• Moreover, genetic and simple obesity share similar structural and functional features of dysbiosis, such as higher production of toxins with known potential to induce metabolic deteriorations (e.g. trimethylamine-N-oxide and indoxyl sulphate), higher abundance of genomes containing genes coding enzymes involved in the production of these toxic co-metabolites and higher abundance of pathways for biosynthesis of bacterial antigens (such as endotoxin) [13-15]. (deepdyve.com)
  • Scientists of the Luxembourg Centre for Systems Biomedicine (LCSB) and the Life Science Research Unit (LSRU) of the University of Luxembourg, in collaboration with US researchers, have now succeeded for the first time in determining key functional genes and the organisms encoding these in such ecological systems, working from extensive data of bacterial genetics and bacterial metabolism. (sciencedaily.com)
  • These are typically not the most abundant species but far more important are organisms carry copies of distinct, essential genes -- researchers here speak of "keystone genes" -- which are also transcribed disproportionately often. (sciencedaily.com)
  • Armed with this knowledge, the researchers then went about first identifying "keystone genes" and linking these to keystone species. (sciencedaily.com)
  • The identified genes and species fulfil essential functions in the ecosystem," Paul Wilmes explains: "Many metabolic pathways and species are dependent on them. (sciencedaily.com)
  • Functional annotation tools such as Rapid Annotation using Subsystem Technology (RAST) or Kyoto Encyclopedia of Genes and Genomes (KEGG) don't always agree on how to best leverage them for metabolic modeling. (energy.gov)
  • It is quite common for functional annotation tools to disagree on the function that should be assigned to certain genes, and this uncertainty can have significant consequences on the resulting metabolic networks and the behavior they predict for the organism. (energy.gov)
  • Once reaction probabilities are associated with all the genes in a genome, researchers can then sample from those probabilities to create an ensemble of metabolic models (Medlock, Moutinho, and Papin 2020). (energy.gov)
  • After performing the RNA sequencing , the researchers used a computational model to systematically identify nearly 5,000 genes involved in PSP in relevant brain cells. (rna-seqblog.com)
  • In the end, the researchers "ranked," or prioritized, 11 high-confidence genes that are unusually elevated in human PSP brains and this model. (rna-seqblog.com)
  • Among the 11 high-confidence genes, researchers found that reducing the levels of DDR2 , KANK2 and STOM showed the most promise in reversing disease and as leading targets for therapeutic development. (rna-seqblog.com)
  • We are seeking a postdoctoral researcher, Research Associate, to study the molecular, physiological, and omics responses to drought in the field pennycress ( Thlaspi arvense ) to uncover the genes and pathways that control acclimation to drought and use them to engineer drought resistant plants. (vacancyedu.com)
  • Such annotations in majority provide information about the function of genes and gene families but not necessarily in association to the gene expression, metabolic and regulatory networks. (oregonstate.edu)
  • RiceCyc version 3.3 features 316 pathways and 6,643 peptide-coding genes mapped to 2,103 enzyme-catalyzed and 87 protein-mediated transport reactions. (oregonstate.edu)
  • The RiceCyc database is hierarchically browsable from pathway diagrams to the associated genes, metabolites and chemical structures. (oregonstate.edu)
  • As a case study to demonstrate the use of RiceCyc network as a discovery environment we carried out an integrated bioinformatics analysis of rice metabolic genes that are differentially regulated under diurnal photoperiod and biotic stress treatments. (oregonstate.edu)
  • When the researchers compared gene expression between the two groups of cells, they found thousands of genes that were either more or less active. (tunisiesoir.com)
  • Many of these genes appeared to work together in large-scale networks and were associated with stress response signaling pathways and metabolic pathways, underlining the importance of these processes in the circadian cycle. (tunisiesoir.com)
  • Rather than differences in the DNA sequence of genes themselves that caused them to be more or less active, the researchers found that their activity hinged on chemical modifications to the DNA of the genes known as DNA methylation. (tunisiesoir.com)
  • All told, the researchers inserted five separate genes into E. coli bacteria, forcing the bacteria to ferment glucose and produce the desired medium-chain fatty acid. (thescitech.com)
  • BioCyc is a massive encyclopedic reference on microbial genes, metabolites, and pathways that integrates information from many sources. (uc.edu)
  • We also integrated six data sets describing 16,119 observations of the growth of single-gene knockout mutants of E. coli K-12 into EcoCyc, which are relevant to antimicrobial drug design, provide clues regarding the roles of genes of unknown function, and are useful for validating metabolic models. (edu.au)
  • The undergraduate student(s) will use these prioritized candidate genes to test their requirement for mitochondrial bioenergetics by placing the gene(s) in the metabolic pathway by using biochemical and molecular genetic techniques. (tamu.edu)
  • Metabolomics uses sophisticated analytical chemistry techniques, combined with software that provides computational methods, to reconstruct cellular pathways of interest. (ddw-online.com)
  • helped create a community of metabolomics researchers. (duke.edu)
  • However, many of the processes by which cells execute these conversions remain mysterious to researchers. (boisestate.edu)
  • Warner also will be learning how to culture bacteria in an oxygen-free environment from NREL, which is an industry pioneer in the field of culturing, engineering and examining the metabolic processes of anaerobic bacteria. (boisestate.edu)
  • This helps them figure out the roles of different proteins and piece together the different players in molecular pathways and processes. (salk.edu)
  • Virtually every area of life science research will benefit in some way from increased knowledge of the metabolic networks that underlie their relevant cellular processes. (ddw-online.com)
  • By understanding the metabolic processes at work in cancer, it is possible to develop new therapies capable of treating the disease in an effective and innovative way. (waset.org)
  • Now, a multidisciplinary team of researchers at UCLA has developed a "roadmap" of the complex signaling processes involved in cancer that could lead to new methods for diagnosing and overcoming such drug resistance. (uclahealth.org)
  • The researchers' knowledge of the complex metabolic processes of the cells has so far been fragmented and inadequate. (sciencenews.dk)
  • Papin suggests that the model developed using Chlamydomonas can be used to identify which metabolic processes are particularly important for use as a biofuel. (springernature.app)
  • The behavioural and biological responses of a child to the obesogenic environment can be shaped by processes even before birth, placing an even greater number of children on the pathway to becoming obese when faced with an unhealthy diet and low physical activity. (who.int)
  • If a newly discovered protein interacts with lots of other proteins involved in cellular metabolism, for instance, researchers can deduce that's a likely role for the new protein and potentially target it for treatments related to metabolic dysfunction. (salk.edu)
  • Don't miss out on the opportunity to network with fellow researchers, explore the latest advancements in cancer metabolism, and present your own research. (waset.org)
  • 2023 promises to be an exciting year for researchers and clinicians alike, as conferences on the topic of cancer metabolism begin to take shape. (waset.org)
  • Cancer metabolism is an emerging field of study that examines the biochemical pathways which fuel the growth and spread of cancer cells and how they respond to treatments. (waset.org)
  • The upcoming conferences on cancer metabolism in 2023 aim to bring researchers from all over the world together to share their work and knowledge in a constructive environment. (waset.org)
  • The 2024 Cancer Metabolism Conferences are essential for healthcare professionals and researchers alike. (waset.org)
  • Lane is among the vanguard of researchers asking why the Krebs cycle, the "perfect circle" at the heart of metabolism, remains so elusive more than eighty years after its discovery. (semcoop.com)
  • It is a snapshot of the substrates, metabolites, enzymes, reactions and pathways of primary and intermediary metabolism in rice. (oregonstate.edu)
  • To construct this consensus model, the researchers combined three existing models for CHO metabolism. (sciencenews.dk)
  • Uniting researchers from the U.S. and the UK, the team draws together a unique set of expertise - including cancer, metabolism, neuroendocrinology, immunology and more. (pbrc.edu)
  • Metabolic network reconstruction of Chlamydomonas offers insight into light-driven algal metabolism. (springernature.app)
  • Our central hypothesis is that cachexia is driven by the tumor, which activates neurohormonal sickness pathways that lead to anorexia, metabolic dysfunction and tissue wasting," Dr. White said. (pbrc.edu)
  • Importantly, individuals with the mutant HD gene suffer from psychiatric symptoms and metabolic dysfunction many years before onset of typical motor symptoms. (lu.se)
  • BioCyc Pathway/Genome Databases (PGDB) describe the genome of an organism, as well as its biochemical pathways and (for a small fraction of organisms) its regulatory network. (uc.edu)
  • A new mapping method let researchers discover new links (gray lines) between two groups of plant proteins (yellow and blue) that have a common structure (the BBX domain), suggesting many different combinations of interactions, rather than a few, are involved in coordinating cellular programs like flowering time and circadian rhythm. (salk.edu)
  • The contributors first discuss the new research framework in terms of theoretical foundations and then take up the relevance of a systems approach, reviewing such topics as nonlinearity, recurrence after treatment, the cellular attractor concept, network theory, and noncoding DNA-the "dark matter" of our genome. (mit.edu)
  • The book provides a comprehensive guide to the mathematical modeling of complex biological systems, including cellular biophysics, gene regulatory networks, metabolic pathways, neural networks, and epidemiology. (sanfoundry.com)
  • The sets of compounds that can support growth of an organism are defined by the presence of transporters and metabolic pathways that convert nutrient sources into cellular components and energy for growth. (edu.au)
  • The REU student will aid in elucidating plant immune signaling networks using genetic, genomic, cellular, and biochemical approaches. (tamu.edu)
  • Mapping this network of interactions, or "interactome," has been slow going in the past because the number of interactions that could be tested at once was limited. (salk.edu)
  • Until now, researchers have typically relied on standard high-throughput yeast two-hybrid (Y2H) assays to determine the interactions between proteins. (salk.edu)
  • Gut microorganisms are the source of many bioactive products that play key functions in human host pathways and microbe-microbe interactions [2]. (deepdyve.com)
  • Intricate network interactions between the Endocrine system and metabolic signalling pathways drive these positive adaptations. (fmpa.co.uk)
  • The µBiospheres Science Focus Area (SFA) at LLNL investigates metabolic interactions in bioenergy-relevant microbial communities. (energy.gov)
  • In the scientific journal Microbiome, the researchers describe that the bacterial community is primarily controlled by the host organism during the early stages of life, while bacteria-bacteria interactions play the lead role in subsequent development. (innovations-report.com)
  • A range of asthma topics were discussed such as the effect of different metabolic pathways, immune cell interactions and clinical biomarkers. (balr.co.uk)
  • The central aim of my research is to elucidate the molecular mechanism, translational remodeling, proteinproteoform networks & proteomic pathways, and metabolic fingerprints involved in nutrientresponse and multi-host resistance and to identify key proteins for modifying such traits in plants using proteome scale analyses of organeller, quantitative and PTM proteomics and system biology. (hupo.org)
  • Whitney Edwards et al, Quantitative proteomic profiling identifies global protein network dynamics in murine embryonic heart development, Developmental Cell (2023). (medicalxpress.com)
  • In a study published March 29 in the journal Science Signaling, the team demonstrates their use of network-scale proteomic experiments and mathematical analyses to build a "system-wide" view of how signaling mutations cause leukemia and to identify points of susceptibility that can be targeted by "cocktail" therapies to prevent drug resistance. (uclahealth.org)
  • These complex networks of chemical reactions convert small molecules - metabolites - into fundamental energy and chemical building blocks, such as proteins, lipids and nucleic acids. (boisestate.edu)
  • The model is called iCHO1766 and includes 6643 metabolic reactions and 2341 unique metabolites such as the products or intermediate molecules. (sciencenews.dk)
  • 2018). In previous work, researchers developed a set of KBase apps to import, compare, and merge functional annotations from a wide range of different functional annotation tools into KBase for metabolic modeling to achieve significantly improved metabolic models. (energy.gov)
  • A dding fuel to the fire, there is early evidence that directing the metabolic programming of immune cells may improve the efficacy and durability of immunotherapies that are completely agnostic to cancer's genetic drivers. (ddw-online.com)
  • The researchers conclude from this that the host - presumably through its innate immune system - controls the composition of the original colony. (innovations-report.com)
  • They address topics such as biochemical networks, gene regulation, signaling pathways, and the immune system. (sanfoundry.com)
  • It is responsible for various metabolic functions such as the immune response of cells and neural regulation. (technologynetworks.com)
  • In a new paper published in Nature Communications , Mayo researchers and collaborators outline new therapeutic targets that may lead to potential future treatments for PSP, as well as Alzheimer's disease and related disorders. (rna-seqblog.com)
  • Lipid storage diseases (also known as lipidoses) are a group of inherited metabolic disorders in which harmful amounts of fatty materials (lipids) accumulate in various cells and tissues in the body. (nih.gov)
  • These include cancer drugs, blood proteins, enzymes for metabolic disorders, vaccines and various human hormones. (sciencenews.dk)
  • The analysis of publicly available rice transcriptome datasets led to the hypothesis that the complete tryptophan biosynthesis and its dependent metabolic pathways including serotonin biosynthesis are induced by taxonomically diverse pathogens while also being under diurnal regulation. (oregonstate.edu)
  • The team is now developing a set of tools to deal with these disagreements in a more systematic manner: by calculating the likelihood of metabolic reactions given the annotations from various sources, and then carrying those reaction likelihoods through into the modeling results. (energy.gov)
  • This rigorous validation effort has also led to some significant improvements in the ModelSEED biochemistry database, beyond the well-curated set of template reactions that are normally used by KBase's metabolic modeling engine. (energy.gov)
  • Enzymes in Swissprot have historically been annotated using Enzyme Commission (EC) numbers, which are far from ideal when needing to map to unique metabolic reactions for modeling. (energy.gov)
  • The team is building support into the Ontology application programming interface (that translates from EC numbers and other annotation vocabularies to ModelSEED reactions) to filter out unbalanced, overly generic, or otherwise unsuitable reactions for metabolic modeling. (energy.gov)
  • The added enzymatic reactions were independent of, or orthogonal to, the bacteria's own enzyme pathways, which worked better than trying to tweak the bacteria's complex metabolic network. (thescitech.com)
  • We can then add or remove reactions and pathways from the Chlamydomonas metabolic network to generate metabolic models specific for the new species," explains Salehi-Ashtiani. (springernature.app)
  • Any reactions or pathways that are not present in Chlamydomonas will be added to the model, and those that are present in Chlamydomonas but not in the new species will be removed. (springernature.app)
  • However, researchers at NREL have found a strain of bacteria that could 'fix' CO 2 and convert it to a precursor for plastics as well. (boisestate.edu)
  • In other words, understanding the pathways within the cells, and combining strains of cultivated bacteria to maximize their best properties, can help researchers design better bacteria. (boisestate.edu)
  • The oral microbiome is composed of a huge number of bacteria and their metabolic activity can cause diseases such as dental caries, periodontitis and bad breath," he said. (asianscientist.com)
  • We want to understand how tomato plants regulate cell death pathways to confer resistance to these bacteria. (tamu.edu)
  • The BioCyc Microbial Genomes and Metabolic Pathways Web Portal is coming to the University of Cincinnati. (uc.edu)
  • Therefore, the tasks of (a) integrating under a single database environment regulatory metabolic networks and existing models, and (b) building tools to help with modeling and analysis are desirable and intellectually challenging computational tasks. (biomedcentral.com)
  • Computational Modeling of Biological Systems: From Molecules to Pathways (Biological and Medical Physics, Biomedical Engineering)" Book Review: This book is a valuable resource for those interested in biological and medical physics, biomedical engineering and related fields. (sanfoundry.com)
  • The book provides a comprehensive overview of the latest computational modeling techniques used to understand biological systems, from the molecular level to complex pathways. (sanfoundry.com)
  • Mathematical Modeling of Biological Systems, Volume II" Book Review: This book is a valuable resource for researchers, professionals, and students in the interdisciplinary field of applied mathematics, computational biology, biochemistry, and medicine. (sanfoundry.com)
  • We then analyze the resulting large-scale, quantitative data using computational algorithms to identify the informative patterns within the network of events. (uclahealth.org)
  • A collection of known nutrient sources can therefore serve both as an impetus for investigating new metabolic pathways and transporters and as a reference for computational modeling of known metabolic pathways. (edu.au)
  • When cells are positive for a protein interaction, the researchers can use genetic sequencing to figure out what the two proteins interacting are, using new high-throughput DNA sequencing technologies similar to those used for human genome sequencing. (salk.edu)
  • Background: Researchers use various types of functional annotations often provided by the large plant genome annotation projects. (oregonstate.edu)
  • Conclusions: Here we describe the RiceCyc network development and discuss its contribution to rice genome annotations. (oregonstate.edu)
  • The BioCyc web portal from SRI International contains genome and metabolic-pathway information for over 10,000 microbes. (uc.edu)
  • Kourosh Salehi-Ashtiani, a biotechnologist at New York University Abu Dhabi (NYUAD), has helped develop the first genome-scale metabolic model for an algal species. (springernature.app)
  • The team plan to sequence the genome of promising algae species and define the metabolic connections. (springernature.app)
  • The new approach, published June 26 in Nature Methods , lets researchers test millions of relationships between thousands of proteins in a single experiment. (salk.edu)
  • The interactome of a cell, like a map of social networks, lets scientists see who's working with who in the world of proteins. (salk.edu)
  • Researchers at the UNC School of Medicine, UNC McAllister Heart Institute, and the UNC Lineberger Comprehensive Cancer Center characterized the expression of thousands of cardiac proteins during eight critical stages of embryonic heart development. (medicalxpress.com)
  • Researchers can use this as the blueprint to figure out the specific pathways or proteins contributing to congenital heart disease. (medicalxpress.com)
  • Their findings can now be used to determine when particular proteins and molecular pathways are active during specific stages of heart development. (medicalxpress.com)
  • Surprisingly, analysis of the cardiac proteome revealed that proteins in the mevalonate pathway , an essential metabolic pathway, are highly expressed midway through heart development. (medicalxpress.com)
  • Proteins function as the main components of the physiological metabolic and signaling pathways of cells. (uclahealth.org)
  • In particular, we use mass spectrometry-based proteomics to measure the activity of proteins involved in mediating the signals that cause cancer cells to grow uncontrollably," said Liudmilla Rubbi, a researcher at UCLA's Crump Institute who helped design the project. (uclahealth.org)
  • This model will allow researchers to design better CHO cells optimized for production of therapeutic proteins, which could result in lower prices and greater availability of many drugs," explains corresponding author and Assistant Professor Nathan Lewis from The Novo Nordisk Foundation Center for Biosustainability working at the University of California, San Diego. (sciencenews.dk)
  • With this combination of metagenomics, metatranscriptomics and metaproteomics, we were able to reconstruct the metabolic networks of the community at a given point in time," says Dr. Anna Heintz-Buschart, LCSB scientist and first author of the publication. (sciencedaily.com)
  • Arnaud Belcour's PhD defense on "Combining knowledge-based and sequence comparison approaches to elucidate metabolic functions, from pathways to communities" will take place on Friday 21st october 2022 at 14:00, room Métivier at IRISA. (irisa.fr)
  • In the hands of skilled scientists, these tools are revealing changes in metabolic pathways that are providing new insights into disease progression. (ddw-online.com)
  • A new study offers insights into this metabolic limbo that might eventually prove medically useful in preserving human tissue after trauma or during long periods of inactivity (by decreasing energy and oxygen demands)-if scientists can find the genetic pathways responsible for these shifts. (scientificamerican.com)
  • They are part of the Cancer Cachexia Action Network (CANCAN), a team of scientists led by Eileen White, PhD, Deputy Director of the Rutgers Cancer Institute of New Jersey and Associate Director, Ludwig Princeton Branch, Ludwig Institute for Cancer Research. (pbrc.edu)
  • PathCase-SB aims to integrate systems biology models data and metabolic network data of selected biological data sources on the web (currently, BioModels Database and KEGG, respectively), and to provide more powerful and/or new capabilities via the new web-based integrative framework. (biomedcentral.com)
  • Instead, PathCase-SB relies on (a) freely available (and curated-only) models in BioModels Database and CellML model repository to populate its model database, and (b) pathways from KEGG pathways data source [ 6 ], obtained via a license, to populate its pathways database. (biomedcentral.com)
  • This project is developing tools for the DOE Systems Biology Knowledgebase (KBase) to give users a principled way to weigh multiple sources of functional annotation against each other, enable better metabolic modeling of hard-to-annotate organisms and pathways, allow analysis of uncertainty in the resulting models network structure or behavior, and provide an infrastructure on which to build more sophisticated machine learning techniques in KBase. (energy.gov)
  • It could also help researchers better understand how organisms maintain flexibility in situations that strain the circadian clock, such as jet lag. (tunisiesoir.com)
  • BioCyc provides executable metabolic models for a small but growing set of organisms. (uc.edu)
  • Leaders in the field will review exciting advances in topics such as metabolic reprogramming in cancer, epigenetic alterations, and metabolic biomarkers. (waset.org)
  • Researchers like Jose U. Scher, MD, director of the Psoriatic Arthritis Center at New York University and the NYU Colton Center for Autoimmunity, are in the thick of using multiple "-omics" tools and other sophisticated technologies to identify new targets and biomarkers. (medscape.com)
  • It was very insightful to hear other researchers' views on the current stance in biologic therapy, particularly as myself and other members of my group are involved in research in this area. (balr.co.uk)
  • Other biologic pathways, yet to be defined, also play a role. (nih.gov)
  • The future of molecular therapies, researchers say, relies on targeting multiple events simultaneously, making it exponentially more difficult for tumor cells to develop the mutations required to escape the effect of drug therapy. (uclahealth.org)
  • We plan to explore the systemic metabolic imbalance between tumor and host, the role of inflammation in controlling appetite, and the potential of dietary and pharmacological interventions. (pbrc.edu)
  • Environmental factors, including air and noise pollution, and the built environment, are typically associated with cardiovascular and metabolic non-communicable diseases (NCDs), e.g. obesity, type 2 diabetes, heart diseases and atherosclerosis. (europa.eu)
  • While researchers have tried for years to learn about the microorganisms that cause these oral diseases, Takahashi was able to identify the metabolic pathways, networks and activities of representative oral microorganisms and actual oral biofilms. (asianscientist.com)
  • Being one of the pioneering proteomics groups in Taiwan, Yu-Ju Chen has devoted her efforts to develop new mass spectrometry-based platforms for membrane proteome and post-translational modificom and their application to delineate the proteome network in biology and diseases. (hupo.org)
  • The study of metabolic impairments in neuropsychiatric diseases including depression, schizophrenia and Alzheimer's disease. (duke.edu)
  • Dr. Ivan Koludarov, a researcher at the Chair for Bioinformatics and a first author of the study says: "It is inferred from previous studies that snakes diverged from other lizards around 120 million years ago. (technologynetworks.com)
  • I was contacted to make a survey of the current status of the bioinformatics and compu- tational biology efforts within the groups and researchers with connections to SWEGENE facilities. (lu.se)
  • Integration of metabolic pathways resources and metabolic network models, and deploying new tools on the integrated platform can help perform more effective and more efficient systems biology research on understanding the regulation of metabolic networks. (biomedcentral.com)
  • Edwards and colleagues also found that the mevalonate pathway has close ties with a particular signaling protein called Yap, which is incredibly important in the function and regulation of cardiac development, homeostasis, and regeneration. (medicalxpress.com)
  • These hormones regulate the body's growth, and are involved in cell to cell communication, control metabolic activity, sleep-wake homeostasis, and altered regulation or dysregulation of adaptive response in various physiologic and pathophysiologic states. (medscape.com)
  • Since her early career, Yu-Ju has played a key role to actively promote proteomics research and networking in Taiwan. (hupo.org)
  • Yu-Ju is happy to continue her enthusiasm and contribution to promoting education and training, networking, and translating proteomics into utility in the real world. (hupo.org)
  • RiceCyc, along with additional species-specific pathway databases hosted in the Gramene project, facilitates comparative pathway analysis. (oregonstate.edu)
  • The researchers modelled the metabolic network of the algae species Chlamydomonas reinhardtii , a popular species for studying molecular biology. (springernature.app)
  • The metabolic network model was developed into a computer simulation that can be used to estimate the effect of genetically engineering an algal species. (springernature.app)
  • Researchers could then explore other species that may perform that specific process more efficiently. (springernature.app)
  • In this way, the metabolic model that we have generated for Chlamydomonas will be used as a guide to generate models specific to the new species," he adds. (springernature.app)
  • Through their thorough analysis, the researchers determined that the mevalonate pathway regulates embryonic heart cell cycling and critical signaling molecules. (medicalxpress.com)
  • Nedergaard, M. A paravascular pathway facilitates the flow of cerebrospinal fluid through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. (ksusentinel.com)
  • Finally, they cover the dominant role of the tissue microenvironment in cancer, analyzing topics including altered metabolic pathways, the disease-defining influence on metastasis, and the interconnectedness of different environmental niches across levels of organization. (mit.edu)
  • They now believe that the pathway controls the cell's ability to divide and, therefore, may be essential for the overall growth of the developing heart. (medicalxpress.com)
  • which is a network of fibers that make up the cell's structural framework. (medlineplus.gov)
  • Dynamics of Complex Interconnected Biological Systems (Mathematical Modeling)" Book Review: The book focuses on mathematical modeling to help researchers understand the behavior of interconnected biological systems. (sanfoundry.com)
  • However, a systems biological analysis of the lipidome, by incorporating pathway information remains challenging, leaving lipidomics behind compared to other omics disciplines. (mdpi.com)
  • Mathematical Modeling of Biological Systems, Volume I" Book Review: This book is aimed at advanced students, researchers, and practitioners in the rapidly growing field of mathematical modeling in the biological sciences. (sanfoundry.com)
  • This resource is an essential guide for advanced students, researchers, and practitioners in the field of mathematical modeling in biological systems. (sanfoundry.com)
  • BioCyc enables exploration of a vast set of biological networks. (uc.edu)
  • This FOA encourages applications to establish partnerships between researchers interested in a biological problem of significant scope and researchers providing high-throughput structure determination capabilities through the NIGMS PSI:Biology network. (nih.gov)
  • It is expected that these awards will lead to new collaborations between researchers emphasizing biological function and researchers emphasizing biological structure. (nih.gov)
  • LONGITOOLS will also allow researchers and policy makers to generate new knowledge - identifying the likely causal (direct and indirect) mechanisms through which exposures to man-made environmental factors affect the risk of NCDs. (europa.eu)
  • A thrilling tour of the remarkable stories behind the discoveries of some of life's key metabolic pathways and mechanisms. (mcnallyjackson.com)
  • That allows us to run it separately, and it uses less energy than it would if you use the native synthase pathway," Chang said. (thescitech.com)
  • It was very encouraging to have my work generate interest amongst senior and early career researchers and to receive valuable feedback that will be useful for the next steps of my project and final publication. (balr.co.uk)
  • We were able to identify metabolic pathways, which are specific to the initial colonisers as well as pathways that only play a role at a later stage," says Dr Johannes Zimmermann from CAU. (innovations-report.com)
  • Ongoing work will identify key molecular pathways and the critical neuronal circuitries affected early in the HD hypothalamus in order to develop disease modifying treatments. (lu.se)
  • After high-throughput analyses, in which we collect giant quantities of data, we can now infer community-wide networks on the computer. (sciencedaily.com)
  • Warner recently was awarded a two-year, $193,997 grant administered by the National Science Foundation's (NSF) Established Program to Stimulate Competitive Research (EPSCoR) program, which will allow her to partner with Colorado's National Renewable Energy Lab (NREL) and continue her work researching and demystifying the metabolic process in cells. (boisestate.edu)
  • NSF's EPSCoR program provides 30 non-tenured researchers across the nation with fellowships that put them in partnership with premier research centers, enhancing their ability to work at the frontiers of science and engineering. (boisestate.edu)
  • The Department of Food Science and Human Nutrition seeks a Research Associate (Postdoctoral Researcher) to work in Dr. Felicia Wu's research program. (vacancyedu.com)
  • EPIC is seeking a Postdoctoral Research Associate to work with an interdisciplinary team of scholars including Dr. Katharine Strunk and other EPIC faculty affiliates and researchers (including Dr. Tanya Wright and faculty at the University of Michigan) to evaluate the impacts and implementation of Michigan's early literacy policy, the Read by Grade Three Law. (vacancyedu.com)
  • Now researchers everywhere can work much more strategically in engineering CHO cells. (sciencenews.dk)
  • Awardee principal investigators will become part of the PSI:Biology Network Steering Committee and will work jointly with other investigators and NIH staff to manage the overall PSI:Biology initiative. (nih.gov)
  • Cancer Research from Technology Networks. (wikipedia.org)
  • For example, cancer, the quintessential genetic disease, is being redefined by metabolic abnormalities, endowing tumours with the ability to outcompete normal cells in the tumour microenvironment. (ddw-online.com)
  • These conferences will be the opportunity to discuss the latest advances in cancer research and therapies, while networking with peers in the field. (waset.org)
  • In this volume, leading researchers argue for a new theory framework for understanding and treating cancer. (mit.edu)
  • What we need is a 'big picture' perspective," said lead author Thomas Graeber, a professor of molecular and medical pharmacology and a researcher at UCLA's Crump Institute for Molecular Imaging , Jonsson Comprehensive Cancer Center and California NanoSystems Institute . (uclahealth.org)
  • Understanding this complex network of events is critical to designing new molecularly targeted anti-cancer therapies to simultaneously target the primary mutation while preventing the development of secondary, resistance-conferring mutations, and we now have additional tools to do this. (uclahealth.org)
  • Cachexia is a form of "metabolic mutiny" characterized by a dramatic loss of skeletal muscle and often accompanied by substantial weight loss, according to the National Cancer Institute. (pbrc.edu)
  • The project should involve both studies of protein function by the applicant researchers and structural studies by the PSI:Biology network. (nih.gov)
  • By combining annotations from multiple sources, researchers can achieve a more complete metabolic network reconstruction, greatly reducing the effort required to curate quality metabolic models (Griesemer et al. (energy.gov)
  • This course focuses on the methodological foundations which have become a prerequisite for researchers and practitioners working with network models. (hpu.edu)
  • An especially uncharted territory is the integration of statistical and network-based approaches for studying global lipidome changes. (mdpi.com)
  • Seeking to understand how a mother's health and diet during pregnancy can affect the children, researchers discovered, in mice, that a maternal high-fat diet disrupts the wiring of brain circuitry and fuels the development of excess body fat and other metabolic conditions in the offspring. (nih.gov)
  • The researchers first pinpointed a critical time for the dietary effects by feeding mice either standard chow or a high-fat diet during pregnancy and lactation. (nih.gov)
  • We have previously shown that hypothalamic changes occur early in clinical HD and we have established a causal relationship between hypothalamic huntingtin and the development of metabolic and psychiatric disturbances in mice. (lu.se)
  • While the cause isn't known, researchers have found that the deteriorating brain cells of people with PSP have excess amounts of a protein called tau. (rna-seqblog.com)
  • In this study, the researchers zeroed in on RNA , the carrier of genetic information in all living cells. (rna-seqblog.com)
  • When venom passes into a snakebite victim, it binds onto receptors on nerve and muscle cells and interrupts communication pathways between them. (technologynetworks.com)
  • When they isolated cells at the extremes of this range and grew them as clones in petri dishes, the researchers found that these cells maintained their periods. (tunisiesoir.com)
  • When the researchers dosed cells with a drug that increased this fluctuation in gene activity, it increased their circadian cycles by about 1.5 hours on average. (tunisiesoir.com)
  • The cells consume enough glucose to survive, but then alongside that, you have your pathway chewing through all the sugar to get higher conversions and a high yield. (thescitech.com)
  • In the offspring of mothers fed the high-fat diet during this stage of development, brain cells did not branch out normally to build a dense network of connections. (nih.gov)
  • The new model identifies, for the first time, the whole network of biosynthetic pathways in CHO cells. (sciencenews.dk)
  • When you design new cell lines with new metabolic functions, this is equivalent to widening the road system at desired places and closing unwanted roads, making sure that the traffic follows specific patterns. (sciencenews.dk)
  • A team of researchers has studied how the protein structure of snake venoms known as three-finger toxins (3FTxs) has changed over the course of evolution. (technologynetworks.com)
  • Searching for other sources for cell periodicity, the researchers examined the exact length of circadian cycles in the short- and long-period groups. (tunisiesoir.com)
  • For example, if researchers want to produce a specific antibody in a CHO cell, the model will tell them which signal paths are used in production and which growth conditions will probably yield the best results. (sciencenews.dk)