Researchers bacterial proteins. Medical search. Frequent questions

Examples include the HU protein in Escherichia coli, a dimer of closely related alpha and beta chains and in other bacteria can be a dimer of identical chains. (wikipedia.org)
HU-type proteins have been found in a variety of bacteria (including cyanobacteria) and archaea, and are also encoded in the chloroplast genome of some algae. (wikipedia.org)
Histone-like proteins were unknown to be present in bacteria until similarities between eukaryotic histones and the HU-protein were noted, particularly because of the abundancy, basicity, and small size of both of the proteins. (wikipedia.org)
Upon further investigation, it was discovered that the amino acid composition of HU resembles that of eukaryotic histones, thus prompting further research into the exact function of bacterial DNA binding proteins and discoveries of other related proteins in bacteria. (wikipedia.org)
Currently, many more functions of bacteria DNA binding proteins have been discovered, including the regulation of gene expression by histone-like nucleoid-structuring protein, H-NS. (wikipedia.org)
H-NS is about 15.6 kDa and assists in the regulation of bacterial transcription in bacteria by repressing and activating certain genes. (wikipedia.org)
By sequencing the DNA of bacteria resistant to viral toxins, TAU researchers identified novel proteins capable of stymieing growth in treacherous antibiotic-resistant bacteria. (eurekalert.org)
Because bacteria and bacterial viruses have co-evolved over billions of years, we suspected the viruses might contain precisely the weapons necessary to fight the bacteria," Prof. Qimron said. (eurekalert.org)
The researchers are continuing their study of bacterial viruses in the hope of identifying compounds and processes that facilitate improved treatment of antibiotic-resistant bacteria using yet uncharacterized bacterial viruses' proteins. (eurekalert.org)
They believe that further basic knowledge on bacterial viruses biology will eventually lead to unexpected breakthroughs in the fight against antibiotic-resistant bacteria. (eurekalert.org)
Described in the American Chemical Society Synthetic Biology journal, the team describes using protein polymers known as "R bodies", which are found in certain bacteria, as retractable nanoneedles that can extend to puncture cellular membranes and release molecules on command. (harvard.edu)
In this time-lapse, retractable protein actuators called "R bodies" - found naturally in certain bacteria - are seen extending from barely-visible tiny coils into long pointy tubes that are capable of rupturing cell membranes. (harvard.edu)
However, scientists uncovered that the BPI protein from scorpionfish successfully slipped past the immune defenses of cystic fibrosis patients and was notably effective in fighting gram-negative bacteria. (chipchick.com)
One bacterial component targeted by the vaccine, pertactin, is a protein believed to help the bacteria attach to cells in the throat. (cdc.gov)
Research in mice and zebrafish shows how a protein from gut bacteria could drive the development of diabetes, opening up new pathways for treatment. (medicalnewstoday.com)
A new study published in Cell Metabolism shows that a protein called beta cell expansion factor A (BefA) secreted by gut bacteria could induce the replication of insulin-producing beta cells in neonatal mice. (medicalnewstoday.com)
Moreover, the authors had also identified a version of the BefA protein synthesized by gut bacteria in humans that could stimulate the proliferation of beta cells in zebrafish. (medicalnewstoday.com)
This is a prime location for gene products involved in infection because many dangerous bacteria secrete toxins or proteins through the membrane to attack the host. (scienceblog.com)
A lack of these proteins impairs the body's immune response to bacteria, leading to recurrent bacterial infections. (medlineplus.gov)
In comparison with similar proteins that build the cytoskeleton of bacteria, which are evolutionary older and simpler cells, the researchers found fundamental differences in the protein folding. (mpg.de)
This new study provides direct evidence to suggest that bacteria can secrete proteins that form an amyloid fibril, which enters the host neurons and promotes protein aggregation and neurodegeneration. (hku.hk)
Inhibiting the ability of the bacteria to secrete such proteins may be a preventative treatment for neurodegenerative diseases. (hku.hk)
Molecular details on how harmful bacteria attach to the human body have been revealed for the first time by researchers from the La Trobe Institute for Molecular Science (LIMS). (edu.au)
The discovery, published today in Nature Communications by researchers from La Trobe University and the University of Queensland, provides details on how proteins in the outer membrane of bacteria - the bacteria's 'superglue' - are able to stick to and populate parts of the human body. (edu.au)
The knowledge we now have on this bacteria's protein gives us the ability to block the bacteria sticking to different parts of the human body," said Dr Heras. (edu.au)
bacteria have had thousands of years to develop these adhesive proteins," Dr Paxman explained. (edu.au)
Tiny proteins found in the genomes of some types of bacteria are effective weapons against a wide range of other bacteria, opening the door for the development of new therapies in the age of antibiotic resistance, according to new research at the University of Notre Dame. (nd.edu)
The team sequenced the genome of a bacterial species isolated from the seed and discovered a portion of one bacteriocin, AS-48, would interact with the membranes of certain types of bacteria like E. coli. (nd.edu)
What's more, bacteria themselves express different genes and make proteins that may predispose certain individuals to gut inflammation or other conditions. (washington.edu)
Researchers report April 16 in the journal Cell Reports that some bacteria use viruses that have infected them (i.e., phages) for self-recognition and thereby show greater fitness, repelling competitors that lack this adaptation. (news-medical.net)
A new virus, SW1, and an old virus protein, YfdM, are used as tools by the cell as it searches for food -- and all bacteria are usually starving,' Wood says. (news-medical.net)
In future studies, the researchers plan to investigate how SW1 avoids attacking its host cells, instead killing primarily bacteria that lack the virus. (news-medical.net)
The researchers then tallied the number of bacteria per unit volume in each volunteer's saliva, including both benign bacteria and germs that can spawn bad breath. (sciencenews.org)
BOCHUM, Germany, Aug. 10, 2023 - To build a flexible sensor for optically detecting a range of viruses and bacteria, a group of researchers from Ruhr University Bochum (RUB), the Fraunhofer Institute for Microelectronic Circuits and Systems (IMS), and ETH Zurich used semiconducting, single-walled, fluorescent carbon nanotubes. (photonics.com)
The system involves the study of what are termed autotransporter proteins, which pathogenic bacteria secrete as virulence factors for infection. (anl.gov)
This begged the question as to how different bacteria could use this protein with different structures to produce a harpoon with the same function across all species. (diamond.ac.uk)
researchers have identified a protein produced by our intestinal bacteria that may function as the source of these disorders. (medicaldaily.com)
Oxazolidinones represent a significant class of synthetic bacterial protein synthesis inhibitors that are primarily effective against Gram-positive bacteria. (bvsalud.org)
In a study the researchers demonstrate how they, by mimicking a substance naturally present in the body, can neutralize toxic substances from bacteria and thereby mitigate harmful inflammation that could otherwise lead to sepsis. (lu.se)
For over two decades, Artur Schmidtchen and his research group have studied endogenous peptides, smaller protein fragments in the body with the ability to both kill bacteria and neutralize the bacterial toxins released during an infection. (lu.se)

Using high-throughput DNA sequencing, the researchers located mutations in bacterial genes that resisted the toxicity of growth inhibitors produced by bacterial viruses. (eurekalert.org)
In a new study, McIver's laboratory and researchers at the University of Maryland School of Medicine identified two genes important for invasive group A Streptococcus infections in mice. (scienceblog.com)
The researchers identified 273 scf genes as potentially involved in establishing infection under the skin, but two genes stood out: scfA and scfB. (scienceblog.com)
Based on patterns in their DNA sequences, these genes likely encode proteins in the bacterial membrane. (scienceblog.com)
Although analyses that give information on the expression of a few genes provide insight and have been responsible for a large proportion of the bacterial pathogenesis literature currently available, our ultimate goal is to understand expression changes across the whole genome. (cdc.gov)
Each of these genes provides instructions for making a protein that plays a role in helping the immune system recognize and fight infections. (medlineplus.gov)
To address this problem, the research team screened for bacterial E. coli genes whose deletion alleviates the PD symptoms in an animal model of PD. (hku.hk)
From a genome-wide screen, Dr Zheng's team identified 38 bacterial genes that can promote neurodegeneration in the animal host. (hku.hk)
Two of these genes code for proteins that form curli, one type of bacterial amyloid fibers. (hku.hk)
Advanced tools of 'multi-omics' technology allow researchers to identify species in the human gut and analyze the bacterial genes and protein products that affect our brain health. (washington.edu)
Their work will allow researchers to explore the links between bacterial genes and proteins, and their effects on human health. (embl.org)
The researchers wanted to identify the enzymes and corresponding genes underlying this detoxification mechanism. (mpg.de)
We based our search on the known bacterial SaxA proteins to select candidate genes for further investigations. (mpg.de)
We then tested whether these genes are actually expressed in greater quantities in fungi exposed to the toxins, and whether the resulting protein can render the toxins harmless,' explains Daniel Vassão, one of the study leaders. (mpg.de)
The human genome contains about 20,000 protein-coding genes, but the coding parts of our genes account for only about 2 percent of the entire genome. (phys.org)
The genetic study showed promising results in "silencing" the genes that translate into tau protein, the primary component behind dementia. (medicaldaily.com)
Datasets for benchmarking antimicrobial resistance genes in bacterial metagenomic and whole genome sequencing. (cdc.gov)
The significantly upregulated genes encode proteins involved in reactions of the energy-generating phosphotransferase system and transcription processing, which could be related to phage transcription. (lu.se)

And it is also how bacterial toxins enter human cells and wreak havoc. (scitechdaily.com)
The study identified the ways in which proteins cross a cell membrane, a finding that could create a scientific foundation for better ways of delivering drugs into cells in the future, or for treating illnesses caused by bacterial toxins. (scitechdaily.com)
Pei's research team at Ohio State has spent years trying to understand how biomolecules such as bacterial toxins get inside a human cell, with the goal of finding ways to get medications into those cells. (scitechdaily.com)
It was through that work that the researchers discovered how some toxins were getting across the cell membranes, said Ashweta Sahni, lead author of the study and a graduate student in Pei's lab at Ohio State. (scitechdaily.com)
The team subsequently observed that two structurally different bacterial toxins also employed this same mechanism. (scitechdaily.com)
Reference: "Bacterial Toxins Escape the Endosome by Inducing Vesicle Budding and Collapse" by Ashweta Sahni and Dehua Pei, 23 September 2021, ACS Chemical Biology . (scitechdaily.com)
We have identified several toxins that belong to protein classes with known efficacy against bacterial pathogens. (idw-online.de)
The research strategy is to develop process-monitoring tools for the quantification of contaminating compounds (e.g. bacterial toxins, viral markers) at extremely low levels. (lu.se)

April 11, 2023 - Researchers developed a protein delivery system that can be customized to target specific human cell types. (nih.gov)
April 4, 2023 - Researchers found evidence that the nervous system plays a key role in the extreme and sometimes deadly allergic reactions known as anaphylaxis. (nih.gov)

The researchers noticed that some peptides cross membranes by pushing against them. (scitechdaily.com)
While working on the team's other projects, Sahni noticed that some fragments of proteins, known as peptides, cross membranes by pushing against them. (scitechdaily.com)
In this prototype solar cell, photosynthetic proteins (spheres embedded in yellow peptides) absorb light and pump electrons (e-) into a silver electrode. (sciencenews.org)
moves (transports) protein fragments (peptides) from foreign invaders into the endoplasmic reticulum. (medlineplus.gov)
There, the peptides are attached to MHC class I proteins. (medlineplus.gov)
Because there are no peptides for MHC class I proteins to bind, they are broken down, which results in a shortage of MHC class I proteins on the surface of cells. (medlineplus.gov)
Mutations in another gene involved in the attachment of peptides to MHC class I proteins very rarely cause BLS I. (medlineplus.gov)
In nature, many of these proteins exist as circular forms, so using this approach assured that the team optimized the peptides to the point where they're as effective as their natural counterparts. (nd.edu)
Antimicrobial proteins and peptides offer a multifaceted mechanism suitable to fight bacterial resistance. (frontiersin.org)
Now, drawing inspiration from the body's own defence mechanisms based on peptides, we have developed a new approach to treating severe bacterial infections", says Artur Schmidtchen, professor in dermatology and venereology and senior consultant at Skåne University Hospital, who led the study. (lu.se)
By mimicking the natural structure of peptides from the protein thrombin, researchers have designed a peptide-based treatment, sHVF18. (lu.se)
The MALDI-TOF method identifies unique patterns of protein and peptides extracted from bacterial cells. (cdc.gov)

We hope our approach will be used to further identify new growth inhibitors and their targets across bacterial species and in higher organisms. (eurekalert.org)
A new study reports that a protein called beta cell expansion factor A (BefA) secreted by certain gut bacterial species could induce the proliferation of beta cells in young mice and zebrafish. (medicalnewstoday.com)
The team, led by Barbara Bendlin, PhD, and Frederico Rey, PhD, collected stool samples from participants and used genetic sequencing technology to identify the bacterial species present, and assess the microbial richness and diversity. (washington.edu)
Bacterial cells that normally colonize our guts can distinguish themselves from other bacterial species using what's traditionally considered their enemy--a virus. (news-medical.net)
New research sheds light onto how different bacterial species can build complex nano-harpoons with different protein building blocks. (diamond.ac.uk)
Many studies have shown that this protein is an integral part of the T6SS machinery, but research into the DNA that encodes this protein show that that between species, there is a lot of variation. (diamond.ac.uk)
Yersinia enterocolitica (see the image below) is a bacterial species in the family Enterobacterales that causes enterocolitis, acute diarrhea, terminal ileitis, mesenteric lymphadenitis , and pseudoappendicitis but, if it spreads systemically, can also result in fatal sepsis. (medscape.com)
In several countries, Y enterocolitica has eclipsed Shigella species and approaches Salmonella and Campylobacter species as the predominant cause of acute bacterial gastroenteritis . (medscape.com)
The mouth is home to hundreds of bacterial species with various nutritional preferences. (medscape.com)

The scorpion fish may appear offputting, but new research suggests that the venomous marine animal could hold the key to treating multidrug-resistant bacterial infections among cystic fibrosis patients. (chipchick.com)
Multidrug-resistant bacterial infections are common in cystic fibrosis patients because of a genetic mutation, which can cause the accumulation of thick mucus in our lungs. (chipchick.com)
So, both our immune system and healthcare professionals find it difficult to tackle these kinds of bacterial infections. (chipchick.com)
A second group of methods, which includes DNA microarrays and proteomics, have advantages that overcome the limitations implicit in signature-tagged mutagenesis and in vivo expression technology, namely, the ability to directly measure expression (gene or protein) levels on a true genome-wide scale, but their application to analysis of bacterial pathogens during real infections is still in its infancy. (cdc.gov)
Victor Huber, Ph.D., assistant professor of Basic Biomedical Sciences at the University of South Dakota Sanford School of Medicine, suspects that certain proteins on the surface of the virus are contributing to secondary bacterial infections, which are a leading cause of death after influenza infection. (usd.edu)
One potential reason for the severe secondary bacterial infections associated with these H3N2 influenza viruses could be the specific proteins that are expressed by these viruses," said Huber, who earned his Ph.D. from the Medical College of Ohio in 2001. (usd.edu)
In our lab, we are attempting to identify the viral proteins that contribute to severe secondary bacterial infections. (usd.edu)
Our goal is to ultimately be able to use surveillance of influenza viruses to predict the severity of these secondary bacterial infections, which would allow us to more rapidly identify when these viruses are present. (usd.edu)
Starting in childhood, most people with BLS I develop recurrent bacterial infections in the lungs and airways ( respiratory tract ). (medlineplus.gov)
Researchers are unsure why people with BLS I do not also get viral infections, but they suspect that other immune processes are able to recognize and fight viruses. (medlineplus.gov)
The study focused on UpaB - the superglue protein of a pathogen known to cause urinary tract infections within 50 per cent of women within their lifetime 1 . (edu.au)
Similar proteins are found in the outer membrane of other pathogens responsible for infections ranging from life-threatening food poisoning to whooping cough, meningitis, typhus fever and chlamydia. (edu.au)
Researchers in a recent study found that a rapid test can reduce antibiotic use for respiratory infections, and could potentially prevent antibiotic resistance . (pharmacytimes.com)
This test is able to detect C-reactive protein (CRP), a blood biomarker for bacterial infections. (pharmacytimes.com)
Nisin is a broad spectrum anti-bacterial, effective against the microbes that cause staph infections and botulism, as well as many types of food spoilage. (preparedfoods.com)
Ganna Petruk and Artur Schmidtchen, two of the reserchers behind the study of a new treatment strategy for severe bacterial infections. (lu.se)
The development of a new treatment strategy for bacterial infections and sepsis is being led by researchers at Lund University. (lu.se)

The upper lobe isolate, for instance, contains a SNP in the ciprofloxacin target topoisomerase parE and a SNP in exsD, a key negative regulator of the type 3 secretion system, which is among the most potent bacterial virulence factors. (genomeweb.com)
Further detailed analyses of these responses will increase understanding of the molecular mechanisms of pathogenesis, identify new bacterial virulence factors, and aid in the design of new vaccines. (cdc.gov)

When plants are attacked by bacterial pathogens, a substance called coronatine from these pathogens uses the jasmonic acid system inside the plant cells to suppress the plant's disease response, making the plant more susceptible to disease. (isaaa.org)
But their venom also contains active substances that could be used against bacterial pathogens in the future. (idw-online.de)
The developing complementary technologies of DNA microarrays and proteomics are allowing the response of bacterial pathogens to different environments to be probed at the whole genome level. (cdc.gov)
Some bacterial pathogens have been shown to substantially modify their surface components in response to the host immune system and modify their energy metabolism and transport pathways to allow efficient growth within the host. (cdc.gov)
Bacterial pathogens must be able to gain access to, persist in, and replicate in normally privileged sites within a host. (cdc.gov)
The primary aim of investigating bacterial pathogenesis is to understand the way that pathogens interact with the host to cause disease. (cdc.gov)

In one type of social activity, when they communicate, bacterial cells secrete chemical signals to communicate. (news-medical.net)

However, a recent study conducted by scientists in Germany discovered the significant potential of a protein derived from scorpion fish, known as bactericidal/permeability-increasing protein (BPI). (chipchick.com)
VERMILLION, S.D. -- As the influenza virus continues to spread rapidly across the country, infecting millions of people from coast to coast, a University of South Dakota researcher is working to help scientists predict the severity of lethal flu strains to better prepare for future outbreaks. (usd.edu)
Using genetic engineering, scientists could make viral proteins (antigens) in the lab in bacterial or other cultures. (davidicke.com)
Science An international team of scientists has collated all known bacterial genomes from the human gut microbiome into a single large database. (embl.org)
Oregon State University scientists have identified proteins that prevent a bacterial cell from becoming misguided by its own messaging, allowing it to instead wait for collective communication from its group. (news-medical.net)
Scientists found that a protein in bird's retinas is sensitive to the Earth's magnetic field thus guiding its migratory patterns. (army.mil)
The research, published in Nature , identified the protein that the scientists believe allows these songbirds to detect the direction of the Earth's magnetic field and navigate their migration. (army.mil)

Researchers have known how small molecules penetrate cell membranes, typically by binding to the membrane and then diffusing through it. (scitechdaily.com)
a new study from researchers at Harvard s Wyss Institute for Biologically Inspired Engineering and Harvard Medical School (HMS) introduces a novel mechanical method for controlling release of molecules inside cells. (harvard.edu)
When they tested the G215A mutant of the marine organism Vibrio alginolyticus, they found that this clockwise motion was because of changes in FliG and the interaction of water molecules around the protein. (phys.org)
Despite the emerging idea of "microbiota-gut-brain" link, little is known about the bacterial molecules that modulate the progression of neurodegeneration. (hku.hk)
He plans to move on to study other bacterial molecules identified from the screen and investigate how they affect host neurodegeneration. (hku.hk)
Simultaneously, the method also records changes in the molecules the protein interacts with - in this case ATP. (nanowerk.com)
Because the magnetic field modifies the cryptochrome protein in a measurable way, cryptochrome proteins or synthetic molecules that mimic the mechanism of cryptochrome's magnetic sensing could be used in a future navigation device. (army.mil)
Traditionally, prediction of the functions of bacterial proteins is carried out for poorly studied molecules or hypothetical proteins predicted based on these genome sequences. (custom-essay.org)
The next step, involving researchers from IMS and ETH Zurich as well as RUB, was to customize the carbon sensors so they could be used with different target molecules in a straightforward manner. (photonics.com)

The commercial success of linezolid, the first FDA-approved oxazolidinone antibiotic, has motivated researchers to develop more potent oxazolidinones by employing various drug development strategies to fight against antimicrobial resistance, some of which have shown promising results. (bvsalud.org)
RESULTS: CAST-R-RGM employs D2O-probed Raman microspectroscopy to monitor RGM metabolic activity, while also revealing bacterial antimicrobial drug resistance mechanisms. (bvsalud.org)

HU is a small (10 kDa) bacterial DNA-binding protein, which structurally differs from a eukaryotic histone but functionally acts similarly to a histone by inducing negative supercoiling into circular DNA with the assistance of topoisomerase. (wikipedia.org)
Researchers from the University of Sheffield found that while the proteins varied, there were structurally similar portions that interacted with the machinery. (diamond.ac.uk)

After sequencing the genomes of 96 isolates from the upper, middle, and lower lobes from three patients, the researchers constructed phylogenetic trees. (genomeweb.com)
Science Researchers have used a metagenomics approach to piece together the genomes of yeasts found in wild lichens. (embl.org)
Consistent with this idea, the researchers found that the demarcation line was also eliminated for an E. coli K-12 strain lacking all nine cryptic prophages--bacteriophage genomes that have integrated into bacterial chromosomes but do not form active phage particles or rupture ('lyse') their host cells. (news-medical.net)

Thus, we measured its damaging effect on tissue using different cell types and the activity of protein-degrading enzymes and compared them with those of the Levantine viper. (idw-online.de)
Protein prediction is an incredibly important goal since it allows to simplify biotechnological research in the process of designing new drugs or enzymes. (custom-essay.org)
In addition, knowledge of protein structure may prompt potential partners for protein interaction and thus encourage researchers to develop or improve new enzymes or antibodies, or, for example, to explain the phenotype of the mutations performed or to help determine the location of the mutations in order to change specific phenotypes. (custom-essay.org)
After FMT, fecal proteomics detected 301 proteins composed of 154 of human origin - mostly related to gut barrier protection - and 147 of bacterial origin - mostly enzymes - at days 7, 30, and up to 90. (medscape.com)
A study in Nature Communications reveals one key piece of the puzzle using bacterial enzymes. (lu.se)

Our research expertise is world-recognized in areas such as bacterial secretion, aging, signal transduction, protein folding, drug metabolism and cellular protein trafficking. (ucl.ac.uk)

Actin has many more protein interaction partners than the bacterial cytoskeletal proteins, but it has lost the ability to fold independently. (mpg.de)
The researchers decided to capitalize on the characteristics that would initiate the interaction, then created 96 different variations of the peptide. (nd.edu)
Using time-resolved infrared spectroscopy, they measured the structural changes in the bacterial membrane protein MsbA and its interaction partner ATP. (nanowerk.com)
The interaction between the detection unit and a bacterial or viral molecule affects the fluorescence of the nanotubes, causing their brightness to increase or decrease. (photonics.com)

The integration host factor (IHF), a dimer of closely related chains which is suggested to function in genetic recombination as well as in translational and transcriptional control is found in Enterobacteria and viral proteins including the African swine fever virus protein A104R (or LMW5-AR). (wikipedia.org)
The research group has focused on the protein Feronia, a receptor kinase protein found in plant cells. (isaaa.org)
LecB of Pseudomonas aeruginosa is a bacterial virulence factor that impairs signaling of growth factor receptors- in other words, proteins found on the surface of host cells that transmit signals to promote the growth and reproduction of tissues. (chemeurope.com)
The inhibitor was found to cripple the activity of a protein vital to bacterial cells -- a protein that maintains the bacterial cell structure. (eurekalert.org)
The researchers analyzed more than 130 proteins released by Coxiella burnetii when this bacterium invades host cells, and found at least one to be capable of prolonging cell longevity by acting directly on mitochondria. (technologynetworks.com)
We found that its protein MceF redirects GPX4 to the mitochondria, where it acts as a potent anti-oxidant, detoxifying the infected cell and preventing cell components from aging, while allowing replication of the bacterium," said Robson Kriiger Loterio, first author of the article, which derived from his PhD research. (technologynetworks.com)
The researchers used phenotypic data to classify the isolates into subpopulations, and found that each patient harbored between 12 and 40 bacterial subpopulations in their lungs and that each lobar region contained between one and three of those sub-populations. (genomeweb.com)
Through a proteomic analysis, the researchers found that regional bacterial populations show protein expression differences. (genomeweb.com)
The researchers solved the protein structure of TRiC to study its function and found that it has a special mode of action for actin folding. (mpg.de)
Researchers found a reduction in antibiotic use in patients, and patients had the same recovery. (pharmacytimes.com)
They found that exposing bacterial cells containing an active lytic phage called SW1 to YfdM stimulated the production of phage particles and caused the lysis of cells, primarily those lacking SW1. (news-medical.net)
The researchers found that the anti-bacterial agent Nisin activates a protein that promotes cell death in cancer cells, but does not harm normal "good" cells. (preparedfoods.com)
They found that despite these differences, there was a very specific conserved region at the other end of the protein. (diamond.ac.uk)
Researchers have found that smoking causes chromosomal damage and speeds up aging. (medicaldaily.com)
Although happiness may vary between people based on personal experiences, the researchers found that life satisfaction - one of the factors that determines happiness - decreases after the age of nine and increases between the ages of 70 and 96. (medicaldaily.com)
We found that the proteins produced after FMT enhance the antibacterial response of [gut] cells," Edwards pointed out. (medscape.com)
Albumin, which is produced by the liver, is often reduced in chronic liver disease but "after FMT, blood albumin levels were found to increase dramatically because the liver is reset to produce this protein. (medscape.com)

In molecular biology, bacterial DNA binding proteins are a family of small, usually basic proteins of about 90 residues that bind DNA and are known as histone-like proteins. (wikipedia.org)
Lectins are proteins that bind to sugar residues on surface receptors and are not catalytically active, meaning they do not accelerate chemical processes. (chemeurope.com)
The TAP1 and TAP2 proteins attach (bind) together to form a protein complex called transporter associated with antigen processing (TAP) complex. (medlineplus.gov)
To demonstrate the potential of the biosensor, the researchers designed sensors for the SARS CoV-2 spike protein and used aptamers to bind to the protein. (photonics.com)
Due to their structure, they can selectively bind to proteins," researcher Justus Metternich said. (photonics.com)

Until now, the most popular hypothesis was that proteins pass through small holes, known as pores, in the membrane, akin to the Parisian statue, Le Passe-Muraille , of a man passing through a wall. (scitechdaily.com)
This is one of the basis that supports the hypothesis that persistent bacterial attacks, associated with irregular host inflammatory response, may have consequences beyond the periodontal tissues and may even influence the occurrence of some systemic diseases (2,3). (bvsalud.org)

Dr Zheng pointed out the importance of the study and said: "This study established a new paradigm for understanding how bacterial components from the gut microbiome can influence neuronal health in animals. (hku.hk)
Researchers are now discovering that a disrupted microbiome, in certain contexts, may contribute to Alzheimer's disease and related conditions that cause dementia. (washington.edu)
Patients with cirrhosis have an underabundance of commensal microbes, an overabundance of pathogenic microbes, and reduced gut microbiome diversity, as well as gut barrier damage and bacterial translocation. (medscape.com)

Within the RNaseA superfamily there is a group of highly cationic proteins secreted by innate immune cells with anti-infective and immune-regulatory properties. (frontiersin.org)

These harpoons are named type VI secretion systems (T6SSs) and since their discovery in 2005 researchers around the world have been trying to understand this miniature feat of engineering. (diamond.ac.uk)

The team witnessed the budding-and-collapse in live cells through confocal microscopy, an imaging technique that allowed them to focus in on what was happening inside the cells, and on the cell membranes, with these specific proteins. (scitechdaily.com)

SEpsis and Bacterial Resistance Alliance (SEBRA) is an awarded cross-professional interdisciplinary group of researchers and clinicians who represent the county hospital SUS Lund, and the Faculties of Medicine and Engineering (LTH) at Lund University. (lu.se)

Understanding the mechanisms underlying the actions of BefA protein could help develop therapies to stimulate beta cell proliferation in individuals with diabetes. (medicalnewstoday.com)
CONCLUSIONS: Ultimately, the rapid, accurate, and low-cost CAST-R-RGM assay offers advantages over conventional culture-based ASTs that warrant its use as a tool for improving patient treatment outcomes and revealing bacterial drug resistance mechanisms. (bvsalud.org)
Now, the researchers have predicted and validated numerous new TAs (1,2), advancing the field of bacterial antiviral immunity mechanisms. (lu.se)

It is necessary to carry out pairwise alignment, which allows revealing conservative residues in the whole family or separate subfamilies of proteins. (custom-essay.org)

in these processes, bacterial DNA binding proteins have an architectural role, maintaining structural integrity as transcription, recombination, replication, or any other DNA-dependent process proceeds. (wikipedia.org)
How does an amino acid sequence that is unfolded when it leaves the ribosome manage to fold properly into a highly ordered, lightning-fast enzyme or sturdy structural protein? (anl.gov)
The make-up and complexity of these molecular machines present perfect problems for structural biology and many of the protein components of these machines have been examined using X-ray crystallography or cryo-Electron Microscopy. (diamond.ac.uk)
Structural and mechanistic understanding of protein function has lagged behind due to the challenging and lowthroughput nature of structural and biochemical approaches. (lu.se)

The role of single-stranded DNA binding (SSB) protein during DNA replication in Escherichia coli cells has been studied, specifically the interactions between SSB and the χ subunit of DNA polymerase III in environments of varying salt concentrations. (wikipedia.org)
But the mechanics of how these proteins enter human cells were a scientific mystery. (scitechdaily.com)
In this way, the team identified a new small protein, growth inhibitor gene product (Gp) 0.6, which specifically targets and inhibits the activity of a protein essential to bacterial cells. (eurekalert.org)
Since bacterial and eukaryotic cells all contain compartmentalized membranes, a reversible system for breaking barriers establishes a mechanical strategy for precisely controlling cells. (harvard.edu)
The study's authors had previously identified such a protein, called BefA, secreted by gut microbes that could stimulate the proliferation of beta cells in zebrafish. (medicalnewstoday.com)
In the present study, the researchers further examined the mechanism through which BefA could facilitate the proliferation of pancreatic beta cells in young mice and zebrafish. (medicalnewstoday.com)
After invading host cells, C. burnetii releases a hitherto unknown protein, which the authors call mitochondrial coxiella effector F (MceF). (technologynetworks.com)
Reallocation of these proteins in cellular mitochondria enables mammalian cells to live longer even when they're infected with a very large bacterial burden," said Dario Zamboni, one of the corresponding authors of the article and a professor at the Ribeirão Preto Medical School (FMRP-USP). (technologynetworks.com)
Proteins must be folded correctly to fulfill their molecular functions in cells. (mpg.de)
Researchers at the Max Planck Institute of Biochemistry (MPIB) have demonstrated that actin, the most abundant protein in higher developed cells, does not have the inbuilt potential to fold and instead requires special assistance to fold into its active state. (mpg.de)
Actin is the most abundant protein in highly developed cells and has diverse functions in processes like cell stabilization, cell division and muscle contractions. (mpg.de)
Misfolded proteins can aggregate into toxic clumps, which damage cells and contribute to Alzheimer's and Parkinson's disease. (mpg.de)
The organization of bacterial cells is less complex than in higher developed cells. (mpg.de)
We know that bacterial cells are more sensitive to drugs than human cells, so we can target them without hitting human cells. (washington.edu)
Greater concentrations of YfdM or phage particles produced thicker demarcation lines between bacterial cells. (news-medical.net)

Because the proteins naturally reside in an aqueous environment inside a cell membrane, it took some creative chemistry to keep the approximately 2 billion isolated proteins functional on a solid surface. (sciencenews.org)
ABC transporters are membrane proteins that transport various substances from one side of the cell membrane to the other. (nanowerk.com)
This lays the foundation for the study of the whole membrane protein, which we are going to tackle next", says Professor Hofmann. (nanowerk.com)
The investigations were supported by the Protein Research Department at the RUB and funds of the collaborative research centre SFB 642 "GTP and ATP dependent membrane processes", whose speaker is Prof. Dr. Klaus Gerwert. (nanowerk.com)
These proteins are synthesized in the bacterial cytoplasm and cross one membrane into the bacterial periplasm. (anl.gov)
Autotransporter proteins then remain in an unfolded state in the periplasm until they pass through the outer bacterial membrane, folding properly along the way. (anl.gov)
Research has shown that the entire system consists of a protein complex that forms a large chamber that is anchored into the membrane. (diamond.ac.uk)

The research shows that Feronia detects the pathogen's attempts to hijack the jasmonic acid system and diminish a protein called MYC2 to fight off the disease. (isaaa.org)
The research, published last month in PNAS , was led by Prof. Udi Qimron of the Department of Clinical Microbiology and Immunology at TAU's Sackler Faculty of Medicine and conducted primarily by TAU researcher Shahar Molshanski-Mor. (eurekalert.org)
Led by Yoann Le Breton, the study's first author and a research assistant professor in McIver's group, the researchers discovered scfA and scfB by performing transposon sequencing on the entire group A Streptococcus genome. (scienceblog.com)
This research opens a new direction to develop preventative measures for neurodegenerative diseases by targeting bacterial curli production in the human gut. (hku.hk)
In one striking example, recent NIH-funded research conducted by researchers in the NeuroGenetics Research Consortium suggested that Corynebacterium helps cause Parkinson's disease, but only in people with a specific genotype. (washington.edu)
Army-funded research finds that a protein in birds' retinas is sensitive to earth's magnetic field thus guiding its migratory patterns. (army.mil)
Fluorescent proteins are likely one of the most famous research tools derived from bioprospecting. (openwetware.org)
Our research covers everything from protein structure to drug discovery. (ucl.ac.uk)
We pride ourselves in doing world-class research in the most collegial and collaborative environment, with emphasis on a positive research culture of mentoring and promoting equal opportunities for researchers at all levels. (ucl.ac.uk)
Recent graduates have become researchers at leading UK and international universities and research centres as well as taking senior roles in industry with companies such as Boehringer Ingelheim, Novartis, UCB-Celltech and Genzyme. (ucl.ac.uk)
The research team started by doing an analysis of the amino acid composition of four different TssA proteins. (diamond.ac.uk)
By identifying new TB proteins, this research may contribute to development of new methods for detecting TB, new tests for diagnosis of TB infection, and to TB vaccine development. (cdc.gov)

What made this so important to us is that the bacterial populations inhabiting different lung regions varied dramatically in terms of their antibiotic resistance and virulence," first author Peter Jorth from the University of Washington School of Medicine said in a statement. (genomeweb.com)
P. aeruginosa isolates from different lung regions exhibited different phenotypes, including virulence and resistance phenotypes, the researchers noted. (genomeweb.com)
Lead researcher at La Trobe University, Dr Begoña Heras, said the study provides unprecedented fundamental science that could inform future solutions to the world health crisis in antibiotic resistance 2 . (edu.au)
UAB researchers, based on a collection of clinical isolates from several countries, have established a link between the cell-to-cell communication system (the quorum sensing) and the virulence and resistance phenotypes in Stenotrophomonas maltophilia. (news-medical.net)

Novagen's pTriEx-1 vector contains bacterial, insect, and mammalian promoters. (the-scientist.com)

For example, a decade ago researchers from Macquarie University conducted a study that was "the first to. (icr.org)
In the current study, the researchers examined whether the BefA protein performed a similar function in mice. (medicalnewstoday.com)
Based on their finding of strong signals of genetic compartmentalization, regional isolates with similar protein expression profiles, and spatially distinct distribution of bacterial phenotypes, the researchers said that their study indicates that isolation in different lung regions helped drive the diversification of P. aeruginosa in the lungs of cystic fibrosis patients. (genomeweb.com)
The study of actin is the first description of a non-folder protein. (mpg.de)
Our study opens up uncharted territory of protein characteristics", says MPIB director F.-Ulrich Hartl. (mpg.de)
In a study published by The Lancet Global Health, researchers recorded antibiotic use for 2000 patients who did or did not receive the rapid test. (pharmacytimes.com)
The study provides important evidence for simple solutions in antibiotic stewardship programs," researcher Nguyen Van Kinh, MD, PhD, concluded. (pharmacytimes.com)
Researchers at the Max Planck Institute for Chemical Ecology and the University of Pretoria have now been able to show in a new study that this defense is also effective to some extent against the widespread and detrimental fungus Sclerotinia sclerotiorum . (mpg.de)

The Bochum researchers have now dynamically tracked the ATP splitting, called hydrolysis, for the first time in the fat transporter MsbA from the bacterium Escherichia coli. (nanowerk.com)
More recently, researchers engineered strains of E. coli and yeast with the capacity to produce taxidene and other isoprenoid compounds [ 4 ][ 6 ]. (openwetware.org)

To make the solar cell, a team of biologists and engineers led by Marc Baldo of the Massachusetts Institute of Technology (MIT) harvested photosynthetic proteins from spinach and the bacterium Rhodobacter sphaeroides and deposited the proteins onto a glass support. (sciencenews.org)

The clarification of the physical properties of the FliG protein in motors is a significant breakthrough in our understanding of the molecular mechanism that switches the direction of rotation of motors, suggesting ways to create compact motors with higher energy conversion efficiency," said Homma. (phys.org)
Molecular assistants called chaperones help proteins exploit their inbuilt folding potential and reach the correct three-dimensional structure. (mpg.de)
Newly-synthesized proteins at the ribosomes are not yet able to fulfill their molecular functions in the cell. (mpg.de)
Nascent proteins are protected from intermolecular interactions that would hamper their folding by chaperones, molecular folding assistants. (mpg.de)
The researchers' approach, which introduces covalent guanine quantum defect chemistry as a potential design concept for biosensors, has broad application and allows molecular sensors to be created without impairing fluorescence in the NIR. (photonics.com)
The defect also acted as a molecular handle, which enabled the researchers to introduce a detection unit into the sensor, that can be adapted to a target molecule for the purpose of identifying a specific viral or bacterial protein. (photonics.com)
The experiment shows that the setup, based on JUNGFRAU detector and Jungfraujoch data-acquisition system, can provide a molecular moving picture of up to 500 microseconds in resolution of protein dynamics - providing ten times finer details than the previously available method. (lu.se)

As the bacterial pathogen tries to trick the plant, the Feronia protein sees through the ploy and counteracts the pathogen. (isaaa.org)
We thus endeavor to understand how the pathogen adapts to the host microenvironment, what selective pressures are acting on the pathogen in each microenvironment, what bacterial factors are responsible for the host damage, and how the immune system is evaded. (cdc.gov)

So we systematically screened for such proteins in the bacterial viruses for over two and a half years. (eurekalert.org)
While TAs have a variety of functions, one function that has recently stepped into the limelight recently is a role in defence against bacterial viruses, bacteriophages. (lu.se)

Because this was derived from a commensal bacterium in a plant source, it may have application as an agricultural product to prevent bacterial infection in plants and crops. (nd.edu)
For this reason, specialists are interested in anticipating a protein abnormal to the host organism in the carrier bacterium so that a drug can be developed in time. (custom-essay.org)

In the meantime, patients are often extremely ill, so doctors may administer a course of broad-spectrum antibiotics (strong medications that can eliminate a range of bacterial classes) as a temporary solution. (labroots.com)

They are commonly referred to as histone-like and have many similar traits with the eukaryotic histone proteins. (wikipedia.org)
In these high salt concentrations, the eukaryotic histone protein is eluted from a DNA solution in which single stranded DNA is bound covalently to cellulose. (wikipedia.org)

Images of a protein involved in creating a potent antibiotic reveal the unusual first steps of the antibiotic's synthesis. (phys.org)

It blocks a receptor, CD14, which plays a key role in detecting bacterial substances and initiating the immune response. (lu.se)
These organisms digest proteins, and several fetid substances arise, leading to bad breath. (medscape.com)
These organisms usually enjoy proteins, and as they digest proteins several fetid substances arise. (medscape.com)

Samples were tested for cytokine production, markers of gut barrier integrity, metabolite profiles, and analysis of the fecal proteins (fecal proteomics). (medscape.com)

C-reactive protein (CRP) is a marker of inflammation that is naturally present in the plasma at levels that may rise due to inflammatory processes, associated with a greater risk of cardiovascular events such as acute myocardial infarction. (bvsalud.org)
Periodontitis is a chronic infection capable of inducing an inflammatory response that increases the level of proteins during the acute phase, such as C-reactive protein, and considering that these proteins are independent risk factors for cardiovascular diseases, this could explain the connection between periodontal disease and heart disease that is, periodontal diseases increase the risk of cardiovascular diseases. (bvsalud.org)

Since bacterial binding proteins have a diversity of functions, it has been difficult to develop a common function for all of them. (wikipedia.org)
Using that sequencing data, the researchers also examined the genetic diversity of the P. aeruginosa from these three patients. (genomeweb.com)
In two recent bioinformatics-driven studies, Virus centre-affiliated researchers Gemma Atkinson and Vasili Hauryliuk took a closer look at the unexplored diversity of toxin-antitoxin (TA) systems (1,2). (lu.se)

We were surprised that LecB does not contribute to the activation of growth factor signaling pathways, but that it triggers this silent internalization of receptors without activation," says Alessia Landi, one of the researchers from the University of Freiburg and the paper's first author. (chemeurope.com)
With the growth of the structure database, such modelling becomes possible for more and more proteins. (custom-essay.org)
UCL is home to one of the largest concentrations in Europe of researchers in the exciting growth field of Bioinformatics and Computational Biology. (ucl.ac.uk)

In other words, the BefA proteins secreted by gut microbes in humans and zebrafish share a similar structure and function. (medicalnewstoday.com)
In particular, the TAP1 and TAP2 proteins aid the function of MHC class I proteins . (medlineplus.gov)
When studying protein function, researchers must often express a protein of interest in different systems for different applications. (the-scientist.com)
This essay on Predicting Bacterial Proteins' Structure and Function was written by a student just like you. (custom-essay.org)
Variation is not normally desirable in proteins that have an essential function, if you have a recipe that works, it's not a good idea to suddenly change a significant part of it. (diamond.ac.uk)
This raised some questions, what does the TssA protein do and what effect do these variations have on the function? (diamond.ac.uk)
How does the TssA protein function? (diamond.ac.uk)
Albumin is also very beneficial to gut barrier function," added the researcher. (medscape.com)
Since protein structure is more conserved over evolutionary timescales than its amino acid sequence, reliable structure prediction by AlphaFold has revolutionised our ability to predict protein function. (lu.se)

However, researchers have confirmed that the types of B. pertussis that cause the most illness in the United States are missing pertactin. (cdc.gov)
For this work, they turned to the N-terminal passenger domain of the pertactin virulence protein from Bordetella pertussis, a typical autotransporter. (anl.gov)

However, unlike the other components of the harpoon, there are distinct variants of the TssA protein that contain radically different amino acid sequences at one end of the protein. (diamond.ac.uk)

The researchers led by Prof. Dr. Eckhard Hofmann and Prof. Dr. Klaus Gerwert from the Biophysics Department report on the results in the current issue of the Journal of Biological Chemistry ( 'Time-resolved Fourier Transform Infrared Spectroscopy of the Nucleotide-binding Domain from the ATP-binding Cassette Transporter MsbA' ). (nanowerk.com)
A broadband cavity-enhanced absorption spectrometer probes the magnetic sensitivity of photochemical reactions in cryptochrome proteins that may be a long-sought sensor for biological navigation. (army.mil)
The authors believe their work will provide important information toward understanding basic questions of protein folding and tests long-held theories about how this remarkable biological process works. (anl.gov)

Using this method, researchers can track minute changes in the protein in the range of nanoseconds. (nanowerk.com)
Detectable changes in the protein would be decoded to indicate the strength and direction of the magnetic field, and thus the navigational position on Earth. (army.mil)

Researchers from the University of Washington School of Medicine dissected 10 pairs of lungs from cystic fibrosis patients - obtained after lung transplantation - and examined some 12,000 isolates of Pseudomona aeruginosa inhabiting various lung regions. (genomeweb.com)

Anatomy16

Organisms26

Diseases1

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment34

Psychiatry and Psychology8

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20232

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Structural4

Cells15

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