• doses
  • Older adults should not usually take high doses of reserpine because it is not as safe as other medications that can be used to treat the same condition. (medlineplus.gov)
  • Animal studies have revealed evidence of teratogenicity after doses of reserpine 125 to 250 times the maximum recommended human dose (MRHD, on a per kg basis) were given to rats. (drugs.com)
  • Pregnancy in rabbits was interrupted when doses of reserpine 10 times the MRHD were given early or late in pregnancy. (drugs.com)
  • serotonin
  • A single injection of 100 micrograms reserpine into the crop of the medicinal leech, Hirudo medicinalis, reduced CNS serotonin and dopamine levels to less than 1% of control values within 3 d. (jneurosci.org)
  • High-pressure liquid chromotography- (HPLC) determined CNS serotonin and dopamine levels remained maximally depressed for approximately 1 month following reserpine injection. (jneurosci.org)
  • Acute exposure of isolated ganglia to 10 microM reserpine for periods up to 6 hr produced a 20-30% reduction of serotonin and dopamine content. (jneurosci.org)
  • To rapidly restore amine levels in reserpine-treated animals, we bathed intact leeches in pond water containing serotonin, dopamine, or octopamine. (jneurosci.org)
  • We found that biting behavior was restored following reserpine treatment by bathing intact leeches in pond water containing serotonin or dopamine, but not octopamine. (jneurosci.org)
  • researchers
  • The reserpine-induced depression is considered by some researchers to be a myth, while others claim that teas made out of the plant roots containing reserpine have a calming, sedative action that can actually be considered antidepressant. (wikipedia.org)
  • tissues
  • After a single intravenous injection most of the reserpine, probably loosely bound to plasma albumin, is distributed to tissues on the basis of their blood flow. (aspetjournals.org)
  • Much of the circulating reserpine would then either be metabolized or be taken up by the lipid depots of the body, leading to a rapid redistribution of the reversibly bound reserpine from the tissues. (aspetjournals.org)
  • injection
  • During this time a relatively small fraction of the total reserpine administered by injection would become associated with monoaminergic granular membranes in a more specific and irreversible manner. (aspetjournals.org)
  • known
  • The relative contributions of serum esterases versus hepatic metabolism in the biotransformation of reserpine in vivo are not known. (aspetjournals.org)
  • drug
  • The Michigan Medicaid surveillance study showed no association between reserpine or thiazide diuretics and congenital defects (written communication, Franz Rosa, MD, Food and Drug Administration, 1994). (drugs.com)
  • Of 229,101 completed pregnancies between 1985 and 1992, 15 were exposed to reserpine at some time during the first trimester, and 42 were exposed to the drug at any time during pregnancy. (drugs.com)
  • Some reserpine molecules do seem to escape metabolism, however, since significant amounts of intact reserpine have been found in fecal samples taken from both experimental animals and human beings after either oral or parenteral drug administration. (aspetjournals.org)
  • Syrosingopine is a drug, derived from reserpine. (wikipedia.org)
  • Tranquilizer, as a term, was brought into existence by F.F. Yonkman (1953), from the conclusions of investigative studies using the drug Reserpine, showed the drug had a calming effect on all animals it was administered to. (wikipedia.org)
  • tell your doctor
  • tell your doctor and pharmacist if you are allergic to reserpine, aspirin, any other medications, tartrazine (a yellow dye in some processed foods and medications), or any of the ingredients in reserpine tablets. (medlineplus.gov)
  • levels
  • Reserpine lowers blood pressure by decreasing the levels of certain chemicals in your blood. (drugs.com)
  • Since most of the blood leaving the GI tract passes through the liver via the portal vein, hepatic metabolism would also be expected to reduce reserpine levels in the blood. (aspetjournals.org)
  • patients
  • In 1987, reserpine was considered a second-line adjunct agent for patients who were uncontrolled on a diuretic alone when cost was an issue. (wikipedia.org)
  • taken
  • In one case report, a stillborn female was born at gestation week 30 to a hypertensive, 30-year-old mother who had taken reserpine from days 13 to 41. (drugs.com)
  • properties
  • Because of its lipophilic properties, reserpine would easily penetrate cell membranes and then bind possibly electrostatically to intracellular membrane components, particularly those rich in phospholipids. (aspetjournals.org)
  • support
  • Join the ' Reserpine / Trichlormethiazide ' group to help and get support from people like you. (drugs.com)
  • These data do not support an association between reserpine or HCTZ and congenital defects. (drugs.com)
  • blood
  • Reserpine and ethanol may have additive effects in lowering your blood pressure. (drugs.com)
  • Presumably reserpine is transported from the blood via the biliary tree into the small intestine where it is either reabsorbed or eliminated in the feces. (aspetjournals.org)