 82% of the trials, and even though the difference in symptom reduction was quite small, they concluded that all 21 "were more efficacious than placebo. (madinamerica.com)

Discussion: This study explores the varying magnitude of the placebo response and the proportion of participants that experience a clinically important placebo effect in OA RCTs. (nottingham.ac.uk)
These determinants may be useful for future studies as it may allow participants to be stratified into groups based on their likely response to placebo. (nottingham.ac.uk)
18 ] argued that the placebo response is robust and enhances the treatment effect when conditions are amenable to placebo, when placebo is given as an analgesic or when participants are properly blinded [ 19 ]. (biomedcentral.com)
After a 4-week baseline phase, 196 participants were randomised to placebo, amitriptyline 25 mg or melatonin 3 mg, and 178 took a study medication and were followed for 3 months (12 weeks). (nih.gov)
SUNRISE 2 was a 12-month, randomized, double-blind, partially placebo-controlled, parallel assessment including participants with ISI total scores ≥15 at baseline-indicating moderate to severe insomnia. (hcplive.com)
A total of 949 trial participants received either 5 mg or 10 mg lemborexant, or placebo for 6 months before being switched to therapy for the latter 6 months. (hcplive.com)
Given that the less-active methionine (val158met, or just "met") polymorphism of COMT has itself been linked with variations in memory function, cognition, confirmational bias, pain processing, and sensitivity, Ted J. Kaptchuk and colleagues revisited their prior clinical study on placebo response in IBS patients to see whether the COMT met polymorphism also impacted on how likely the participants were to have responded to placebo therapy. (genengnews.com)
Participants in one arm were not given any treatment (the "waitlist" group, which acted as a control), those in a second "limited placebo" group were treated using placebo acupuncture in a businesslike, clinical manner (i.e., with little support), while the third cohort of patients was treated using the same placebo acupuncture, but from a warm and supportive healthcare provider who expressed confidence in its effectiveness. (genengnews.com)
Twenty-five participants with DSM-IV trichotillomania participated in a 12-week, randomized, double-blind, placebo-controlled trial of flexible-dose olanzapine for trichotillomania. (psychiatrist.com)
Eleven of 13 participants (85%) in the olanzapine group and 2 of 12 (17%) in the placebo group were considered responders according to the CGI-I ( P ' ‰ = ' ‰ .001). (psychiatrist.com)
Participants were randomly assigned to receive subcutaneous rezpegaldesleukin 12 µg/kg or 24 µg/kg or placebo every 2 weeks for 12 weeks. (medscape.com)
Among these 38 participants, 22 had achieved SVR in the PEDS-C trial while 16 were non-responders or relapsers. (hivandhepatitis.com)
The proportion of responders on CBD was nearly three times higher than that of participants on placebo (Odds Ratio of 2.65). (cannabis-med.org)

It compares two antidepressants to placebo. (metafilter.com)
The aim of this study was to compare the cerebral and behavioral response to positive treatment effects of antidepressants or placebo. (uni-koeln.de)
At the conclusion of the study, most of those who received the placebo saw a gradual improvement in their depression symptoms, while nearly 20 percent of those taking antidepressants saw a worsening of their symptoms. (cchrint.org)
Those taking antidepressants rather than a placebo were grouped into one of two groups - "responders" or "non-responders. (cchrint.org)
The Swedish national board is pointing to a simple bottom line: randomized, placebo-controlled, double-blind trials have found antidepressants to be "efficacious," and that is why the board recommends their use for treating depression and anxiety. (madinamerica.com)

While the hydrocortisone group had increased adverse events compared to placebo most were clinically insignificant and overall hydrocortisone appears fairly safe. (emra.org)
There were no serious adverse events and an overall frequency of adverse events very similar to placebo. (cannabis-med.org)
We also summarised data on adverse events from placebo-controlled trials and calculated risk differences (RDs) and numbers needed to harm (NNHs). (cochrane.org)

CBD was consistently superior to placebo in relevant aspects of the disease, for example for the Clinical Global Impression of Severity and for the Clinical Global Impression of Improvement. (cannabis-med.org)
In one trial each, carbamazepine and levetiracetam were significantly superior to placebo in reducing headache frequency, and there was no significant difference in proportion of responders between zonisamide and active comparator. (cochrane.org)

On average, 75 % of the analgesic effect from OA treatments in clinical trials can be attributed to a placebo response, and this response varies greatly from patient to patient. (nottingham.ac.uk)
Secondary end points were responder rate, migraine intensity, duration and analgesic use. (nih.gov)
In the first case, placebo analgesia is typically blocked by the opioid antagonist naloxone, whereas in the second case it is not, depending on the procedure that is applied to induce the placebo analgesic response. (jneurosci.org)

9-11 We aimed to study the effect of melatonin in a double-blind, placebo controlled trial with an active comparator. (bmj.com)

We will use the IPD of placebo-controlled RCTs held by the OA Trial Bank for this project. (nottingham.ac.uk)
Furthermore, a systematic review [ 14 ] involving 198 randomised controlled trials (RCTs) also suggested that placebo is effective at relieving pain and improving function and stiffness. (biomedcentral.com)

The phase II, double-blind, randomized, placebo-controlled trial was conducted in adults patients with long-term suppressed HIV infection and suboptimal CD4 recovery, at nine hospitals in China . (bvsalud.org)
The patients were 111 assigned to receive oral LLDT-8 0.5 mg or 1 mg daily, or placebo combined with antiretroviral therapy for 48 weeks. (bvsalud.org)
A total of 149 patients were enrolled from Aug 30, 2019 and randomly allocated to receiving LLDT-8 0.5 mg daily (LT8, n = 51), 1 mg daily (HT8, n = 46), or placebo (PL, n = 52). (bvsalud.org)
Methods Patients (n=237) with inadequate response to methotrexate were randomly assigned to receive monthly subcutaneous injections of secukinumab 25 mg, 75 mg, 150 mg, 300 mg or placebo. (bmj.com)
A total of 38 patients will have 80% power to detect a probability of 0.231 that an observation in the treatment group is less than an observation in the placebo group using a Wilcoxon rank-sum test with a 0.050 two-sided significance level assuming a true difference of 2.5 points between nabilone and placebo in the primary outcome measure and a standard deviation of the change of 2.4 points. (springer.com)
I would argue that if there was a third arm in many of the studies, that gave no active pill, and no active placebo, lots of these less-ill to begin with patients will do about as well as both the active pill and placebo. (dr-bob.org)
I postulate that this class of patients does not experience the placebo effect that is found in the unrealistic patient group from the clinical trial. (dr-bob.org)
The intent-to-treat population included 357 patients: 178 received pramipexole and 179 received placebo. (nih.gov)
Results presented showed that in the SETTLE study safinamide significantly improved 'super responder' rates in fluctuating PD patients as add-on to levodopa and other dopaminergic therapies. (news-medical.net)
The responder rate analysis using multiple and combined criteria show compelling evidence that a substantial proportion of Parkinson's disease patients, even in advanced stage treated with safinamide obtain significant clinical benefits in all major motor symptoms thus significantly improving their quality of life', said Marco Sardina, Zambon's CSO. (news-medical.net)
Patients who were experiencing a minimum of one and a half hours of 'OFF' time during the day were randomized equally to treatment with once a day safinamide (50-100mg) or placebo (standard of care including levodopa), as adjunctive treatment. (news-medical.net)
Patients who carry one particular functional polymorphism of an enzyme responsible for clearing dopamine from the prefrontal cortex region of the brain are more likely to respond to placebo therapy than those with a different variant of the enzyme, as long as the placebo is administered in a caring, positive manner, researchers report. (genengnews.com)
To see whether there may be a genetic component to the likelihood of placebo response the Beth Deaconess have now gone back, genotyped blood samples from the patients involved in the study, and used regression analysis to marry genotype data with the type of treatment received. (genengnews.com)
The results were striking, but only among patients in the augmented placebo arm. (genengnews.com)
A much smaller met/met-associated effect was observed among patients in the limited placebo treatment cohort, and there was no effect at all in the waitlist control group. (genengnews.com)
Effectively, the data indicate that the COMT val158met allele could represent a marker for placebo responders in IBS patients at least, the investigators state. (genengnews.com)
And inclusion of the control waitlist patients, who were by far the least likely to "respond" and didn't show any link between response and COMT polymorphism, acted to support the notion that met is a true predictor of the placebo effect, and not just improvements in general. (genengnews.com)
In fact, they point out, although a number of studies have previously looked at the placebo response, it's the addition of a no-treatment control arm (the waitlist group in this case), and an 'augmented' therapy arm that has provided a clear demonstration that a genetic factor can play a role in whether patients will respond to placebo, albeit with subjective (in the case of IBS), but measurable improvements in symptoms. (genengnews.com)
Even in this selected study that was deemed by Effexor as worthy of turning into an ad, it only helped 20% of patients above placebo. (metafilter.com)
More than 40 patients were randomly assigned to receive one of two doses of a highly selective recombinant interleukin (IL)-2 conjugate, rezpegaldesleukin or placebo for 12 weeks, after which responders were observed out to 48 weeks. (medscape.com)
In this trial, septic shock patients were randomized to receive 3 mg/kg dexamethasone, or 30 mg/kg methylprednisolone, or placebo. (emra.org)
5 The patients were subdivided into ACTH stimulation responders and non-responders. (emra.org)
In this randomized double-blind study ( ClinicalTrials.gov identifier: NCT02686138), patients with IBS-C received tenapanor 50 mg b.i.d. or placebo b.i.d. for 26 weeks. (lww.com)
placebo: n = 300) and 481 patients (77.6%) completed the 26-week treatment period. (lww.com)
Diarrhea led to study drug discontinuation for 19 (6.5%) and 2 patients (0.7%) receiving tenapanor and placebo, respectively. (lww.com)
Guar gum was the only fiber supplement tested that was able to significantly improve irritable bowel syndrome symptom frequency, with 45% of patients reporting reduced frequency compared with 5% in the placebo group at 8 weeks ( P = .025). (medscape.com)
FOSTER CITY, Calif.--( BUSINESS WIRE )--Geron Corporation (Nasdaq: GERN), a late-stage clinical biopharmaceutical company, today announced poster presentations of data from IMerge, the Company's Phase 3 clinical trial evaluating its first-in-class investigational telomerase inhibitor imetelstat vs. placebo in patients with lower risk myelodysplastic syndromes (MDS) at the eleventh annual Society of Hematologic Oncology Annual Meeting (SOHO) held in Houston, Texas and virtually. (businesswire.com)
0.001) over time compared to placebo patients. (businesswire.com)
Patient-reported outcomes (PRO) data reported a sustained meaningful improvement in fatigue for imetelstat-treated patients vs. placebo. (businesswire.com)
The Phase 3 portion of the IMerge Phase 2/3 study is a double-blind, 2:1 randomized, placebo-controlled clinical trial to evaluate imetelstat in patients with IPSS Low or Intermediate-1 risk (lower risk) transfusion dependent MDS who were relapsed after, refractory to, or ineligible for, erythropoiesis stimulating agent (ESA) treatment, had not received prior treatment with either a HMA or lenalidomide and were non-del(5q). (businesswire.com)
Ninety-two fibromyalgia patients participated in a 12-week, double-blind, placebo-controlled clinical trial with milnacipran, a serotonin-norepinephrine reuptake inhibitor. (uni-koeln.de)
Perspective: This study presents neural and psychophysical correlates to positive treatment responses in patients with fibromyalgia, treated with either milnacipran or placebo. (uni-koeln.de)
In the trial, patients remained on their anti-psychotic medication and were randomized to receive CBD or placebo as adjunct therapy. (cannabis-med.org)
The state of knowledge on the antidepressant effects of SSRIs is not based on theories of [their] mechanisms of action but on clinical studies comparing drug effects in patients with placebo. (madinamerica.com)
Hepion has created a proprietary Artificial Intelligence deep machine learning ("AI/ML") platform designed to better understand disease processes and identify patients that are rencofilstat responders. (news10.com)
Long-term treatment improves the quality of life and survival rate in patients who are proven responders to calcium channel blockers (CCBs). (medscape.com)

Six of the eight drugs investigated in placebo-controlled trials were not better than placebo in reducing headache frequency per 28-day period during treatment (clonazepam, lamotrigine, oxcarbazepine, and vigabatrin) and/or in the proportion of responders (acetazolamide, carisbamate, lamotrigine, oxcarbazepine). (cochrane.org)

The results of this study may also be useful for pharmaceutical companies, who could improve the design of their studies in order to separate the specific treatment from the non-specific contextual (i.e. placebo) effects. (nottingham.ac.uk)
Of 51 currently available treatment options for the symptomatic management of OA, most do not achieve a minimum clinically important difference (MCID) (i.e. an effect size ≥0.5) over placebo [ 4 , 5 ]. (biomedcentral.com)
Previous studies suggest that the benefits of placebo interventions are mainly for patient symptoms and distress, which are considered to be the principal treatment targets in people with OA [ 6 ]. (biomedcentral.com)
Use of the placebo effect as a medical treatment has been controversial throughout history, and was common until the mid twentieth century. (wikipedia.org)
To do this, a sham treatment (the placebo) is given, but the patient believes it is effective and expects a clinical improvement. (jneurosci.org)
The placebo effect, or response, is the outcome after the sham treatment. (jneurosci.org)
The trial data showed that the cohort that received the more positively administered placebo treatment were far more likely to respond to therapy in terms of improved IBS symptoms and other measures. (genengnews.com)
It is also the first study to demonstrate a relationship between different levels of placebo treatment and COMT genotype. (genengnews.com)
Following treatment, milnacipran responders exhibited significantly higher activity in the posterior cingulum compared with placebo responders. (uni-koeln.de)
We report segregated neural mechanisms for positive responses to treatment with milnacipran and placebo, reflected in the posterior cingulum. (uni-koeln.de)
The comparison between placebo responders and milnacipran responders may shed light on the specific mechanisms involved in antidepressant treatment of chronic pain. (uni-koeln.de)
This AI/ML has the potential to shorten development timelines and increase the observable differences between placebo and treatment groups. (itbusinessnet.com)
SELECTION CRITERIA: We included randomised controlled trials which compared the treatment drug with placebo. (who.int)

After three years, 28.5% of children on the lower atropine dose - 0.01% atropine - were considered to be 'responders. (newsmax.com)

This is largely due to the fact that the placebo response is measured as the overall change from baseline in the placebo group [ 14 ]. (biomedcentral.com)
At 48 weeks, change of CD4 counts was 49 cells /mm3 in LT8 group (95% confidence interval [CI] 30, 68), 63 cells /mm3 in HT8 group (95% CI 41, 85), compared to 32 cells /mm3 in placebo group (95% CI 13, 51). (bvsalud.org)
The NMS-Nab Study is as a mono-centric phase II, randomized, placebo-controlled, double-blind, parallel-group, enriched enrollment withdrawal study. (springer.com)
Weight loss was found in the melatonin group, a slight weight gain in placebo and significantly for amitriptyline users. (nih.gov)
Of kids on the higher atropine dose (0.02%), 22% were responders - which was not different, in statistical terms, from the placebo group. (newsmax.com)
Responder rates (clinical and patient global impression and IRLS) were also significantly higher in the pramipexole group. (nih.gov)
After 24 weeks, non-responders in the placebo group crossed over to receive pegylated interferon/ribavirin for 24 or 48 weeks. (hivandhepatitis.com)
This will involve the conduct of a formative phase focus group and then a pilot feasibility study with Northwell-affiliated WTC responders who have PTSD. (cdc.gov)

A randomised, double-blind, placebo-controlled study was carried out. (nih.gov)
Therefore, it is important to emphasize that the study of the placebo effect is the study of the psychosocial context around the patient. (jneurosci.org)
The study of the placebo effect, at its core, is the study of how the context of beliefs and values shape brain processes related to perception and emotion and, ultimately, mental and physical health. (jneurosci.org)
The study of the placebo effect reflects a current neuroscientific thought that has as its central tenet the idea that "subjective" constructs such as expectation and value have identifiable physiological bases, and that these bases are powerful modulators of basic perceptual, motor, and internal homeostatic processes. (jneurosci.org)
The study of the placebo effect also has immediate clinical and ethical implications, because the use of inactive (placebo) conditions in clinical trials when effective treatments are available has created an ethical controversy. (jneurosci.org)
In the same study, if the placebo response was obtained after exposure to opioid drugs, it was naloxone reversible, whereas if it was obtained after exposure to non-opioid drugs, it was naloxone insensitive. (jneurosci.org)
SETTLE study was a six-month (24-week), randomized, double-blind, placebo-controlled international Phase III trial. (news-medical.net)
To our knowledge, this is the first study to demonstrate genetic modulation of true placebo effects disassociated from changes related to disease natural history and regression to the mean," they write in their published paper in PLoS One. (genengnews.com)
Ralitza Gueorguieva, lead author of the study from the Yale University School of Health, and her colleagues conducted trials on 2,500 people, all of whom were given either Cymbalta, various other antidepressant drugs, or a drug-free placebo for two months. (cchrint.org)
In one study each, carbamazepine and levetiracetam were better than placebo, and there was no significant difference between zonisamide and topiramate (a drug proven to be effective for migraine prophylaxis). (cochrane.org)
In Sub-study 2, the first dose may be IV or SC Risankizumab or placebo followed by once every 8 weeks of SC Risankizumab. (who.int)

Placebo rates are often around 30% or more in depression trials. (dr-bob.org)
Someone with chronic and refractory depression has a much lower placebo response. (dr-bob.org)
Dopamine has previously been linked with placebo response in pain, Parkinson's disease, and depression, and the prefrontal cortex-where COMT is crucial for dopamine clearance-is a brain region activated during the placebo response, report the investigators at Beth Israel Deaconess Medical Center. (genengnews.com)
If the effect of not publishing the negative findings is so huge, it kind of implies the major effect of the pills was the placebo effect and that those taking them were not suffering from depression in the first place. (metafilter.com)

Ravi Anand, Newron's CMO, stated: 'The results presented indicate a magnitude of benefit with safinamide which is of clinical relevance, i.e. improvements of more than one hour in the patient and caregiver-rated ON and OFF time plus 30 per cent or greater improvement in motor symptoms (UPDRS Part III, as rated by a neurologist) in a significantly super responders' and have not been observed with other treatments to date. (news-medical.net)
Abdominal symptoms and global symptoms of IBS were significantly improved with tenapanor compared with placebo. (lww.com)

They randomly assigned 411 to use either of two doses of atropine eye drops, and 165 to use placebo drops. (newsmax.com)

This individual patient data (IPD) meta-analysis aims to identify placebo responders and the potential determinants of the placebo response in OA. (nottingham.ac.uk)
Responders to placebo will be compared with non-responders to identify predictors of response. (nottingham.ac.uk)
Potential determinants of the placebo response will also be investigated. (nottingham.ac.uk)
However, debate continues as to whether the estimation of placebo response is adequate and accurate. (biomedcentral.com)
He suggests to solve this dilemma by appropriating the meaning response in medicine, that is make use of the placebo effect, as long as the "one administering. (wikipedia.org)
You can't keep them on placebo forever but usually the response wanes over time. (dr-bob.org)
In an experimental model of pain ( Amanzio and Benedetti, 1999 ), the placebo response could be blocked by naloxone if it was induced by strong expectation cues, whereas if the expectation cues were reduced, it was insensitive to naloxone. (jneurosci.org)
It is unlikely that a single locus like COMT fully accounts for a complex behavioral phenotype like placebo response," the team admits. (genengnews.com)
Stimulus response assessments revealed specific antihyperalgesic effects in milnacipran responders, which was also correlated with reduced clinical pain and with increased activation of the posterior cingulum. (uni-koeln.de)

The placebo effect is a psychobiological phenomenon that can be attributable to different mechanisms, including expectation of clinical improvement and pavlovian conditioning. (jneurosci.org)
Thus, we have to look for different mechanisms in different conditions, because there is not a single placebo effect but many. (jneurosci.org)

0.001), with median TI duration approaching one year for imetelstat 8-week TI responders. (businesswire.com)

Insomnia severity index responders including those from the severe insomnia subgroup reported greater CFB in subjective sleep-onset latency and subjective wake after sleep onset than the full analysis set that was somewhat dose dependent," they concluded. (hcplive.com)
For headache frequency data, we calculated mean differences (MDs) between antiepileptic drugs and comparators (placebo, active control, or same drug in a different dose) for individual studies and pooled these across studies. (cochrane.org)

Melatonin significantly reduced headache frequency compared with placebo (p=0.009), but not to amitriptyline (p=0.19). (nih.gov)

In the real world, the choices are real pill or nothing: a placebo isn't an option. (metafilter.com)
And that's with using non-active placebo (in other words, a sugar pill instead of something that has some physical effects), which essentially un-blinds most studies. (metafilter.com)

Responders allegedly saw some improvement from the drugs, while non-responders saw no improvement at all. (cchrint.org)

Scientists are interested in placebo responses because the effects of belief on human experience and behavior provide an entry point for studying internal control of affective, sensory, and peripheral processes. (jneurosci.org)

Thus, placebo effects may represent points of either strength or vulnerability for the expression and maintenance of various pathological states and their inherent therapeutic interventions. (jneurosci.org)

Background: The management of osteoarthritis (OA) is unsatisfactory, as most treatments are not clinically effective over placebo and most drugs have considerable side effects. (nottingham.ac.uk)
In 1955 Henry K. Beecher published an influential paper entitled The Powerful Placebo which proposed idea that placebo effects were clinically important. (wikipedia.org)
the existence of placebo effects suggests that we must broaden our conception of the limits of endogenous human capability. (jneurosci.org)
However, it has been well documented that placebo effects can obscure those of active conditions, even for treatments that were eventually demonstrated to be effective. (jneurosci.org)

National Geographic's riveting narrative explores the world of placebos, hypnosis, false memories, and neurology to reveal the groundbreaking science of our suggestible minds. (barnesandnoble.com)

Adults with moderate or severe RLS were randomized to receive placebo or pramipexole (flexibly titrated from 0.25 to 0.75mg), 2-3h before bedtime for 12 weeks. (nih.gov)
Subjects receive once every eight weeks SC risankizumab or SC placebo. (who.int)

World Trade Center (WTC) responders have high rates of Posttraumatic Stress Disorder (PTSD) and experience barriers to engagement in mental health care. (cdc.gov)

For example, a placebo can reduce pain by both opioid and non-opioid mechanisms ( Colloca and Benedetti, 2005 ) ( Fig. 1 ). (jneurosci.org)

While responders continue to focus on ending transmission, the number of Ebola survivors is now higher than in any previous Ebola outbreak. (who.int)

Anatomy9

Organisms2

Diseases21

Chemicals and Drugs106

Analytical, Diagnostic and Therapeutic Techniques and Equipment79

Psychiatry and Psychology9

Phenomena and Processes22

Disciplines and Occupations3

Anthropology, Education, Sociology and Social Phenomena2

Technology, Industry, Agriculture1

Humanities2

Information Science3

Named Groups3

Health Care44

Versus17

Efficacy9

Better than placebo for migraine1

Double-blinded2

Nonresponders2

Reduction8

Participants13

Antidepressants5

Adverse3

Superior to placebo2

Analgesic3

Active comparator1

RCTs2

Patients36

Proportion1

Treatment13

0.011

Group8

Study11

Depression4

Symptoms2

Doses1

Response9

Effect2

0.0011

Dose2

Frequency1

Pill2

Improvement1

Responses1

Interventions1

Effects4

Explores1

Weeks2

Rates1

Pain1

Higher1