• Extensive evidence has revealed that the core clock machinery involves "clock genes" and "clock proteins" functioning as molecular cogs. (bioone.org)
  • To test the basis for defects in patterning, genes required for segment formation in the Drosophila embryo were examined. (sdbonline.org)
  • The conserved family of Transcription Intermediary Factors (TIF1) proteins consists of key transcriptional regulators that control transcription of target genes by modulating chromatin state. (elifesciences.org)
  • The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
  • The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
  • This domain occurred 395 times on human genes ( 899 proteins). (umbc.edu)
  • The core targets and related signaling pathways of MSMY active ingredients for the treatment of ALL were predicted by protein-protein interaction network (PPI), gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) functional enrichment analysis. (bvsalud.org)
  • In some embodiments, one or more genes of interest in the translocation-bearing altered insect population encodes for a disease prevention protein/disease refractory protein, or a gene conferring conditional lethality, inability to undergo diapause, sterility, inability to fly. (justia.com)
  • To date, two-thirds of fALS are associated with mutations in any of more than 25 genes [ 3 , 4 , 5 ], encoding proteins involved in protein homeostasis, RNA metabolism, vesicular trafficking, and cytoskeletal organization. (en-journal.org)
  • Protein pigeon homolog also known as gamma-secretase activating protein (GSAP) is a protein that in humans is encoded by the PION gene. (wikipedia.org)
  • The name of the human PION gene derives the corresponding Drosophila gene. (wikipedia.org)
  • Members of the Wnt gene family are defined by their sequence similarity to mouse Wnt-1 and Wingless in Drosophila. (embl-heidelberg.de)
  • Wnts are a recently described family of secreted glycoproteins related to the Drosophila segment polarity gene, wingless, and to the proto-oncogene, int-1. (embl-heidelberg.de)
  • Mutation in the Drosophila retained/dead ringer ( retn ) gene leads to female behavioral defects and alters a limited set of neurons in the CNS. (sdbonline.org)
  • A variety of approaches, including biochemical purification, gene isolation by homology, and genetic screens, have been successfully used for the identification of putative protein kinases and phosphatases. (rupress.org)
  • Our studies have demonstrated that several of the proteins encoded by cellular oncogenes function in fundamental aspects of gene regulation. (stanford.edu)
  • The function of the Drosophila extramacrochaetae ( emc ) gene has been characterized almost exclusively in relation to the pat-terning of the fly's sensory organs (chaetae and other types of sensilla). (biologists.com)
  • This gene product is predicted to be a single-pass type II Golgi membrane protein but it may also be secreted and proteolytically processed like the related proteins in mouse and Drosophila (PMID: 9187150). (prosci-inc.com)
  • Drosophila protein neurotactin (gene nrt) which may mediate or modulate cell adhesion between embryonic cells during development. (expasy.org)
  • Drosophila protein glutactin (gene glt), whose function is not known. (expasy.org)
  • Our lab focuses on investigating the structure, function, and regulation of proteins involved in cell signaling, epigenetics, and gene regulation. (bu.edu)
  • Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
  • The transcribed human pigeon homolog protein is 854 amino acid residues in length. (wikipedia.org)
  • The Plasmodium falciparum reticulocyte-binding protein homolog 5 (PfRH5) has recently emerged as a leading candidate antigen against the blood-stage human malaria parasite. (nature.com)
  • Using a yeast two-hybrid screen, we identified the human homolog of Drosophila Tribbles 3, TRIB3, as an interactor for APOBEC3A and APOBEC3C. (pasteur.fr)
  • We found that 14-3-3 proteins interact with Ataxin-1 in a S776-dependent manner and that 14-3-3 augments levels of Ataxin-1 when phosphorylated at S776 by Akt kinase. (bcm.edu)
  • Serine/Threonine Kinases (STKs), cAMP-dependent protein kinase (PKA) subfamily, PRKX-like kinases, catalytic (c) subunit. (umbc.edu)
  • The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. (umbc.edu)
  • Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. (umbc.edu)
  • PPI network showed that 27 targets such as triptolide, RAC-alpha serine/threonine-protein kinase (AKT1), vascular endothelial growth factor A and Caspase-3 (CASP3) were the core targets. (bvsalud.org)
  • KEGG enrichment analysis related signaling pathways included cancer pathway, phosphatidylinositol 3 kinase, PI-3K/protein kinase B (PI3K-Akt) signaling pathway, apoptosis and mitogen-activated protein kinase (MAPK) signaling pathway and IL-17 signaling pathway. (bvsalud.org)
  • STP, serine/threonine protein phosphatase. (rupress.org)
  • The reversible phosphorylation of proteins on serine, threonine, and tyrosine residues represents a fundamental strategy used by eukaryotic organisms to regulate a host of biological functions, including DNA replication, cell cycle progression, energy metabolism, and cell growth and differentiation. (rupress.org)
  • Catalytic domain of PRKX-like Protein Serine/Threonine Kinases. (umbc.edu)
  • STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. (umbc.edu)
  • As is the case for lipases and serine proteases, the catalytic apparatus of esterases involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine. (expasy.org)
  • Structural and biochemical comparisons between DOPAL synthase and DDC in Drosophila identified that the key active site residue, Asn192, in insect DOPAL synthase can be used to distinguish all available insect DOPAL synthases from DDC sequences [ 15 ]. (biomedcentral.com)
  • RCC1, known as PRP20 or SRM1 in yeast, pim1 in fission yeast and BJ1 in Drosophila, is a protein that contains seven tandem repeats of a domain of about 50 to 60 amino acids. (embl.de)
  • Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
  • The functional importance of conserved amino acid residues is discussed in relation to the crystal and NMR structures of MbraCSPA6. (gc.ca)
  • The DNA binding domain of the Drosophila transcription factor (Antennapedia), a 60 amino acid protein, has the ability to penetrate biological membranes. (lifetein.com)
  • If Extramacrochaetae par-ticipates in cell specification by dimerizing with basic-region-helix-loop-helix proteins, the variety of defects and tissues affected by the insufficiency of extramacrochaetae suggests that helix-loop-helix proteins are involved in many embryonic developmental processes. (biologists.com)
  • Polyglutamine-binding protein 1 ( PQBP1 ) is an RNA-splicing factor that, when mutated, in humans causes Renpenning syndrome, an X-linked intellectual disability disease characterized by severe cognitive impairment, but also by physical defects that suggest PQBP1 has broader functions in embryonic development. (xenbase.org)
  • Histone methylation by the Drosophila epigenetic transcriptional regulator Ash1. (wikigenes.org)
  • This important study advances our understanding of the functions and regulation of the Drosophila transcriptional regulator Bonus, an ortholog of mammalian TIF1 family members. (elifesciences.org)
  • They encode proteins of ~350-400 residues in length, with orthologues identified in several, mostly vertebrate, species. (embl-heidelberg.de)
  • The peptide has the same translocating properties as the entire protein and can facilitate the cytoplasmic uptake of CTL epitope 9-mer peptides. (lifetein.com)
  • Here, we identify Pins-mediated planar cell polarized divisions in several of the mitotic domains of the early Drosophila embryo. (elifesciences.org)
  • Post-translational modifications of histone proteins play a pivotal role in DNA packaging and regulation of genome functions. (sdbonline.org)
  • In mice, rapamycin treatment increases expression of histone proteins and Wdfy3 transcription, and alters chromatin organisation in the small intestine, suggesting the mTORC1-histone axis is at least partially conserved in mammals and may offer new targets for anti-ageing interventions. (sdbonline.org)
  • The chromodomain of the HP1 family of proteins recognizes histone tails with specifically methylated lysines. (ox.ac.uk)
  • Here, we present structural, energetic, and mutational analyses of the complex between the Drosophila HP1 chromodomain and the histone H3 tail with a methyllysine at residue 9, a modification associated with epigenetic silencing. (ox.ac.uk)
  • In Drosophila neuroblasts, asymmetric division and spindle orientation is dependent on Pins/LGN recruitment to the apical cortex. (elifesciences.org)
  • These participate in transcriptional/translational feedback loops and many homologous clock-components in the fruit fly Drosophila are also expressed in mammalian clock tissues with circadian rhythms. (bioone.org)
  • Cell 75:495, 1993), and a series of unique E6-AP homologous proteins have been identified (Huibregtse et al. (justia.com)
  • skeletal regions of other and Serotonergic students are typical in download Common knowledge homologous proteins into activation component. (erik-mill.de)
  • As the Drosophila homologue of mammalian DENN/MADD and Caenorhabditis elegans AEX-3, Rab3-GEF is a guanine nucleotide exchange factor (GEF) for Rab3 that stimulates GDP to GTP exchange. (eneuro.org)
  • Cas9 nuclease can be converted into an RNA-guided DNA binding protein (dCas9) via inactivation of its two catalytic domains 12 , 13 and then fused to transcription activation domains. (cdc.gov)
  • Most, although not all, of the mutations causing skeletal abnormalities involve conserved residues that are predicted to play an important structural role in the correct folding of FGFRs, and substitutions with other residues result in constitutive activation of FGFRs with ligand-independent dimerization (11) . (aacrjournals.org)
  • This phenotype co-segregates with either of two frameshift mutations, 1988delAGAG and 2469delGTCA, in ESPN , which encodes a calcium-insensitive actin-bundling protein called espin. (bmj.com)
  • Protein phosphorylation can regulate enzyme function, mediate protein-protein interactions, alter subcellular localization, and control protein stability. (rupress.org)
  • 88:7351, 1991) and it appears that each E2 enzyme can act with one or more E3 proteins (Nuber et al. (justia.com)
  • Duck acyl-[acyl-carrier protein] hydrolase, medium chain (EC 3.1.2.14 ), an enzyme that may be associated with peroxisome proliferation and may play a role in the production of 3-hydroxy fatty acid diester pheromones. (expasy.org)
  • Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
  • The p53 interacting partner protein NUMB (homology of numb protein) preserves this intrinsic cellular asymmetry by preventing ubiquitin-mediated proteolysis of p53 catalyzed by the MDM2 E3 ubiquitin ligase 11 . (nature.com)
  • These results strongly support the view that the HD is connected through a flexible linker to the main body in the Antp protein and that the minor groove contacts by the N-terminal arm (residues 1-6) in the Antp HD-DNA complex are an intrinsic feature of the DNA-binding interactions of the intact Antp protein. (unibas.ch)
  • In vertebrates this subfamily contains four proteins: TIF1α/TRIM24, TIF1β/TRIM28, TIF1γ/TRIM33, and TIF1δ/TRIM66, while only one protein, Bonus (Bon), is present in Drosophila , making it an attractive model to understand the conserved functions of TIF1 proteins. (elifesciences.org)
  • Acetylcholinesterase (EC 3.1.1.7 ) (AChE) from vertebrates and from Drosophila. (expasy.org)
  • Co-expression of Ov-phy-1 with the O. volvulus homologue of protein disulfide isomerase in a baculovirus system resulted in the production of enzymatically active O. volvulus prolyl 4-hydroxylase. (embl.de)
  • Elevated expression of H3/H4 in intestinal enterocytes in Drosophila alters chromatin organization, induces intestinal autophagy through transcriptional regulation, prevents age-related decline in the intestine. (sdbonline.org)
  • While their genomic structure is distinct from other glycosyltransferases, fringe proteins have a fucose-specific beta-1,3-N-acetylglucosaminyltransferase activity that leads to elongation of O-linked fucose residues on Notch, which alters Notch signaling. (prosci-inc.com)
  • Notch Co-Activator and Co-Repressor isoforms: This download Common alters annotated by at least one traditional -domain residues( Co-R) produced to CSL in the water of Notch box-containing. (erik-mill.de)
  • Our analysis of SCA1 transgenic mice revealed that the mutant protein aggregates in the nuclei of cerebellar Purkinje cells and that these aggregates stain positively for ubiquitin, the proteasome, and some chaperones. (bcm.edu)
  • 1) Characterize novel families of oncoproteins (Pbx and Meis) that dimerize with and regulate the DNA binding properties of Hox proteins. (stanford.edu)
  • Proteins that regulate vesicle exocytosis cluster at AZs, composing the cytomatrix at the active zone (CAZ). (eneuro.org)
  • We use chemical, semi-synthetic, biophysical, and cellular approaches to elucidate mechanisms for how post-translational modifications regulate protein function. (bu.edu)
  • Deamination is rapidly followed by excision of uracil residues and can lead to double-stranded breaks. (pasteur.fr)
  • DOPAL synthase is a member of the insect DDC-like protein family. (biomedcentral.com)
  • Drosophila esterase 6, produced in the anterior ejaculatory duct of the male insect reproductive system where it plays an important role in its reproductive biology. (expasy.org)
  • Insect OS-D-like proteins, also known as chemosensory (CSP) or sensory appendage proteins (SAP), are broadly expressed in various insect tissues, where they are thought to bind short to medium chain length fatty acids and their derivatives. (gc.ca)
  • Although their specific function remains uncertain, OS-D-like members have been isolated from sensory organs (including the sensillum lymph in some cases), and a role in olfaction similar to that of the insect odorant binding proteins (OBP) has been suggested for some.We have identified 15 new OS-Dlike sequences: four from cDNA clones described herein and 11 from sequencedatabases. (gc.ca)
  • Salei OA receptors remains in the α-adrenergic-like OARα clade that includes well characterized insect OAMB receptors that are normally coupled to Gq and/or Gs proteins (Han et al. (link-insta.xyz)
  • Keap1 is a cysteine-rich protein, known to be anchored to actin cytoskeleton [ 5 ], serving as an adaptor protein for the Cul3-dependent E3 ubiquitin ligase complex. (springer.com)
  • When resulting your due download Common( P2 as an dehydrogenase computer, a residue in ER or proteins for your adaptor), promote this superfamily. (erik-mill.de)
  • Levels of cellular protein phosphorylation are modulated both by protein kinases and phosphatases. (rupress.org)
  • Using a fluorescent sulfhydryl probe as well as a sulfhydryl inhibitor, one observes a strong cell density response, supporting the hypothesis that cellular redox potential could alter protein stability. (embl.de)
  • Oxidative stress generated during such stressful conditions may damage DNA and proteins, and as a consequence the cellular processes are disturbed. (springer.com)
  • Our studies reveal that Rab3 and Rab3-GEF act within the same molecular mechanism and support a model wherein Rab3-GEF serves as a Rab3 effector to control active zone protein composition. (eneuro.org)
  • Recognizing the importance of protein interactions for mediating SCA1 pathogenesis, and given that SCA1 shares clinical and pathological features with several other inherited ataxias, we proposed that understanding the interactions of Ataxin-1 as they relate to the interactions of proteins implicated in other ataxias might provide better insight about molecular mechanisms leading to Purkinje cell degeneration and ataxia. (bcm.edu)
  • Apical proteins recruit Inscuteable (Insc), which in turn recruits Pins/LGN and the spindle rotation complex. (elifesciences.org)
  • At synapses, neurotransmitter exocytosis is regulated by a complex of release machinery proteins. (eneuro.org)
  • Degradation of a protein via the ubiquitin pathway proceeds by two discrete and successive steps: (a) covalent attachment of multiple ubiquitin molecules to the protein substrate, and (b) degradation of the targeted protein by the 26S proteasome complex. (justia.com)
  • A variety of extracellular stimuli including mitogens, cytokines, antigens, stress inducing agents, UV light and viral proteins initiate a signal transduction pathway that ultimately leads to NF-κB release and activation. (justia.com)
  • We found that disrupting forces through chemical inhibitors, depletion of an adherens junction protein, or blocking mesoderm invagination disrupted Pins planar polarity and spindle orientation. (elifesciences.org)
  • SCOP: Structural Classification of Proteins and ASTRAL. (berkeley.edu)
  • Cholinesterase-like domains in enzymes and structural proteins: functional and evolutionary relationships and identification of a catalytically essential aspartic acid. (expasy.org)
  • This model predicts that most proteins that interact with wild-type Ataxin-1 should interact with the mutant protein and that modifications of Ataxin-1 that might alter its conformation are critical to pathogenesis. (bcm.edu)
  • To assess the pathogenic effects of this variant, we have used patient-derived skin fibroblasts and motor neuron-specific overexpression of the RAPGEF2-E1357K mutant protein in Drosophila . (en-journal.org)
  • Our results indicate that loss of Rab3-GEF results in the development of NMJs that are structurally and functionally indistinguishable from NMJs that lack the protein Rab3. (eneuro.org)
  • Despite the hydrophobic nature of this tetrapeptide motif, the N-terminal arm consisting of residues -14 to 6 is flexibly disordered, and the well-defined part of the HD structure with residues 7-59 is indistinguishable from that of the shorter Antp HD polypeptide (where positions 0, 1, and 67 are methionine, arginine, and glycine, respectively). (unibas.ch)
  • The regulator of chromosome condensation (RCC1) [ ( PUBMED:8480369 ) ] is a eukaryotic protein which binds to chromatin and interacts with ran, a nuclear GTP-binding protein IPR002041 to promote the loss of bound GDP and the uptake of fresh GTP, thus acting as a guanine-nucleotide dissociation stimulator (GDS). (embl.de)
  • In Drosophila, this role organelle is of at least three regulatory experience Uncertainties: direct, Groucho, and dCtBP( Drosophila C-terminal Binding Protein). (erik-mill.de)
  • This led us to propose that wild-type Ataxin-1 might take on a conformation that resists clearance or interacts strongly with other proteins and that such conformation is favored by the expanded polyglutamine tract. (bcm.edu)
  • The Drosophila Extramacrochaetae protein antagonizes the proneural function of the Achaete and Scute proteins in the generation of the adult fly sensory organs. (biologists.com)
  • Taxonomic distribution of proteins containing WNT1 domain. (embl-heidelberg.de)
  • The complete taxonomic breakdown of all proteins with WNT1 domain is also avaliable . (embl-heidelberg.de)
  • Click on the protein counts, or double click on taxonomic names to display all proteins containing WNT1 domain in the selected taxonomic class. (embl-heidelberg.de)
  • TRIM/RBCC is an ancient protein family characterized by the presence of an N-terminal RING finger domain closely followed by one or two B-boxes and a coiled coil domain. (elifesciences.org)
  • In symmetric epithelial cell divisions, spindle orientation also depends on Pins, which is recruited to the lateral cortex by the lateral domain protein, Discs large (Dlg). (elifesciences.org)
  • Outside the repeat region, there is just a small N-terminal domain of about 40 to 50 residues and, in the Drosophila protein only, a C-terminal domain of about 130 residues. (embl.de)
  • Once active eNOS have found used into the vasoactive protein by the ubiquitin homes, the domain match recognizes. (erik-mill.de)
  • The Wnt proteins seem to adhere to the plasma membrane of the secreting cells and are therefore likely to signal over only few cell diameters. (embl-heidelberg.de)
  • Membrane enclosed crystal proteins from slime mold. (expasy.org)
  • γ-secretase activating protein (GSAP) increases β-amyloid production through a mechanism involving its interactions with both γ-secretase and its substrate, the amyloid precursor protein (APP). (wikipedia.org)
  • This suggested to us that the nuclear inclusions are probably protective by sequestering the glutamine-expanded protein and reducing its native interactions. (bcm.edu)
  • Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins. (justia.com)
  • Salei biogenic amine receptor series match partly to the Drosophila residues that were made use of to create this antibody. (link-insta.xyz)
  • A 16 kDa fragment (GSAP-16K) derived from 121 residues from the C-terminus region of the full length protein is known as the γ-secretase activating protein (GSAP). (wikipedia.org)
  • This work identifies Drosophila S2 cells as a clinically-relevant platform suited for the production of 'difficult-to-make' proteins from Plasmodium parasites, and identifies a PfRH5 sequence variant that can be used for clinical production of a non-glycosylated, soluble full-length protein vaccine immunogen. (nature.com)
  • The cloning of cDNA and genomic DNA encoding the PTH/parathyroid hormone-related protein (PTHrP) receptor. (massgeneral.org)
  • The 16-mer peptide (RQIKIWFQNRRMKWKK), residues 43-58, known as penetratin, from antennapedia preferentially targets the Class I pathway. (lifetein.com)
  • The secondary structure of an N-terminally elongated Antennapedia (Antp) homeodomain (HD) polypeptide containing residues -14 to 67, where residues 1-60 constitute the HD, has been determined by NMR in solution. (unibas.ch)
  • Our current focus is on understanding the function and regulation of deubiquitinases and RNA-modifying proteins, which are emerging as attractive therapeutic targets in several cancers. (bu.edu)
  • Quantification, nature and bioavailability of bound 14C-pesticide residues in soil, plants and food : proceedings of the Final Research Co-ordination Meeting on Isotopic Tracer-Aided Studies of Unextractable or Bound Pesticide Residues in Soil, Plants and Food / organized by the Joint FAO/IAEA Division of Isotope and Radiation Applications of Atomic Energy for Food and Agricultural Development and held in Gainesville, Florida, from 25 to 29 March 1985. (who.int)