Researchers cell. Medical search. Frequent questions

Sensitization of trigeminal ganglion neurons contributes to primary headache disorders such as migraine, but the specific neuronal and non-neuronal trigeminal subtypes that are involved remain unclear," the researchers wrote. (genengnews.com)
Astrocytes play a variety of roles with neurons, but until now, scientists did not know that these cells carry electrical impulses. (medicalnewstoday.com)
However, scientists still considered astrocytes to be supporting actors behind neurons , which are the primary cells of the brain and nervous system. (medicalnewstoday.com)
He also pointed out that the study highlights a bidirectional relationship between these brain cells, as astrocytes influence the neurons as well. (medicalnewstoday.com)
With the addition of four proteins, adult human skin cells can be transformed into neurons over a month-long period. (stanforddaily.com)
The researchers showed they could convert human embryonic stem cells to neurons by infecting them with a virus that expressed the same proteins used in the study. (stanforddaily.com)
This treatment, nicknamed "BAM" after an acronym of the three proteins, converted the embryonic stem cells into functional neurons within six days. (stanforddaily.com)
it triggered the skin cells' transformation into functional neurons within about four to five weeks. (stanforddaily.com)
The cells expressed electrical activity characteristic of neurons and even integrated and interacted with mouse neurons on a laboratory dish. (stanforddaily.com)
While they found that approximately 20 percent of mouse skin cells transform directly into functional neurons, under current culture conditions only about two to four percent of human skin cells do the same. (stanforddaily.com)
Insufficient cell death can cause cancer by allowing cells to become immortal while excessive cell death of neurons may be a cause of neurodegenerative conditions. (edu.au)
The inner cells transmit those vibrations to the neurons to create the sounds we hear. (hearingreview.com)
Considering that they only managed to realize their discovery after setting up their initial experiment, which consisted of growing neurons or nerve cells on a sheet of graphene, the researchers were quick to adapt to the circumstances. (naturalnews.com)
When immune cells move throughout the brain, they act as the first line of defense against viruses, toxic materials and damaged neurons, rushing over to clear out them. (iu.edu)
These include neurons and glial cells, which are known to be important for cell repair and cell replacement in different brain regions. (medica-tradefair.com)

Dec. 28, 2022 Researchers are bridging mouse and human data to reveal the biology of senescent cells. (sciencedaily.com)
June 30, 2022 Senescent cells -- those that have lost the ability to divide -- accumulate with age and are key drivers of age-related diseases, such as cancer, dementia and cardiovascular disease. (sciencedaily.com)
Alex J. B. Kreutzberger et al, SARS-CoV-2 requires acidic pH to infect cells, Proceedings of the National Academy of Sciences (2022). (phys.org)

However, it remains unclear which genes and cell types of the TG are involved. (genengnews.com)
Now, by analyzing mouse and human TG, researchers from Brigham and Women's Hospital and Massachusetts General Hospital profiled, at single-cell resolution, the genes expressed in each TG cell type. (genengnews.com)
We now have an atlas of the genes that are expressed in each of the cell types in the TG, the key relay center for migraine and facial pain, and we are now using this tool to identify potential therapeutic targets that are selectively expressed in cell types that drive head pain. (genengnews.com)
Importantly, they found that while cell types between mice and humans are largely conserved, some of the genes known to be involved in pain are expressed in different subsets of cells in mice versus humans. (genengnews.com)
This trigeminal ganglion cell atlas improves our understanding of the cell types, genes, and epigenomic features involved in headache pathophysiology and establishes a rich resource of cell-type-specific molecular features to guide the development of more selective treatments for headache and facial pain," concluded the researchers. (genengnews.com)
The paper explains how proteins, known as epigenetic activators (such as Ash1 from the fruit fly Drosophila), bind to their target DNA and activate genes that determine what function a cell will have in the body. (biologynews.net)
Over the last few years, researchers have focused on how noncoding RNAs silence genes," said Anthony Carter, of the National Institute of General Medical Sciences, which partially funded the research. (biologynews.net)
Shin compared fibroblasts from different aged animals - young, middle-aged and older - to understand which particular genes are changing with advanced age and how they might contribute to the cell dysfunction. (ucalgary.ca)
Using the tool we developed, researchers in the future can develop therapeutics that target some of these genes to halt the cancer metastasis," Betty Li said. (utoronto.ca)
We identified 244 different genes that are differentially expressed between the cancer cells that invaded versus the ones that didn't invade," Li said. (utoronto.ca)
Using both fetal and adult human skin cells, the researchers introduced the four genes previously reported sufficient for cell reprogramming and compared the efficiency of reprogramming in the presence or absence of large T antigen. (hopkinsmedicine.org)
Our scientists pursue every aspect of cancer research-from exploring the biology of genes and cells, to developing immune-based treatments, uncovering the causes of metastasis, and more. (mskcc.org)
The researchers determined that a whole suite of genes help determine how much UCP1 a brown fat cell will produce once it has matured, and those genes control UCP1 production in different ways. (scitechdaily.com)
Controlling the genes might allow scientists to make mediocre brown fat cells work better. (scitechdaily.com)
The ATOH1 and GF1 genes are needed to make a cochlear hair cell from a non-hair cell. (hearingreview.com)
The considerably greater cell-to-cell variation than person-to-person variation suggests that changes within different areas of the body over a person's lifetime, such as certain infections and inflammation, are more likely to cause mutations linked with cancer and disease than inherited mutations in genes. (york.ac.uk)
Researchers have identified two genes that may contribute to Raynaud phenomenon, a condition where blood vessels in the extremities constrict and limit blood flow. (medscape.com)
The researchers identified two genes that are likely involved with Raynaud. (medscape.com)
Scientists were initially interested in somatic-cell nuclear transfer as a means of determining whether genes remain functional even after most of them have been switched off as the cells in a developing organism assume their specialized functions as blood cells, muscle cells, and so forth. (who.int)
The fact that the DNA of a fully differentiated (adult) cell could be stimulated to revert to a condition comparable to that of a newly fertilized egg and to repeat the process of embryonic development demonstrates that all the genes in differentiated cells retain their functional capacity, although only a few are active. (who.int)
These medicines differ from 'ordinary' medicines because the active substance is produced in or purified from materials of biological origin such as living cells, genes or tissue," says Johan Flygare, researcher at the Lund Stem Cell Center and the Division of Molecular Medicine and Gene Therapy at Lund University. (lu.se)
These are therapies based on cells, genes or tissues and fall under the umbrella term ATMP (Advanced Therapy Medicinal Products). (lu.se)

Quiescence can be a dangerous source of tumor recurrence because cancer drugs don't typically destroy quiescent cells. (upmc.com)
Successful cancer therapy often is hampered by tumor cell quiescence because these cells remain viable and are a reservoir for tumor progression," said Anette Duensing, M.D., assistant professor of pathology at UPCI. (upmc.com)
Unlike traditional chemotherapy, which kills all rapidly dividing cells, targeted therapy stops cancer by interfering with specific molecules needed for tumor growth. (upmc.com)
The Center for Nuclear Receptors and Cell Signaling at the University of Houston has developed a new way to detect very rare and highly heterogeneous circulating tumor cells with high specificity and sensitivity. (uh.edu)
Circulating tumor cells, which are detached from primary tumors to enter the bloodstream, are particularly hard to detect. (uh.edu)
Dr. Shaun Zhang, M.D. Anderson Professor of biology and biochemistry and director of the Center for Nuclear Receptors and Cell Signaling, invented the UniPro which finds rare circulating tumor cells. (uh.edu)
Current methods of detecting CTCs mainly rely on immunological detection of protein markers on the tumor cells. (uh.edu)
First, when tumor cells get into the blood, they intend to undergo a biological change called epithelial-mesenchymal transition (EMT). (uh.edu)
Unambiguously detecting live circulating tumor cells opens the door for many clinical applications, such as convenient and instantaneous monitoring of the effectiveness of clinical cancer treatment and monitoring cancer relapse. (uh.edu)
In the past few years, Memorial Sloan Kettering Cancer Center (MSK) researchers found a startling reason: Some prostate tumor cells completely change their identity to survive. (mskcc.org)
This research highlights the great promise of plant-originated compounds as natural medicine for controlling the malignant growth of human brain tumor cells,' Ray said in a statement. (wraltechwire.com)
In this treatment, patients receive a drug that releases the brakes on their T cells allowing them to kill virally infected or tumor cells. (stjude.org)
The tumor-fighting T cells detect a protein called an antigen on the cancer cells' surface that triggers the attack. (stjude.org)
The clinical significance of T cell exhaustion is huge, because when a person comes into the clinic with a tumor, it is likely they have had it for many months," he said. (stjude.org)
And their T cells, which would be responding to that tumor, have been exposed to the tumor antigen for a long time. (stjude.org)
In preclinical studies, the researchers explored the mechanism by which both viral infection and a tumor caused T cell exhaustion. (stjude.org)
They found the culprit was a so-called "epigenetic program" that repressed the T cells' ability to respond to tumor antigens. (stjude.org)
The researchers found the enhanced T cell proliferation was coupled with significant control of tumor growth. (stjude.org)
We take advantage of the similarity between neural developmental processes and cancer hierarchy to mitigate, if not completely abolish, the malignant nature of tumor cells and pave the way for new intervention strategies. (lu.se)

A study published in the journal Nature Communications has identified a new pathway that human immunodeficiency virus (HIV) uses to enter the nucleus of a healthy cell, where it can then replicate and go on to invade other cells. (israelnationalnews.com)
Researchers at UMass Medical School have discovered a new pathway that triggers regeneration of beta cells in the pancreas, a key development that may aid in the development of diabetes treatments. (umassmed.edu)
Importantly, the study also found that the key elements of this pathway are active in human beta cells too. (umassmed.edu)
While signs of disease progression occurred among all 10 types of iPSC-derived RPE cells used in the study, they were worse in the iPSC-derived RPE from patients with high-risk variants in the alternate complement pathway, compared to those with low-risk variants, which gave the researchers a way to discern specific effects of genotype on disease characteristics. (nih.gov)
The screen flagged two drugs for their ability to inhibit RPE atrophy and drusen formation: A protease inhibitor called aminocaproic acid, which likely directly blocks the complement pathway outside cells and a second agent (L745), which stops complement induced inflammation inside the cell indirectly via inactivation of the dopamine pathway. (nih.gov)
Boston, MA -- Scientists have discovered a previously unknown molecular signaling pathway in body fat cells that normally acts to suppress harmful inflammation. (webwire.com)
What activates the M2 pathway within fat tissues, Lee and his colleagues discovered, is the fat cells production of the kind of cytokines that activate M2 macrophages. (webwire.com)
The finding offers a new pathway to more powerful and durable immunotherapies, as well as immune therapies for viruses such as HIV that would marshal the immune system to kill the virus, researchers said. (stjude.org)
The team's previous research revealed that inhibition of the Notch signaling pathway increases hair cell differentiation and can help restore hearing to mice with noise-induced deafness. (science20.com)
In their latest work, the investigators found that blocking the Notch pathway increases the formation of new hair cells not from remaining hair cells but from certain nearby supporting cells that express a protein called Lgr5. (science20.com)
What the researchers discovered is that the lamina progenitor cells may be responsible for insulating the fibers immediately after they leave the eye, supporting the connections between nerve cells on the pathway to the brain. (medica-tradefair.com)

This creates uncertainty about whether it is at all possible to create new eggs with the help of stem cells," says Kui Liu, a researcher at the Department of Chemistry and Molecular Biology at the University of Gothenburg. (sciencedaily.com)
This is of relevance not only for hair cell research, but the broader cell biology discipline. (news-medical.net)
Boyle and the team at the Centre for Cancer Biology, together with collaborators interstate, discovered the previously unknown way in which breast cancer cells hijack normal cells nearby to help tumours to grow and invade. (cosmosmagazine.com)
The study was conducted by Oishee Chakrabarti, Ph.D. and Ramanujan S. Hegde, M.D., Ph.D., of the NICHD Cell Biology and Metabolism Program. (nih.gov)
If we ever want to prevent hair loss from happening or resurrect hair growth once you start to lose your hair, we need to focus on maintaining the function of these hair follicle dermal stem cells," says Biernaskie, associate professor of comparative biology and experimental medicine at UCVM, and the Calgary Firefighters Burn Treatment Society Chair in Skin Regeneration and Wound Healing. (ucalgary.ca)
Dr Peter Czabotar , Professor Peter Colman and colleagues in the institute's Structural Biology division , together with Dr Dana Westphal from the institute's Molecular Genetics of Cancer division , made the discovery which is published in the latest edition of the journal Cell . (edu.au)
In a study published online Dec. 6 in Cell Chemical Biology , Stanford researchers used that fact to selectively deliver a drug to beta cells. (stanford.edu)
CTCs, like the tumors they are originally detached from, lack unique and well-defined universal biomarkers highlighting the challenges of detection specificity," reports Dr. Shaun Zhang, M.D. Anderson Professor of biology and biochemistry and director of the Center for Nuclear Receptors and Cell Signaling. (uh.edu)
Zhang's research team includes Xinping Fu and Lihua Tao, both from the Department of Biology and Biochemistry and Center for Nuclear Receptor and Cell Signaling at UH. (uh.edu)
Amusingly enough, measuring the pH of the nostril cavity has rarely been done before," noted co-senior author Tomas Kirchhausen, professor of cell biology in the Blavatnik Institute at Harvard Medical School and HMS professor of pediatrics at Boston Children's Hospital. (phys.org)
Normally, if you introduce a new material in biology, you'd expect to see a certain number of cells killed in the process," Savchenko said. (phys.org)
We thought there should be epigenetic changes that affected the biology of the T cells, but it was a real surprise how much impact the changes had on their biology," Youngblood said. (stjude.org)
This is a strategy for greatly improving our ability to perform cellular reprogramming, which could enable the regeneration of lost tissues and the study of diseases that cannot be biopsied from living patients today," said Justin Ichida , PhD, assistant professor in the department of stem cell biology and regenerative medicine at the Keck School of Medicine of USC . (usc.edu)

And now that the same mechanism has been identified in liver cells, the same strategy might lead to novel therapies for fatty liver. (webwire.com)
Understanding the cellular and molecular mechanisms that define cancer and how these mechanisms differ from normal cells is crucial for developing new innovative therapies," says Bentires-Alj. (unibas.ch)
He expressed hope that one day the cells could be used for human therapies. (stanforddaily.com)
Publishing online in Stem Cells on May 29, the team describes a faster and more efficient method of reprogramming cells that might speed the development of stem cell therapies. (hopkinsmedicine.org)
Gene and cell therapies that improve cancer treatments. (lu.se)
Modern breakthroughs, such as the mapping of the human genome, the Nobel Prize-winning CRISPR gene editing scissors, the ability to rapidly map large amounts of DNA, and the Nobel Prize-winning discovery of how mature cells can be reprogrammed, have led to an increasing number of innovative biological therapies reaching patients. (lu.se)
In the long term, the knowledge about C3 can be used to develop new treatments aimed at protecting the insulin-producing cells, such as stem cell therapies for treating type 1 diabetes and type 2 diabetes. (lu.se)

Dr. Dulla maintains that human brain cells work the same way as mouse tissue. (medicalnewstoday.com)
Senescent cells accumulate with age and at sites of multiple chronic conditions, such as in fat tissue in diabetes, the lungs in chronic pulmonary diseases, the aorta in vascular disease, or the joints in osteoarthritis," says James Kirkland, M.D., Ph.D., director of the Robert and Arlene Kogod Center on Aging. (sciencedaily.com)
Presently, doctors who wish to collect cells or manipulate a bit of tissue inside a patient's body often use tethered microgrippers connected to thin wires or tubes. (campustechnology.com)
Additionally, the microgrippers are triggered to close and extricate cells from tissue when exposed to certain biochemicals or biologically relevant temperatures. (campustechnology.com)
These stimuli induce the activation of immune cells residing within fat tissues, called M1 macrophages, which in turn release pro-inflammatory cytokines, such as TNFalpha, that cause fat tissue dysfunction and insulin resistance. (webwire.com)
This is a really important study in highlighting how aging impacts tissue-resident stem cells and the molecular changes behind this degenerative process. (ucalgary.ca)
Adult (or tissue-specific) stem cells reside in many different organs and play important roles in maintaining the integrity of those tissues," says Shin, the lead author of the paper and an Alberta Innovates MD PhD scholar. (ucalgary.ca)
In the paper, the researchers describe how they used a collagen matrix coated with a layer of basal membrane extract to mimic the structure of the breast tissue seen by breast cancer cells during the first step of metastasis. (utoronto.ca)
By placing cancer cells outside of these tissue mimics, researchers could observe the invasion process in detail, including measurements of speed and location. (utoronto.ca)
Some invaded into the tissue mimics while others did not, which prompted us to look at what gives the invaded cells such an advantage. (utoronto.ca)
We think this type of tool will be quite useful to the community, as cell invasion is important in cancer and also a host of other (non-pathological) processes, like tissue growth, differentiation and repair," Wheeler said. (utoronto.ca)
Then Annes had a thought: Researchers have known since the 1940s that beta cells collect about 1,000 times more zinc than surrounding tissue cells. (stanford.edu)
Researchers have mostly used that fact as a way to stain and visually identify beta cells in pancreatic tissue samples. (stanford.edu)
This week, Pulmonary Center researchers from the Center for Regenerative Medicine (CReM) report their successes in developing new techniques to implant engineered cells into damaged lung tissue. (bu.edu)
We believe these cells, called neural progenitor cells, are present in the optic nerve tissue at birth and remain for decades, helping to nourish the nerve fibers that form the optic nerve," said study leader Steven Bernstein, MD, PhD, Professor and Vice Chair of the Department of Ophthalmology and Visual Sciences at the University of Maryland School of Medicine. (medica-tradefair.com)
In turn, that leads to more efficient cellular reprogramming, which increases the number of cells capable of simultaneous transcription and proliferation, which is needed to promote tissue growth. (usc.edu)
In an early study of 13 patients who received liver tissue from a living donor, researchers found that the approach was safe and feasible. (msdmanuals.com)

Dr. Moritz Armbruster , a research assistant professor of neuroscience at Tufts, led a team of researchers in harnessing novel technology to study astrocyte-neuron exchanges. (medicalnewstoday.com)
A team of researchers has discovered a way to increase energy-burning human brown fat cells and to make them more active, a discovery that could have therapeutic potential for diabetes, obesity, and other metabolic diseases. (scitechdaily.com)
Michael Strano, professor of Chemical Engineering at MIT had the following to say about the team of researchers new invention: â€œItâ€™s a fundamentally new kind of photovoltaic cell. (greengeek.ca)
Ichida is the lead author, joined by a team of researchers at the Keck School. (usc.edu)

He said that mouse and human brain cells use the same proteins and molecules involved in brain activity. (medicalnewstoday.com)
A key regulator of the cancer cell sleep process is a protein complex called DREAM, which is named for the multiple proteins involved. (upmc.com)
The researchers, led by Aurelio Lorico, MD PhD, Professor of Pathology and interim Chief Research Officer at Touro University Nevada College of Osteopathic Medicine, also identified three proteins that are needed for the virus to carry out the invasion and have in turn synthesized molecules (potential drugs) that can target one of the proteins, potentially leading to new treatments for AIDS. (israelnationalnews.com)
Such optogenetic approaches utilizing light-activatable proteins for modulating the function of cells are being explored in many biological systems and have fueled efforts toward the development of a new genre of treatments. (newswise.com)
These other cells include a cell type called fibroblasts that produce proteins to make up the extracellular matrix or ECM. (cosmosmagazine.com)
Upon correct folding, proteins are transported to specific locations within cells where they can perform their various functions. (nih.gov)
The first part of the video shown here follows a virus engineered to sprout SARS-CoV-2 spike proteins (labeled pink) as it is captured at a cell surface and engulfed by a cellular compartment called an endosome. (phys.org)
Human brown fat progenitor cells express the calorie-burning, UCP1 proteins (green) as the cell differentiates. (scitechdaily.com)
The immune cells cannot move closer to plaques to try to clear up the proteins. (iu.edu)
amyloid beta proteins clump together and form plaques, which destroy nerve cell connections. (iu.edu)

Researchers at Lund University have successfully explained how iron-based dyes work on a molecular level in solar cells. (lu.se)
We collaborate with many other researchers in particular within NanoLund, elsewhere at Lund University, and internationally. (lu.se)
The brain behind the nanowire research is mainly that of Lars Samuelson, a physics researcher at the Faculty of Engineering who created the nanometer consortium at Lund University. (lu.se)
Johan Flygare and Aurélie Baudet, stem cell researchers at Lund University. (lu.se)
Researchers at Lund University have instead chosen to investigate what protects the insulin-producing cells. (lu.se)
Researchers at Lund University have studied a protein called C3, which plays a central role in the body's immune system. (lu.se)
We have chosen a different approach that aims to understand what protects the insulin-producing cells," says Anna Blom, professor of protein chemistry at Lund University, who led the study. (lu.se)
If we can increase the production of intracellular C3 in these cells, it may help the cells survive longer so that the treatment can be more effective," says Ben C King, associate professor of inflammation research at Lund University, and co-senior author of the study. (lu.se)

There is good evidence that similar fibroblasts, or progenitor cells, reside in most organs in the body and so they may undergo similar age-related degeneration to what Wisoo has uncovered in the hair follicle," says Biernaskie. (ucalgary.ca)
We could take fat samples from patients undergoing liposuction and we could purify this specific population of progenitor cells," keeping only those that would eventually make highly active brown fat cells, "and let them differentiate into brown cells, and then get them back into the individual," Tseng said. (scitechdaily.com)
This is the first time that neural progenitor cells have been discovered in the optic nerve. (medica-tradefair.com)
The presence of neural stem/progenitor cells opens the door to new treatments to repair damage to the optic nerve, which is very exciting news. (medica-tradefair.com)
It took 52 trials to successfully grow the lamina progenitor cells in a culture," said Bernstein, "so this was a challenging process. (medica-tradefair.com)

The goal would be to reprogram supporting cells, which are latticed among the hair cells and provide them with structural support, into outer or inner hair cells. (hearingreview.com)

In other words, researchers might be able boost the number of beta cells in the pancreas, but in the process they'd get lots of other cell types to replicate as well. (stanford.edu)

The hair cells do this by deploying a protein called XIRP2, which has the ability to sense damage to the cores, which are made of a substance called actin. (news-medical.net)
The study found ER stress pathways actually send a signal to the cell nucleus, via an ER protein called ATF6 that says "proliferate. (umassmed.edu)
They found that the compounds showing the most promising results were inhibitors of an essential cell cycle protein called polo-like kinase 1 (PLK1). (unibas.ch)
Unlike energy-storing white, or "bad," fat cells, "good" brown fat cells make a protein called UCP1 that converts energy stored in glucose and fatty acids into heat to keep the body warm. (scitechdaily.com)
The WIPI4 protein is involved in a process called autophagy, which helps clear unneeded materials from cells, including excess amounts of an iron storage protein called ferritin . (medlineplus.gov)
It is already known that a protein called IL-1B can cause inflammation and damage to the insulin-producing cells. (lu.se)

Hair cells' found in the inner ear, are important both for our ability to hear and our sense of balance. (news-medical.net)
The light-switchable cells are designed to compensate for the lower insulin production or reduced insulin response found in diabetic individuals. (newswise.com)
Researchers found that transplanting the engineered pancreatic beta cells under the skin of diabetic mice led to improved tolerance and regulation of glucose, reduced hyperglycemia, and higher levels of plasma insulin when subjected to illumination with blue light. (newswise.com)
We have found that growing cancers can release chemical signals into their environment that hijack fibroblasts, making these cells more cancer-promoting and also making them produce more ECM. (cosmosmagazine.com)
We have found that cancer cells subjected to mechanical pressure are more aggressive and multiply quicker, and tumours grow bigger. (cosmosmagazine.com)
Although it was previously known that too much ER stress is bad for beta cells, causing them to die, our study found that a modest amount of stress is actually good for them, because it provides pressure to increase beta cell number to produce more insulin and keep blood sugar regulated," Dr. Alonso said. (umassmed.edu)
Normally, PrP is found on the surface of many cells in the body, including in the brain. (nih.gov)
They had found that many of the abnormal forms of PrP were located in the wrong part of the cell. (nih.gov)
The researchers found that the key to the Th2 activation switch is a molecule known as PPAR-d within macrophages. (webwire.com)
To their surprise, Lee and his coworkers found that the same switching mechanism is present in hepatocytes, or liver cells, and macrophages in the liver, where they control metabolism of fats. (webwire.com)
The researchers found that BAM treatment to skin cells from fetuses and newborns didn't have the same effect as it did on the stem cells. (stanforddaily.com)
But a study from the University of Calgary Faculty of Veterinary Medicine (UCVM) has found that it's actually a small population of specialized cells within the hair follicle called fibroblasts, and the dermal stem cells that maintain them, that may cause hair loss. (ucalgary.ca)
We found that with the hair follicle dermal stem cells, not only are the numbers declining, but their ability to acquire certain functions is also impaired. (ucalgary.ca)
After initial lab tests showed it did, they attached a beta-cell regenerating drug to the zinc-chelating agent, and found that the drug would also build up in beta cells in a lab dish. (stanford.edu)
Only a few of these rare malignant cells are typically found among millions of white blood cells and billions of red blood cells per milliliter of blood. (uh.edu)
The acidic environment allows enzymes in the endosome or on the cell surface-including TMPRSS2, a key enabler of SARS-CoV-2 infection-to cut the spike protein and facilitate membrane fusion, the team found. (phys.org)
Not only did T speed up reprogramming, we also found that it increases the total number of reprogrammed cells, which is great because often in reprogramming, not all cells go all the way," says Cheng, who explains that rigorous follow-up tests are required to determine if the reprogrammed cells really behave like pluripotent embryonic stem cells. (hopkinsmedicine.org)
Harvard Stem Cell Institute (HSCI) scientists have found a way to both make more energy-burning human brown fat cells and make the cells themselves more active, a discovery that could have therapeutic potential for diabetes, obesity, and other metabolic diseases. (scitechdaily.com)
Now, a group of researchers from Vanderbilt University has found yet another one to add to the ever-growing list. (naturalnews.com)
Graphene is said to be an effective material to help boost nerve cell signaling in the human brain, and the researchers who found out about this did so completely by accident. (naturalnews.com)
However, when they began conducting their tests, they soon found out that it enabled nerve cell membranes to pull in more cholesterol, which in turn increased the vesicles that packaged neurotransmitters. (naturalnews.com)
Once they found out that graphene was acting on the nerve cell membrane, which was made up mainly of cholesterol, they then asked themselves if cholesterol was somehow specifically involved. (naturalnews.com)
Published in Nature, the research found that the mutations seen in healthy B cells were largely similar to those seen in cancerous B-cells, suggesting that the development of cancer arises from the same mutational processes. (york.ac.uk)
They found that the number and patterns of mutations in B-cells and T-cells varied extensively from cell to cell. (york.ac.uk)
They also found that, while in normal cells the concentration of cholesterol in the inner layer is low, in cancer cells it's much higher. (analytica-world.com)
Cho and his coworkers found that treating cells with a statin dramatically lowered the level of cholesterol in the inner layer, leading to suppression of cell growth activity. (analytica-world.com)
Researchers at Indiana University School of Medicine have been investigating how these immune cells in the brain—microglia—relate to a gene mutation recently found in Alzheimer’s disease patients. (iu.edu)
Researchers have found that smoking causes chromosomal damage and speeds up aging. (medicaldaily.com)
Although happiness may vary between people based on personal experiences, the researchers found that life satisfaction - one of the factors that determines happiness - decreases after the age of nine and increases between the ages of 70 and 96. (medicaldaily.com)
In preclinical model systems studying viral infections or tumors, the researchers found that a chemotherapy drug already in use can reverse that exhaustion. (stjude.org)
In their experiments, the researchers found that the exhaustion program was passed on to successive generations of T cells. (stjude.org)
They also found that the exhaustion program persisted, even after the T cells were not exposed to the triggering antigen. (stjude.org)
The researchers found that treating the T cells with a widely used immune-checkpoint inhibitor called PD-1 did not erase the epigenetic exhaustion finding. (stjude.org)
Whereas previous research indicated that hair cells are not replaced, this latest study found that replacement does indeed occur, but at very low levels. (science20.com)
Eventually the research team found the stem cells could be coaxed into differentiating into several different types of neural cells. (medica-tradefair.com)
USC scientists have found a solution to untangle twisty DNA, removing kinks so the molecules can be used to reprogram cells to advance regenerative medicine to treat disease. (usc.edu)
The protein is secreted from cells and is found in large quantities in the blood. (lu.se)

Their findings are published in the journal Neuron , in a paper titled, " Human and mouse trigeminal ganglia cell atlas implicates multiple cell types in migraine . (genengnews.com)
The researchers hope that their findings may lead to treatments for traumatic brain injury, Alzheimer's disease, and other brain disorders. (medicalnewstoday.com)
The findings, which will be published in the August 15 issue of the journal Cancer Research and are available online, are the first to show that it is possible to therapeutically target cancer cells to keep them from entering a cellular state called quiescence, or "cell sleep. (upmc.com)
The findings could hold promise for the advancement of cancer and stem-cell research. (biologynews.net)
The findings were published in the current issue of the journal Cell. (nih.gov)
The findings, reported yesterday in Nature, suggest a process that doesn't require the reprogrammed adult somatic cells called induced pluripotent stem (iPS) cells. (stanforddaily.com)
The research team's findings are described in the study "19.3% Binary Organic Solar Cell and Low Non-Radiative Recombination Enabled by Non-Monotonic Intermediate State Transition" published in Nature Communications . (edu.hk)
The findings could help shed light on why some cells go on to develop into cancer, particularly in some blood cancers. (york.ac.uk)
In a paper appearing in the June 29 edition of Cell , researchers led by Ben Youngblood, Ph.D. , an assistant member of the St. Jude Department of Immunology , reported findings that explain the failure of a form of immunotherapy called immune checkpoint blockade. (stjude.org)
If the findings can be applied to older animals, they may lead to ways to help stimulate cell replacement in adults and to the design of new treatment strategies for people suffering from deafness due to hair cell loss. (science20.com)
The findings appeared Sept. 12 in Cell Stem Cell in a research paper titled, "Mitigating antagonism between transcription and proliferation allows near-deterministic cellular reprogramming. (usc.edu)
Findings from flow cytometric DNA analysis suggest that PVNS and giant cell tumors of the tendon sheath are histopathologically similar but clinically distinct lesions. (medscape.com)
The new findings will accelerate the development of inexpensive and environmentally friendly solar cells. (lu.se)

Our finding gives us the first clear cell switch to make one type versus the other," said lead study author Jaime García-Añoveros, PhD , professor of anesthesiology and neuroscience and in the Ken and Ruth Davee Department of Neurology . (hearingreview.com)

Newswise - MEDFORD/SOMERVILLE, Mass. (November 1, 2019) -Tufts University researchers have transplanted engineered pancreatic beta cells into diabetic mice, then caused the cells to produce more than two to three times the typical level of insulin by exposing them to light. (newswise.com)
Current treatments include the administration of drugs that enhance the production of insulin by pancreatic beta cells, or direct injection of insulin to supplement the naturally produced supply. (newswise.com)
Pancreatic beta cells were engineered with a gene that encodes a photoactivatable adenylate cyclase (PAC) enzyme. (newswise.com)
Insulin, a hormone that regulates blood sugar, is made in pancreatic beta cells. (umassmed.edu)

May 25, 2023 The many types of cells in the human body are produced through the process of differentiation, in which stem cells are converted to more specialized types. (sciencedaily.com)
The researchers were able to use differentiation to treat an especially aggressive type of carcinoma called triple negative breast cancer. (unibas.ch)
Tbx2 is a master regulator of inner versus outer hair cell differentiation. (hearingreview.com)
While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on reduction in tumorigenicity are limited. (lu.se)
Most importantly, forced differentiation substantially reduces tumorigenicity of GBM cells in an in vivo xenotransplantation model. (lu.se)

However, many researchers, including my research group, have tried to replicate these studies and not succeeded. (sciencedaily.com)
Justin Annes, Tim Horton and colleagues developed a zinc-loving chemical compound (light blue) that helps deliver drugs that trigger insulin-producing cells in the pancreas (dark blue), but not others (gray), to replicate (red). (stanford.edu)
That advance might have given new hope to diabetes patients, but there was a catch: The way to get beta cells to start dividing and replicating is the same way to get lots of other cells to divide and replicate. (stanford.edu)
Bernstein and his collaborators needed to identify the correct mix of growth factors and other cell culture conditions that would be most conducive for the stem cells to grow and replicate. (medica-tradefair.com)
As a result, nucleotides become much more difficult to work with and cells won't replicate properly, Ichida explained. (usc.edu)
It's the equivalent of a DNA detangler that relaxes the tension of reprogramming transcription and makes it easier to replicate new cell colonies or tissues in a lab. (usc.edu)

One characteristic of cancer cells is their high adaptability to different environments in the body and to drug treatments. (unibas.ch)
Cancer cells are adept at developing ways to evade treatments. (mskcc.org)
An objective among many diabetes researchers is to create treatments where stem cells are taken from the patient and converted into insulin-producing cells, which are then transplanted back into the patient. (lu.se)

His group specialises in the study of the genetic and epigenetic regulation of female germ cell development. (sciencedaily.com)
This gave the researchers new ideas about which cells to study further. (genengnews.com)
A major value of this study is that it wasn't limited to one specific cell type or branch of the trigeminal ganglion," said Jochen K. Lennerz, MD, PhD, medical director of the Center for Integrated Diagnostics in the department of pathology at MGH. (genengnews.com)
The study, HIV-1-induced nuclear invaginations mediated by VAP-A, ORP3, and Rab7 complex explain infection of activated T cells , was the result of a collaboration of researchers from Touro University Nevada College of Osteopathic Medicine, Touro College of Osteopathic Medicine in New York, researchers from the Biotechnology Center (BIOTEC) of TUD Dresden University of Technology in Germany, and researchers from Italy. (israelnationalnews.com)
and despite the increased secretion of insulin, the amount of oxygen consumed by the cells does not change significantly as our study shows. (newswise.com)
In an innovative study in mice, Laura Alonso, MD, the George F. and Sybil H. Fuller Foundation Term Chair in Diabetes and associate professor of medicine, and Rohit Sharma, PhD, a postdoctoral associate, discovered how the pancreas knows that more insulin-producing beta cells are needed. (umassmed.edu)
A recent study of human cell cultures shows that the drugs, fisetin and two BCL-XL inhibitors -- A1331852 and A1155463 -- cleared senescent cells in vitro. (sciencedaily.com)
The compounds used in this study are already in clinical trials to treat other cancer types, including blood-borne, lung, and pancreatic cancer," the researcher continues. (unibas.ch)
In this study, researchers embedded the stem cells in a gel. (kpbs.org)
An oversimplified system like cells in petri dishes doesn't mimic what happens in the body, while in an animal model, it's difficult to isolate and study parameters that govern the invasiveness of a cell," said Betty Li , a senior Institute of Biomedical Engineering PhD student and lead author of the paper. (utoronto.ca)
One challenge to studying blood diseases like sickle cell anemia is that blood stem cells can't be kept alive for very long in the lab, so researchers need to keep returning to patients for more cells to study," says Cheng. (hopkinsmedicine.org)
In this study, the researchers generated heart cells from donated skin cells, via an intermediary cell type called an induced pluripotent stem cell (iPSC). (phys.org)
In a study featured as the cover article appearing today in the journal Science Advances , a UCF research team showed that by combining two promising nanomaterials into a new superstructure, they could create a nanoscale device that mimics the neural pathways of brain cells used for human vision. (ucf.edu)
In the study, researchers from the University of York, the Wellcome Sanger Institute, and collaborators grew and sequenced colonies of immune cells - lymphocytes known as B- and T-cells - from a single cell. (york.ac.uk)
Cellular reprogramming has enormous potential as a disease cure because it enables scientists to study cells and molecular processes at each step of disease progression in controlled conditions that have, until now, been impossible. (usc.edu)
In this study, researchers examined what happens when mice breathe in carbon nanotube s. (cdc.gov)
We study primarily semiconductors for light-emitting diodes, solar cells, low-energy electronics, and computation. (lu.se)
Now, their latest study in PNAS shows that the protein C3 protects insulin-producing cells from damage and death when it is present inside the cells. (lu.se)
Our new study shows that the protein plays a different role when it is located inside the cell. (lu.se)

By understanding this, scientists will be better positioned to develop new ways to battle hearing loss - even the kind that comes from aging, the researchers say. (news-medical.net)
Almost half of the brain's cells can execute a function that was previously unknown by scientists. (medicalnewstoday.com)
They are called glial cells because scientists originally thought that these starlight-shaped structures serve as "nerve glue. (medicalnewstoday.com)
An international research team led by University of Pittsburgh Cancer Institute (UPCI) scientists discovered that by preventing cancer cells from entering a state of cellular sleep, cancer drugs are more effective, and there is a lower chance of cancer recurrence. (upmc.com)
Scientists at the Walter and Eliza Hall Institute have for the first time visualised the molecular changes in a critical cell death protein that force cells to die. (edu.au)
In a first, scientists have captured on video all the steps a virus follows as it enters and infects a living cell in real time and in three dimensions. (phys.org)
The research team, made up of scientists at Harvard University and at Harvard-affiliated Joslin Diabetes Center and led by HSCI principal faculty member Yu-Hua Tseng, determined that the amount of energy burned varies from person to person and from cell to cell. (scitechdaily.com)
Hearing loss due to aging, noise, and certain cancer therapy drugs and antibiotics has been irreversible because scientists have not been able to reprogram existing cells to develop into the outer and inner ear sensory cells - essential for hearing - once they die. (hearingreview.com)
But Northwestern Medicine scientists have discovered a single master gene that programs ear hair cells into either outer or inner ones, overcoming a major hurdle that had prevented the development of these cells to restore hearing, according to new research published in Nature . (hearingreview.com)
Currently, scientists can produce an artificial hair cell, but it does not differentiate into an inner or outer cell, which provide different essential functions to produce hearing. (hearingreview.com)
The master gene switch Northwestern scientists discovered that programs the ear hair cells is TBX2 . (hearingreview.com)
The protocol we have developed in order to expand cells can also be applied to other areas of research, and we hope that it will be as valuable to other scientists as it is to us. (york.ac.uk)
For years, scientists have thought that these cells are not replaced once they're lost, but new research appearing online February 20 in the journal Stem Cell Reports reveals that supporting cells in the ear can turn into hair cells in newborn mice. (science20.com)
Combining this new knowledge about Lgr5-expressing cells with the previous finding that Notch inhibition can regenerate hair cells will allow the scientists to design new hair cell regeneration strategies to treat hearing loss and deafness. (science20.com)
USC scientists have surmounted a big roadblock in regenerative medicine that has so far constrained the ability to use repurposed cells to treat diseases. (usc.edu)

Only fully mature insulin-producing beta cells are able to use this stress mechanism to sense that the body needs more insulin than the current allotment of beta cells can provide. (umassmed.edu)
For years, Annes' goal has been to develop a medication that would promote the regeneration of insulin-producing beta cells. (stanford.edu)

Scrutinizing the first days of development in abnormal embryonic stem cells, researchers have uncovered a basic mechanism underlying fragile X syndrome, the most common inherited cause of mental retardation in boys. (sciencenews.org)
The research also highlights the value of embryonic stem cells for studying genetic diseases, says Yang Xu, a stem cell researcher at the University of California, San Diego. (sciencenews.org)
Researchers at Johns Hopkins have established a human cell-based system for studying sickle cell anemia by reprogramming somatic cells to an embryonic stem cell like state. (hopkinsmedicine.org)
The research team first sought to improve previously established methods for reprogramming of adult cells into so-called induced pluripotent stem (iPS) cells, which look and behave similarly to embryonic stem cells and can differentiate into many different cell types. (hopkinsmedicine.org)
Without large T, cells form embryonic stem cell-like clusters in three to four weeks. (hopkinsmedicine.org)
With large T, the cells started looking like embryonic stem cells in just 12 to 14 days. (hopkinsmedicine.org)
Embryonic stem cell-like clusters were visible 14 days after they initiated reprogramming and from these clusters the researchers established three different cell lines that both look and behave like human embryonic stem cells. (hopkinsmedicine.org)

Researchers at universities and technology companies are looking for ways to convert body heat, motion, RF signals and ambient light to energy. (pcworld.com)
To find new ways to treat triple-negative breast cancer, researchers have differentiated cancer cells to convert them into less harmful cells that no longer divide. (unibas.ch)
University of Basel researchers have identified compounds that artificially mature breast cancer cells of the highly aggressive triple negative subtype and convert them to a state that resembles normal cells. (unibas.ch)
We show here that we can convert breast cancer cells to less harmful cells that stop growing," says Bentires-Alj who is a group leader at the Department of Biomedicine. (unibas.ch)
To the researchers' surprise, this did not just convert the triple-negative breast cancer cells to a more manageable type of cancer cells. (unibas.ch)
MSK researchers Charles Sawyers and Dana Pe'er discovered that inflammatory signaling pathways play a key role when prostate cancer cells convert to a different cell type - a transformation known as lineage plasticity. (mskcc.org)
This transformation, known as lineage plasticity, allows cancer cells to convert to a different cell type. (mskcc.org)
In 2014, Cowan identified two drugs with the potential to convert stem cells that make white fat into those that would make brown. (scitechdaily.com)
Imagine if this energy could be harnessed in much the same way that traditional photovoltaics cells convert sunlight (in the visible range) into useful electricity. (greengeek.ca)
Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. (lu.se)

A group of researchers from the University of Toronto has developed a credit-card sized tool for growing cancer cells outside the human body, which they believe will enhance their understanding of breast cancer metastasis. (utoronto.ca)
The project also involves one group of researchers from Uppsala University. (lu.se)

The researchers are looking forward to improving upon their current atlas by sequencing additional human tissues. (genengnews.com)
Cancer cells that lack this ability are unable to grow and invade surrounding tissues effectively. (cosmosmagazine.com)
We decided to apply our expertise in microfluidics to develop a new tool to aid in studying how cancer cells begin to invade into surrounding tissues in the first steps in metastasis. (utoronto.ca)
For more than 20 years, Dr. Kotton's team has pursued ways to engraft cells into injured lung tissues with the goal of regenerating lung airways or alveoli. (bu.edu)

By using an inhibitor of Notch signaling, we could push even more cells to differentiate into hair cells," says Dr. Edge. (science20.com)

Cancers consist of many other cell types in addition to cancer cells," says Dr Sarah Boyle who is researching how the environment surrounding breast cancer cells helps them to grow. (cosmosmagazine.com)
In contrast, in a fraction of breast cancers cells that express the estrogen receptor proliferate significantly. (unibas.ch)
Researchers have designed ever more potent AR-targeting drugs to overcome this hurdle, but some prostate cancers still escape - and it's not been clear why. (mskcc.org)
Cancer of the immune cells is known as lymphoma - a group of cancers including non-Hodgkin's lymphoma - impacts more than 13,000 people in the UK per year. (york.ac.uk)
The finding is important because patients treated with immunotherapies against cancers are often non-responsive or experience a relapse of their disease, and it has been suggested that these challenges may be due to T cell exhaustion. (stjude.org)
MPNs are a group of blood cancers where the bone marrow makes too many blood cells. (cdc.gov)

Michael Herriges, PhD, Kotton lab postdoc and first-author of "Durable alveolar engraftment of PSC-derived lung epithelial cells into immunocompetent mice. (bu.edu)
However, when researchers treated mice that had tumors with the chemotherapy drug decitabine, their T cells showed properties indicating enhancement. (stjude.org)
When we treated the mice with PD-1, their T cells proliferated actively and had the properties of rejuvenated T cells. (stjude.org)
The technique works with near-perfect efficiency in mice and humans for all types of cells tested in the laboratories of USC's stem cell center. (usc.edu)
Strong inflammation produced swelling, scarring, and genetic mutations to cells in the lungs of the mice. (cdc.gov)

The classical theory is based on the idea that the eggs a woman has are the ones she has had from birth, but there are researchers who claim that stem cell research could lead to the creation of new eggs. (sciencedaily.com)
Ever since 2004, the studies on stem cell research and infertility have been surrounded by hype. (sciencedaily.com)
This shows not only that the use of stem cell research in the clinical treatment of childlessness is unrealistic but also that clinics should focus on using the eggs that women have had since birth in treating infertility," says Professor Kui Liu. (sciencedaily.com)
But the new UVA Health research shows these delicate cells have the ability to repair themselves from damage caused by loud noises or other forms of stress. (news-medical.net)
For many years, auditory research has placed considerable emphasis on the regeneration of sensory hair cells. (news-medical.net)
Research suggests that these cells control the growth of axons, or the neuronal projections that carry electrical impulses. (medicalnewstoday.com)
The long-term clinical goal of this research is to design drugs that stop the cancer cells from hijacking fibroblasts. (cosmosmagazine.com)
Mayo Clinic researchers, working in collaboration with the University Medical Center Groningen and The Scripps Research Institute, induced senescence in human cell cultures by radiating human primary preadipocytes, Human Umbilical Vein Endothelial Cell cultures and IMR90 cell cultures. (sciencedaily.com)
Led by Kapil Bharti, Ph.D., who directs the NEI Ocular and Stem Cell Translational Research Section, and Ruchi Sharma, Ph.D., a staff scientist in the lab and lead author of the paper, the investigators developed the model using stem cell-derived mature RPE cells. (nih.gov)
In 2010, the same research group showed that a similar method worked on mouse skin cells, although it works much less efficiently with human cells. (stanforddaily.com)
If you would like to give to a specific research program or support the work of a particular researcher, contact our fundraising team today. (edu.au)
As well as explaining the detail of how cell death occurs, our research could provide clues about how to design potential new therapeutic agents that target Bax," Dr Czabotar said. (edu.au)
The research was funded by the National Institutes of Health and the Johns Hopkins Institute for Cell Engineering. (hopkinsmedicine.org)
Most biomedical research relies on individual cells or cell cultures grown in plastic petri dishes or on glass plates. (phys.org)
Prof. Li has been recognised as a Highly Cited Researcher 9 years in a row since 2014, which testifies to his significant impact on global research. (edu.hk)
His pioneering contributions to research on polymer solar cells since 2005 have brought sustainable influence on printable solar energy development with global recognition. (edu.hk)
The benefits from this research to brain cancer patients will bring great satisfaction to researchers and clinicians who are trying to find a successful treatment for this devastating cancer," he added. (wraltechwire.com)
The other grants will fund additional mouse and cell models for the team to further investigate how the ABI3 gene in microglia affects Alzheimer's disease pathologies as well as fund state-of-the-art techniques, including brain imaging using the Bruker BioSpec 9.4T PET-MRI scanner , located in the Roberts Translational Imaging Facility at Stark Neurosciences Research Institute. (iu.edu)
St. Jude Children's Research Hospital immunologists have discovered how immune cells called T cells become "exhausted" - unable to do their jobs of attacking invaders such as cancer cells or viruses. (stjude.org)
Somatic-cell nuclear transfer, the technique by which Dolly was created, was first used 40 years ago in research with tadpoles and frogs. (who.int)
Nanotechnology researchers in Lund have spent a couple of billion Swedish crowns over the past 10-15 years on academic and industrial research and development of nanowires. (lu.se)
His most important current research project is being implemented with grants from the Swedish Energy Agency and deals with nanowire-based solar cells for cheap renewable energy, and the equivalent development of efficient light-emitting diodes - the latter with funding from the Foundation for Strategic Research matched by funding from the EU. (lu.se)
Much research on diabetes focuses on understanding what happens when the insulin-producing cells are destroyed. (lu.se)
Their research shows that a protein of the immune system protects the insulin-producing cells from inflammation and death. (lu.se)
Much research on diabetes focuses on trying to understand what happens when the insulin-producing cells are destroyed. (lu.se)

Researchers at the University of California, Riverside have discovered a molecular mechanism directing the fate and function of cells during animal development. (biologynews.net)
Dr Peter Czabotar (left) and Dr Dana Westphal have visualised the molecular changes in a critical cell death protein that force cells to die. (edu.au)
Molecular and materials predictions of emerging solar energy technologies including Dye-Sensitized Solar Cells (DSSCs), Organic Photovoltaics (OPVs), nanoscale energy converters, Light-emitting materials, as well as Solar Fuels including Artificial Photosynthesis. (lu.se)

Mammary cancer": Image of a slice of a mammary cancer that has been labelled immunofluorescently for cancer cells (outlined in green), which produce a protein (pink) that hijacks fibroblast cells (aqua) in their surrounding environment to become cancer-promoting. (cosmosmagazine.com)
But there needs to be a sufficient number of fibroblast cells available to send a strong enough signal to trigger this process to occur. (ucalgary.ca)

Bharti's group initially developed the cells using skin fibroblasts or blood samples donated from AMD patients. (nih.gov)
In Bharti's laboratory, the fibroblasts or blood cells were programmed to become induced pluripotent stem cells (iPSC), and then programmed again to become RPE cells. (nih.gov)
A loss of dermal stem cells prevents production of new fibroblasts and so the population can't be maintained. (ucalgary.ca)

Combining these two changes resulted in much stronger signals between nerve cells in the human brain. (naturalnews.com)

In type I diabetes, the beta cells, which are the only cells in the body that produce insulin, are destroyed by the immune system resulting in complete lack of the hormone. (newswise.com)
Especially in the era of immunotherapies, it has been suggested that "normal-like" cells can be cleared by the immune system while "cancerous" cells evade killing by immune cells. (unibas.ch)
B-cells and T-cells are part of the adaptive immune system. (york.ac.uk)
Among researchers studying the immune system, there is no consensus on whether C3 plays a significant role inside our cells. (lu.se)
It has long been known that C3 plays a crucial role for the immune system in the bloodstream where it helps white blood cells to engulf infectious microorganisms. (lu.se)
A week before the transplant, the recipient receives an infusion of specific immune system cells from the donor -- ones that, in theory, could tone down any immune system attack on the new "foreign" liver. (msdmanuals.com)
Beyond that, the researchers saw promising signals when they examined patients' immune system activity. (msdmanuals.com)

The researchers were able to confirm the presence of these stem cells by using antibodies and genetically modified animals that identified the specific protein markers on neuronal stem cells. (medica-tradefair.com)
Hantaviruses are transmitted by aerosolized excreta viruses, DOBV-Aa/Lipetsk and DOBV-Ap/Sochi, were iso- of their natural hosts, mainly rodents (family Muridae) but lated through Vero E6 cells, genetically characterized, and also shrews (family Soricidae). (cdc.gov)
A second technique uses genetically modified cells that glow faintly when they are infected with the influenza virus. (cdc.gov)

New studies done by researchers at the University of Gothenburg and Karolinska Institute now show that the dream of successfully treating infertility with stem cells will probably not be realized. (sciencedaily.com)
University of Virginia School of Medicine researchers have discovered how the cells that let us hear can repair themselves after being damaged. (news-medical.net)
Researchers at Ohio State University have developed circuitry that converts radio signals from a handset into energy, which is then fed back to the device's battery. (pcworld.com)
The University of SA has more than 300 researchers working to prevent and treat cancer and to support the growing numbers of survivors of this disease. (cosmosmagazine.com)
So far, the Emeryville, California-based firm has built its business by providing customers, usually pharmaceutical companies interested in antibody production, with the ability to trap and assay cells using proprietary, optics-based technology developed by Ming Wu, a professor at the University of California, Berkeley. (genomeweb.com)
Johns Hopkins University researchers have invented dust-particle-sized devices that can be used to grab and remove living cells from hard-to-reach places without the need for electrical wires, tubes, or batteries. (campustechnology.com)
Researchers at the University of Basel and the University Hospital Basel have tested the possibility of artificially maturing (or more precisely, differentiating) breast cancer cells as an approach to turn them into a more normal type of cell. (unibas.ch)
Now, a team of Stanford University endocrinologists and chemists has taken a step toward targeting the right cells more precisely, using a property that researchers have long known about but never exploited for treatment: Beta cells, the insulin-producing cells in the pancreas, have a particularly strong taste for zinc. (stanford.edu)
Researchers at University of California San Diego School of Medicine and their collaborators have developed a technique that allows them to speed up or slow down human heart cells growing in a dish on command-simply by shining a light on them and varying its intensity. (phys.org)
University of Central Florida researchers are helping to close the gap separating human and machine minds. (ucf.edu)
Researchers from The Hong Kong Polytechnic University (PolyU) have achieved a breakthrough power-conversion efficiency (PCE) of 19.31% with organic solar cells (OSCs), also known as polymer solar cells. (edu.hk)
Researchers at the University of Maryland School of Medicine (UMSOM) have for the first time identified stem cells in the region of the optic nerve, which transmits signals from the eye to the brain. (medica-tradefair.com)
And one year later, the patients were showing signs of a modified immune response to the donor liver, said senior researcher Angus Thomson , a professor of immunology and surgery at the University of Pittsburgh School of Medicine. (msdmanuals.com)

Researchers have developed a new technique to grow and sequence colonies of immune cells, giving new insights into how and when they accumulate mutations. (york.ac.uk)
Understanding more about the factors that cause these mutations to develop into cancer in some cells and not others could help shed light on the origins of the disease. (york.ac.uk)
While cancer can develop at any point in a person's life, age can be a risk factor in some types of cancer as over time these cells acquire more genetic mutations, with some of these mutations giving a higher risk of developing cancer. (york.ac.uk)
In HNPCC, a mutation that inactivates an MMR gene leads to the accumulation of cell mutations and greatly increases the likelihood of malignant transformation and cancer. (medscape.com)

To test this hypothesis, the researchers exposed 10 iPSC-derived RPE cell lines involving different genetic variants to anaphylatoxins from human serum. (nih.gov)
Then they grew these iPSC-derived heart cells on a graphene surface. (phys.org)

At Mayo Clinic, we discovered the first senolytic drugs -- agents that selectively eliminate senescent cells while leaving normal cells unaffected. (sciencedaily.com)
By selectively changing the water-repelling properties of the surface at various points, researchers can 'pinch' off the water droplets and form precise shapes. (utoronto.ca)

By inhibiting a key regulator of quiescence, we are able to kill a larger fraction of cancer cells. (upmc.com)
Adelaide researchers are coming ever closer to figuring out how cancer cells hijack normal cells in their vicinity to help them to grow. (cosmosmagazine.com)
This pressure can cause changes in the biochemistry within cancer cells. (cosmosmagazine.com)
Cancer cells resemble stem cells in being extremely adaptable. (unibas.ch)
Cancer cells differ from normal cells in many ways. (unibas.ch)
Similarly, agents that drive Bax into its active form could force immortal cells such as cancer cells to die, providing the basis for a potential new class of anti-cancer agents. (edu.au)
The device, described in a paper published on July 15 in Science Advances , reproduces various environments within the human body where breast cancer cells live. (utoronto.ca)
If cancer cells would simply stay in one spot, it would be 'easy' to excise them and cure the disease. (utoronto.ca)
But when cancer metastasizes, cancer cells move through the body, making the disease difficult to treat. (utoronto.ca)
One interesting thing we observed is that not all cancer cells within the same population have the same invasiveness," Li said. (utoronto.ca)
Li and her team extracted cancer cells at various distances from the invasion point and subjected these cells to genetic sequencing. (utoronto.ca)
According to the researchers, the garlic compounds killed the brain cancer cells by producing reactions that capitalized on the cells' high metabolism and need for oxygen. (wraltechwire.com)

Each adult stem cell population acts a little bit differently in the body and, as a result, how they change due to aging is also different. (ucalgary.ca)
The nucleus of an adult somatic cell (such as a skin cell) is removed and transferred to an enucleated egg, which is then stimulated with electric current or chemicals to activate cell division. (who.int)
if it implants and the pregnancy goes to term, the resulting individual will carry the same nuclear genetic material as the donor of the adult somatic cell. (who.int)

One promising approach may be to stimulate the regeneration of those cells with drugs. (stanford.edu)

Oxygen starvation is a common problem in studies involving transplanted pancreatic cells. (newswise.com)

A mouse trachea cut open longitudinally, with green fluorescence indicating transplanted engineered basal cells. (bu.edu)

The challenge was to do the same for skin cells without stem cells as an intermediary. (stanforddaily.com)

HIV infection requires the virus to enter a cell and gain access to the well-guarded nucleus in order for the viral components to be integrated into the healthy cell's DNA. (israelnationalnews.com)
However, an animal created through this technique would not be a precise genetic copy of the source of its nuclear DNA because each clone derives a small amount of its DNA from the mitochondria of the egg (which lie outside the nucleus) rather than from the donor of cell nucleus. (who.int)

Since our device mimics vision-related brain cells, facial recognition is one of the most important tests for our neuromorphic building block. (ucf.edu)

We thus developed a cell atlas in which human and mouse trigeminal ganglia are transcriptionally and epigenomically profiled at single-cell resolution. (genengnews.com)
In addition to analyzing the TG of four human donors, the researchers studied two mouse models of headache. (genengnews.com)
This wealth of information further demonstrates similarities between human and mouse cells and lets researchers deduce that the same processes are happening in each. (medicalnewstoday.com)
The main difference is that human cells are larger and more abundant. (medicalnewstoday.com)
Having established a faster, more efficient method, the team then reprogrammed human cells that contain the mutation associated with sickle cell anemia. (hopkinsmedicine.org)
It was proven in human and animal cells. (usc.edu)
To this end, we overexpressed key transcriptional regulators of astroglial development in human GBM and GBM stem cell lines. (lu.se)

The researchers said they plan to continue their collaboration to refine the device, including using it to develop a circuit-level system. (ucf.edu)
These studies are done in tight collaboration with researchers at Lund Laser Centre (LLC). (lu.se)

To treat diabetes directly, rather than manage its symptoms, doctors need a way to get drugs to cells that produce insulin. (stanford.edu)
An insulin injection can manage diabetes symptoms, but actually curing the disease would mean healing cells in the pancreas that produce insulin, a hormone that regulates the amount of sugar in blood. (stanford.edu)
Stem cells programmed to produce insulin in people with type 1 diabetes or to repair the heart muscle after a heart attack. (lu.se)

Cancer occurs when cells grow uncontrollably and spread to other organs in the body. (unibas.ch)

We knew it could play an important role in cell regulation - for example, in proliferation or development," he said. (analytica-world.com)

Prof. Li Gang invented a novel technique to achieve a breakthrough efficiency with organic solar cell. (edu.hk)
Dr. Andreas Bett and Dr. Frank Dimroth of the Fraunhofer Institute for Solar Energy Systems ISE in Freiburg developed metamorphic triple-junction solar cell consisting of III-V compound semiconductors: gallium indium phosphide, gallium indium arsenide and germanium. (azooptics.com)
Our triple solar cell consists of more than 20 individual layers, all of which we have optimized,' says Dr. Frank Dimroth. (azooptics.com)
Single-walled (pure) carbon nanotubes in the form of C60 was the breakthrough that enabled them to build the new solar cell â€" as opposed to convectional cells that is relying on a layer of polymer to hold the nanotubes in place. (greengeek.ca)
It will be interesting to see if Strano and his team are able to improve on the solar cell in the near future. (greengeek.ca)
The efficiency of an ordinary solar cell is currently around 15 per cent, but the vision is to use nanowires to eventually produce solar cells with an efficiency of up to 50 per cent. (lu.se)
Currently, 90 per cent of the solar cell market consists of silicon cells, but if the thin film is applied over a normal standard solar cell, its efficiency increases dramatically, for example from 15 to 25 per cent. (lu.se)

We've demonstrated tiny inexpensive tools that can be triggered en masse by nontoxic biochemicals," said Gracias, an assistant professor of chemical and biomolecular engineering in Johns Hopkins' Whiting School of Engineering . (campustechnology.com)
In their lab experiments, the Johns Hopkins researchers used a microgripper, guided by a magnet, to grab and transport a dyed bead from among a group of colorless beads in a water solution. (campustechnology.com)
Gracias, who also is affiliated with the Institute for NanoBioTechnology at Johns Hopkins, hopes to collaborate with medical researchers who can help to move the microgrippers closer to use as practical biopsy and drug delivery tools in humans. (campustechnology.com)

The Beacon platform can trap up to 56,000 cells in so-called "light pens" and then assay them to provide data on cell shape, size, protein output, or other important features. (genomeweb.com)
Then, using an ATPLite and a crystal violet assay, researchers measured cell viability and demonstrated that fisetin and BCL-XL inhibitors A1331852 and A1155463 cleared senescent cells in vitro. (sciencedaily.com)

The probe provides high specificity as it is sent only inside the CTC and not to other blood cells. (uh.edu)
People who live to 100 years have lower measures of creatinine, glucose and uric acid in their blood compared to those with a comparatively shorter lifespan, researchers say. (medicaldaily.com)
For every 10,000 children who have a CT scan, 1-2 cases of blood cancer can be expected in the next 12 years after the examination, a researcher said. (medicaldaily.com)
Reprogramming involves changing one cell into another type of cell, such as a blood cell into a muscle or nerve cell. (usc.edu)
The main gene finding, ADRA2A , "points to a receptor on the cells that regulate the tone of these blood vessels," she continued. (medscape.com)
PV is a rare form of cancer of the blood that causes the body to make too many red blood cells. (cdc.gov)
This in turn leads to the bone marrow not producing enough red blood cells, which means that the affected patient needs repeated blood transfusions," says Johan Flygare. (lu.se)
If we succeed, patients will be able to receive treatment that will allow their own blood stem cells to leave the bone marrow. (lu.se)
A few weeks ahead of a patient's planned transplant, the donor gave a blood sample, from which the researchers isolated monocytes, a type of white blood cell. (msdmanuals.com)

Organisms1

Diseases1

Chemicals and Drugs1

Analytical, Diagnostic and Therapeutic Techniques and Equipment37

Psychiatry and Psychology26

Phenomena and Processes6

Disciplines and Occupations37

Anthropology, Education, Sociology and Social Phenomena41

Technology, Industry, Agriculture4

Humanities19

Information Science67

Named Groups6

Health Care94

Geographicals9

Neurons15

20223

Genes22

Tumor19

Pathway11

Biology13

Therapies7

Tissue17

Team of researchers4

Proteins10

Lund University8

Progenitor cells5

Reprogram suppo1

Beta cells in the pancreas1

Protein called6

Found37

Findings13

Neuroscience1

Pancreatic beta cells4

Differentiation5

Replicate6

Treatments3

Study19

Scientists15

Insulin-producing2

Embryonic7

Convert10

Group of researchers2

Tissues4

Differentiate1

Cancers6

Mice5

Research25

Molecular3

Fibroblast cells2

Fibroblasts3

Nerve cells1

Immune system7

Genetically3

University13

Mutations4

IPSC-derived2

Selectively2

Cancer cells12

Adult3

Regeneration1

Involving transplanted1

Transplanted engineered1

Intermediary1

Nucleus2

Mimics1

Human7

Collaboration2

Produce insulin3

Organs in the body1

Proliferation1

Solar cell7

Johns Hopkins3

Assay2

Blood9