• Chromosome 20 open reading frame 111, or C20orf111, is the hypothetical protein that in humans is encoded by the C20orf111 gene. (wikipedia.org)
  • C20orf111 a valid, protein coding gene that is found on the minus strand of chromosome 20 at q13.12 by searching the UCSC Genome Browser, but q13.11 according to Refseq on NCBI. (wikipedia.org)
  • 30 predicted Serine phosphorylation sites 5 predicted Threonine phosphorylation sites 3 predicted Tyrosine phosphorylation sites PELE (Protein Secondary Structure Prediction) was used to predict the secondary structure of C20orf111. (wikipedia.org)
  • In the present study, we have revised the structure of the USH3 gene, including a new translation start site, 5' untranslated region, and a transcript encoding a 232-amino acid protein. (nih.gov)
  • The mature form of the protein is predicted to contain three transmembrane domains and 204 residues. (nih.gov)
  • The p.Asn173His mutation affects a residue in the forkhead domain that is 100% conserved among vertebrate orthologs and is predicted to participate in protein-protein interactions. (molvis.org)
  • The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue protein with 12 putative transmembrane domains. (aspetjournals.org)
  • The hOAT3 protein was shown to be localized in the basolateral membrane of renal proximal tubules and the hOAT3 gene was determined to be located on the human chromosome 11q12-q13.3 by fluorescent in situ hybridization analysis. (aspetjournals.org)
  • Positional cloning of lymphopenia ( lyp ) in the BB rat revealed a frameshift mutation in Gimap5 , a member of at least seven related GTPase Immune Associated Protein genes located on rat chromosome 4q24. (hindawi.com)
  • Gimap5 is a member of at least seven related GTPase Immune Associated Protein ( Gimap ) genes located within 150 Kilobases (Kb) on rat chromosome (RNO) 4 [ 2 , 3 ]. (hindawi.com)
  • Gimap5 was identified as the lyp gene in the BBDP rat through a frameshift mutation and premature truncation of the Gimap5 protein [ 2 , 6 ] and can be rescued in a P1-derived artificial chromosome (PAC) transgenic rat [ 7 ]. (hindawi.com)
  • To investigate whether sheep infected with scrapie prions could be another source of infection, we inoculated transgenic mice that overexpressed human prion protein with brain tissue from sheep with natural field cases of classical and atypical scrapie, sheep with experimental BSE, and cattle with BSE. (cdc.gov)
  • Klapholz-Brown Z, Walmsley GG, Nusse YM, Nusse R, Brown PO "Transcriptional program induced by wnt protein in human fibroblasts suggests mechanisms for cell cooperativity in defining tissue microenvironments. (openwetware.org)
  • The National Center for Biotechnology Information, or NCBI, shows that it is located at q13.11 on chromosome 20, however the genome browser at the University of California-Santa Cruz (UCSC) website shows that it is at location q13.12, and within a million base pairs of the adenosine deaminase locus. (wikipedia.org)
  • C20orf111 gene has no clear paralogs in the human genome. (wikipedia.org)
  • Human genetics is the study of the human genome and the transmission of genes from one generation to the next. (amboss.com)
  • A fifth ( glycophorin E ) has been identified within the human genome but cannot easily be detected on routine gel staining. (wikidoc.org)
  • Diehn M, Bhattacharya R, Botstein D, Brown PO "Genome-Scale Identification of Membrane-Associated Human mRNAs. (openwetware.org)
  • Has a single circular genome (chromosome). (ecosh.com)
  • The sequenced genome (a method used to determine the entire genetic makeup of a certain organism or cell type to find changes in areas of the genome) of B. subtilis contains 4 214 630 base pairs. (ecosh.com)
  • The sequences are about 300 base pairs long and are repeated several thousand times throughout the genome. (ojp.gov)
  • We therefore decided to investigate comprehensively the global and high-resolution DNA methylation dynamics during early development of a non-human primate (rhesus monkey, Macaca mulatta ). (nature.com)
  • Monkeys have served as one of the most valuable models for understanding DNA methylation dynamics during early embryogenesis in human due to their similarities in genetics and early embryonic development 17 , 18 . (nature.com)
  • Cytosine 5-methylation, overall features of the TALE scaffold, and TALE amino acid positions engineered in this study to obtain TALE scaffolds with increased C/5mC selectivity. (nature.com)
  • Cytosine C5 methylation is an important epigenetic control mechanism in a wide array of eukaryotic organisms and generally carried out by proteins of the C-5 DNA methyltransferase family (DNMTs). (mdpi.com)
  • DNA methylation, particularly 5-methylcytosine (5mC) at CpG sequences, is widely conserved in eukaryotes. (elifesciences.org)
  • CaSR primarily consists of a dimer linked by a covalent disulfide bond between two cysteine residues (cys129 and cys131). (biomedcentral.com)
  • The forkhead box D3 ( FOXD3 ) gene encodes a forkhead transcription factor that plays an important role in neural crest specification in vertebrates and therefore may be involved in human eye disease. (molvis.org)
  • The apolipoprotein E (APOE) gene is located on chromosome 19 and encodes a glycoprotein that is 299 amino acids long. (dovepress.com)
  • Exon 1 encodes residues 1-16, exon 2 residues 17-35, exon 3 residues 36-63 and exon 4 residues 64-128. (wikidoc.org)
  • Each monomer of the human CaSR contains 1078 amino acid residues organized into three structural domains: an extracellular domain (ECD) composed of 612 residues at the hydrophilic N-terminus, a hydrophobic transmembrane domain (TMD) composed of 250 amino acids further organized into seven TMDs, and an intracellular domain (ICD) composed of 216 residues at the hydrophilic C-terminus (Fig. 2 a). (biomedcentral.com)
  • Genomic DNA Length:14,968 base pairs (bp) Most common mRNA Length: 2,260 bp with 4 exons. (wikipedia.org)
  • The gene encoding Sec31B is located on chromosome 10q24 and contains 29 exons. (biologists.com)
  • [4] The GPC gene is organized in four exons distributed over 13.5 kilobase pairs of DNA . (wikidoc.org)
  • The direct repeated segments containing these exons is 3.4 kilobase pairs long and may be derived from a recent duplication of a single ancestral domain. (wikidoc.org)
  • The second is a relatively poorly conserved leucine zipper region characterised by leucine in the last position of every seven amino acids, and hydrophobic residues at positions 3 and 4. (biomedcentral.com)
  • Current known regulators of calcium homeostasis include calcium-sensing receptor (CaSR) responsible for adjusting cytoplasmic calcium level based on extracellular concentrations, and inositol 1,4,5-trisphosphate receptors (IP3Rs) responsible for balancing cytoplasmic, mitochondrial, and endoplasmic reticulum (ER) calcium storage via the ryanodine receptors (RyRs). (biomedcentral.com)
  • The positional cloning and subsequent identification of the Gimap5 gene on RNO4 were in part established through generation of the DR. lyp congenic rat line along with recombination events following our method of marker assisted breeding of DP with F344 rats [ 2 , 4 , 5 ]. (hindawi.com)
  • Eukaryotic DNA polymerase β (pol β), the polymerase thought to be responsible for DNA repair synthesis, has been extensively characterized in rats and humans. (biomedcentral.com)
  • Among the OAT isoforms, rOAT3, as well as rOAT1, exhibits a markedly wide substrate selectivity, and its human homolog is considered a key molecule in the renal handling of organic anions. (aspetjournals.org)
  • After analyzing the amino acid content of C20orf111, it was found to be rich in serine residues. (wikipedia.org)
  • We have also identified mouse (chromosome 3) and rat (chromosome 2) orthologues, as well as two human paralogues on chromosomes 4 and 10. (nih.gov)
  • Moreover, repeats with selectivity for 5-methylcytosine (5mC) and its oxidized derivatives can be designed for analytical applications. (nature.com)
  • Human Genetics & Genomic Advances , 4 , 100204. (otago.ac.nz)
  • 5-Methylcytosine (5mC) and DNA methyltransferases (DNMTs) are broadly conserved in eukaryotes but are also frequently lost during evolution. (elifesciences.org)
  • One approach involves the experimental transmission of disease by inoculating homogenized brain tissue from affected animals into transgenic mice that are overexpressing 1 of the 2 common polymorphic forms of the human PrP (either methionine or valine at residue 129) on a mouse PrP null background ( 16 ). (cdc.gov)
  • Progress in therapy is usually hampered by the difficulties of inadequate positive predictive value of antibody detection and clinical scores in suspected HIT, very limited availability of practical platelet activation assays, and the paucity of new agents in human clinical trials. (immune-source.com)
  • Over the past three decades, clinical and pharmacological studies have accumulated a body of evidence that not only demonstrated these therapeutic effects, but also provided significant insights into the pharmacokinetic behavior, therapeutic profile, and mode of action of scutellarin in humans and animal models. (cdc.gov)
  • According to a simplified model of this theory a newly-conceived human embryo consists of pluripotent stem cells (Type A), ones that can potentially divide into any body cells. (anti-agingfirewalls.com)
  • G-rich DNA strands are naturally involved in duplex-DNA architecture through association with their complementary C-rich DNA strands by the canonical Watson-Crick pairing [ 1 - 3 ]. (hindawi.com)
  • Indeed, given that four guanine residues can self-associate in a planar arrangement through a Hoogsteen-type hydrogen-bonding network [ 4 ] to form a structure called G-quartet, G-rich strands can adopt a peculiar three-dimensional arrangement called G-quadruplex DNA [ 5 - 9 ] resulting from the stacking of several contiguous G-quartets (Figure 1 ). (hindawi.com)
  • the wild species has pods that are 5 to 10 cm (2 to 4 in) long and 1 cm diameter, but many modern cultivars developed for food use have pods 15 to 25 cm (6 to 10 in) long and 2-3 cm thick. (wikipedia.org)
  • In much of the English-speaking world , the name "broad bean" is used for the large-seeded cultivars grown for human food, while "horse bean" and "field bean" refer to cultivars with smaller, harder seeds that are more like the wild species and used for animal feed , [ citation needed ] though their stronger flavour is preferred in some human food recipes, such as falafel . (wikipedia.org)
  • In a study of this gene among the Hominoidea two finding unique to humans emerged: (1) an excess of non-synonymous divergence among species that appears to be caused solely by accelerated evolution and (2) the ability of the single GYPC gene to encode both the GPC and GPD proteins. (wikidoc.org)
  • A related, often sympatric species is Borrelia bissettii , but this species has not been associated with human disease. (cdc.gov)
  • Each configuration contains a contact zone, consisting of the set of amino acids from both interacting proteins that are with interaction distance, usually spanning from 3 to 5 Ångströms. (biomedcentral.com)
  • 5 , 6 In concordance with the role of nodal cilia in L-R asymmetry, mutations in the motor proteins Kif3A and Kif3B, and the transcription factor Foxj1 in the mouse have demonstrated that ciliary motility is important for L-R asymmetry. (bmj.com)
  • The proteins encoded by members of the Dbl family share a common domain, presented in this entry, of about 200 residues (designated the Dbl homology or DH domain) that has been shown to encode a GEF activity specific for a number of Rho family members. (embl-heidelberg.de)
  • The mRNA from human erythroblasts is ~1.4 kilobases long and the transcription start site in erythroid cells has been mapped to 1050 base pairs 5' of the start codon. (wikidoc.org)
  • T cells have been recently identified by using key molecular markers such as CD4 and CD8 ( 4 , 5 ). (aai.org)
  • Unlike non- ionizing radiation (such as microwaves and ultraviolet radiation), which has insufficient energy to eject molecular electrons, ionizing radiation deposits sufficient energy to remove electrons from atomic orbits and create molecular ion pairs along particle tracks. (cdc.gov)
  • Each cell (except for red blood cells) contains a nucleus that houses these chromosomes. (cdc.gov)
  • Interleukin-21 (IL-21) was first identified in 2000 through screening of a cDNA library from CD3+ human T cells [ 1 ]. (intechopen.com)
  • A cDNA encoding a multispecific organic anion transporter 3 (hOAT3) was isolated from a human kidney cDNA library. (aspetjournals.org)
  • Targeting APOE may be a potential approach for diagnosis, risk assessment, prevention, and treatment of various neurodegenerative and cardiovascular diseases in humans. (dovepress.com)
  • 3 In this review, we discuss the biological functions of human APOE and its role in Alzheimer's disease (AD), Parkinson's disease (PD), cardiovascular diseases (CVD), multiple sclerosis (MS), type 2 diabetes mellitus (T2DM), vascular dementia (VD), and ischemic (occlusive) stroke (IS). (dovepress.com)
  • OMIM [3], what I call "Wikipedia for Smart Medical Students," is essential when considering any and all human genetic diseases. (nakedcapitalism.com)
  • However, mounting evidence has suggested that CD8+ T cells, in particular, play an important role in the induction, progression, pathogenesis, and protection for autoimmune diseases ( 5 ). (frontiersin.org)
  • 7] If you look at figure 4 you will see that the progression of beta gene expression through life is seen with greatest complexity in primates and humans but is not a feature of marsupials or monotremes where only embyronic and fetal/adult forms of the beta and alpha components of haemoglobin is produced. (educatetruth.com)
  • Rubins KH, Hensley LE, Wahl-Jensen V, Daddario Dicaprio KM, Young H, Reed DS, Jahrling PB, Brown PO, Relman DA, Geisbert TW "The temporal program of peripheral blood gene expression in the response of non-human primates to Ebola hemorrhagic fever. (openwetware.org)
  • Palmer C, Diehn M, Alizadeh AA, Brown PO "Cell-type specific gene expression profiles of leukocytes in human peripheral blood. (openwetware.org)
  • Sood R, Zehnder JL, Druzin ML, Brown PO "Gene expression patterns in human placenta. (openwetware.org)
  • However, our understanding of the genetic causality for laterality defects in human beings remains relatively limited. (bmj.com)
  • A commonly used genetic typing test that uses antibodies to detect variations on the surface of human red blood cells. (ojp.gov)
  • They are round to oval and have a 5-10 mm diameter in the wild plant, but are usually flattened and up to 20-25 mm long, 15 mm broad and 5-10 mm thick in food cultivars . (wikipedia.org)
  • The crystal structures of human topoisomerase I comprising the core and carboxyl-terminal domains in covalent and noncovalent complexes with 22-base pair DNA duplexes reveal an enzyme that 'clamps' around essentially B-form DNA. (embl.de)
  • To understand the contribution of CTCF-mediated chromatin organization to cell lineage commitment, we analyzed 3D chromatin architecture during the differentiation of human embryonic stem cells into pancreatic islet organoids. (bvsalud.org)
  • Both GIMAP4 and GIMAP7 from human Jurkat cells [ 3 ] localize to the endoplasmic reticulum and Golgi apparatus while mouse Gimap3 from murine IL-3-dependent 32D myeloid precursor cells was expressed at the outer mitochondrial membrane [ 15 ]. (hindawi.com)
  • The remethylation pathway comprises 2 intersecting biochemical pathways and results in the transfer of a methyl group (CH 3 ) to homocysteine from methylcobalamin, which receives its methyl group from S-adenosylmethionine (SAM), from 5-methyltetrahydrofolate (an active form of folic acid), or from betaine (trimethylglycine). (medscape.com)
  • More recently we have begun a programme to test the effect of antioxidant compounds on biochemical markers of heart disease in both animal and human trials. (otago.ac.nz)
  • Biochemical studies have shown that pol β releases the 5'-terminal dRP residues from the aprinic/apyrimidinic sites and fills short gaps of one to six nucleotides. (biomedcentral.com)
  • The core domain and the first eight residues of the carboxyl-terminal domain of the enzyme, including the active-site nucleophile tyrosine-723, share significant structural similarity with the bacteriophage family of DNA integrases. (embl.de)
  • The bZIP TF family is named after the bZIP domain [ 5 ]. (biomedcentral.com)
  • Phosphorylates Tyr residues at the C-terminus of PTPN11 creating a binding site for the SH2 domain of GRB2. (abcam.com)
  • The former domain possesses a template-binding function and a dRPase activity to remove the 5'-deoxyribose phosphate, the latter domain possesses DNA polymerase activity. (biomedcentral.com)
  • Public and animal health controls to limit human exposure to animal prions are focused on bovine spongiform encephalopathy (BSE), but other prion strains in ruminants may also have zoonotic potential. (cdc.gov)
  • These data are consistent with the conclusion that prion disease is less likely to develop in humans after exposure to naturally occurring prions of sheep than after exposure to epizootic BSE prions of ruminants. (cdc.gov)
  • This increase has rekindled speculation that atypical scrapie in small ruminants might be a source of human prion disease ( 11 ). (cdc.gov)
  • Furthermore, due to ethical and legal concerns, very limited techniques can be applied to human embryos to validate some of significant conclusions drawn from descriptive studies regarding human embryonic development. (nature.com)
  • The BSE prion is an epizootic agent and causes variant Creutzfeldt-Jakob disease (vCJD) in humans after dietary exposure ( 1 - 4 ). (cdc.gov)
  • Glycophorin C (GPC) is a single polypeptide chain of 128 amino acids and is encoded by a gene on the long arm of chromosome 2 (2q14-q21). (wikidoc.org)
  • Because the time lag between exposure and development of vCJD may be decades, uncertainty about the extent of the pathogenicity of BSE for humans continues ( 5 ), and subclinical forms of infection may exist ( 6 , 7 ). (cdc.gov)
  • NtbZIP s were unevenly distributed across twenty-two tobacco chromosomes, and we found sixteen pairs of segmental duplication. (biomedcentral.com)
  • [6] The location of the base pair starts at 18,529,703 and ends at 18,691,812 bp and translates into 1354 amino acids . (cloudfront.net)
  • Soen Y, Mori A, Palmer TD, Brown PO "Exploring the regulation of human neural precursor cell differentiation using arrays of signaling microenvironments. (openwetware.org)
  • MolPharm articles become freely available 12 months after publication, and remain freely available for 5 years. (aspetjournals.org)
  • Human adipose-derived stem cells (hADSCs) have been widely utilised for bone tissue engineering applications. (bvsalud.org)
  • Life depends on constant replenishment of human body cells with new cells created by differentiation of adult stem cells. (anti-agingfirewalls.com)
  • The human body has nearly 1013 cells. (cdc.gov)
  • This gene controls calcium homeostasis by regulating the release of parathyroid hormone (PTH), whose gene is located on human chromosome 3 122.18 (NM_000388) and mouse chromosome 16 36.49 (NM_013803). (biomedcentral.com)
  • J Cell Sci (2006) 119 (5): 958-969. (biologists.com)
  • Many human body cell types have a remarkable rate of turnover. (anti-agingfirewalls.com)
  • [5] ROCK1 plays a role in cancer and in particular cell motility , metastasis , and angiogenesis . (cloudfront.net)