• gene
  • Contrary to this, using mice with a deletion of the R-ras gene, we found that R-Ras facilitates DMBA/TPA-induced skin tumour induction. (uta.fi)
  • Mice that are homozygous null for the Ccr4 gene are viable, fertile, normal in size and do not display any gross physical or behavioral abnormalities. (jax.org)
  • skeletal muscle
  • Since hormones like erythropoietin are secreted less in ESRD, renalase may also be a kidney hormone, although it is also expressed in heart muscle, skeletal muscle and liver cells in humans, and in mouse testicles. (wikipedia.org)
  • found
  • The DMBA/TPA skin tumourigenesis-model is highly dependent upon inflammation, and we found a greatly attenuated skin inflammatory response to DMBA/TPA-treatment in the R-Ras KO mice in the context of leukocyte infiltration and proinflammatory cytokine expression. (uta.fi)
  • Contrarily, activation of GPER has been found to be anxiogenic in mice, while activation of ERβ has been found to be anxiolytic. (wikipedia.org)
  • It was found that after blocking NPY expression in mouse olfactory epithelium, the amount of olfactory precursor cells decreased by half. (wikipedia.org)
  • studies
  • These mice may be useful in studies related to leukocyte trafficking and inflammation and infection. (jax.org)
  • Recent studies indicate that the metabolism by ALOXE3 of the R stereoisomer of 12-HpETE made by ALOX12B and therefore possibly the S stereoisomer of 12-HpETE made by ALOX12 or ALOX15 is responsible for forming various hepoxilins in the epidermis of human and mouse skin and tongue and possibly other tissues. (wikipedia.org)
  • genes
  • A targeting vector containing neomycin resistance and thymidine kinase genes was used to disrupt the entire Ccr4 coding region. (jax.org)
  • Indeed, when LCAD mice are exposed to the cold, the expression of fatty acid oxidation genes was elevated in liver. (wikipedia.org)
  • deposition
  • This supported the hypothesis that IL-13Rα2 is a negative regulator of IL-13-induced response and illustrated significantly reduced production of TGF-β1 and deposition of collagen in the lungs of mice. (wikipedia.org)
  • leukocyte
  • Sub-primate mammals, such as the mouse, rat, rabbit, cow, and pig, express platelet type 12-lipoxygenase but also a leukocyte type 12-lipoxygenase (also termed 12/15-lipoxygenase, 12/15-LOX or 12/15-LO) which is an ortholog of, and metabolically equivalent to, human 15-LO-1 in that it forms predominantly 15(S)-HpETE with 12(S)-HpETE as a minor product. (wikipedia.org)
  • fatty
  • In mice, LCAD deficient mice have been shown to expend less energy, and are also subject to hypothermia, which can be explained by the fact that a reduced rate of fatty acid oxidation is correlated with a lowered capacity to generate heat. (wikipedia.org)
  • Development
  • Abnormal signaling in vascular cells in diabetes and nondiabetic insulin resistance causes functional abnormalities long before the development of morphological manifestations of atherosclerosis. (ahajournals.org)
  • It has been proposed that stimulation of WNT16 expression in nearby normal cells is responsible for the development of chemotherapy-resistance in cancer cells. (wikipedia.org)
  • Type
  • The tumours appeared in wild-type (WT) mice on average 6 weeks earlier than in R-Ras knockout (R-Ras KO) mice. (uta.fi)
  • Mice also express an epidermal type 15-lipoxygenase (e-12LO) which has 50.8% amino acid sequence identity to human 15-LOX-2 and 49.3% sequence indetity to mouse Arachidonate 8-lipoxygenase. (wikipedia.org)
  • diabetes
  • 4 An alternative mechanism, producing a more sustained increase in DAG concentration, is through a pathway that begins with hydrolysis of phosphatidylcholine by phospholipase D. 5 Much less is known about the chronic activation of PKC through synthesis of DAG from glucose or lipid metabolites in diabetes and insulin resistance (see next section). (ahajournals.org)
  • normal
  • Although some normal responses to bacterial lipopolysaccharide (LPS) administration are observed (shivering and lethargy), these mice are resistant to LPS-induced lethality. (jax.org)
  • skin
  • Consistently, loss of even 1 allele of Smad2 in mice is sufficient to increase susceptibility to skin carcinogenesis ( 7 , 9 ) due, in part, to increased Snail-mediated epithelial-to-mesenchymal transition (EMT) ( 7 ). (pubmedcentralcanada.ca)
  • levels
  • Furthermore, our previous MCAO study indicated that infarct size and blood-brain barrier breakdown are enhanced in mice with pericyte-specific overexpression of Nox4, relative to levels observed in controls. (mdpi.com)
  • blood
  • Injection of renalase in rodents transiently decreases blood pressure, heart rate, heart muscle contractility, and blood vessel resistance. (wikipedia.org)
  • heart
  • In the heart, LCAD knockout mice rely more heavily on glucose oxidation, concurrently while there is a large need for replenishment of metabolic intermediates, or analplerosis. (wikipedia.org)
  • body
  • Male GPER knockout mice are observed to have increased growth, body fat, insulin resistance and glucose intolerance, dyslipidemia, increased osteoblast function (mineralization), resulting in higher bone mineral density and trabecular bone volume, and persistent growth plate activity resulting in longer bones. (wikipedia.org)
  • treatment
  • This implies a mechanism by which cycles of genotoxic therapy might enhance subsequent treatment resistance in the tumor microenvironment. (wikipedia.org)