Researchers gene library. Medical search. Frequent questions

RS is related to various mutations on the MECP2 gene, which codes for methyl-CpG binding protein-2 (MECP2). (medscape.com)
The researchers then constructed mutant libraries in 14 RBD backgrounds spanning the RBD phylogeny to explore how easily RBDs can acquire the ability to bind ACE2 due to single amino acid mutations. (news-medical.net)
For many questions in biology, we want to know how different genes interact, and for this we need to introduce mutations into multiple genes," says Rudolf -Jaenisch, a biologist at the Whitehead Institute in Cambridge Massachusetts. (technologyreview.com)
In contrast, -Jaenisch and his colleagues, including MIT researcher Feng Zhang (a 2013 member of our list of 35 innovators under 35 ), reported last spring that CRISPR had allowed them to create a strain of mice with multiple mutations in three weeks. (technologyreview.com)
It will allow biologists to do experiments that compare many versions of a gene, hunting for mutations that lead to specific traits and tracking their evolution over time. (aau.edu)
To speed things up, Stevenson and his colleagues designed a way to compress hundreds or even thousands of possible mutations into a single "library. (aau.edu)
That design means that instead of individually injecting many individual worms with different versions of a gene, researchers can inject the whole library of mutations into one worm. (aau.edu)
A new technique developed by researchers at the University of Oregon allows them to inject genetic material (above) into C. elegans worms and test many mutations at once. (isaaa.org)
Prof. Lukas Dow, biochemistry, and his team published a study in Nature on Aug. 16, detailing a new, more specific gene editing tool that they created to study cancer mutations through preclinical mice models. (cornellsun.com)
He is currently creating a library of guide RNAs that help induce hundreds and thousands of mutations found in tumors. (cornellsun.com)
KRAS mutations are found in about one quarter of all tumors, making them one of the most common gene mutations in cancer. (scienceblog.com)
The researchers say that the new approach could pave the way not only for combination treatments in cancers with KRAS mutations, but also other similar pairings of targeted drugs with immunotherapies. (scienceblog.com)
The accepted method to address this challenge is to produce mutations, that is, to modify genes in different ways and then to examine changes in the plant's traits as a result of the mutation in the DNA and to learn from this about the function of the gene. (phys.org)
Gene therapies "fix" genetic mutations by replacing or changing a gene that doesn't work with one that does. (medlineplus.gov)
These treatments "fix" the genetic mutations (harmful changes) that cause some diseases by replacing or changing a gene that doesn't work with one that does. (medlineplus.gov)
In some rare diseases, DNA mutations cause a gene or protein to work incorrectly. (medlineplus.gov)
Some muscular dystrophies are caused by mutations in genes that make important muscle proteins. (medlineplus.gov)

The new library includes 4 guide RNAs per gene and is half the size of the company's current three-module CRISPR 150K Human Genome-Wide Knockout Library. (genomeweb.com)
The reduced library size enables researcher to study how cells respond to the disruption of each gene across the entire human genome in a single screening experiment. (genomeweb.com)
Genetic improvement of this important crop depends on a complete and through understanding of the genes that make up the genome and how they have evolved. (usda.gov)
A first step to understanding the soybean genome is to identify all genes in the genome and then to infer functions for them in order to identify genes that may play a role in traits of agronomic importance. (usda.gov)
The identification of potential gene sequences (pHaps) from soybean allows us to begin to get a picture of the genomic history of the organism as well as begin to observe the evolutionary fates of gene copies in this highly duplicated genome. (usda.gov)
The researchers used this computer brain to their advantage by working backward and feeding it ancient demographic models, including the Neanderthal-Denisovan hybrid, until it came up with a genome that mirrored the modern human genome. (syfy.com)
We have found a way to scan the genome of a wild relative of a crop plant and pick out the resistance genes we need: and we can do it in record time. (phys.org)
To further validate and understand the functional role of specific eRNAs, I conducted ChIRP-Seq to identify its potential location in the genome to regulate target genes. (tmc.edu)
To address this, a single gene copy that produces APOBEC is integrated into the cell's genome and controlled by gene expression regulator doxycycline in order to determine how much APOBEC is produced. (cornellsun.com)
For the first time, researchers from Tel Aviv University have developed a genome-scale technology that makes it possible to reveal the role of genes and traits in plants previously hidden by functional redundancy. (phys.org)
But until this recent development, it was only possible to examine the functions of single genes , which make up only 20% of the genome. (phys.org)
For the remaining 80% of the genome, made up of genes grouped in families, there was no effective way, on the large scale of the whole genome, to determine their role in the plant. (phys.org)
One of them was the need to identify as precisely as possible which genes in the plant's genome are responsible for a specific desired trait to cultivate. (phys.org)
When cells are positive for a protein interaction, the researchers can use genetic sequencing to figure out what the two proteins interacting are, using new high-throughput DNA sequencing technologies similar to those used for human genome sequencing. (salk.edu)
The project will build on other areas of cooperation between Serbia and the Chinese gene giant, including the Center for Genome Sequencing and Bioinformatics that opened in December 2021. (globalsecurity.org)
They found that the sunflower genome is 20 percent larger than the human genome, with about twice the number of genes. (nationalgeographic.com)

WEDNESDAY, March 8, 2023 (HealthDay News) -- Some people may have a gene that helps protect them from respiratory diseases like COVID-19 -- and helped their ancestors fight the plague. (chkd.org)
2023 MAC Conference Scholarship The Membership and Recruitment Committee of the Mid-Atlantic Chapter (MAC) of the Medical Library Association invites new librarians to apply for a conference scholarship to attend the 2023 MAC Annual Meeting. (macmla.org)
The Membership and Recruitment Committee of the Mid-Atlantic Chapter (MAC) of the Medical Library Association invites library students to apply for a conference scholarship to attend the 2023 MAC Annual Meeting,which will be held from October 15-17, 2023 in Pittsburgh, Pennsylvania. (macmla.org)

IDT said that oPools' low error rate of less than 1 in 2,000 nucleotides, coupled with high per-oligo yields, allow researchers to immediately proceed into their downstream workflows including CRIPSR library construction, protein screening, and gene assembly. (genomeweb.com)
While 2'-5'-oligoadenylate synthetase (OAS)-like gene was upregulated at the 6th hour post infection up to 3.3 fold, Mx protein was downregulated marginally. (usda.gov)
Researchers can also utilize mRNA enrichment kits (sold separately) and focus RNA-seq library construction on protein coding mRNAs. (qiagen.com)
The researchers showed with studies on both isolated protein and human cells that the most promising antibody they had identified could bind tightly to the drug ARS1620 as well as the ARS1620-KRAS complex. (scienceblog.com)
The gene codes for a protein, complement factor H (CFH), that is involved in controlling one part of the immune system. (ophthalmologytimes.com)
If a newly discovered protein interacts with lots of other proteins involved in cellular metabolism, for instance, researchers can deduce that's a likely role for the new protein and potentially target it for treatments related to metabolic dysfunction. (salk.edu)
This way, they're no longer limited to testing one "bait" protein at a time, but could test the interactions between all the proteins in a library at once. (salk.edu)
Nusinersen targets another gene called SMN2 that also makes a small amount of the SMN protein. (medlineplus.gov)
It helps muscles and nerves work properly by changing the SMN2 gene product to make more of the SMN protein than it usually would. (medlineplus.gov)
Typically, nucleotide sequences encoding the protein/peptide library are fused to a gene encoding a phage coat protein thus allowing them to be displayed on the phage exterior. (cdc.gov)
In this work, we have developed antibodies to NPs from a phage library containing approximately 2x109 unique single-chain variable fragment (scFv) antibodies each displayed monovalently on the gene III coat protein of a M13 filamentous phage. (cdc.gov)
An attractive approach is to develop systems that allow for clonal selection of interacting protein pairs from large molecular libraries. (lu.se)
In addition to infrastructures for bioimaging, protein and genes & cells, we also provide other resources e.g., databases, networks and specialized labs. (lu.se)

Gene expression is the chemical pathway from genes to the gene products, such as proteins, that organisms can use. (visionlearning.com)
The process , known as "gene expression," is the chemical pathway leading to the particular enzyme that each type of gene makes, resulting in physical characteristics. (visionlearning.com)
The complete solution includes online access to the RNA-seq analysis portal (for supported species), which allows researchers to start with FASTQ files and perform read alignment, differential gene expression and pathway analysis. (qiagen.com)

Therefore, vast libraries of fly driver lines expressing fluorescent reporter genes in sets of neurons have been created and imaged using confocal light microscopy (LM). (janelia.org)
Usage of reporter genes need to be specified in iLab before project start and the exact sequence information and gene co-ordinates need to be submitted to be included during sequencing read alignment. (lu.se)

Yet scientists have until recently remained largely ham-fisted when they've tried to directly modify genes in a living cell. (technologyreview.com)

They focused on a family of regulatory genes that are expressed in neurons and that in previous studies have been associated with regeneration of axons following injury. (brightfocus.org)
In order to exploit this knowledge base, researchers target individual neurons and study their function. (janelia.org)
There's another gene-based therapy for children under age 2 that uses a safe virus to deliver a new copy of the SMN gene into specific neurons to improve muscle movement. (medlineplus.gov)

Many human illnesses, including heart disease, diabetes, and assorted neurological conditions, are affected by numerous variants in both disease genes and normal genes. (technologyreview.com)
The U.S. National Library of Medicine has more on gene variants . (chkd.org)
For a specific condition to be included in MedlinePlus Genetics, it must have a known or suspected genetic component, meaning that gene variants cause the condition or increase the risk of development of the condition. (medlineplus.gov)

We used the ESTminer suite of programs to identify potential soybean gene transcripts from a single genetic background allowing us to observe functional classifications between gene families as well as structural differences between genes and gene paralogs within families. (usda.gov)
Functional annotation of gene sequences indicate functional classifications are not randomly distributed among gene families containing few or many genes. (usda.gov)
By correlating this information with the DNA sequences of the plants, they were able to reveal the identity of functional resistance genes across the population. (phys.org)
What we have now is a library of disease resistance genes and we have developed an algorithm that enables researchers to quickly scan that library and find functional resistance genes," explains Dr. Sanu Arora, first author of the paper. (phys.org)
The BKL is great for research applications including gene set enrichment analysis, functional analysis, SNP analysis, gene expression analysis, and drug discovery. (mit.edu)
The technology typically involves obtaining antibody genes from source cells including hybridomas and phage display libraries, amplifying and cloning the genes into an expression vector, introducing the vector into a host (bacteria, yeast, or mammalian cell lines), and achieving adequate expression of the functional antibody. (labmanager.com)
Flies containing functional circadian genes did become sensitized to cocaine. (sciencedaily.com)

The simple workflow utilizes the FastSelect RNA removal reagents to suppress ribosomal RNA and other unwanted RNAs to enable gene expression and transcript identification from a variety of model systems including human, mouse, rat and related species, plants, yeast, zebrafish, flies, worms and bacteria. (qiagen.com)
With the recent advances in next-generation sequencing, researchers discovered that active enhancers are pervasively transcribed into RNAs, which are named enhancer RNAs (eRNAs). (tmc.edu)
In addition, recurrent tumors expressed genes associated with an epithelial-to-mesenchymal-type transition, and had lost, or at least reduced, expression of mouse homologs of the human RNAs encoding prostate-specific antigens in the ASEL. (genengnews.com)

This technology could allow researchers to perform microsurgery on genes, precisely and easily changing a DNA sequence at exact locations on a chromosome. (technologyreview.com)
I am proud of the leadership role that TMG has played in the evolution of genealogical software and I encourage TMG users to continue to press developers to raise their standards and implement features that allow researchers to do the same. (whollygenes.com)

We also found that interferon (IFN) and IFN-inducible genes were regulated differentially in A/ph/CA/2373/98 (H9N2) virus infected Macrophages. (usda.gov)
Library preparation can be a source of bias in RNA-sequencing studies, leading to false positives in genes identified as differentially expressed between conditions. (pitt.edu)
Differential gene expression analysis was performed with DESeq2, EdgeR, and Limma-Voom, and differentially expressed genes were annotated using BiomaRt. (pitt.edu)
All bioinformatics were conducted in R. There were 13827 differentially expressed genes, including ACTB and GADPH (housekeeping genes), identified in this study. (pitt.edu)

This gene essentially chops up proteins for the immune system," said lead author Fergus Hamilton , a fellow at the University of Bristol. (chkd.org)
The new approach, published June 26 in Nature Methods , lets researchers test millions of relationships between thousands of proteins in a single experiment. (salk.edu)
A new mapping method let researchers discover new links (gray lines) between two groups of plant proteins (yellow and blue) that have a common structure (the BBX domain), suggesting many different combinations of interactions, rather than a few, are involved in coordinating cellular programs like flowering time and circadian rhythm. (salk.edu)
Until now, researchers have typically relied on standard high-throughput yeast two-hybrid (Y2H) assays to determine the interactions between proteins. (salk.edu)
The genes for two proteins, each on their own circle of DNA, are added to the same cell. (salk.edu)
If the proteins of interest interact inside the cell, a gene called Cre is activated. (salk.edu)
When turned on, Cre physically splices the two individual circles of DNA together, thus pairing the genes of interacting proteins together so the team can easily find them through sequencing. (salk.edu)
The team can generate a massive library of yeast cells-each containing different pairs of proteins by introducing random combinations of genes on circular DNA called plasmids. (salk.edu)
Below is a non-exhaustive list of in-house infrastructures that are categorized into three overarching themes: bio-imaging, proteins, genes & cells and other resources. (lu.se)
Below you can see some examples of the infrastructure for proteins, available for researchers at Lund University. (lu.se)

This study examined potential gene sequences identified in EST libraries of soybean and assigned the potential gene sequences with molecular functions. (usda.gov)
As well as the established molecular markers (AFLPs and SS Rs), the "ASGEN" study will employ the novel and innovative approach of association genetics in order to identify markers that are linked to gum quality or genes responsible for gum quality. (europa.eu)
The researcher will improve and diversify his expertise in plant molecular technologies, as well as a variety of complementary skills. (europa.eu)
The work laid the foundation for the current studies elaborating the possible molecular bases for cocaine addiction in people, including other recently published findings in the current online issue of Current Biology, ( http://www.biomednet.com/library/abstract/JCUB.bb9p35 ) that implicate tyramine, one of the body's naturally occurring molecules, as the likely perpetrator of cocaine sensitization in fruit flies. (sciencedaily.com)
As part of the research, the team of researchers used the innovative technology "CRISPR" for gene editing and methods from the field of bioinformatics and molecular genetics to develop a new method for locating genes responsible for specific traits in plants. (phys.org)
The center aims to bring together researchers from BGI with their Serbian counterparts under the umbrella of Serbia's state-run Institute of Molecular Genetics and Genetic Engineering. (globalsecurity.org)
The medical research team in the project Treatments of the Future at Lund University aims to develop a new molecular gene therapeutic method that will give the possibility to cure the disease. (lu.se)

Large scale gene analysis of most organisms is hampered by incomplete genomic sequences. (usda.gov)
RESULTS: We identified approximately 45,000 potential gene sequences (pHaps) from EST sequences of Williams/Williams82, an inbred genotype of soybean (Glycine max L. Merr. (usda.gov)
Analysis of these sequences revealed single base substitutions and single base indels are the most frequently observed form of sequence variation between genes within families in the dataset. (usda.gov)
It enables researchers to search a genetic "library" of resistance genes discovered in wild relatives of modern crops so they can rapidly identify sequences associated with disease fighting capability. (phys.org)
This genetic editing method allows us to design different sgRNA sequences to allow Cas9 to cut almost any gene that we want to change. (phys.org)

With this goal in mind, Dr. Trakhtenberg and colleagues are working to identify gene products within RGCs that regulate the process of regeneration, genes whose function shuts down not long after birth. (brightfocus.org)
To accomplish his goal, Dow moved to optimizing base editing enzymes and developing a system that allows him to turn the expression of these enzymes on and off with doxycycline, an antibiotic also typically used to regulate gene expression. (cornellsun.com)

A new gene editing technique developed by UO researchers compresses what previously would have been years of work into just a few days, making new kinds of research possible in animal models. (aau.edu)

In a Novartis-sponsored study in the New England Journal of Medicine, researchers found that a CRISPR-Cas9-based treatment targeting promoters of genes encoding fetal hemoglobin could reduce disease symptoms. (genomeweb.com)
Along with a technique called TALENs, invented several years ago, and a slightly older predecessor based on molecules called zinc finger nucleases, CRISPR could make gene therapies more broadly applicable, providing remedies for simple genetic disorders like sickle-cell anemia and eventually even leading to cures for more complex diseases involving multiple genes. (technologyreview.com)
One is Gang Bao, a bioengineering researcher at the Georgia Institute of Technology, who has already used CRISPR to correct the sickle-cell mutation in human cells grown in a dish. (technologyreview.com)
After harvesting blood cell precursors called hematopoietic stem cells from the bone marrow of a sickle-cell patient, scientists would use CRISPR to correct the defective gene. (technologyreview.com)
Some researchers have explored whether CRISPR technology might help to edit out the typo that is HER2 before it becomes cancer. (curetoday.com)
Researchers in Germany have developed a universal approach for CRISPR-Cas12a-assisted PCR tagging of mammalian genes, using scalable live cell imaging to optimize their methods. (tecan.com)
The gene editing tool utilizes technology from CRISPR-Cas9, according to Dow. (cornellsun.com)
Researchers including Orna Therapeutics Inc. co-founder Daniel Anderson presented in Nature Biotechnology a set of inhalable nanoparticles, built using biodegradable ionizable lipids, that are capable of delivering messenger RNA and CRISPR-Cas9 gene editors to lung tissues. (biocentury.com)
Easy gene alterations in weird creatures make CRISPR a killer app for evolutionary developmental biology. (nature.com)
The precise, efficient CRISPR-Cas9 gene-editing technique has already taken life-sciences labs by storm . (nature.com)
His team used CRISPR to engineer zebrafish lacking various combinations of the several hox13 genes they possess - genes that researchers already thought played an important role in laying down fin rays. (nature.com)
The researchers explain that despite the development of genetic editing technologies, such as CRISPR, several challenges remained that limited its application to agriculture. (phys.org)
The current study sought to find a solution to the problem of genetic redundancy by using an innovative gene editing method called CRISPR. (phys.org)

Researchers in Human Genetics and Genomics Advances report that how researchers describe genomic studies may alienate potential participants. (genomeweb.com)
Identifying links between genetics and susceptibility to disease can pave the way for potential treatments, researchers noted. (chkd.org)
Reverse genetics: NS1 genes will be altered through site mutagenesis and mutated viruses will be generated through co-transfection of macropahges with a reverse genetics system to determine which part of the NS1 genes is responsible for the observed differences in cytopathogenic effect (apoptosis) and the modulation of the immnue genes detected by microarray analysis. (usda.gov)
Genetics researchers have long been able to manipulate genes in fruit flies for investigations of nervous system pathways. (sciencedaily.com)
MedlinePlus Genetics is part of MedlinePlus, a resource for consumer health information from the National Library of Medicine (NLM). (medlineplus.gov)
MedlinePlus Genetics provides information for the general public about the main features and inheritance of genetic conditions as well as the normal function of related genes and chromosomes and how genetic variations contribute to conditions. (medlineplus.gov)
For a particular gene to be associated with a condition in MedlinePlus Genetics, genetic variations must have been identified in two or more affected, unrelated individuals or families or have a significant influence on the risk of the development of the condition. (medlineplus.gov)
The name of each condition on MedlinePlus Genetics reflects terminology used by researchers, clinicians, and patients. (medlineplus.gov)
How are gene names and symbols chosen in MedlinePlus Genetics? (medlineplus.gov)
MedlinePlus Genetics uses standardized gene terminology from the National Center for Biotechnology Information (NCBI) Gene database. (medlineplus.gov)
MedlinePlus Genetics italicizes symbols for human genes in accordance with the HGNC Guidelines for Gene Nomenclature. (medlineplus.gov)
MedlinePlus Genetics lists many genes under more than one name or symbol, especially when the same gene is known by different scientific, informal, and historical names. (medlineplus.gov)

This work will be used by soybean researchers and potentially soybean breeders to help identify genes that may play a role in soybean physiology and traits. (usda.gov)
The way that genes translate into physical traits has to do with the particular enzyme that each type of gene makes, a discovery that was made by two scientists by way of the mutant bread mold they created, winning them the Nobel Prize in 1958. (visionlearning.com)
It wasn't until 1941 that George Beadle and Edward Tatum figured out the mechanism by which genes are translated into physical traits . (visionlearning.com)

To find such a gene, the researchers analyzed embryonic, neonatal, and adult (both injured and uninjured) RGC gene expression libraries. (brightfocus.org)
These results indicate that library preparation influences differential gene expression analysis and subsequently affects the downstream analyses that investigate the biological pathways impacted by gene expression level. (pitt.edu)
Especially in cancer, enhancers modulate tumor gene expression, and in some cases directly drive tumorigenesis. (tmc.edu)
In addition, the gene expression of APOBEC varies among different types of cells. (cornellsun.com)
Thus, Dow inserted two copies of the gene in these cells instead of one to compensate for the lower expression of APOBEC. (cornellsun.com)
However, creating a fly line for driving gene expression within a single neuron found in the EM connectome remains a challenge, as it typically requires identifying a pair of fly lines where only the neuron of interest is expressed in both. (janelia.org)

Petersen, M, Hagen, N, Torkelson, E & Lundin, S 2016 ' Clinical experiments for Huntington's disease: Recommendations to medical researchers regarding how to inform potential participants ' Working Paper in Medical Humanities, Lund University Libraries, Lund, s. 1-33. (lu.se)

This aids the researchers ability to identify genetic elements that are functionally important in biological responses and identify new therapeutic targets. (genomeweb.com)
However, since the discovery of neurite growth inhibitors by Professor Martin E. Schwab at the University of Zurich, clinical researchers have been exploring new therapeutic approaches to treat cerebral stroke and spinal cord injury. (tecan.com)
Researchers at the University Hospital Düsseldorf are using automation to develop a more personalized approach to cancer medicine, performing rapid drug screening to identify novel therapeutic strategies to improve the chances of survival. (tecan.com)
One promising approach uses an injection of small, harmless viruses to deliver therapeutic dystrophin-producing genes directly into cells in the muscle. (medlineplus.gov)

Researchers interested in exploring the virtues of the sunflower recently formed a worldwide team to examine the plant's genetic library. (nationalgeographic.com)

In many organisms, such as soybean, the best source of sequence information is the existence of expressed sequence tag (EST) libraries. (usda.gov)
While mass gene editing tricks have been developed for single-celled organisms like bacteria and yeast, this is the first time it has been possible on this scale in an animal. (aau.edu)
Genes cannot be used directly by organisms. (visionlearning.com)
Since organisms have two genes for everything, even If one gene of a pair produces a defective enzyme or no enzyme at all, the other gene in the pair will make enough enzyme to do its job. (visionlearning.com)

To address the problem of tumor recurrence, the researchers evaluated combinations of vaccination with differ-ent libraries. (genengnews.com)

Interestingly, RNA-seq of arlr mutant adipose tissues and RIP-seq suggest that Arlr affects lipid metabolism through the degradation of the mRNAs of lipolysis genes - a model further supported by the observation that knockdown of Lsd-1, regucalcin, yip2 or CG5162, which encode genes involved in lipolysis, rescue the LD defects of arlr mutants. (bvsalud.org)

A review of more than 100 public documents by Reuters, however, did show that BGI had worked with Chinese military hospitals to study the genomes of fetuses since 2010 and had published more than a dozen joint studies with military researchers to trial and improve its prenatal tests. (globalsecurity.org)
A comprehensive and high-quality collection of Escherichia coli genomes and their genes. (cdc.gov)

In a study published in Nature , researchers have been investigating sarbecovirus lineages and the ability of those lineages to evolve the ability to bind angiotensin-converting enzyme 2 (ACE2). (news-medical.net)
To test this, the researchers investigated viruses from Africa and Europe that were reported after the initiation of the study. (news-medical.net)
In addition to the reported Neanderthal and Denisovan introgressions, our results support a third introgression in all Asian and Oceanian populations from an archaic population," said population geneticist Oscar Lao, evolutionary biologist Mayukh Mondal, and their team of researchers in the study, which was recently published in Nature Communications . (syfy.com)
To study this, researchers looked at infection, autoimmune disease and parental longevity across participants in three large genetic studies. (chkd.org)
Researchers from the Universities of Edinburgh, Oxford, Cardiff, and Imperial College London also worked on the study. (chkd.org)
This study points to a potential new, innovative approach to rescuing injured nerve cells in the early stages of the disease, while the cells are still alive, by down-regulating genes that inhibit regeneration. (brightfocus.org)
This study aims to illustrate the impact of using different library preparations in RNA sequencing. (pitt.edu)
For example, Oregon Health & Science University researchers have used recombinant antibodies to study the structure and function of the human serotonin transporter. (labmanager.com)
A new study published in Science indicates that cocaine sensitization -- which is linked to addiction -- might be associated with circadian genes, the genes that set the biological clock. (sciencedaily.com)
This study opens up the field of drug studies to thinking how a totally unexpected set of genes functions in response to drugs," says Jay Hirsh, professor of biology at U.Va. and senior author of the report. (sciencedaily.com)
The handbook focuses on several major themes:- Social Institutions such as Politics, Economics, Education, Health and Social Welfare- Family and the Life Cycle- Inequality- Social Control- Culture- Religion as a Social Institution and in a Global PerspectiveThis handbook will be of interest to social scientists including sociologists, anthropologists, political scientists, and other researchers whose study brings them in contact with the study of religion and its impact on social institutions. (lu.se)
The authors', social- and cultural scientists, mission is to develop recommendations for how information should be designed to potential research subjects in an experimental gene therapy study regarding HD. (lu.se)
Lind L, Elmståhl S, Bergman E, Englund M, Lindberg E, Michaelsson K, Nilsson PM, Sundström J. EpiHealth: a large population-based cohort study for investigation of gene-lifestyle interactions in the pathogenesis of common diseases. (lu.se)

His research interests and expertise in bone marrow transplant, gene therapy and genetic testing paved the way for many advances at St. Jude, including breakthroughs in sickle cell disease and other hematological disorders. (wikipedia.org)
After completing his tenure at St. Jude Children's Research Hospital, Nienhuis returned to the laboratory, where he continued with his research which included the development of gene transfer for the treatment of hemophilia. (wikipedia.org)
Past research has found that survivors of the bubonic plague pandemic in the Middle Ages, known as Black Death, carried a variant -- or allele -- in a gene known as ERAP2. (chkd.org)
The research published today in the journal Nature Biotechnology reveals that AgRenSeq has been successfully trialled in a wild relative of wheat-with researchers identifying and cloning four resistance genes for the devastating stem rust pathogen in the space of months. (phys.org)
The Pan Am Historical Foundation announces the seventh annual Dave Abrams and Gene Banning Pan Am Research Grant competition. (aaslh.org)
Up to $1,500 will be awarded to support scholarly research using the Pan American World Airways, Inc. Records held by the University of Miami Libraries' Special Collections. (aaslh.org)
The Special Collections of the University of Miami Libraries preserves and provides access to research materials focusing on the history and culture of Florida, the Caribbean and Latin America. (aaslh.org)
The scholarships support the most innovative young researchers at a critical stage of their careers-their postdoctoral research-as they develop the new ideas and directions that will help establish them as independent neuroscientists. (nyas.org)
I recognize too and regret the degree to which it may leave researchers uneasy about the future of their data and the prospects for their research tools. (whollygenes.com)
I am taking a necessary step back from the genealogical community but with the hope that my contribution to it has left researchers better equipped to accomplish their research goals. (whollygenes.com)
Those increases were approved to let researchers take advantage of exciting new advances in biological and medical research, such as the deciphering of the human genetic code, which some believe will lead to new treatments and cures for disease. (harvard.edu)
The Medical Library Association (MLA) is now accepting applications for the Eugene Garfield Research Fellowship. (macmla.org)
This fellowship aims to stimulate research into the history or discoverability and dissemination of information in the medical or health sciences, recognizing that this key knowledge area helps practitioners and researchers interpret the present and prepare for the future. (macmla.org)
Besides enabling the potential development of drugs to treat cocaine addiction, this research holds out the prospect that so-called "clock" genes -- which are involved in setting and maintaining the body's internal clock -- might have other, as yet undiscovered, roles in the body and brain. (sciencedaily.com)
This article describes two rare diseases - spinal muscular atrophy and Duchenne muscular dystrophy - and how NIH supports research and development on gene therapies to treat them. (medlineplus.gov)
Sources for GARD and other hard-to-find information include the National Library of Medicine, scientific conferences, support groups, and clinical trials and research. (cdc.gov)
In creating the Rare Diseases PHGKB, we sought to connect directly the GARD database A-to-Z list of more than 5000 rare diseases with contents of PHGKB, such as epidemiologic studies of prevalence and gene-disease associations, translation and evaluation studies of interventions, implementation research studies, as well as systematic reviews and guidelines. (cdc.gov)
This network consists of researchers and other staff associated with epidemiological research at Lund and Uppsala universities. (lu.se)
The ambition is to let the network stimulate exchanges between researchers and to promote interdisciplinary research and new project ideas. (lu.se)

Sequence based assays will be developed following the creation of cDNA libraries from selected tissues of A. senegal. (europa.eu)
The Mayo Clinic's Richard Vile, M.D., and colleagues, describe their findings in a paper titled "Broad antigenic coverage induced by vaccination with virus-based cDNA libraries cures established tumors. (genengnews.com)
Nevertheless, building on the positive aspects of this approach, the researchers postulated that it may be possible to provide a broad antigenic repertoire for in vivo immune selection of relevant tumor-associated antigens by expressing a cDNA library of a normal tissue using a systemically delivered, immunogenic vector. (genengnews.com)
The team cloned a cDNA library from normal human prostate, which they termed altered self antigen and epitope library (ASEL) into VSV, and systemically injected the antigen-expressing vector into normal experimental mice. (genengnews.com)
They then went on to test the virus-expressed human cDNA library in mice with established prostate tumors. (genengnews.com)
They first tried a second vaccination comprising virally expressed immune-escape epitope libraries (IEELs) constructed using cDNA from the recurrent tumors of ASEL-treated mice. (genengnews.com)

Because the pools are delivered in picomoles, researchers do not need to perform any pre-amplification or other pre-work before using the pool. (genomeweb.com)
During sample indexing and final library amplification, up to 768 different unique dual indices can be utilized. (qiagen.com)

QIAseq FastSelect RNA Library Kits are also supported with on-site software through QIAGEN's CLC Genomics Workbench (sold separately). (qiagen.com)
The aim is to provide expertise, accessibility, proximity and service to researchers in need of single-cell genomics. (lu.se)
Comparative genomics of ESBL-producing Escherichia coli (ESBL-Ec) reveals a similar distribution of the 10 most prevalent ESBL-Ec clones and ESBL genes among human community faecal and extra-intestinal infection isolates in the Netherlands (2014-17). (cdc.gov)

Our results demonstrate that AgRenSeq is a robust protocol for rapidly discovering resistance genes from a genetically diverse panel of a wild crop relative," he says. (phys.org)

This library was then cloned into a yeast surface display platform to enable high-throughput measurement of ACE2 binding avidities through titration assays combining fluorescence-activated cell sorting (FACS) and deep sequencing. (news-medical.net)
Also, learn about ExPlain Analysis Systems to perform gene regulation and systems biology focused biological interpretation of high throughput experiments like microarrays, proteomic data, and ChIP-chip experiments. (mit.edu)
The team identified candidate nanoparticles via high-throughput combinatorial synthesis and screening of a library of 720 novel lipids. (biocentury.com)
The emerging field of proteomics has created a need for new high-throughput methodologies for the analysis of gene products. (lu.se)

Enhancers are essential regulatory elements that precisely control gene transcription during development and disease. (tmc.edu)

In the mid-1900s, George Beadle and Edward Tatum showed that a defective gene leads to a defective enzyme. (visionlearning.com)

Understanding researcher behaviour and workflow is instrumental to developing reflective service. (uwaterloo.ca)
QIAseq FastSelect RNA Library Kits utilize a simple and fast workflow for complete transcriptomics starting from 1 ng of total RNA. (qiagen.com)
QIAseq FastSelect RNA Library Kits are versatile and contain all the reagents to make stranded RNA-seq libraries for complete transcriptomics or 3' RNA-seq, depending on the workflow selected and type of RNA used. (qiagen.com)

This terminology typically includes the official gene name and gene symbol as designated by the HUGO Gene Nomenclature Committee ( HGNC ). (medlineplus.gov)

Our work by using several novel methods to manipulate eRNAs has provided important knowledge of enhancer functions in gene regulation and cancer development. (tmc.edu)

Curing disease through human gene therapy. (wikipedia.org)
Precise and easy ways to rewrite human genes could finally provide the tools that researchers need to understand and cure some of our most deadly genetic diseases. (technologyreview.com)
It is likely to be at least several years before such efforts can be developed into human therapeutics, but a growing number of academic researchers have seen some preliminary success with experiments involving sickle-cell anemia, HIV, and cystic fibrosis (see table below). (technologyreview.com)
With the shift of mutated KRAS from the inside to the outside of cells, the UCSF team was next able to screen a library of billions of human antibodies to identify those that could now recognize this KRAS flag. (scienceblog.com)
Researchers have developed a virus-based vaccine expressing a broad spectrum of undefined antigens from normal human prostate tissue that they claim completely eradicates established mouse prostate tumors in experimental animals. (genengnews.com)

Researchers report in mSystems that infants experienced an enrichment in Clostridium sensu stricto 1 and Finegoldia and a depletion of Bacteroides before developing eczema. (genomeweb.com)

GIS is a still-developing application, but the Robert Wood Johnson Foundation notes it has potential to help researchers make sense of the way physical environment affects health. (time.com)
Another startup speeds the publication of valuable-but-time-consuming gene libraries that help researchers look for new drugs to treat serious diseases. (jhu.edu)

One next step will be to knock out hox13 genes in fish species that more closely resemble the ancient fish that gained limbs, say Aditya Saxena and Kimberly Cooper, evolutionary developmental biologists at the University of California, San Diego. (nature.com)
In a January Current Biology paper, he and colleague Nipam Patel, at the University of California, Berkeley, found that inactivating different Hox genes in the species messes with the development of specialized appendages such as antennae and claws 3 . (nature.com)

Most conventional gene therapies crudely place new genetic material at a random location in the cell and can only add a gene. (technologyreview.com)
This symposium presents a remarkable opportunity to convene with other researchers, clinicians, and industry leaders to discuss the extraordinary progress and immense potential of new drug therapies and technologies in paving the way for a brighter future in cancer treatment. (nyas.org)
Because of this, gene therapies - treatments where certain genes are adjusted to treat someone's disease - are a promising approach for some diseases. (medlineplus.gov)
There's no cure for DMD, but there are treatments that can help with the symptoms, including gene-based therapies that help the muscles make more dystrophin. (medlineplus.gov)

Many EST libraries were constructed from RNA extracted from various genetic backgrounds, thus gene identification from these sources is complicated by the existence of both gene and allele sequence differences. (usda.gov)

All 10x Genomic services include a final report containing a Cell Ranger web summary file for quality control (QC) of the sequencing outcome, as well as FASTQ, BAM, gene count matrix containing all single cells or nuclei passing QC, basic visualization and clustering. (lu.se)

Then the gene--corrected stem cells would be returned to the patient, producing healthy red blood cells to replace the sickle cells. (technologyreview.com)
The information stored in genes must be used to make products, such as enzymes, that cells need to perform different functions. (visionlearning.com)
A gene whose product inhibits regeneration would be expected to be expressed at greater levels in cells that regenerate poorly, such as following aging or injury. (brightfocus.org)
Dow proposed that various other delivery methods could be used in lieu of the gene editing tool, such as using viruses or zapping cells to open up the cell membrane. (cornellsun.com)
Now, UC San Francisco researchers have developed a drug that overcomes some of these barriers, marking cancer cells for destruction by the immune system. (scienceblog.com)

A disease caused by a single mutation, in a single gene, that involves only a single cell type. (technologyreview.com)
In each offspring, one book from the mutation library gets randomly selected to complete the gene being targeted. (aau.edu)

using a redundancy criterion to identify reproducible sequence differences between related genes within gene families. (usda.gov)
Due to this phenomenon, called genetic redundancy, it is difficult to create a change in the plant itself and to determine the function of the gene and its link to a specific trait. (phys.org)

[ 1 3 ] A number of autosomal dominant, autosomal recessive, and X-linked single gene disorders are characterized by hair abnormalities. (medscape.com)

As Mendel observed, 3/4ths of the offspring possess at least one copy of the dominant tall gene T , while 1/4th of the offspring possess two copies of the short gene t . (visionlearning.com)
Although I know I am not a scientist, and understand my cancer may take a lifetime, I contemplate why I ended up with too many copies of the HER2 gene. (curetoday.com)

The technique called AgRenSeq or speed cloning has been developed by John Innes Centre researchers alongside colleagues in the United States and Australia to speed up the fight against pathogens that threaten food crops worldwide. (phys.org)

As a result of this unique development, the team of researchers managed to isolate and identify dozens of new features that had been overlooked until now. (phys.org)

Researchers or others who would like to make further use of these materials should contact the Veterans History Project for assistance. (loc.gov)
Because muscles make up a large portion of our body mass, the dose of viral gene-based therapy needs to be very high to be effective, which can cause unwanted side effects. (medlineplus.gov)
I was contacted to make a survey of the current status of the bioinformatics and compu- tational biology efforts within the groups and researchers with connections to SWEGENE facilities. (lu.se)

Researchers claim systemic vaccination with broad antigenic repertoire from normal prostate stimulates anticancer immune response but not autoimmunity. (genengnews.com)

The development of gene editing technologies now allows precise changes to be made in a large number of plants. (phys.org)

BIOBASE offers curated databases and analysis tools designed to help biomarker, systems biology and life science researchers accelerate discovery processes. (mit.edu)

Dow also encountered difficulties delivering components of the gene editing tool, or doxycycline, into certain tissues such as the brain. (cornellsun.com)

These four viruses have been selected because they have NS1 genes that belong to the A and B alleles, respectively. (usda.gov)

Anatomy2

Organisms7

Diseases1

Chemicals and Drugs23

Analytical, Diagnostic and Therapeutic Techniques and Equipment47

Psychiatry and Psychology11

Phenomena and Processes42

Disciplines and Occupations21

Anthropology, Education, Sociology and Social Phenomena14

Technology, Industry, Agriculture5

Humanities10

Information Science85

Named Groups4

Health Care50

Geographicals2

Mutations17

Genome16

20233

Protein13

Pathway3

Reporter genes2

Modify genes1

Neurons3

Variants3

Functional7

RNAs3

Allow researchers2

Differentially4

Proteins10

Molecular7

Sequences5

Regulate2

Compresses what previously1

CRISPR13

Genetics12

Traits3

Expression6

Lund University Libraries1

Therapeutic4

Plant's1

Organisms4

Combinations1

MRNAs1

Genomes2

Study13

Research19

CDNA6

Amplification2

Genomics3

Genetically1

High throughput4

Precisely1

Defective gene1

Workflow3

Typically1

Manipulate1

Human5

Enrichment1

Help researchers2

Species2

Therapies4

Allele1

Genomic1

Cells5

Mutation2

Redundancy2

Single gene disorders1

Copies2

Colleagues1

Team of researchers1

Make3

Systemic1

Development of gene1

Biology1

Tissues1

Viruses1