• therapeutic
  • Therapeutic cloning would involve cloning cells from a human for use in medicine and transplants, and is an active area of research, but is not in medical practice anywhere in the world, as of April 2017[update]. (wikipedia.org)
  • Kevin Eggan (born 1974 in Normal, Illinois) is a Professor of Stem Cell and Regenerative Biology at Harvard University, known for his work in stem cell research (also known as "therapeutic cloning"), and as a spokesperson for stem cell research in the United States. (wikipedia.org)
  • oocyte
  • To achieve this goal, clinical scientist linkurl:Doug Turnbull;http://www.cnmd.ac.uk/researchgroups/dougturnbull and his colleagues at Newcastle University in the UK transplanted the nuclei from one human oocyte (termed pronuclei) into an oocyte whose pronuclei had been removed. (the-scientist.com)
  • The resulting embryos, which contained predominately mtDNA from the recipient oocyte, were then raised in culture for about a week. (the-scientist.com)
  • The technique consists of taking an enucleated oocyte (egg cell) and implanting a donor nucleus from a somatic (body) cell. (wikipedia.org)
  • work
  • In her work with chick embryos, Margaret Lewis studied connective tissue formation within the tissues as well as outside of an environment where factors involved in coagulation are present. (wikipedia.org)
  • Based on the publication of this work, Morgan was awarded his Ph.D. from Johns Hopkins in 1890, and was also awarded the Bruce Fellowship in Research. (wikipedia.org)
  • The groups initially collaborated in researching diabetes before Eggan's group switched to work on neurodegenerative diseases. (wikipedia.org)
  • Eggan's work as of 2007[update] has succeeded in developing a technique of merging stem and skin cells that has obtained considerable public attention as a possible avenue to avoid moral objections regarding stem cell research in the context of serious illness. (wikipedia.org)
  • Eggan himself is cautious about his team's work, with an early stage 2005 profile in Nature noting there was still much work to do: The hybrids still contain two nuclei: one from a skin cell and one from an embryonic stem cell. (wikipedia.org)
  • medical
  • Nonetheless, the results are "very promising," said neurogeneticist linkurl:Carolyn Sue;http://www.kolling.usyd.edu.au/research/neurogenetics-group/csue.php of the Kolling Institute of Medical Research at the University of Sydney in Australia, who was also not directly involved in the research. (the-scientist.com)
  • Eggan took on a second role as the assistant investigator for Stowers Institute for Medical Research, a philanthropical medical research group in Kansas City, Missouri. (wikipedia.org)
  • study
  • The oocytes used in the study were abnormally fertilized embryos generated during in vitro fertilization (IVF) treatments that would have otherwise been discarded, but, to be approved for clinical use, the technique would have be tested in healthy embryos, researchers say. (the-scientist.com)
  • With so many avenues opened by cell culture to explore, Margaret Lewis and her husband diverged in their area of study, with Margaret Lewis choosing to focus on microbiological problems, which involved close observations of chick embryo intestines reacting to typhoid bacilli in the medium in which it was grown. (wikipedia.org)
  • There he worked with German biologist Hans Driesch, whose research in the experimental study of development piqued Morgan's interest. (wikipedia.org)
  • process
  • Eggan began to explore both this process and also the reasons that cloned animals often appeared to develop abnormally, with organ defects and immunological problems - his first contact with stem cell research. (wikipedia.org)
  • technique
  • They suggest the technique could ultimately prevent the transmission of mitochondrial diseases if doctors moved nuclei from a fertilized egg carrying the disease to another egg with disease-free mitochondria. (the-scientist.com)
  • Refining their technique, the researchers were able to limit the amount of mitochondrial transfer, creating manipulated embryos with less than 2 percent donor mitochondria, "which we felt was a significant breakthrough in this area," Turnbull said. (the-scientist.com)
  • It is a technique for cloning in which the nucleus of a somatic cell is transferred to the cytoplasm of an enucleated egg. (wikipedia.org)
  • made
  • Margaret Adaline Reed Lewis (1881-1970) was an American cell biologist and embryologist who made contributions to cancer research and cell culture techniques, and was likely the first person to successfully grow mammalian tissue in vitro. (wikipedia.org)
  • At the time, stem cell research in the United States was threatened by political pressure due to concerns over the ethics of human embryo research, and research such as this was at risk of potentially being made illegal. (wikipedia.org)