Residue structure avian proteins. Medical search. Frequent questions

We used NMR to determine conformational ensembles of E627 and K627 forms of 627-NLS of PB2 in complex with avian and human ANP32A. (nature.com)
In order to elucidate the conformational alterations that accompany Ca(2+) binding, we have obtained the solution structure of the Ca(2+)-free protein using NMR spectroscopy and compared it to the Ca(2+)-loaded protein, solved by X-ray crystallography. (cornell.edu)
The Ca(2+)-free structure also provides added insight into the magnitude of ligation-linked conformational alteration compatible with a high-affinity metal-ion-binding signature. (cornell.edu)
The largest conformational change involves the basic residues at the C terminus 350 which become ordered at IPP binding. (morainetownshipdems.org)
Dynamic and conformational switching in proteins. (rochester.edu)
Improvement of the treatment of loop structures in the UNRES force field by inclusion of coupling between backbone- and side-chain-local conformational states. (rochester.edu)
However, spike protein conformational masking and glycan shielding are critical ways that coronaviruses evade host immune response. (openaccesspub.org)
Proteolytic cleavage of the S protein causes conformational changes so that they cannot revert to the original structure and profound enough to prime the S2 subunit for the fusion of viral and cellular membranes. (pubannotation.org)

Both pufferfish genomes encode five tenascin genes: two tenascin-C paralogs, a tenascin-R with domain organization identical to mammalian and avian tenascin-R, a small tenascin-X with previously undescribed GK repeats, and a tenascin-W. Four tenascin genes corresponding to tenascin-C, tenascin-R, tenascin-X and tenascin-W were also identified in the X. tropicalis genome. (biomedcentral.com)

The prediction models were trained on influenza protein sequences isolated from both avian and human samples, which were transformed into amino acid physicochemical properties feature vectors. (springer.com)
Similarities between the physical structures of avian and mammalian MHC class I glycoproteins have been proposed by comparative alignment of their amino acid sequences. (usda.gov)
Alignment of the BFIV21 sequence with previously published BFIV sequences revealed polymorphisms at position 34 (HLA34), a monomorphic residue in HLA and H-2. (usda.gov)
We adopted the strategy of sequencing peptides released from these insoluble membranes after protease treatment - aiming to find the corresponding peptide sequences in the translated avian genome. (udel.edu)
While we could place a number of these peptides within proteins that had already been identified, there were many cysteine-rich peptides that traced to fragments of avian nucleic acid sequences that have yet to find their proper place in the chicken genome. (udel.edu)
the alphabet is the 20 proteinogenic amino acids for proteins and the sense codons (i.e., the 61 codons that encode amino acids in the standard genetic code ) for aligned protein-coding gene sequences. (wikipedia.org)
In fact, substitution models can be developed for any biological characters that can be encoded using a specific alphabet (e.g., amino acid sequences combined with information about the conformation of those amino acids in three-dimensional protein structures [7] [8] ). (wikipedia.org)
We have developed a new method for the identification of domains in unassigned regions through indirect connections and scaled up its application to the analysis of 434 unassigned regions in 726 protein sequences of Mycoplasma gallisepticum genome. (biomedcentral.com)
Domain assignment to the protein sequences has paramount importance in the post genomic era. (biomedcentral.com)
In recent work we developed the first bioinformatic representation of protein dynamics, and are currently using this tool, in combination with earlier studies of the static physical properties of amino acid sequences, to elucidate basic mechanisms of protein folding. (rochester.edu)
We have extended our studies to encompass intrinsically disordered proteins, and are using the sequences of those proteins as an added resource in the study of folding and stability in proteins. (rochester.edu)
In earlier work, we have applied novel bioinformatic methods to the comparison of protein sequences and protein structures, and used the resulting data to address problems at the foundations of bioinformatics. (rochester.edu)
Global informatics and physical property selection in protein sequences. (rochester.edu)
Homolog detection using global sequence properties suggests an alternate view of structural encoding in protein sequences. (rochester.edu)
Beyond supersecondary structure: the global properties of protein sequences. (rochester.edu)
From the alignment studies, we learned that the RBD sequences lie between the residues 331 and 524 of the S protein 8 . (openaccesspub.org)
Prediction of protein antigenic determinants from amino acid sequences. (geneticsmr.com)
Whole genome sequences of 58 strains of S. aureus in the public domain and data from multi-strain microarrays were compared to assess variation in the sequence of proteins known or putatively interacting with host. (biomedcentral.com)
The researchers began by exploring a genome database to compare the genetic sequences of avian and human TRPV1. (phys.org)

In poly I:C stimulated mink lung cells the NS1 protein of influenza A virus showing high pathogenicity in mink down regulated the type I interferon promoter activity to a greater extent than the NS1 protein of the virus showing low pathogenicity in mink. (biomedcentral.com)

The delineation of protein domains within a polypeptide chain, namely at the genome scale, can be achieved in several ways but may remain problematic in many instances. (biomedcentral.com)
Our study provides high-resolution structures of medically relevant FluPol A , as well as insights into the replication mechanisms of the viral RNA genome. (nature.com)
2014 . Comparative genomics reveals insights into avian genome evolution and adaptation. (sc.edu)
The annotation of the full genome sequence revealed the absence of genes encoding for a non-flagellar type 3 protein secretion system (NF-T3SS). (assignster.com)
What concerns us more is that the 2019-nCoV, by the process of modification of genome structure, might become more and more fitted to humans to profoundly affect those who have already escaped - children and young people without a pre-existing condition. (pubannotation.org)

Understanding and predicting host tropism of influenza proteins lay an important foundation for future work in constructing computation models capable of directly predicting interspecies transmission of influenza viruses. (springer.com)
A large number of influenza A viruses naturally reside in avian species where they constantly circulate and evolve. (springer.com)
The numerous global outbreaks and continuous reassortments of highly pathogenic avian influenza (HPAI) A(H5N6/H5N8) clade 2.3.4.4 viruses in birds pose a major risk to the public health. (cdc.gov)
Many avian species, including wild aquatic birds, domestic poultry, and zoo birds, are susceptible to the infection or support transmission of clade 2.3.4.4 viruses, resulting in unprecedented panzootic waves accompanied by massive culling and major economic losses to the poultry industry ( 1 , 2 ). (cdc.gov)
The persistent circulation of clade 2.3.4.4 viruses among bird populations enables continuous reassortment with prevailing low pathogenicity avian influenza (LPAI) viruses. (cdc.gov)
However, for these avian (av) viruses to efficiently replicate in mammalian cells, host adaptation of the viral polymerase is necessary. (nature.com)
The Qinghai-like Clade 2.2 virus was found to possess a high genetic relationship with viruses isolated from other countries on the migratory flyway of wild birds 4 , suggesting that the migration of wild birds played an important role in circulating H5N1 HPAIV viruses between the different avian populations. (nature.com)
3.2.1.18) that are found, along with the sialic acid-binding protein Hemagglutinin, on the surface of influenza viruses that are pathogenic to mammalian or avian species. (cazypedia.org)
RNA viruses may escape acquired humoral and cellular immune responses by mutations in protective antigenic epitopes (e.g., avian influenza viruses), while accessory nonstructural proteins or multifunctional structural proteins interfere with the interferon system (e.g. (imperial.ac.uk)
The unique property of some avian H10 viruses, particularly the ability to cause severe disease in mink without prior adaptation, enabled our study. (biomedcentral.com)
Coupled with previous experimental data and genetic characterization here we tried to investigate the possible influence of different genes on the virulence of these H10 avian influenza viruses in mink. (biomedcentral.com)
Our study also showed that there are no genetic differences in receptor specificity or the cleavability of the haemagglutinin proteins of these viruses regardless of whether they are of low or high pathogenicity in mink. (biomedcentral.com)
The ON mapping showed a close genomic relationship between the mink isolate (A/Mink/Sweden/3900/84) and the concomitant avian H10N4 viruses from fowl (A/fowl/Hampshire/378/85) and mallard (A/mallard/Gloucestershire/374/85) respectively, and a weaker genomic relationship with the H10 prototype [ 7 ] virus (A/chicken/Germany/N/49) [ 4 ]. (biomedcentral.com)
Here, using crystallography and cryo-electron microscopy, we determine the structures of FluPol A from human influenza A/NT/60/1968 (H3N2) and avian influenza A/duck/Fujian/01/2002 (H5N1) viruses at a resolution of 3.0-4.3 Å, in the presence or absence of a cRNA or vRNA template. (nature.com)
In addition, since the gene encoding the A56 protein is non-essential, it can be used as an insertion point for foreign genes and has been deleted in some viruses that are in clinical development as oncolytic agents. (microbiologyresearch.org)
Low pathogenicity avian influenza A(H9N2) viruses, enzootic in poultry populations in Asia, are associated with fewer confirmed human infections but higher rates of seropositivity compared to A(H5) or A(H7) subtype viruses. (cdc.gov)
Co-circulation of A(H5) and A(H7) viruses leads to the generation of reassortant viruses bearing A(H9N2) internal genes with markers of mammalian adaptation, warranting continued surveillance in both avian and human populations. (cdc.gov)

Similar to H5N1 strains, this further affirms the potential of avian influenza strains capable of directly infecting human, causing severe illnesses. (springer.com)
The HPAI A(H5N6/H5N8) avian isolates replicated productively but with lower competence than the influenza A(H1N1)pdm09, HPAI A(H5N1), and HPAI A(H5N6) isolates from humans in both or either models. (cdc.gov)
The genetic evolution of the highly pathogenic avian influenza (HPAI) subtype H5N1 A/goose/Guangdong/1/1996 lineage has resulted in the divergence and generation of 10 distinct virus clades (0-9) and multiple subclades ( 1 , 2 ). (cdc.gov)
Avian influenza H5N1 has shown high mortality rate in human. (tokushima-u.ac.jp)
Non-structural protein 1 (NS1) is a virulence factor of H5N1. (tokushima-u.ac.jp)
Mutation at the 42nd residue within the RNA-binding domain (RBD) of NS1 dramatically changes the degree of pathogenicity of H5N1 in mice. (tokushima-u.ac.jp)
Human ANP32A ( h ANP32A) lacks an insertion of 33 disordered residues compared to av ANP32A, restricting av H5N1 polymerase activity in mammalian cells. (nature.com)
The causative agent behind this outbreak was identified as H5N1 highly pathogenic avian influenza virus (HPAIV). (nature.com)
Fig. 1: Structures of human H3N2 and avian H5N1 FluPol A . (nature.com)
Infection of ATI or ATII alveolar epithelial cells of the distal lung has been Roflumilast N-oxide detected in fatal cases of avian (H5N1) and 2009 pandemic (pH1N1) IAV, RSV, and SARS-CoV (Johnson et al. (cancercurehere.com)

Most influenza strains evolve exclusively in the large reservoir of water birds, but some highly pathogenic avian strains (e.g. (nature.com)
ADP-ribosylation is a protein modification process that occurs widely in pathogenic mechanisms, intracellular signaling systems, DNA repair, and cell division. (expasy.org)

Catalytically active TR mART domains hallmark catalytic residues in the active site. (expasy.org)

1974. Pesticide residues in the top soil of 5 west Alabama counties. (cdc.gov)
1981. General method for determination of pesticide residues in samples of plant origin, soil, and water. (cdc.gov)

A chicken gene that produces a protein important for viral disease resistance was obtained and its DNA sequence was determined. (usda.gov)
One of these structural changes altered the protein so that it could no longer function for viral resistance. (usda.gov)
The other structural change allowed normal viral resistance to occur but affected the shape of the protein on the surface of cells. (usda.gov)
These studies aid in understanding how genes determining cell surface proteins can affect interactions between cells and confer viral disease resistance. (usda.gov)
Studies with HLA-A2 have shown that changes in residue 34 do not affect viral peptide presentation. (usda.gov)
A limited subset of ISGs were found to control viral infection, including endosomal factors inhibiting viral entry, RNA binding proteins suppressing viral RNA synthesis, and a highly enriched cluster of endoplasmic reticulum (ER)/Golgi-resident ISGs inhibiting viral assembly/egress. (bvsalud.org)
Among the broad-acting ISGs was BST2/tetherin, which impeded viral release and is antagonized by SARS-CoV-2 Orf7a protein. (bvsalud.org)
However, trapping of the covalent enzyme intermediate of the viral neuraminidase using 3-fluorosialosyl fluorides [ 2 ] confirmed a covalent structure. (cazypedia.org)
The catalytic machinery of this family of viral sialidases includes two key residues: an acid/base glutamate residue and a catalytic tyrosine nucleophile. (cazypedia.org)
Varicella-Zoster virus IE63, a major viral latency protein, is required to inhibit the alpha interferon-induced antiviral response. (geneticsmr.com)
Herpes simplex virus type 1 immediate-early protein ICP22 is required for VICE domain formation during productive viral infection. (geneticsmr.com)
The A56 protein is capable of binding two viral proteins, a serine protease inhibitor (K2) and the vaccinia virus complement control protein (VCP), and anchoring them to the surface of infected cells. (microbiologyresearch.org)
We determined the structure of the RSV intasome containing viral DNA by single-particle cryo-EM (1). (nature.com)
The non-structural rep gene encodes four regulatory proteins essential for viral replication, whereas cap encodes three structural proteins (VP1-3) that assemble into a 60-mer capsid shell. (justia.com)

Avian polyomavirus (APV) causes a fatal, multi-organ disease among several bird species. (rcsb.org)
Yet when some avian strains do acquire the ability to overcome species barrier, they might become adapted to humans, replicating efficiently and causing diseases, leading to potential pandemic. (springer.com)
In addition, host-driven selection presumably results in the high levels of genetic variation found in ama -1 of avian Plasmodium species. (biomedcentral.com)
Mycoplasma gallisepticum causes chronic respiratory disease in chickens and other avian species. (biomedcentral.com)
Pseudorabies virus EP0 protein counteracts an interferon-induced antiviral state in a species-specific manner. (geneticsmr.com)

We here studied the impact of this mutation on the function of RBD, and found that RBD with serine at the 42th residue binds doublestranded RNA (dsRNA), whereas that with proline at the 42th residue does not. (tokushima-u.ac.jp)
In particular, mutation of PB2 residue 627 from E to K rescues polymerase activity in mammalian cells. (nature.com)
In search of novel painkillers, researchers at Butantan Institute's Special Pain and Signaling Laboratory (LEDS) in São Paulo, Brazil, studied TRPV1, a sensory neuron receptor that captures noxious stimuli, including heat and the burning sensation conveyed by chili peppers, and discovered a potential pain insensitivity mutation in the gene that encodes this protein. (phys.org)
After the introduction of mutation to the residue insertion and furin cleavage site, the S1/S2 cleavage of the SARS-CoV 2 S did not longer take place. (pubannotation.org)

XopAI uses an altered mART domain to bind its own N-terminal peptide containing a conserved Arg residue [ 8 ]. (expasy.org)
Two peptide fragments, corresponding to the amino acid residues 106-126 (PrP[Ac-106-126-NH2]) and 106-114 (PrP[Ac-106-114-NH2]) of the human prion protein have been synthesised in the acetylated and amide form at their N- and C-termini, respectively. (cnr.it)

Investigating these genes in avian malaria parasites, where diversity is particularly high, offers new insights into the processes that confer malaria pathogenesis. (biomedcentral.com)
In general, most genes that encode antigens of Plasmodium parasites are highly polymorphic and encode proteins that are important targets for host protective antibody responses [ 5 ]. (biomedcentral.com)
Many surface protein genes were missing or truncated, unlike immune evasion genes, and several distinct variants were identified. (biomedcentral.com)
Furthermore, phylogenetic analyses of the avian β-keratin genes from the chicken and zebra finch genomes have shown that the avian scale β-keratin subfamily is closely related to the β-keratins of crocodilians and basal to the claw β-keratin subfamily, which is basal to the feather-like and feather β-keratin subfamilies (Greenwold and Sawyer, 2010). (sc.edu)
In order to learn more about their origins and relationships to each other, as well as to clarify the nomenclature used to describe them, the tenascin genes of the urochordate Ciona intestinalis , the pufferfish Tetraodon nigroviridis and Takifugu rubripes and the frog Xenopus tropicalis were identified and their gene organization and predicted protein products compared with the previously characterized tenascins of amniotes. (biomedcentral.com)

Using a computational approach, they identified five avian mutations they believed to be linked to resistance to pain. (phys.org)
Cryogenic electron microscopy (which does not require large sample sizes or crystallization and is therefore suited to the visualization of structures at near-atomic resolution) showed that the five avian mutations were located in K710, an amino acid residue believed to control gating (opening and closing) of the TRPV1 channel. (phys.org)

Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
Amongst these, the autophagy regulator TBC1 domain family member 5 (TBC1D5), which binds Rab7 to enable fusion of autophagosomes and lysosomes, was found to control IAV replication in vitro and in vivo and to promote lysosomal targeting of IAV M2 protein. (bvsalud.org)

Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
pronounced "sarc", as it is short for sarcoma), is a non-receptor tyrosine kinase protein that in humans is encoded by the SRC gene. (wikipedia.org)
c-Src phosphorylates specific tyrosine residues in other tyrosine kinases. (wikipedia.org)
This induces long-range allostery via protein domain dynamics, causing the structure to be destabilized, resulting in the opening up of the SH3, SH2 and kinase domains and the autophosphorylation of the residue tyrosine 416. (wikipedia.org)
c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein coupled receptors and cytokine receptors. (wikipedia.org)
Therefore, the mechanism of these neuraminidases is a classic Koshland type double-displacement involving a covalent sialyl-enzyme intermediate on a Tyrosine residue. (cazypedia.org)
Tyrosine 116 of the herpes simplex virus type 1 IEalpha22 protein is an ocular virulence determinant and potential phosphorylation site. (geneticsmr.com)

They are distinct structural units defining a large family of proteins that often exhibit a modular domain architecture three-dimensional structures of UBX domains reveal a close structural relationship with ubiquitin despite the lack of significant sequence homology UBX domain is very similar to ubiquitin which gives us some indication of evolution. (wikipedia.org)
Most of the work on substitution models has focused on DNA/ RNA and protein sequence evolution. (wikipedia.org)
Difficulties in identifying the domain content of a given sequence arise when the query sequence has no homologues with experimentally determined structure and searching against sequence domain databases also results in insignificant matches. (biomedcentral.com)
Experimental and/or computational methods can be used to identify domains in the given protein sequence. (biomedcentral.com)
Due to high evolutionary divergence, it is not always possible to identify distantly related protein domains by sequence search techniques. (biomedcentral.com)
Sequence-specific dynamic information in proteins. (rochester.edu)
Beyond Supersecondary Structure: Physics-Based Sequence Alignment. (rochester.edu)
Sequence-, structure-, and dynamics-based comparisons of structurally homologous CheY-like proteins. (rochester.edu)
Sequence determinants of protein architecture. (rochester.edu)
A beta-hairpin comprising the nuclear localization sequence sustains the self-associated states of nucleosome assembly protein 1. (colorado.edu)
The amino acid sequence (31-32 residues) of the central filament region of β-keratins is highly conserved throughout all reptiles and birds suggesting that this domain has changed little in ~285 Ma of evolution (Fraser and Parry, 2010). (sc.edu)
A) Venn diagram identifying 5 missense TRPV1 variants that intersect when examining the human TRPV1 missense variants from the gnomAD and avian genetic divergence from the human TRPV1 sequence. (phys.org)

In molecular biology, the UBX protein domain is found in ubiquitin-regulatory proteins, which are members of the ubiquitination pathway, as well as a number of other ubiquitin-like proteins including FAF-1 (FAS-associated factor 1), the human Rep-8 reproduction protein and several hypothetical proteins from yeast. (wikipedia.org)
C. elegans hypothetical proteins C04D8.1, K06H7.4 and ZK632.12. (embl.de)
S. cerevisiae hypothetical proteins YBR129c and YHR155w. (embl.de)

Our results provide evidence for the molecular mechanism utilised by IAV M2 protein to escape lysosomal degradation and traffic to the cell membrane, where it supports IAV budding and growth. (bvsalud.org)
Previous analyses based on molecular modeling and binding studies examined the potential mode of inhibition of vertebrate FPPS (13 18 Several 38231 studies suggested that N-BPs bind to the GPP substrate-binding site because N-BPs might mimic the structure of the enzyme's natural substrates GPP/DMAPP and act as carbocation transition state analogs (18). (morainetownshipdems.org)
Presently we are using molecular dating approaches, such as BEAST, to gain a better understanding of the how the molecular evolution of the avian β-keratins relates to the evolutionary origin of feathers. (sc.edu)
Our approach is to combine molecular dating techniques with knowledge of the sauropsid fossil record, feather development, molecular evolution of the avian β-keratins, and the biophysical properties of feathers to gain a better understanding of feather evolution. (sc.edu)
2011 . Linking the molecular evolution of avian beta keratins to the evolution of feathers. (sc.edu)
C) 3D structure of WT TRPV1, K710N, and T708I based on the closed-state rat TRPV1 molecular model (PDB ID: 3J5P). (phys.org)
and 3) the molecular basis of diseases that involve spectrin or any of its associated proteins, including contributions of the cortical cytoskeleton to the phenotypic alterations of malignant cells and the molecular pathology of acquired and inherited disorders involving this structure. (yale.edu)
Our studies on the erythrocyte focus on a molecular understanding of how specific proteins that cause human disease. (yale.edu)

Alterations were made in this gene that affected the protein's structure. (usda.gov)
Two transcript variants encoding the same protein have been found for this gene. (wikipedia.org)
In this experiment, we observed cytokine gene expression changes in Gallus gallus embryo after challenge with Delta SARS-CoV-2 RBD spike protein antigen, from a concentration of 10 µg/mL to a series of highly diluted forms in ethanol, along with controls. (openaccesspub.org)
In the tests described in this specific article, we used gene microarray evaluation to correlate modifications in ribonucleic acidity (RNA) transcription in AVMs and CCMs towards the previously released abnormal protein appearance in these lesions. (health-e-nc.org)
The protein encompassing the predicted MetT-PCP domains of HEV ORF1 was tested for deubiquitinating activity using fluorogenic substrates - ubiquitin-7-amino-4-methylcoumarin (AMC), IFN-stimulated gene 15 (ISG15)-AMC, Nedd8-AMC and SUMO-AMC. (microbiologyresearch.org)

Our interest in the enzymology of disulfide-bond generation [ PubMed ] has led to the discovery of a novel disulfide-rich protein that seems to be an important component of avian eggshell membranes [ Ref ]. We call these newly-recognized proteins " c yst(e)ine- r ich e ggshell m embrane p roteins" ( CREMP s). (udel.edu)
Why has the protein makeup of avian eggshell membranes (ESMs) remained uncertain for decades? (udel.edu)
Using a double-checking liquid chromatography ESI-Q-TOF mass spectrometry routine, we traced the origin of colored eggs to their non-avian dinosaur ancestors by providing the first record of the avian eggshell pigments protoporphyrin and biliverdin in the eggshells of Late Cretaceous oviraptorid dinosaurs. (peerj.com)

The mosaic evolution of supposedly avian traits in non-avian theropod dinosaurs, however, such as the supposed evolution of partially open nesting behavior in oviraptorids, argues against this long-established theory. (peerj.com)
Remarkable fossils of theropod dinosaurs displaying a wide range of epidermal structures (Fucheng et al. (sc.edu)

The outbreak of severe respiratory disease in mink ( Mustela vison) in 1984 was linked to an avian influenza virus of subtype H10N4. (biomedcentral.com)

Functional analysis employing site directed mutagenesis identified BF amino acid residues forming serologic epitopes as well as residues important in antigen presentation to ALV induced cytotoxic T lymphocytes. (usda.gov)
In this study, we have developed a biolayer interferometry (BLI)-based assay to determine dominant binding epitopes of the HA1 in antibody response to influenza vaccines using a panel of recombinant HA1 proteins of A(H1N1)pdm09 virus with each carrying a single amino acid substitution. (cdc.gov)

To investigate the physical structure of the chicken class I glycoprotein we have cloned the cDNA representing the BFIV locus of the B21 haplotype. (usda.gov)
In contrast, a site directed substitution in residue 34 dramatically alters ALV antigen presentation by the BFIV21 class I glycoprotein. (usda.gov)
The cell surface sialic acids they cleave are linked α(2,3) or α(2,6) to galactose or N -acetyl galactosamine residues that terminate glycolipid or glycoprotein structures. (cazypedia.org)

Evidence for positive selection has also been reported for the Plasmodium surface proteins DBP (Duffy-binding protein), EBA-175 (erythrocyte-binding antigen 175) and a large number of other antigens [ 8 ]. (biomedcentral.com)

BF residues 78 and 81 (HLA 79 and 82) form an antibody epitope with a slight effect on ALV antigen presentation, consistent with their predicted orientation based on the HLA-A2 crystal structure. (usda.gov)
Analysis of the transcriptome identified several orthologues required for intra-erythrocytic survival and erythrocyte invasion, including the rhoptry neck protein 2 (RON2) and the apical membrane antigen-1 (AMA-1). (biomedcentral.com)

We investigated the tropism and innate host responses of 5 recent HPAI A(H5N6/H5N8) avian isolates of clades 2.3.4.4b, e, and h in human airway organoids and primary human alveolar epithelial cells. (cdc.gov)
Our results suggest zoonotic potential but low transmissibility of the HPAI A(H5N6/H5N8) avian isolates among humans. (cdc.gov)

In this study, computational models for 11 influenza proteins have been constructed using the machine learning algorithm random forest for prediction of host tropism. (springer.com)
We are interested in computational studies of protein folding and dynamics, and particularly in the information about protein physics which is available through bioinformatic studies. (rochester.edu)

Receptor binding activates proteases that can carry out proteolytic cleavage of the S protein. (pubannotation.org)

Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
From the prediction models constructed, all achieved high prediction performance, indicating clear distinctions in both avian and human proteins. (springer.com)
Avian influenza polymerase undergoes host adaptation in order to efficiently replicate in human cells. (nature.com)
Human ANP32A IDD lacks a 33 residue insertion compared to avian ANP32A, and this deletion restricts avian influenza polymerase activity. (nature.com)
Results Structure Determination of Human FPPS. (morainetownshipdems.org)
Human FPPS exhibits the all α-helical prenyltransferase YIL 781 fold described earlier for the avian form of FPPS (17). (morainetownshipdems.org)
Surprisingly, sequenced strains from four animal S. aureus strains had surface and immune evasion proteins remarkably similar to those found in human strains, yet putative targets of these proteins vary substantially between different hosts. (biomedcentral.com)
FIG. 11 depicts enzyme-linked immunosorbent assay (ELISA) measurements of human glial-derived neurotrophic factor (hGDNF) protein in retinal homogenates 2 and 3 months following intravitreal delivery of ShH10.Y445F.scCAG-hGDNF. (justia.com)

The SARS-CoV-2 spike protein is a significant type 1 trans-membrane protein with two subunits, S1 and S2. (openaccesspub.org)

All of the cysteine residues are found as disulfides in ESM. (udel.edu)
Hepatitis E virus (HEV) ORF1 protein (pORF1) contains methyltransferase (MetT), papain-like cysteine protease (PCP), RNA helicase (Hel) and RNA-dependent RNA polymerase (RdRp) domains. (microbiologyresearch.org)

CD results showed that PrP[Ac-106-126-NH2] mainly adopts an alpha-helical conformation in TFE water mixture and in SDS micelles, while a predominantly random structure is observed in aqueous solution. (cnr.it)

Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
Src contains at least three flexible protein domains, which, in conjunction with myristoylation, can mediate attachment to membranes and determine subcellular localization. (wikipedia.org)
a waste, both for the mineralized shell, and for the protein-rich membranes. (udel.edu)

Multi‐fluorescence imaging enables multiplexed analyses of proteins with improved sensitivities. (harvard.edu)

E627 interrupts the polyvalency of the interaction, an effect compensated by an avian-unique motif in the IDD. (nature.com)
Presumably, the increase in ANS emission observed in the presence of unliganded ATH reflects the interaction of these hydrophobic residues with the fluorescent probe. (cornell.edu)
The capsid and tegument of the alphaherpesviruses are linked by an interaction between the UL25 and VP1/2 proteins. (geneticsmr.com)

Pleckstrin homology (PH) domains are small modular domains that occur in a large variety of proteins. (embl.de)

While originally characterized as a haemagglutinin protein, A56 has other functions as well. (microbiologyresearch.org)

However, the plug density is more prominent in APV and may include VP4, a minor capsid protein unique to bird polyomaviruses. (rcsb.org)
The present disclosure provides adeno-associated virus (AAV) virions with altered capsid protein, where the AAV virions exhibit greater infectivity of retinal cells compared to wild-type AAV. (justia.com)

Pseudomonas syringae type III effector HopU1, a mono-ADP-ribosyltransferase that is injected into plant cells by the type III protein secretion system. (expasy.org)

When used together as a host tropism prediction system, zoonotic strains could potentially be identified based on different protein prediction results. (springer.com)
We have recently shown that it is possible to enhance prediction of domains in the unassigned regions by 25% through indirect connections in the class III adenylyl cyclase domain containing proteins [ 10 ]. (biomedcentral.com)
Alternative approach to protein structure prediction based on sequential similarity of physical properties. (rochester.edu)

In addition, features from all 11 proteins were used to construct a combined model to predict host tropism of influenza virus strains. (springer.com)
Differences in pathogenicity and virulence in mink between these strains could be related to clear amino acid differences in the non structural 1 (NS1) protein. (biomedcentral.com)

The type II alveolar (ATII) cells produce pulmonary Rabbit polyclonal to PAI-3 surfactant that is required to prevent alveolar collapse and proteins that participate in innate defense of the lung (Mason, 2006). (cancercurehere.com)

2 SARS-CoV2 cell entry is not complex Fig. 1 is a schematic illustration of the minimum proteins required to mediate the SARS-CoV2 cell entry. (pubannotation.org)

AMA-1 and RON2 of P. gallinaceum are evolutionarily and structurally conserved, suggesting that these proteins may play essential roles for avian malaria parasites to invade host erythrocytes. (biomedcentral.com)

Protein domains are the structural, functional and evolutionary units of proteins. (biomedcentral.com)

Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
Oxysterol binding proteins OSBP, S. cerevisiae OSH1 and YHR073w. (embl.de)
Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
2007). Coiled coil structures and transcription: an analysis of the S. cerevisiae coilome. (geneticsmr.com)

Expressed miRNAs target feather related mRNAs involved in cell signaling, cell adhesion and structure during chicken epidermal development. (sc.edu)

Ama - 1 of avian malaria parasites exhibits high levels of genetic diversity and evolves under positive diversifying selection, ostensibly due to protective host immune responses. (biomedcentral.com)
to address this global challenge we bring to the forefront the options for medical treatment and summarize SARS‑CoV2 structure and functions, immune responses and known treatments. (spandidos-publications.com)
The dynamic configuration of the immune-active S protein happens when the S1 protein trimer aligns on top of the trimeric S2 9 . (openaccesspub.org)

Comprehensive knowledge of the genetic factors involved in avian malaria parasite invasion is lacking and has been hampered by difficulties in obtaining nuclear data from avian malaria parasites. (biomedcentral.com)
Colocalization of the herpes simplex virus 1 UL4 protein with infected cell protein 22 in small, dense nuclear structures formed prior to onset of DNA synthesis. (geneticsmr.com)

The function of the UBX domain is not known although the fragment of avian FAF-1 containing the UBX domain causes apoptosis of transfected cells. (wikipedia.org)
The UBX domain comprises about 80 amino acid residues. (wikipedia.org)
Domain commonly found in eukaryotic signalling proteins. (embl.de)
The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
There are no totally invariant residues within the PH domain. (embl.de)
Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
Taxonomic distribution of proteins containing PH domain. (embl.de)
The complete taxonomic breakdown of all proteins with PH domain is also avaliable . (embl.de)
Click on the protein counts, or double click on taxonomic names to display all proteins containing PH domain in the selected taxonomic class. (embl.de)
The mART domain adopts a mixed α/β-fold with a characteristic β-sandwich structure. (expasy.org)
Study of proteins at the domain level has had a profound impact on the study of individual proteins. (biomedcentral.com)
The globular head domain of influenza virus surface protein hemagglutinin (HA1) is the major target of neutralizing antibodies elicited by vaccines. (cdc.gov)

Several influenza proteins have been shown to be major determinants in host tropism. (springer.com)

Anatomy3

Organisms4

Chemicals and Drugs35

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes38

Information Science4

Health Care2

Conformational8

Mammalian and avian1

Sequences19

Influenza A vir1

Genome5

Viruses17

H5N110

Pathogenic2

Catalytic Residues1

Pesticide residues2

Viral14

Species5

Mutation4

Peptide2

Genes5

Mutations2

Binds2

Tyrosine7

Sequence12

Hypothetical proteins3

Molecular8

Gene5

Eggshell3

Theropod dinosaurs2

Subtype1

Epitopes2

Glycoprotein3

Surface proteins1

Antigen2

H5N82

Computational2

Proteolytic cleavage1

Human8

Subunits1

Cysteine2

Conformation1

Membranes3

Analyses1

Interaction3

Homology1

Haemagglutinin1

Capsid protein2

Secretion system1

Prediction3

Strains2

Alveolar1

Mediate1

Structurally1

Evolutionary1

Cerevisiae4

Adhesion1

Immune3

Nuclear2

Domain12

Determinants1