• ligand
  • 21. A method of promoting anabolic bone growth in a subject, the method comprising administering to the subject a biased ligand for the parathyroid hormone (PTH)/PTH-related protein receptor (PTH1R) in an amount sufficient to effect promotion of anabolic bone growth. (patentsencyclopedia.com)
  • 28. A method of treating a bone disorder, the method comprising administering to a subject in need thereof a biased ligand for the PTH1 receptor, in an amount sufficient to treat the bone disorder. (patentsencyclopedia.com)
  • CXCR4 ligand analogs containing a non-natural amino acid photocrosslinker, benzophenylalanine and a biotin tag for complex isolation were chemically synthesized and crosslinked to CXCR4 expressed on intact cells. (ubc.ca)
  • Individual components of the receptor-ligand complex were identified by western blotting and tandem mass spectrometry. (ubc.ca)
  • Regions on the bound receptor that were protected from protease treatment and consequently tandem MS/MS sequencing were identified as potential sites of ligand-receptor contact. (ubc.ca)
  • These regions were identified as the receptor N-terminus and/or the first extracellular loop for ligand binding/docking. (ubc.ca)
  • binds
  • 4. A non-cytotoxic agent for treating pain comprising a botulinum neurotoxin serotype A LH N fragment chemically coupled to a substance P peptide, wherein the substance P peptide is SEQ ID NO: 1, or a fragment of SEQ ID NO:1 that binds to a substance P receptor. (google.com)
  • The invention relates to a method for determining whether a test compound binds preferentially to a membrane receptor R1 or to a membrane receptor R2, these receptors being known to be expressed on the surface of the cells in monomeric, homodimeric or heterodimeric form. (patentsencyclopedia.com)
  • sequences
  • Comparison of IAPP AS-605240 sequences among species and establishment of transgenic rodent models IAPP residues at the N-terminus and C-terminus are conserved in mammals whereas the amyloidogenic core region is species specific (Physique 3). (health-media.net)
  • internal
  • Pain can be experienced when the free nerve endings which constitute the pain receptors in the skin as well as in certain internal tissues are subjected to mechanical, thermal or chemical stimuli. (google.com)
  • More particularly, the present invention provides highly soluble lipopeptides wherein the lipid moiety is attached to the terminal side-chain group of an internal lysine or lysine analog, preferably to the terminal side-chain group of an internal diamino acid residue. (patentsencyclopedia.com)
  • method
  • 8. A method of treating breast cancer, comprising administering to a patient in need of treatment an effective dose of HGFIN with an amino acid sequence of SEQ ID NO:2 in a pharmaceutically acceptable carrier. (patentsencyclopedia.com)