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  • gene
  • Contrary to this, using mice with a deletion of the R-ras gene, we found that R-Ras facilitates DMBA/TPA-induced skin tumour induction. (uta.fi)
  • Mice that are homozygous null for the Ccr4 gene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. (jax.org)
  • cardiac
  • LCAD knockout mice displayed a higher level of cardiac hypertrophy, as indicated by increased left ventricular wall thickness and an increased about of metabolic cardiomyopathy. (wikipedia.org)
  • Carnitine supplementation did lower the triglyceride levels in these knockout mice, but did not have any effect on hypertrophy or cardiac performance. (wikipedia.org)
  • overexpression
  • Furthermore, our previous MCAO study indicated that infarct size and blood-brain barrier breakdown are enhanced in mice with pericyte-specific overexpression of Nox4, relative to levels observed in controls. (mdpi.com)
  • found
  • The DMBA/TPA skin tumourigenesis-model is highly dependent upon inflammation, and we found a greatly attenuated skin inflammatory response to DMBA/TPA-treatment in the R-Ras KO mice in the context of leukocyte infiltration and proinflammatory cytokine expression. (uta.fi)
  • In experiments, which were conducted in mice, the scientists found that the body s internal biological clock affects the survival of immune cells that are targets of the anti-cancer drug cyclophosphamide (CY). (innovations-report.com)
  • However, when the researchers analyzed the activity of the knockout animals immune system B cells, they found evidence that the activity of the Clock and Bmal1 genes determined the cells sensitivity to CY. (innovations-report.com)
  • Contrarily, activation of GPER has been found to be anxiogenic in mice, while activation of ERβ has been found to be anxiolytic. (wikipedia.org)
  • It was found that after blocking NPY expression in mouse olfactory epithelium, the amount of olfactory precursor cells decreased by half. (wikipedia.org)
  • genes
  • A targeting vector containing neomycin resistance and thymidine kinase genes was used to disrupt the entire Ccr4 coding region. (jax.org)
  • Indeed, when LCAD mice are exposed to the cold, the expression of fatty acid oxidation genes was elevated in liver. (wikipedia.org)
  • deposition
  • This supported the hypothesis that IL-13Rα2 is a negative regulator of IL-13-induced response and illustrated significantly reduced production of TGF-β1 and deposition of collagen in the lungs of mice. (wikipedia.org)
  • studies
  • These mice may be useful in studies related to leukocyte trafficking and inflammation and infection. (jax.org)
  • Recent studies indicate that the metabolism by ALOXE3 of the R stereoisomer of 12-HpETE made by ALOX12B and therefore possibly the S stereoisomer of 12-HpETE made by ALOX12 or ALOX15 is responsible for forming various hepoxilins in the epidermis of human and mouse skin and tongue and possibly other tissues. (wikipedia.org)
  • leukocyte
  • Sub-primate mammals, such as the mouse, rat, rabbit, cow, and pig, express platelet type 12-lipoxygenase but also a leukocyte type 12-lipoxygenase (also termed 12/15-lipoxygenase, 12/15-LOX or 12/15-LO) which is an ortholog of, and metabolically equivalent to, human 15-LO-1 in that it forms predominantly 15(S)-HpETE with 12(S)-HpETE as a minor product. (wikipedia.org)
  • genetically
  • To examine the mechanism for this difference, Antoch and her colleagues used mice that genetically lack different components of the body s internal clock. (innovations-report.com)
  • cells
  • L6 cells were acutely (2 h) and chronically (6 and 12 h) exposed to palmitate, and the expression of several proteins involved in insulin resistance, ER stress and inflammation were analyzed. (springer.com)
  • These results link ER stress, inflammation and insulin resistance in L6 cells. (springer.com)
  • It has been proposed that stimulation of WNT16 expression in nearby normal cells is responsible for the development of chemotherapy-resistance in cancer cells. (wikipedia.org)
  • This in turn caused the mice to develop an lower amount of olfactory cells overall. (wikipedia.org)
  • animals
  • The initial experiments with normal mice, performed by Antoch during her tenure in Takahashi s lab, confirmed that animals treated with CY survived better when they received treatment in late afternoon than those whose treatments were initiated early in the morning. (innovations-report.com)
  • Type
  • The tumours appeared in wild-type (WT) mice on average 6 weeks earlier than in R-Ras knockout (R-Ras KO) mice. (uta.fi)
  • Mice also express an epidermal type 15-lipoxygenase (e-12LO) which has 50.8% amino acid sequence identity to human 15-LOX-2 and 49.3% sequence indetity to mouse Arachidonate 8-lipoxygenase. (wikipedia.org)
  • high
  • They discovered that Clock-mutant and Bmal1-knockout mice showed high sensitivity to the drug at any time it was administered - as if the drug were administered early in the morning or late at night. (innovations-report.com)
  • blood
  • Injection of renalase in rodents transiently decreases blood pressure, heart rate, heart muscle contractility, and blood vessel resistance. (wikipedia.org)
  • skin
  • Consistently, loss of even 1 allele of Smad2 in mice is sufficient to increase susceptibility to skin carcinogenesis ( 7 , 9 ) due, in part, to increased Snail-mediated epithelial-to-mesenchymal transition (EMT) ( 7 ). (pubmedcentralcanada.ca)
  • treatment
  • One of the first questions she will ask is whether metformin, an insulin-sensitizing drug often used in the treatment of PCOS, has fertility benefits for the mice. (eurekalert.org)
  • Knowing the molecular mechanism of internal clock function lets us make some important predictions of how these mice may respond to drug treatment," said Antoch. (innovations-report.com)
  • This implies a mechanism by which cycles of genotoxic therapy might enhance subsequent treatment resistance in the tumor microenvironment. (wikipedia.org)