- This active site contains specific amino acid residues that interact with the lactose molecule, allowing the enzyme to catalyze the hydrolysis reaction. (pediaa.com)
- The active site of beta-galactosidase contains specific amino acid residues that interact with the β-galactoside substrate, facilitating the cleavage of the glycosidic bond. (pediaa.com)
- Further in silico study was performed to explain the binding mode between flavonoid pyranoside or galactoside and flavonoid aglycone in the 15-LOX cavity and their amino acid residues interaction. (ui.ac.id)
- Typically, CRDs are located at the C-terminal end of the protein and consist of a classic β -sandwich fold of approximately 130 amino acid residues. (fdocuments.net)
- The amino acid analysis indicates approximately 1,170 residues per subunit. (toyobo-global.com)
- It hydrolyzes terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. (novusbio.com)
- Background Beta-Galactosidase is an enzyme involved in hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. (agrisera.com)
- Both exhibit substrate specificity for β-galactosides, meaning they are specialized in catalyzing the hydrolysis of compounds that contain β-galactose molecules. (pediaa.com)
- Subsequently, several groups identified new members of the galectin family in protein extracts obtained from various tissues by using their ability to bind galactose residues on rabbit erythrocytes and cloning approaches based on sequence homology. (fdocuments.net)
- Subfamily AA5_2 contains galactose 6-oxidases ( EC 1.1.3.9 ), which oxidize the C-6 hydroxyl of diverse galactosides to the corresponding aldehyde [ 4 , 5 , 6 ]. (cazypedia.org)
- β-galactosides include carbohydrates containing galactose where the glycosidic bond lies above the galactose molecule. (wikidoc.org)
- [3] Beta-gal is inhibited by L-ribose , non-competitive inhibitor iodine , and competitive inhibitors phenylthyl thio-beta-D-galactoside (PETG), D-galactonolactone, isopropyl thio-beta-D-galactoside (IPTG) , and galactose. (wikidoc.org)
- These enzyme catalyse the hydrolysis of terminal, non-reducing terminal beta-D-galactoside residues. (wikipedia.org)
- The main difference between lactase and beta galactosidase is that lactase is specialized for the hydrolysis of lactose specifically, while beta-galactosidase is a more versatile enzyme capable of breaking down a variety of galactoside compounds, including lactose. (pediaa.com)
- Its structure consists of a single polypeptide chain with a specific active site responsible for the hydrolysis of β-galactosides. (pediaa.com)
- The primary function of beta-galactosidase is the hydrolysis of β-galactosides, particularly lactose. (pediaa.com)
- β-galactosidase , also called lactase , beta-gal or β-gal , is a glycoside hydrolase enzyme that catalyzes the hydrolysis of β-galactosides into monosaccharides through the breaking of a glycosidic bond . (wikidoc.org)
- Hydrolysis of terminal, non-reducing β-D-fructofuranoside residues in β-D-fructofuranosides. (megazyme.com)
- Background: Galectin-3 (Gal-3) is a ß-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been suggested to predict a poor response to immune checkpoint therapy with the anti-PD-1 monoclonal antibody pembrolizumab. (bvsalud.org)
- The trimer structure contains three active sites and each subunit contributes to two active sites via residues located on two surfaces. (nih.gov)
- Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. (nih.gov)
- Active galactoside acetyltransferase is trimeric, with active sites located at the interface between two LbH subunits. (nih.gov)
- In 1994, a joint effort by several investigators in the field led to a new nomenclature in which the term "galectins" was used to define lectins with an affinity for - galactosides and with sequence similarity in the carbohydrate-binding site [3]. (fdocuments.net)
- Many stages of the metastatic cascade involve cellular interactions mediated by cell surface components, such as carbohydrate-binding proteins, including galactoside-binding lectins (galectins). (johnshopkins.edu)
- This allows the enzyme to break down lactose and other β-galactosides into their constituent monosaccharides. (pediaa.com)
- MytiLec binds to the sugar moiety of globotriose (Gb3), an α-galactoside, leading to apoptosis of Gb3-expressing Burkitt's lymphoma cells. (go.jp)
- Purpose: The aim of this study was to determine whether modified citrus pectin, a complex polysaccharide rich in galactosyl residues, could inhibit spontaneous metastasis of prostate adenocarcinoma cells in the rat. (johnshopkins.edu)
- Xyloglucan (XG), the principal load-bearing hemicellulose of dicotyledonous plants, has a terminal fucosyl residue. (unl.edu)
- They were initially de- scribed in the electric eel, Electrophorus electri- cus , as low-molecular-weight, -galactoside- binding, soluble proteins (electrolectins) [1]. (fdocuments.net)
- Binding to a glycolipid, any compound containing one or more monosaccharide residues bound by a glycosidic linkage to a hydrophobic group such as an acylglycerol, a sphingoid, a ceramide (N-acylsphingoid) or a prenyl phosphate. (mcw.edu)
- Likely via a radical-pair mechanism 12 , T 1 reacts within microseconds to the signaling state, characterized by a covalent thioadduct between a highly conserved cysteine residue in the LOV photosensor and the C4a atom of the flavin isoalloxazine ring system. (nature.com)
- Bradyrhizobium NodZ is an alpha 1,6-fucosyltransferase involved in the biosynthesis of the nodulation factor, a lipo-chitooligosaccharide formed by three-to-six beta-1,4-linked N-acetyl-d-glucosamine (GlcNAc) residues and a fatty acid acyl group attached to the nitrogen atom at the non-reducing end. (unl.edu)
- Structure of LacY with an α-substituted galactoside: Connecting the binding site to the protonation site. (ucsf.edu)
- Cooking unsoaked seeds brought about a greater reduction in the total alpha-galactoside content than soaking for nine hours. (researchgate.net)
- greater reduction in the total α -galactoside content than soaking for nine hours. (researchgate.net)
- A highly conserved glutamine residue in strand Iβ is situated immediately adjacent to the flavin and has been identified as instrumental in reading out the flavin N5 position and eliciting the downstream transitions. (nature.com)
- NodZ transfers L-fucose from the GDP-beta-L-fucose donor to the reducing residue of the chitin oligosaccharide backbone, before the attachment of a fatty acid group. (unl.edu)
- The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions. (cancerindex.org)
- 15. O-linked sialic acid residues on platelet membrane glycoprotein (GP) IIb mask the human HPA-9b alloepitope. (nih.gov)
- They can be further modified by the addition of fucose or sialic acid residues at the terminal positions and are joined by a multitude of linkages. (biomedcentral.com)
- Here, it interacts with the -galactoside residues of several glycoproteins, thus forming higher order supramolecular structures resulting in galectin-ligand lattices within the cell surface [5]. (biotech2012.org)
- Further in silico study was performed to explain the binding mode between flavonoid pyranoside or galactoside and flavonoid aglycone in the 15-LOX cavity and their amino acid residues interaction. (ui.ac.id)
- The phylogenetic analysis showed the high degree of identity between the identified O. ochengi and the O. volvulus galectin-1 (ß-galactoside-binding protein-1) consisting only in one exchange of alanine for serine. (biomedcentral.com)
- It's rich in galactoside residues - molecules that have an affinity for binding to certain types of unwanted cells. (myvites.com)