The glucocorticoid receptor (GR or GCR) also known as NR3C1 (nuclear receptor subfamily 3, group C, member 1) is the receptor to which cortisol and other glucocorticoids bind. (wikipedia.org)
After the receptor is bound to glucocorticoid, the receptor-glucocorticoid complex can take either of two paths. (wikipedia.org)
The endogenous glucocorticoid hormone cortisol diffuses through the cell membrane into the cytoplasm and binds to the glucocorticoid receptor (GR) resulting in release of the heat shock proteins. (wikipedia.org)
In central nervous system structures, the glucocorticoid receptor is gaining interest as a novel representative of neuroendocrine integration, functioning as a major component of endocrine influence - specifically the stress response - upon the brain. (wikipedia.org)
Dexamethasone and other corticosteroids are agonists, while mifepristone and ketoconazole are antagonists of the GR. Anabolic steroids also prevent cortisol from binding to the glucocorticoid receptor. (wikipedia.org)
Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
The activated GR complex up-regulates the expression of anti-inflammatory proteins in the nucleus or represses the expression of pro-inflammatory proteins in the cytosol (by preventing the translocation of other transcription factors from the cytosol into the nucleus). (wikipedia.org)
Bind1
When glucocorticoids bind to GR, its primary mechanism of action is the regulation of gene transcription. (wikipedia.org)
Response2
The HPA axis is activated in response to real or perceived stressors and culminates in the production and secretion of glucocorticoids by the adrenal glands. (nature.com)
Gβ2 was associated with GR/glucocorticoid response elements (GREs) in vivo and suppressed activation function-2-directed transcriptional activity of the GR. We conclude that the Gβγ complex interacts with the GR and suppresses its transcriptional activity by associating with the transcriptional complex formed on GR-responsive promoters. (rupress.org)
Central1
The DEC-205 monomer forms a compact structure comprising two intercalated rings of C-type lectin-like domains, where the N-terminal cysteine-rich and fibronectin domains reside at the central intersection. (uci.edu)
Cell1
Extracellular stimuli that activate cell surface receptors modulate glucocorticoid actions via as yet unclear mechanisms. (rupress.org)
Endogenous2
The endogenous glucocorticoid hormone cortisol diffuses through the cell membrane into the cytoplasm and binds to the glucocorticoid receptor (GR) resulting in release of the heat shock proteins. (wikipedia.org)
Carbon 18 and 19 position are referred to as glucocorticoids because of their anabolic effect of nandrolone decanoate is combined with conviction, and work towards a great case outcome. (worldblindnesssummit.com)
Glucocorticoids also antagonize the action of anabolic regulators such as insulin further exacerbating the loss of protein and muscle mass. (frontiersin.org)
Transcription1
When glucocorticoids bind to GR, its primary mechanism of action is the regulation of gene transcription. (wikipedia.org)
Protein3
In response to stress in the form of perceived danger or acute inflammation, glucocorticoids are released from the adrenal gland, rapidly mobilizing energy from carbohydrate, fat and protein stores. (frontiersin.org)
Glucocorticoids elicit the atrophy of muscle by increasing the rate of protein degradation by the ubiquitin-proteasome system and autophagy lysosome system. (frontiersin.org)
Named for their ability to increase serum glucose, glucocorticoids have important roles in modifying carbohydrate, fat and protein metabolism as well as numerous other physiologic functions. (frontiersin.org)
Body1
A growing body of evidence demonstrates that glucocorticoid signaling is a common mediator of wasting, irrespective of the underlying initiator or disease state. (frontiersin.org)