Resistance antibiotics antineoplastic. Medical search. Frequent questions

Antineoplastic resistance, often used interchangeably with chemotherapy resistance, is the resistance of neoplastic (cancerous) cells, or the ability of cancer cells to survive and grow despite anti-cancer therapies. (wikipedia.org)
Antineoplastic resistance, synonymous with chemotherapy resistance, is the ability of cancer cells to survive and grow despite different anti-cancer therapies, i.e. their multiple drug resistance. (wikipedia.org)
The over amplification of oncogenes can occur in response to chemotherapy, thought to be the underlying mechanism in several classes of resistance. (wikipedia.org)
Bloodstream infections (BSI) are a severe complication of antineoplastic chemotherapy or hematopoietic stem cell transplantation (HSCT), especially in the presence of antibiotic resistance (AR). (uni-frankfurt.de)
The induced differential stress resistance results in improved resistance to cytotoxicity in normal cells, which, in turn, reduces cytotoxic side-effects due to chemotherapy, as well as improved effectiveness of chemotherapeutic agents. (justia.com)
In particular, the present invention provides methods for enhancing the effectiveness of chemotherapy by inducing differential stress resistance in normal cells and cancer cells via short-term starvation, cell growth inhibitors, or reduced caloric or glucose intake. (justia.com)
In another aspect, the invention features methods of contacting a cancer cell with a chemotherapy agent and methods of increasing resistance of a non-cancer cell to a chemotherapy agent. (justia.com)
In its non- oncological use, the term may also refer to antibiotics ( antibacterial chemotherapy ). (wikidoc.org)
The lack of effective antibiotics may have a negative impact on the success of common medical procedures such as chemotherapy, organ transplantation and surgery. (healthhub.sg)
OC incidence is growing in the last few decades, because of the increase in some immune-correlated chronic illnesses (diabetes, cancer, human immunodeficiency virus (HIV)) and the intensive use of some drugs, such as antibiotics, chemotherapy, and immunosuppressants [ 12 ] . (encyclopedia.pub)

They contribute to the emergence of low immunity, the use of antibiotics, antineoplastic agents, cytotoxic agents, corticosteroids, and others to treat them, as well as for the treatment of severe fungal infections of the skin and mucous membrane antifungals are used as drugs for systemic use. (antiinfectivemeds.com)
DBL Cisplatin Injection belongs to a group of medicines known as antineoplastic or cytotoxic agents. (news-medical.net)

Analysis of heterologous expression systems of rOAT1 in oocytes and culture cells revealed that rOAT1 has the ability to transport anionic drugs, such as β-lactam antibiotics, NSAIDs, methotrexate, and antiviral drugs, as well as various endogenous organic anions and exogenous substances. (aspetjournals.org)

Antibiotic- Broad spectrum antibacterial activity-inhibits growth of E.Coli, B.dysenteriae, Pseudomonas spp. (foundationlabs.us)
Ten prodrugs were synthesized and screened for antibacterial activity against seven Gram-negative and two Gram-positive isolates fully susceptible to traditional antibiotics, alongside six Gram-negative and five Gram-positive isolates with resistance mechanisms. (nih.gov)
Previous researches revealed that BF-30 is a phenylalanine- and lysine-rich polypeptide exhibiting broad spectrum and strong antibacterial properties without drug resistance. (jcancer.org)
Moreover, BF-30 exerted antibacterial acitivities through enhancing the permeability of cytoplasmic membrane which is superior to the common antibiotics [ 2 ]. (jcancer.org)

Quinupristin-dalfopristin, the first formulation of a distinct class of antibiotics known as the streptogramins, has activity against a range of gram-positive bacteria that are usually resistant to other agents, including vancomycin-resistant Enterococcus faecium . (aafp.org)
This class of antibiotics is an important addition to the options available for the treatment of severe infections caused by gram-positive organisms, including nosocomial pneumonia and infections related to the use of intravascular catheters. (aafp.org)
Particular groups of patients, including those with cystic fibrosis , immune dysfunction, and certain chronic infectious disease, are more likely to be treated with this class of antibiotics. (medscape.com)

In some cases, cancers can evolve resistance to multiple drugs, called multiple drug resistance. (wikipedia.org)
Since cancer is a genetic disease, two genomic events underlie acquired drug resistance: Genome alterations (e.g. gene amplification and deletion) and epigenetic modifications. (wikipedia.org)
Certain populations of cancer cells may possess inherent characteristics, such as genetic mutations and/or epigenetic changes, that confer drug resistance. (wikipedia.org)
Gene deletion is the opposite of gene amplification, where a region of a chromosome is lost and drug resistance occurs by losing tumor suppressor genes such as TP53. (wikipedia.org)
Epigenetic modifications in antineoplastic drug resistance play a major role in cancer development and drug resistance as they contribute to the regulation of gene expression. (wikipedia.org)
The T-lineage phenotype in children with acute lymphoblastic leukaemia (ALL) is associated with in vitro drug resistance and a higher relapse-risk compared to a precursor B phenotype. (prinsesmaximacentrum.nl)
Our study was aimed to investigate whether mutations in the ATM gene occur in childhood T-lineage acute lymphoblastic leukaemia (T-ALL) that are linked to drug resistance and clinical outcome. (prinsesmaximacentrum.nl)
While drug resistance may be a natural evolutionary phenomenon, the overuse and misuse of antibiotics have contributed to the increased occurrence of antibiotic resistance around the world. (healthhub.sg)
Licorice constituents reduce or reverse drug resistance in MRSA when combined with beta-lactam antibiotics. (interactionsguide.com)

The present invention provides a novel approach to cancer therapy by providing a method to differentially enhance the resistance of normal cells to chemotherapeutic agents, thereby, improving the effectiveness of chemotherapeutic agents in killing cancerous cells. (justia.com)
6) Briefly present the comparison of therapeutic effects of alkylating agents, antimetabolites, antibiotics, plant alkaloids and others. (biokaryon.com)
cycloSal-GEM-monophosphate (MP) prodrugs 20a and 20b were the most active agents against Gram-positive bacteria (Enterococcus faecalis and Staphylococcus aureus) and retained their activity against antibiotic-resistant isolates. (nih.gov)
Seroepidemiology of Hepatitis Klisyri 1 Topical identifiable only as Antineoplastic Alkylating Agents Use this medication FDA given the experiencing a burst chronically infected in. (ripyard.com)
Therapy-related AML (t-AML) is a subtype of AML caused by prior treatment with certain antineoplastic drugs (eg, alkylating agents, hydroxyurea , and topoisomerase II inhibitors). (msdmanuals.com)

Use additional code (U80-U89), (U82-U84), if desired, to identify the antibiotic to which a bacterial agent is resistant. (who.int)
The aminoglycosides are bactericidal antibiotics that bind to the 30S ribosome and inhibit bacterial protein synthesis. (medscape.com)
The implications of this resistance mechanism in the context of the algal-bacterial symbiosis are discussed. (princeton.edu)
A: Antibiotic resistance is a specific type of antimicrobial resistance, referring to the resistance to antibiotics that are used to treat bacterial infections such as skin infections, urine infections and lung infections. (healthhub.sg)
the empirical treatment of presumed fungal infections in febrile neutropenic patients, where the fever has failed to respond to broad spectrum antibiotics and appropriate investigations have failed to define a bacterial or viral cause. (medicines.org.uk)

On the other hand, antimicrobial resistance is a broader term that includes resistance to medication used to treat infections caused by microorganisms other than bacteria, including parasites (such as malaria), viruses (such as influenza, dengue and HIV) and fungi (such as yeast and mould). (healthhub.sg)

resistance to antimicrobial drugs. (who.int)
Antimicrobial resistance among gram-positive organisms has been increasing steadily during the past several decades. (aafp.org)
With antimicrobial resistance (AMR) becoming a serious threat around the world, we spoke to Associate Professor David Lye, who is a senior consultant to the One Health Antimicrobial Resistance Workgroup, which comprises Singapore Ministry of Health (MOH), Health Promotion Board (HPB), Singapore Food Authority (SFA), National Parks, National Environment Agency (NEA) and Public Utilities Board (PUB), to find out how we can protect ourselves against superbugs. (healthhub.sg)
A: AMR occurs when germs (such as bacteria, fungi and viruses) develop resistance to a specific antimicrobial drug (such as antibiotics and antivirals) after being exposed to it. (healthhub.sg)
Q: What is the difference between antibiotic resistance and antimicrobial resistance? (healthhub.sg)

Data on antifungal use are important for understanding practice patterns, assessing emergence of antifungal resistance and developing antifungal stewardship programmes. (cdc.gov)
The available pharmacological treatments (e.g., antifungal drugs) are very effective but present some critical points, such as frequent side effects and, in particular, antifungal resistance [ 1 ] . (encyclopedia.pub)

New therapeutic options are needed, including treatments for infections caused by antibiotic-resistant gram-positive organisms. (aafp.org)
1 Unfortunately, extensive use of antibiotics provides selective pressure for the emergence of resistant organisms, which, in turn, limits therapeutic options. (aafp.org)

These five coding alterations seem to occur more frequently in T-ALL (13%) than controls (5%, P = 0.06), but did not associate with altered expression levels of ATM or in vitro resistance to daunorubicin. (prinsesmaximacentrum.nl)
Other Smo inhibitors exist with antineoplastic effects in vitro and in clinical trials for patients with BCC or medulloblastoma (9-12). (acancerjourney.info)

Cancer cells are constantly using a variety of tools, involving genes, proteins, and altered pathways, to ensure their survival against antineoplastic drugs. (wikipedia.org)
Antineoplastic drugs kill susceptible sub-populations and the tumour mass may shrink as an initial response to the drug, resistant cancer cells will survive treatment, be selected and then propagate, eventually causing a cancer relapse. (wikipedia.org)
Use additional code (U85) , if desired, to identify resistance, non-responsiveness and refractive properties of the neoplasm to antineoplastic drugs. (who.int)
2) Briefly, describe the major factors used for selection of drugs for antineoplastic therapy. (biokaryon.com)
5) Briefly, present the mechanisms of action of antineoplastic drugs. (biokaryon.com)
7) Give your rationale why patients can respond favorably to antitumor drugs, but later develop a resistance. (biokaryon.com)
9) Present the major or typical undesirable side effects of the use of antineoplastic drugs. (biokaryon.com)
10) Explain why adjuvant antineoplastic drugs are becoming more common in the treatment of neoplastic diseases. (biokaryon.com)
In popular usage, it usually refers to antineoplastic drugs used to treat cancer or the combination of these drugs into a standardized treatment regimen . (wikidoc.org)

15) Briefly, present the mechanism of action of inhibitors of intracellular signaling used for antineoplastic therapy. (biokaryon.com)
Level of resistance to Smo inhibitors happens with Protopanaxdiol IC50 obtained Smo mutations (17 18 This research uncovered development inhibitory reactions to Smo inhibition in varied cancer cells utilizing a robotic-based system with a Protopanaxdiol IC50 hereditary data source. (acancerjourney.info)

Previous exposure to antibiotics, especially to carbapenems, was significantly associated with resistant Gram-negative BSI while previous colonization with methicillin-resistant S. aureus was associated with BSI due to this pathogen. (uni-frankfurt.de)
The steady increase in resistant organisms is related to the widespread use of antibiotics in community and hospital settings. (aafp.org)
3 When resistance has emerged during the treatment of vancomycin-resistant E. faecium infections, it has been to both components of the formulation. (aafp.org)
What can you do to fight the threat of superbugs- germs that have become resistant to a wide range of antibiotics? (healthhub.sg)
For example, farm animals that are fed antibiotics to encourage faster growth or prevent infections may develop antibiotic-resistant germs. (healthhub.sg)
Oral and respiratory tract infections caused by bacteria such as Streptococcus pneumoniae and Klebsiella pneumoniae pose a particular threat because of the rise of antibiotic-resistant strains, with vulnerable patient populations at high risk of infection [ 2 , 3 ]. (springer.com)

Cardiovascular- Increases cardiac contractility, lower blood pressure, increase resistance to hypoxia in cardiac muscles. (foundationlabs.us)
Excessive blood levels may cause changes in cardiac output, total peripheral resistance, and mean arterial pressure. (nih.gov)

This is certainly the case with tropodithietic acid (TDA), a broad-spectrum antibiotic generated by marine bacteria that engage in dynamic symbioses with microscopic algae. (princeton.edu)
A semisynthetic cephamycin antibiotic with a broad spectrum of activity against both gram-positive and gram-negative microorganisms. (drugbank.com)

16) Briefly, present the benefits of clinical use and differences in the pharmacokinetics of antimetabolites for antineoplastic therapy. (biokaryon.com)
17) Briefly, present the most common clinical problems related to antineoplastic therapy. (biokaryon.com)

Principal mechanisms of resistance include high levels of bleomycin hydrolase, cell mutations altering DNA sequences to prevent intercalation, poor cell accumulation of drug, and rapid plasma removal. (medscape.com)
Although resistance to quinupristin-dalfopristin can develop through one of several mechanisms (i.e., modification of the target binding site, enzymatic inactivation, or active efflux), it is not common. (aafp.org)

this identification is useful in identifying antibiotic resistance patterns. (medscape.com)

There are two general causes of antineoplastic therapy failure: Inherent genetic characteristics, giving cancer cells their resistance and acquired resistance after drug exposure, which is rooted in the concept of cancer cell heterogeneity. (wikipedia.org)
Underlying disease in relapse/progression, previous exposure to antibiotics, and need of ICU admission were significantly associated with mortality. (uni-frankfurt.de)

3 antibiotics were significantly associated with higher risk of ICU admission. (uni-frankfurt.de)

The combination of quinupristin and dalfopristin is synergistic, and is generally bactericidal compared with either agent used alone or compared with similar antibiotics in the macrolide group. (aafp.org)

An example of misuse is when antibiotics are prescribed for common respiratory illnesses such as cold and flu, which are not caused by bacteria and therefore not treatable by antibiotics. (healthhub.sg)
Common viral infections that cause prolonged fever, such as glandular fever and dengue fever, cannot be treated with antibiotics as well. (healthhub.sg)

The abolition of the antineoplastic DFX effects when cells were co-treated with ferric ammonium sulfate supports the hypothesis that its effects result from its ability to chelate iron. (biomedcentral.com)

In addition, we identify an operon that confers TDA resistance to the producing marine bacteria. (princeton.edu)
Q: Why are antibiotics effective against bacteria but ineffective against viruses? (healthhub.sg)
A: Antibiotics kill bacteria either by attacking their cell walls or by inhibiting their growth. (healthhub.sg)

Overcoming resistance to treatment is an essential issue in many cancers including glioblastoma (GBM), the deadliest primary tumor of the central nervous system. (biomedcentral.com)

they have a tendency to chronic course, and resistance to even the most modern methods of treatment. (antiinfectivemeds.com)

Recent virus epidemics and rising antibiotic resistance highlight the importance of hygiene measures to prevent and control outbreaks. (springer.com)

Antibiotic resistance is rising to dangerously high levels worldwide [ 1 ]. (springer.com)
Patients were eligible for this examine if with elastic bands with purple colour-coded resistance levels, and they had type 1 (characterized by prominence of the inferior progressed by way of inexperienced and blue bands. (ehd.org)

This invention relates to methods of inducing differential stress resistance in a subject with cancer by starving the subject for a short term, administering a cell growth inhibitor to the subject, or reducing the caloric or glucose intake by the subject. (justia.com)
More specifically, in one aspect, the invention features methods of inducing differential stress resistance in a subject with cancer. (justia.com)

Germ infections worldwide are becoming increasingly difficult to treat as antibiotics become less effective. (healthhub.sg)

Venous thrombosis or as convenience, this rate in patients due to the acyclovir for three changes indicative of potential resistance to or technique used. (ripyard.com)
Unspecified septicaemia, HIV and antineoplastic therapy were among the top primary diagnosis codes for patients who received antifungals. (cdc.gov)

In fact, doctors are concerned that even simple infections that arise from a cut may lead to death due to AMR and the lack of effective antibiotics. (healthhub.sg)

Using cytological profiling, we herein determine the MoA of TDA and surprisingly find that it acts by a mechanism similar to polyether antibiotics, which are structurally highly divergent. (princeton.edu)

2 They belong to the macrolidelin-cosamide-streptogramin group of antibiotics. (aafp.org)

Particulars as to the optimal dosage and the eventual development of resistance are as yet incomplete. (medicines.org.uk)

Anatomy6

Organisms23

Diseases22

Chemicals and Drugs104

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Phenomena and Processes61

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Technology, Industry, Agriculture3

Information Science3

Named Groups1

Health Care11

Chemotherapy10

Cytotoxic agents2

Antiviral drugs1

Antibacterial4

Class of antibiotics3

Drug resistance9

Agents5

Bacterial5

Medication1

Antimicrobial5

Antifungal resistance2

Therapeutic2

Vitro2

Drugs9

Inhibitors2

Resistant6

Cardiac2

Broad spectrum2

Clinical2

Mechanisms2

Patterns1

Exposure2

Significantly associated1

Agent1

Common2

Cells1

Bacteria3

Cancers1

Treatment1

Prevent1

Levels2

Subject2

Treat1

Patients2

Effective1

Similar1

Group1

Development1